Review
Chemistry, Analytical
Yu Deng, Yubi Zhang, Meng Zhou, Bin Wu, Jing Zhou
Summary: Breast cancer metastasis is a significant issue with high mortality rates, making early diagnosis crucial. Biosensors, with their ease of use, portability, and real-time analysis capabilities, play a key role in early detection. This review provides a comprehensive overview of various sensors for detecting breast cancer metastasis and compares their performance.
Article
Medicine, General & Internal
Chengjun Zhu, Jing Xu, Jinyu Sun, Shiyun Cui, Yue Sun, Tao Yu, Cenzhu Wang, Tianyao Wang, Yufeng Wu, Feng Ju, Jiafeng Yao, Kai Liu, Wenwen Zhang, Xiaoxiang Guan
Summary: This study investigates the association between circulating tumor cells (CTCs) and breast cancer metastasis. The results show that CTC enumeration is significantly associated with liver metastasis in breast cancer patients, and CTCs >= 5 are a risk factor for tumor metastasis. Furthermore, high CTC levels may be associated with an increased risk of liver metastasis in patients with metastatic breast cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Weihua Li, Lei Guo, Wanxiangfu Tang, Yutong Ma, Xiaonan Wang, Yang Shao, Hong Zhao, Jianming Ying
Summary: This study aimed to construct a model for predicting liver metastasis risk in CRC patients by utilizing differential methylation signals in primary tumors. A total of 241,573 DMRs were identified, with 182 hypermethylated DMRs associated with metastasis in stage II CRC patients. The predictive model showed promising performance with an AUC of 0.701 and was able to distinguish metastases in different sites with an AUC of 0.933. Identified DMRs in the promoter region of known prognostic biomarkers suggest their potential role in predicting liver metastasis in early-stage CRC patients.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Clemens Hinterleitner, Yanjun Zhou, Claudia Tandler, Jonas S. Heitmann, Korbinian N. Kropp, Martina Hinterleitner, Andre Koch, Andreas D. Hartkopf, Lars Zender, Helmut R. Salih, Stefanie Maurer
Summary: The study shows that TACI expression on platelets is significantly increased in breast cancer patients and correlates with tumor progression, making it a potential prognostic marker for breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lingxia Liu, Xiliu Zhang, Huayi Ding, Xin Liu, Donghui Cao, Yingqi Liu, Jiwei Liu, Cong Lin, Na Zhang, Guannan Wang, Jingyao Hou, Baiqu Huang, Yu Zhang, Jun Lu
Summary: This study uncovered a unique mechanism of controlling OXPHOS through arginine and lysine methylation, and highlighted the impact of the PRMT7-SETD6-MRPS23 axis during breast cancer metastasis.
Article
Medicine, General & Internal
Yanjun Zhou, Jonas S. Heitmann, Korbinian N. Kropp, Martina Hinterleitner, Andre Koch, Andreas D. Hartkopf, Helmut R. Salih, Clemens Hinterleitner, Stefanie Maurer
Summary: The study found that platelet-derived ADAM17 (pADAM17) in breast cancer patients is regulated upon platelet activation, unlike in healthy individuals. The downregulation of pADAM17 on platelets of cancer patients was correlated with clinical parameters related to tumor progression.
Article
Biochemistry & Molecular Biology
Lili Gao, Junzhe Zhang, Qianqian Long, Yang Yang, Yiming Li, Guoqiang Li, Peng Pu, Shanshi Tong, Yamin He, Qing Li, Yang Chen, Yingbin Liu, Xianming Kong
Summary: This study reveals a novel pathway, the SETD7/YY1 axis, which regulates epithelial-mesenchymal transition and tumor cell migration via the ERK/MAPK pathway in triple-negative breast cancer (TNBC). These findings suggest a potential therapeutic target for advanced TNBC treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
John W. W. Weaver, Jinyu Zhang, Juan Rojas, Phillip R. R. Musich, Zhiqiang Yao, Yong Jiang
Summary: Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks well-defined molecular targets. Exosomes play an important role in the tumorigenesis and treatment of TNBC, serving as biomarkers for diagnosis, monitoring, and treatment, as well as a nanosized drug-delivery system.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Nahim Adnan, Tanzira Najnin, Jianhua Ruan
Summary: Accurate prediction of breast cancer metastasis risks is crucial for cancer treatment and overall survival. This study proposes a computational method to construct personalized models for breast cancer prediction, where different models are trained for each patient using a selected group of training patients. Experimental results show that the proposed method achieves significantly better prediction accuracy and identifies robust features associated with subtype-specific metastasis.
Review
Oncology
Maria Teresa Vietri, Giovanna D'Elia, Giuditta Benincasa, Giuseppe Ferraro, Gemma Caliendo, Giovanni Francesco Nicoletti, Claudio Napoli
Summary: This review discusses the DNA methylation changes potentially involved in breast cancer development and their potential clinical utility in diagnosis, prognosis, and therapy. The inactivation of tumor suppressor genes through promoter hypermethylation, detection of targeted and genome-wide DNA methylation changes through liquid-based assays, and the use of epigenetic drugs in combination with anticancer therapies show promise in personalized treatment strategies for breast cancer patients.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Review
Genetics & Heredity
Mengying Zhou, Menglu Dong, Xue Yang, Jun Gong, Xinghua Liao, Qi Zhang, Zeming Liu
Summary: Breast cancer, with its high molecular heterogeneity, is the leading cause of cancer deaths in women. N6-methyladenosine (m6A), the most common mRNA internal modification in eukaryotic cells, has reversible modification process regulated by writer, reader, and eraser enzymes. Abnormal m6A modifications in breast cancer can impact key signaling pathways and serve as markers, targets, or regulators for diagnosis, prognosis prediction, and treatment.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Justine Marsolier, Pacome Prompsy, Adeline Durand, Anne-Marie Lyne, Camille Landragin, Amandine Trouchet, Sabrina Tenreira Bento, Almut Eisele, Sophie Foulon, Lea Baudre, Kevin Grosselin, Mylene Bohec, Sylvain Baulande, Ahmed Dahmani, Laura Sourd, Eric Letouze, Anne-Vincent Salomon, Elisabetta Marangoni, Leila Perie, Celine Vallot
Summary: The persistence of drug-resistant cancer cells is a major clinical challenge, particularly in triple-negative breast cancer. This study reveals that the repressive histone mark H3K27me3 plays a crucial role in regulating cell fate and chemotherapy tolerance in cancer cells. Manipulating H3K27me3 levels effectively enhances the potential of cancer cells to tolerate chemotherapy and delays tumor recurrence. These findings underscore the importance of understanding chromatin landscapes in shaping cancer cell response to initial therapy.
Article
Medicine, General & Internal
Jinqi Xue, Xudong Zhu, Xinbo Qiao, Yulun Wang, Jiawen Bu, Xiaoying Zhang, Qingtian Ma, Lu Liang, Lisha Sun, Caigang Liu
Summary: This study evaluated the role of CEMIP in the survival outcome of breast cancer (BC) patients and explored its regulatory mechanism. The results showed that CEMIP expression was higher in BC tissues and was associated with a worse prognosis. CEMIP and its coexpressed genes were found to participate in the progression of BC. Therefore, CEMIP may serve as a potential biomarker for the treatment of BC patients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biology
Jeremias Ivan, Gabriella Patricia, David Agustriawan
Summary: This study analyzed the methylation pattern of White breast cancer patients across different cancer stages using the TCGA dataset, identifying three potential stage-specific detection biomarkers. These findings suggest ABCC9, SHISA3, and POU4F1 as promising biomarkers for early detection and monitoring of breast cancer in White individuals. Further research is needed to investigate their roles in other racial groups.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Mingkuan Chen, Wenfang Zheng, Lin Fang
Summary: In this study, differentially expressed genes (DEGs) between BC and liver metastases were identified using the GSE124648 dataset, and a protein-protein interaction (PPI) network was constructed to identify hub genes related to metastasis. Further analysis revealed that SPARCL1 acts as a tumor suppressor in breast cancer and is associated with the clinicopathological characteristics of patients. In vitro experiments showed that SPARCL1 expression is correlated with the proliferation and migration ability of breast cancer cells. Therefore, SPARCL1 may be a potential target for the treatment and diagnosis of breast cancer and liver metastasis.
Article
Oncology
Mohamad F. Al Sayed, Michael A. Amrein, Elias D. Buehrer, Anne-Laure Huguenin, Ramin Radpour, Carsten Riether, Adrian F. Ochsenbein
Article
Oncology
Ramin Radpour, Carsten Riether, Cedric Simillion, Sabine Hopner, Remy Bruggmann, Adrian F. Ochsenbein
Article
Multidisciplinary Sciences
Carla A. Jaeger-Ruckstuhl, Magdalena Hinterbrandner, Sabine Hopner, Colin E. Correnti, Ursina Luthi, Olivier Friedli, Stefan Freigang, Mohamad F. Al Sayed, Elias D. Buhrer, Michael A. Amrein, Christian M. Schurch, Ramin Radpour, Carsten Riether, Adrian F. Ochsenbein
NATURE COMMUNICATIONS
(2020)
Review
Cell & Tissue Engineering
Harpreet K. Mandhair, Miroslav Arambasic, Urban Novak, Ramin Radpour
WORLD JOURNAL OF STEM CELLS
(2020)
Article
Cell Biology
Carsten Riether, Ramin Radpour, Nils M. Kallen, Damian T. Burgin, Chantal Bachmann, Christian M. Schurch, Ursina Luthi, Miroslav Arambasic, Sven Hoppe, Christoph E. Albers, Gabriela M. Baerlocher, Adrian F. Ochsenbein
Summary: CD93 signaling plays a critical role in regulating self-renewal and proliferation of stem cells, promoting gene transcription via SCY1-like pseudokinase 1 in murine and human LSCs. The anti-emetic agent metoclopramide efficiently blocks CD93 signaling, reducing LSCs numbers and prolonging survival in CML mice by downregulating stemness and proliferation pathways.
Article
Multidisciplinary Sciences
S. S. Hoepner, Ana Raykova, R. Radpour, M. A. Amrein, D. Koller, G. M. Baerlocher, C. Riether, A. F. Ochsenbein
Summary: The study demonstrates that LIGHT and its receptor LT beta R promote quiescence and self-renewal of HSCs, while LT beta R deficiency contributes to survival in a mouse leukemia model.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Ramin Radpour, Miriam Stucki, Carsten Riether, Adrian F. Ochsenbein
Summary: In AML, IC ligands and receptors are mainly upregulated in leukemia stem cells, while downregulated in bone marrow-infiltrating CD8(+) T cells due to pathological chromatin remodeling. This suggests that dysfunctional CD8(+) T cells in AML are mainly caused by pathological epigenetic silencing of activating IC receptors, rather than signaling by immune inhibitory IC receptors.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell & Tissue Engineering
Harpreet K. Mandhair, Urban Novak, Ramin Radpour
Summary: Aberrant epigenetic alterations play a decisive role in cancer initiation and propagation by regulating key tumor suppressor genes and oncogenes. Autophagy, a highly regulated mechanism, has a divergent role in cancer, promoting tumor growth by facilitating metabolic adaption while also exerting pro-survival mechanisms on cancer cells. Tumor suppressor genes and oncogenes involved in autophagy are tightly regulated via epigenetic modifications, offering opportunities for novel cancer therapeutics.
WORLD JOURNAL OF STEM CELLS
(2021)
Article
Medicine, Research & Experimental
Magdalena Hinterbrandner, Viviana Rubino, Carina Stoll, Stefan Forster, Noah Schnuriger, Ramin Radpour, Gabriela M. Baerlocher, Adrian F. Ochsenbein, Carsten Riether
Summary: The study showed that leukemia stem cells (LSCs) in chronic myeloid leukemia (CML) can be killed by CD8(+) cytotoxic T cells (CTLs) in vitro, but Tregs in CML bone marrow protect LSCs from CTL-mediated elimination in vivo. TNFRSF4 was identified as a potential target to reduce the function of Tregs and enhance antileukemic immunity in CML.
Article
Cell Biology
Kristina Seiler, Magali Humbert, Petra Minder, Iris Mashimo, Anna M. Schlafli, Deborah Krauer, Elena A. Federzoni, Bich Vu, James J. Moresco, John R. Yates, Martin C. Sadowski, Ramin Radpour, Thomas Kaufmann, Jean-Emmanuel Sarry, Joern Dengjel, Mario P. Tschan, Bruce E. Torbett
Summary: This study found that HK3 is dispensable for glycolytic activity in AML cells while promoting cell survival, possibly through direct interaction with the BH3-only protein BIM during ATRA-induced neutrophil differentiation.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Stefan Forster, Ramin Radpour
Summary: Multiple myeloma is a common malignant disease of plasma cells, and current treatments include chemotherapy, immunomodulatory agents, and monoclonal antibodies. The tumor microenvironment plays a crucial role in the development and progression of multiple myeloma, and understanding how different components of the bone marrow promote plasma cell dissemination is important for preventing the spread of the disease to other sites.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Elias D. Buhrer, Michael A. Amrein, Stefan Forster, Stephan Isringhausen, Christian M. Schuerch, Salil S. Bhate, Tess Brodie, Joel Zindel, Deborah Stroka, Mohamad Al Sayed, Cesar Nombela-Arrieta, Ramin Radpour, Carsten Riether, Adrian F. Ochsenbein
Summary: The study demonstrated that in CML, LSCs preferentially accumulate in the spleen, where red pulp macrophages form a niche for maintaining LSCs, leading to disease progression and resistance to therapy.
Article
Medicine, General & Internal
Samira Negahdari, Mina Zamani, Tahereh Seifi, Sahar Sedighzadeh, Neda Mazaheri, Jawaher Zeighami, Alireza Sedaghat, Alihossein Saberi, Mohammad Hamid, Bijan Keikhaei, Ramin Radpour, Gholamreza Shariati, Hamid Galehdari
INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
(2020)
Review
Oncology
Stefan Forster, Ramin Radpour
FRONTIERS IN ONCOLOGY
(2020)
Meeting Abstract
Medicine, General & Internal
Regula Burkhard, Irene Keller, Miroslav Arambasic, Darius Juskevicius, Alexandar Tzankov, Pontus Lundberg, Remy Bruggmann, Stephan Dirnhofer, Ramin Radpour, Urban Novak
SWISS MEDICAL WEEKLY
(2019)
