Article
Multidisciplinary Sciences
Anna Thulin, Carola Andersson, Elisabeth Werner Ronnerman, Shahin De Lara, Chaido Chamalidou, Arnd Schoenfeld, Aniko Kovacs, Henrik Fagman, Fredrik Enlund, Barbro K. Linderholm
Summary: This study aimed to investigate mutations in breast cancer brain metastasis, with TP53 and PIK3CA mutations being the most common, and mutations in other genes also identified. Discordant mutation patterns were found in some matched cases, indicating the need to develop methods for assessing mutational status in brain metastasis.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Jinggao Feng
Summary: This study reveals the correlation between p53 pathway-related genes and prognosis of colon cancer, as well as their role in regulating the tumor immune microenvironment.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Oncology
Kaouther Ben Arfi, Christophe Schneider, Amar Bennasroune, Nicole Bouland, Aurore Wolak-Thierry, Guillaume Collin, Cuong Cao Le, Kevin Toussaint, Cathy Hachet, Veronique Lehrter, Stephane Dedieu, Olivier Bouche, Hamid Morjani, Camille Boulagnon-Rombi, Aline Appert-Collin
Summary: This study found that high expression of DDR1 is associated with worse event-free survival in CRC patients, and it may play a role in the invasive properties of colon adenocarcinoma.
Article
Cell Biology
Jing Yuan, Tao Liu, Yuhong Zhang
Summary: Iron ion, as an essential microelement, plays a crucial role in cell proliferation, metabolism, and differentiation. This study identified the prognostic value of two iron metabolism-related genes (SLC39A8 and SLC48A1) in colon adenocarcinoma (COAD) and established a nomogram model to predict patient overall survival. Functional analysis showed differences in tumor microenvironment and immune cell infiltrate between low risk and high risk subgroups.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Zizhen Wu, Bo Wang, Yingjiang Ye, Shan Wang, Kewei Jiang
Summary: The study constructed a pyroptosis-related model to effectively predict the prognosis of colon cancer patients. It also explored the potential functions of pyroptosis-related genes and validated their differential expression in tumor and non-tumor tissues.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Ming Jin, Hui Zhang, Jun Yang, Zhen Zheng, Kaitai Liu
Summary: This study comprehensively examined the expression patterns and prognostic roles of FXYD family members in colon cancer using data from TCGA, revealing differential expression and prognostic significance for several members. Functional analysis showed involvement in cancer progression, while immune cell analysis indicated interactions with tumor immune infiltrating cells. The study provides insights for further research on the potential clinical utility of FXYD family as biomarkers for colon cancer.
Review
Obstetrics & Gynecology
Christina L. Rasmussen, Hanna K. Bertoli, Freja L. Sand, Alexander K. Kjaer, Louise T. Thomsen, Susanne K. Kjaer
Summary: This systematic review suggests that women with HPV- and p16-positive vaginal cancer have a better prognosis compared to those with HPV- or p16-negative vaginal cancer. Results for p53 were varied, and no definitive conclusion could be drawn. Further larger studies are needed to determine the prognostic impact of HPV, p16, and p53 in vaginal cancer.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Medicine, General & Internal
Jiang Yan, Chuming Zhu
Summary: This study showed that hyperuricemia is associated with poor prognosis and survival in patients with colon cancer. Tumor grade and stage were also identified as independent predictors for the prognosis of colon cancer patients. Further studies are needed to explore the cellular and molecular mechanisms underlying the prognostic value of hyperuricemia in colon cancer.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
German Calderillo-Ruiz, Horacio Noe Lopez-Basave, Wendy Rossemary Munoz-Montano, Maria Consuelo Diaz-Romero, Berenice Carbajal-Lopez, Carolina Castillo-Morales, Eloy Andres Perez-Yepez, Alejandra Albarran-Garcia
Summary: This study evaluated the impact of ileostomy complications on the adherence to adjuvant treatment and overall survival of colon cancer patients. The results showed that early stoma reversal can prevent severe complications and improve chemotherapy adherence and overall survival.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Surgery
Hao Zhang, Yunxiao Liu, Chunlin Wang, Zilong Guan, Hang Yu, Chao Xu, Mingyu Zheng, Yuliuming Wang, Hanqing Hu, Rui Huang, Guiyu Wang
Summary: A modified TNM staging system was constructed for stage I-III colon cancer patients with lymph nodes examined less than 12, using lymph node ratio to predict prognosis accurately. The mStage system showed superior predictive power compared to the conventional TNM staging system in predicting cancer-specific survival for these patients.
WORLD JOURNAL OF SURGERY
(2021)
Article
Oncology
Yunxiao Liu, Hao Zhang, Yuliuming Wang, Chunlin Wang, Huan Xiong, Yang Wang, Haoyu Jing, Xia Jiang, Hanqing Hu, Qingchao Tang, Guiyu Wang
Summary: This study found that in stage III colon cancer, the status or number of tumor deposits (TD) (mpN and npN) may be superior to the positive lymph nodes (pN) stage in assessing prognosis, emphasizing the importance of including TD information in the pN stage.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Nikhil Lal, Dedrick Kok Hong Chan, Minn E. Ng, Louis Vermeulen, Simon James Alexander Buczacki
Summary: High lymph node (LN) yield is predictive of overall and disease-free survival in non-metastatic colon cancer. There is no association between higher LN yield and increasing nodal positivity, but it is strongly linked with gene expression changes associated with the adaptive and dendritic cell immune response, especially in node-negative cancers. These findings were validated in an independent dataset.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Ruitong Xu, Bingrong Zhou, Ping Hu, Bingyan Xue, Danyang Gu, Xiaolin Li, Qiyun Tang
Summary: This study conducted a retrospective analysis of 1196 patients with colon neuroendocrine neoplasms, and developed and validated nomograms containing various clinically important parameters to predict the prognosis more accurately. The new nomograms showed superior performance in predicting overall survival and cancer-specific survival compared to the AJCC TNM classification.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Yixing Yang, Fengwen Ye, Tianxiang Xia, Qianwen Wang, Yujie Zhang, Jun Du
Summary: This study suggests that MICAL-L2 is a promising biomarker for determining prognosis and is correlated with immune infiltration levels in colon adenocarcinoma (COAD).
Article
Biochemistry & Molecular Biology
Doil Park, Ji Hoon Jung, Hyun Min Ko, Wona Jee, Hyungsuk Kim, Hyeung-Jin Jang
Summary: This study found that Cycloastragenol (CY) induces apoptosis through p53 activation and inhibits the proliferation of colon cancer cells. CY enhances p53 expression and is expected to have a synergistic effect when used in combination with existing treatments for colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Eva Rademaker, Esther Bastiaannet, Jan Oosting, Neeltje G. Dekker-Ensink, Peter J. K. Kuppen, Noel F. C. C. de Miranda, Gerrit J. Liefers
Summary: In this study of 651 colon cancer patients, it was found that beta 4 expression was not associated with worse clinical prognosis, but decreased with advanced pathological tumor stage. Future studies should further determine whether loss of beta 4 expression promotes invasive characteristics of colon cancer cells.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Letter
Gastroenterology & Hepatology
Diantha Terlouw, Frederik J. Hes, Manon Suerink, Arnoud Boot, Alexandra M. J. Langers, Carli M. Tops, Monique E. van Leerdam, Christi J. van Asperen, Steve G. Rozen, Emilia K. Bijlsma, Tom van Wezel, Hans Morreau, Maartje Nielsen
Article
Hematology
Paul G. Kemps, Timo C. E. Zondag, Helga B. Arnardottir, Nienke Solleveld-Westerink, Jelske Borst, Eline C. Steenwijk, Demi van Egmond, Joost F. Swennenhuis, Ellen Stelloo, Irene Trambusti, Robert M. Verdijk, Carel J. M. van Noesel, Arjen H. G. Cleven, Marijn A. Scheijde-Vermeulen, Marco J. Koudijs, Lenka Krskova, Cynthia Hawkins, R. Maarten Egeler, Jesper Brok, Tatiana von Bahr Greenwood, Karel Svoijr, Auke Beishuizen, Jan A. M. van Laar, Ulrike Poetschger, Caroline Hutter, Elena Sieni, Milen Minkov, Oussama Abla, Tom van Wezel, Cor van den Bos, Astrid G. S. van Halteren
Summary: Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder caused by somatic genetic alterations in hematopoietic precursor cells. LCH clinical manifestation is highly heterogeneous and the associations between BRAF and MAP2K1 mutations with clinical features are still not completely understood.
Article
Gastroenterology & Hepatology
Jessica Roelands, Manon Van der Ploeg, Marieke E. Ijsselsteijn, Hao Dang, Jurjen J. Boonstra, James C. H. Hardwick, Lukas J. A. C. Hawinkels, Hans Morreau, Noel F. C. C. de Miranda
Summary: Spatial profiling of pT1 CRC samples revealed the molecular and immunological landscape of early-stage colorectal cancer, identifying biomarkers associated with disease progression and targetable immune processes applicable in a clinical setting.
Article
Multidisciplinary Sciences
Natasja L. de Vries, Joris van de Haar, Vivien Veninga, Myriam Chalabi, Marieke E. Ijsselsteijn, Manon van der Ploeg, Jitske van den Bulk, Dina Ruano, Jose G. van den Berg, John B. Haanen, Laurien J. Zeverijn, Birgit S. Geurts, Gijs F. de Wit, Thomas W. Battaglia, Hans Gelderblom, Henk M. W. Verheul, Ton N. Schumacher, Lodewyk F. A. Wessels, Frits Koning, Noel F. C. C. de Miranda, Emile E. Voest
Summary: DNA mismatch repair-deficient (MMR-d) cancers with inactivation of beta 2-microglobulin (B2M) retained responsiveness to immune checkpoint blockade (ICB) and showed increased infiltration by gamma delta T cells expressing PD-1 and high reactivity to HLA-class-I-negative tumour cells. Dual PD-1 and CTLA-4 blockade increased the frequency of gamma delta T cells in B2M-deficient cancers, suggesting the potential of gamma delta T cells in cancer immunotherapy.
Article
Pathology
Anne-Sophie van der Werf-'t, Diantha Terlouw, Carli M. Tops, Merel S. van Kan, Liselotte P. van Hest, Hans J. P. Gille, Floor A. M. Duijkers, Anja Wagner, Ellis L. Eikenboom, Tom G. W. Letteboer, Mirjam M. de Jong, Sanne W. Bajwa-ten Broeke, Fonnet E. Bleeker, Encarna B. Gomez Garcia, Niels de Wind, J. Tom van Wezel, Hans Morreau, Manon Suerink, Maartje Nielsen
Summary: This study aimed to identify the various causes of the discordant phenotypes in MSH6-associated Lynch syndrome, including abnormal immunohistochemical staining and mutations in the mismatch repair genes. The results suggest that genetic analysis should be considered in colorectal cancer patients with a strong family history.
Article
Biochemistry & Molecular Biology
Jessica Roelands, Peter J. K. Kuppen, Eiman I. Ahmed, Raghvendra Mall, Tariq Masoodi, Parul Singh, Gianni Monaco, Christophe Raynaud, Noel F. C. C. de Miranda, Luigi Ferraro, Tatiana C. Carneiro-Lobo, Najeeb Syed, Arun Rawat, Amany Awad, Julie Decock, William Mifsud, Lance D. Miller, Shimaa Sherif, Mahmoud G. Mohamed, Darawan Rinchai, Marc Van den Eynde, Rosalyn W. Sayaman, Elad Ziv, Francois Bertucci, Mahir Abdulla Petkar, Stephan Lorenz, Lisa Sara Mathew, Kun Wang, Selvasankar Murugesan, Damien Chaussabel, Alexander L. Vahrmeijer, Ena Wang, Anna Ceccarelli, Khalid A. Fakhro, Gabriele Zoppoli, Alberto Ballestrero, Rob A. E. M. Tollenaar, Francesco M. Marincola, Jerome Galon, Souhaila Al Khodor, Michele Ceccarelli, Wouter Hendrickx, Davide Bedognetti
Summary: The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In this cohort study, comprehensive genomic analyses were performed on fresh-frozen samples from 348 patients with primary colon cancer. The study revealed a gene expression signature called Immunologic Constant of Rejection that outperformed conventional prognostic molecular biomarkers. Additionally, a favorable outcome was associated with a microbiome signature driven by Ruminococcus bromii.
Article
Gastroenterology & Hepatology
Quisette P. Janssen, Rutger Quispel, Marc G. Besselink, Bert A. Bonsing, Marco J. Bruno, Michael Doukas, Arantza F. Sarasqueta, Marjolein Y. V. Homs, Jeanin E. van Hooft, Geertjan van Tienhoven, Marie-Louise F. van Velthuysen, Joanne Verheij, Rogier P. Voermans, Johanna W. Wilmink, Bas Groot Koerkamp, Casper H. J. van Eijck, Lydi M. J. W. van Driel
Summary: This study evaluates the performance of endoscopic tissue acquisition procedures for borderline resectable and resectable pancreatic ductal adenocarcinoma (PDAC). The results show that EUS-guided tissue acquisition had a sensitivity of over 85% for both initial and repeat procedures, meeting international standards.
Article
Multidisciplinary Sciences
Nannan Guo, Na Li, Li Jia, Qinyue Jiang, Mette Schreurs, Vincent van Unen, Susana M. Chuva de Sousa Lopes, Alexandra A. Vloemans, Jeroen Eggermont, Boudewijn Lelieveldt, Frank J. T. Staal, Noel F. C. C. de Miranda, M. Fernanda Pascutti, Frits Koning
Summary: This study reveals the changes in immune subsets in the developing human foetal intestine, showing the sequential appearance of different types of immune cells between gestational weeks 14 and 22. The presence of immune subset-committed cells capable of local proliferation suggests their important role in the development of organized immune structures and potential influence on microbial colonization after birth.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Jitske van den Bulk, Manon van der Ploeg, Marieke E. Ijsselsteijn, Dina Ruano, Ruud van der Breggen, Rebekka Duhen, Koen C. M. J. Peeters, Arantza Farina-Sarasqueta, Els M. E. Verdegaal, Sjoerd H. van der Burg, Thomas Duhen, Noel F. C. C. de Miranda
Summary: Expression of CD103 and CD39 can specifically identify neoantigen-specific CD8(+) T cells in colorectal cancers (CRCs) with low mutation burden.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Multidisciplinary Sciences
Noah Cornelis Helderman, Diantha Terlouw, Laia Bonjoch, Mariano Golubicki, Marina Antelo, Hans Morreau, Tom van Wezel, Sergi Castellvi-Bel, Yael Goldberg, Maartje Nielsen
Summary: MCM8 and MCM9 are recently discovered minichromosome maintenance proteins that play roles in various DNA-related processes and diseases, including DNA replication, meiosis, homologous recombination, and mismatch repair. Variants of MCM8/MCM9 may predispose carriers to infertility and cancer and should be included in relevant diagnostic testing.
Article
Cell Biology
Tetje C. van der Sluis, Guillaume Beyrend, Esme T. I. van der Gracht, Tamim Abdelaal, Simon P. Jochems, Robert A. Belderbos, Thomas H. Wesselink, Suzanne van Duikeren, Floortje J. van Haften, Anke Redeker, Laura F. Ouboter, Elham Beyranvand Nejad, Marcel Camps, Kees L. M. C. Franken, Margot M. Linssen, Peter Hohenstein, Noel F. C. C. de Miranda, Hailiang Mei, Adriaan D. Bins, John B. A. G. Haanen, Joachim G. Aerts, Ferry Ossendorp, Ramon Arens
Summary: Immune checkpoint therapy (ICT) has the potential to eliminate cancer, but the underlying mechanisms determining its effectiveness are not fully understood. By using high-dimensional single-cell profiling, this study investigates if the T cell landscape in peripheral blood can predict responses to combinatorial targeting of the OX40 costimulatory and PD-1 inhibitory pathways. The findings reveal dynamic activation states of therapy-responsive T cells and emphasize the importance of NK cell receptors and chemokine receptors in therapy-induced anti-tumor immunity.
CELL REPORTS MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Noah c. Helderman, Anne-Sophie van der Werf-'T Lam, Hans Morreau, Arnoud Boot, Tom Van Wezel, Maartje Nielsen
Article
Oncology
Riet Hilhorst, Adrienne van den Berg, Piet Boender, Tom van Wezel, Tim Kievits, Rik de Wijn, Rob Ruijtenbeek, Willem E. Corver, Hans Morreau
Summary: STK activity profiling can accurately differentiate benign and malignant thyroid tumors and generate unbiased hypotheses regarding differentially active kinases. This approach can serve as a model for selecting novel kinase inhibitors for the treatment of recurrent thyroid and other cancers.
Article
Gastroenterology & Hepatology
Hao Dang, Tom J. Harryvan, Chen-Yi Liao, Erik H. J. Danen, Vienna N. L. N. Spalburg, Szymon M. Kielbasa, Hailiang Mei, Jelle J. Goeman, Eveline S. de Jonge-Muller, Stefanus G. T. Janson, Johan J. van der Reijden, Stijn Crobach, James C. H. Hardwick, Jurjen J. Boonstra, Noel F. C. C. de Miranda, Lukas J. A. C. Hawinkels
Summary: Cancer-associated fibroblasts (CAFs) promote the progression of early stage colorectal cancer (T1CRC) by inducing invasion of tumor cells through direct interactions and stage-specific, cathepsin H-dependent extracellular matrix (ECM) remodeling.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)