Article
Multidisciplinary Sciences
Weihua Ren, Fucheng Zhao, Yanru Han, Zhenzhou Liu, Jianli Zhai, Kui Jia
Summary: Through in vitro experiments, we demonstrate for the first time that muscone treatment alleviates cerebral hypoxia injury by blocking activation of the TLR4/NF-kappa B signaling pathway. In the cell model, miR-142-5p is significantly upregulated by muscone treatment, and downregulation of miR-142-5p eliminates the neuroprotective effects of muscone against cerebral hypoxia injury.
Article
Cell Biology
Peiyao Li, Xuemiao Li, Wenbin Wu, Mengjia Hou, Guanyi Yin, Zhonghang Wang, Ziyu Du, Yuanfang Ma, Yinxiang Wei, Qiang Lou
Summary: This study investigated the impact of Tim-3 on cisplatin-induced acute kidney injury. Tim-3 expression was found to increase in mice kidney tissues and BUMPT cells in response to cisplatin. Knockout of Tim-3 resulted in worsened kidney function and increased cell apoptosis. Intervention with sTim-3 further enhanced cell apoptosis and inflammation markers, while inhibiting anti-inflammatory markers. It was also observed that Tim-3 inhibition reduced renal injury and oxidative stress. These findings suggest that Tim-3 may have a protective effect against cisplatin-induced kidney injury through inhibition of inflammation and oxidative stress mediated by NF-kappa B.
CELL DEATH DISCOVERY
(2023)
Article
Multidisciplinary Sciences
Xuejiao Liu, Simin Zhao, Keke Wang, Liting Zhou, Ming Jiang, Yunfeng Gao, Ran Yang, Shiwen Yan, Wen Zhang, Bingbing Lu, Feifei Liu, Ran Zhao, Wenting Liu, Zihan Zhang, Kangdong Liu, Xiang Li, Zigang Dong
Summary: Spatial transcriptomics analysis revealed expression changes in TAGLN2 and CRNN during the progression from esophageal squamous precancerous lesions (ESPL) to esophageal squamous cell carcinoma (ESCC). TAGLN2 expression significantly increased, while CRNN expression decreased along with ESCC progression. These findings suggest that TAGLN2 and CRNN can serve as candidate indicators for predicting the risk of ESCC at the ESPL stage.
NATURE COMMUNICATIONS
(2023)
Article
Agriculture, Dairy & Animal Science
Zhanyou Cao, Chenghong Xing, Xinyi Cheng, Junrong Luo, Ruiming Hu, Huabin Cao, Xiaoquan Guo, Fan Yang, Yu Zhuang, Guoliang Hu
Summary: Avian colibacillosis is a major cause of animal death and egg-production decline in the poultry industry. Luteolin has been found to alleviate inflammation and oxidative stress caused by E. coli and may be used as an alternative to antibiotics for controlling avian colibacillosis.
Article
Immunology
Shuai Teng, Zhaowei Zhu, Chenkai Wu, Yuhu He, Shenghua Zhou
Summary: This study discovers that Inflachromene (ICM) can inhibit the phenotypic conversion of vascular smooth muscle cells (VSMCs) and reduce excessive neointimal hyperplasia. ICM regulates the Toll-like receptor 4 (TLR4)-nuclear factor-κB (NF-κB) pathway by inhibiting the expression of high mobility group box proteins (HMGBs) 1 and 2, thereby attenuating neointimal hyperplasia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kyung-Hye Roh, Yeojin Lee, Je-Hyun Yoon, Danbi Lee, Eunju Kim, Eunchong Park, In Young Lee, Tae Sung Kim, Hyun Kyu Song, Jaekyoon Shin, Dae-Sik Lim, Eui-Ju Choi
Summary: MST1/STK4 acts as a negative regulator of the TLR4-NF-kappa B signaling pathway, inhibiting TRAF6 autoubiquitination and downstream signaling, thereby limiting inflammation induced by LPS. The research also suggests that MST1/STK4 can regulate the production of proinflammatory cytokines in macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Ahmed M. Awad, Sally L. Elshaer, Rajashekhar Gangaraju, Rania R. Abdelaziz, Manar A. Nader
Summary: This study explored the renoprotective effect of montelukast (Mon) in streptozotocin (STZ)-induced diabetic nephropathy (DN) in rats compared to a standard insulin treatment. Mon administration for 8 weeks significantly improved renal function, reduced inflammation and fibrosis, restored redox hemostasis, and ameliorated dysregulation in autophagy. The renoprotective effect of Mon is potentially associated with its modulation of inflammatory cytokines, antioxidant properties, and autophagy.
INFLAMMOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jing-Mei Lu, Guang-Nan Jin, Yu-Nan Lu, Xu-Dong Zhao, Hui-Wen Lan, Shuai-Ru Mu, Xin-Yu Shen, Guang-Hua Xu, Cheng-Hua Jin, Juan Ma, Xuejun Jin, Xiang Xu, Lian-Xun Piao
Summary: The study demonstrates that resveratrol can protect liver injury induced by T. gondii infection by intervening in the HMGB1/TLR4/NF-kappa B signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lu Li, Huiquan Liu, Weili Tao, Su Wen, Xiaofen Fu, Shiying Yu
Summary: This study demonstrates the cachectic role of HMGB1 in colon cancer, whether it is in soluble form or secreted from tumor cells as exosomes. The HMGB1 inhibitor glycyrrhizin shows promise in relieving muscle wasting and attenuating cachexia progression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dermatology
Chryssoula Papageorgiou, Ioannis Spyridis, Sofia Magdalini Manoli, Iuliana Busila, Irina Elena Nasturica, Konstantinos Lallas, Angeliki Panagopoulou, Ilias Papadimitriou, Nikolaos Sideris, Theodosia Gentsidi, Ruben Gonzalez-Cuevas, Andjelka Ilieva, Dimitrios Ioannides, Zoe Apalla, Aimilios Lallas
Summary: The study aimed to investigate dermoscopic criteria for the differential diagnosis between irritated seborrheic keratosis (ISK) and squamous cell carcinoma (SCC), finding significant predictors for each entity that can help distinguish between the two conditions.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Immunology
Dabin Huang, Ping Wang, Juncao Chen, Yanbin Li, Mingwei Zhu, Yaping Tang, Wei Zhou
Summary: In this study, it was found that MD2 is significantly increased in patients with neonatal necrotizing enterocolitis (NEC). Pretreatment with MD2 inhibitor (MI) can reduce the occurrence and severity of NEC in rats, as well as alleviate intestinal mucosal injury and the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yangyang Xu, Jie Zhang, Fei Gao, Wenna Cheng, Ye Zhang, Chuanmei Wei, Shuping Zhang, Xinfu Gao
Summary: In this study, it was found that engeletin, a derivative of Smilax glabra rhizomilax, possesses anti-inflammatory activity and protects against cerebral ischemia reperfusion injury by suppressing the HMGB1/TLR4/NF-kappa B inflammatory network.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Surgery
Haixia Liu, Yun Shen, Bingkun Zhao, Enoch H. Poon, Shengcai Qi, Dai Fei Elmer Ker, Timothy R. Billiar, Gregory M. Cooper, Yuanzhi Xu, Dan Wang
Summary: This study found that short-term application of saquinavir can improve skull bone repair by promoting osteoclastogenesis and modulating the inflammatory response. This finding is clinically relevant and provides potential for repurposing saquinavir for skeletal repair.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Pharmacology & Pharmacy
Marwa E. Abdelmageed, Manar A. Nader, Marwa S. Zaghloul
Summary: The study found that protocatechuic acid (PCA) had a protective effect against L-arginine induced acute pancreatitis (AP) and multiple organs injury (MOI) in rats, restoring normal tissue architecture and enzyme levels, as well as balancing oxidant/antioxidant status. PCA also reduced inflammatory markers and ameliorated AP and MOI through the HMGB1/TLR4/NF-kappa B pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Chen Yi, Xiliu Zhang, Hongyu Li, Guanhui Chen, Binghui Zeng, Yiming Li, Chao Wang, Yi He, Xun Chen, Zixian Huang, Dongsheng Yu
Summary: The study revealed that EPHB4 is highly expressed in OSCC tissues, and is related to tumor stage and lymphatic metastasis. Mechanistically, EPHB4 promotes proliferation and metastasis in OSCC tumors by activating the HMGB1-mediated NF-kappa B signaling pathway.