A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells

A new generation of human artificial chromosomes for functional genomics and gene therapy

(2012) Natalay Kouprina et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly

(2012) Jun-ichirou Ohzeki et al.   EMBO JOURNAL

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

tRNA genes protect a reporter gene from epigenetic silencing in mouse cells

(2011) Thomas Ebersole et al.   CELL CYCLE

Targeting aneuploid cancer cells

(2011) Riccardo Colombo et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells

(2011) J.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

(2011) S. L. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression

(2010) Y. Iida et al.   DNA RESEARCH

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Potential thresholds for genotoxic effects by micronucleus scoring

(2010) A. Elhajouji et al.   MUTAGENESIS

Microtubule-binding agents: a dynamic field of cancer therapeutics

(2010) Charles Dumontet et al.   NATURE REVIEWS DRUG DISCOVERY

Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer

(2010) C K Ingemarsdotter et al.   ONCOGENE

Targeting the Mitotic Checkpoint to Kill Tumor Cells

(2010) Aniek Janssen et al.   Hormones & Cancer

Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing

(2009) J.-H. Kim et al.   GENOME RESEARCH

Chemical induction of the bystander effect in normal human lymphoblastoid cells

(2009) Rajalakshmi S. Asur et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

ZM447439, a Novel Promising Aurora Kinase Inhibitor, Provokes Antiproliferative and Proapoptotic Effects Alone and in Combination with Bio- and Chemotherapeutic Agents in Gastroenteropancreatic Neuroendocrine Tumor Cell Lines

(2009) I. Georgieva et al.   NEUROENDOCRINOLOGY

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal instability determines taxane response

(2009) C. Swanton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An in vitro micronucleus assay with size-classified micronucleus counting to discriminate aneugens from clastogens

(2009) Kiyohiro Hashimoto et al.   TOXICOLOGY IN VITRO

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

(2008) Megumi Nakano et al.   DEVELOPMENTAL CELL

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY