☆ 4.6 Article

SULT1A1 rs9282861 polymorphism-a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer?

BMC CANCER (2012)

获取全文
添加到收藏夹

期刊

BMC CANCER
卷 12, 期 -, 页码 -

出版社

BMC
DOI: 10.1186/1471-2407-12-257

关键词

-

类别

Oncology

资金

  1. Kuopio University Hospital
  2. Vaasa Central Hospital
  3. Finnish Breast Cancer Group
  4. Kuopio University Hospital Research Foundation
  5. Northern Savo Cancer Society
  6. Finnish Cancer Organisation
  7. Academy of Finland
  8. Cancer Center of University of Eastern Finland

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

Background: Sulfotransferase 1A1 (SULT1A1) participates in the elimination of 4-hydroxy-tamoxifen (4-OH-TAM), which is one of the major active metabolites of tamoxifen (TAM). Homozygous SULT1A1 variant allele genotype has been associated with lower catalytic activity and thermostability of the enzyme. Previous clinical studies suggest that the SULT1A1 rs9282861 polymorphism may influence the survival of breast cancer patients treated with TAM in the adjuvant setting. We investigated the effect of rs9282861 genotypes on the survival of Finnish breast cancer patients treated with adjuvant chemotherapy or TAM. Methods: The rs9282861 genotypes of 412 Finnish breast cancer patients with early breast cancer were identified by using PCR-RFLP method. Seventy six patients were treated with adjuvant cyclophosphamide based chemotherapy only, 65 patients received adjuvant TAM, and four patients were treated with both adjuvant chemotherapy and TAM. Overall long-term survival (OS), breast cancer specific survival (BCSS), and relapse-free survival (RFS) by rs9282861 genotypes were evaluated by the Kaplan-Meier method and Cox regression analysis. Results: The multivariate analysis of 145 patients receiving either adjuvant TAM or chemotherapy showed a statistically significantly improved OS in patients with the rs9282861 homozygous variant AA genotype (hazard ratio [HR] = 0.50, 95% confidence interval [CI] = 0.29-0.88, P = 0.015). In the separate analyses of patients receiving only chemotherapy or adjuvant TAM, there were no statistically significant differences in survival. Conclusions: In this prospective study, we observed a previously unreported association between the SULT1A1 rs9282861 genotype and OS of breast cancer patients treated with adjuvant chemotherapy or TAM. This novel finding suggests that the rs9282861 polymorphism modifies the long-term clinical outcome of patients receiving adjuvant TAM or chemotherapy.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Oncology

Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers

Hyuna Sung, Montserrat Garcia-Closas, Jenny Chang-Claude, Fiona M. Blows, H. Raza Ali, Jonine Figueroa, Heli Nevanlinna, Rainer Fagerholm, Paivi Heikkila, Carl Blomqvist, Graham G. Giles, Roger L. Milne, Melissa C. Southey, Catriona McLean, Arto Mannermaa, Veli-Matti Kosma, Vesa Kataja, Reijo Sironen, Fergus J. Couch, Janet E. Olson, Emily Hallberg, Curtis Olswold, Angela Cox, Simon S. Cross, Peter Kraft, Rulla M. Tamimi, A. Heather Eliassen, Marjanka K. Schmidt, Manjeet K. Bolla, Qin Wang, Douglas Easton, William J. Howat, Penny Coulson, Paul D. P. Pharoah, Mark E. Sherman, Xiaohong R. Yang

BRITISH JOURNAL OF CANCER (2016)

添加到收藏夹
Article Oncology

Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization

Ben Zhang, Xiao-Ou Shu, Ryan J. Delahanty, Chenjie Zeng, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Wanqing Wen, Jirong Long, Chun Li, Alison M. Dunning, Jenny Chang-Claude, Mitul Shah, Barbara J. Perkins, Kamila Czene, Hatef Darabi, Mikael Eriksson, Stig E. Bojesen, Borge G. Nordestgaard, Sune F. Nielsen, Henrik Flyger, Diether Lambrechts, Patrick Neven, Hans Wildiers, Giuseppe Floris, Marjanka K. Schmidt, Matti A. Rookus, Katja van den Hurk, Wim L. A. M. de Kort, Fergus J. Couch, Janet E. Olson, Emily Hallberg, Celine Vachon, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Julian Peto, Isabel dos-Santos-Silva, Olivia Fletcher, Nichola Johnson, Heli Nevanlinna, Taru A. Muranen, Kristiina Aittomaki, Carl Blomqvist, Jingmei Li, Keith Humphreys, Judith Brand, Pascal Guenel, Therese Truong, Emilie Cordina-Duverger, Florence Menegaux, Barbara Burwinkel, Frederik Marme, Rongxi Yang, Harald Surowy, Javier Benitez, M. Pilar Zamora, Jose I. A. Perez, Angela Cox, Simon S. Cross, Malcolm W. R. Reed, Irene L. Andrulis, Julia A. Knight, Gord Glendon, Sandrine Tchatchou, Elinor J. Sawyer, Ian Tomlinson, Michael J. Kerin, Nicola Miller, Georgia Chenevix-Trench, Christopher A. Haiman, Brian E. Henderson, Fredrick Schumacher, Loic Le Marchand, Annika Lindblom, Sara Margolin, Maartje J. Hooning, John W. M. Martens, Madeleine M. A. Tilanus-Linthorst, J. Margriet Collee, John L. Hopper, Melissa C. Southey, Helen Tsimiklis, Carmel Apicella, Susan Slager, Amanda E. Toland, Christine B. Ambrosone, Drakoulis Yannoukakos, Graham G. Giles, Roger L. Milne, Catriona McLean, Peter A. Fasching, Lothar Haeberle, Arif B. Ekici, Matthias W. Beckmann, Hermann Brenner, Aida Karina Dieffenbach, Volker Arndt, Christa Stegmaier, Anthony J. Swerdlow, Alan Ashworth, Nick Orr, Michael Jones, Jonine Figueroa, Montserrat Garcia-Closas, Louise Brinton, Jolanta Lissowska, Martine Dumont, Robert Winqvist, Katri Pylkas, Arja Jukkola-Vuorinen, Mervi Grip, Hiltrud Brauch, Thomas Bruening, Yon-Dschun Ko, Paolo Peterlongo, Siranoush Manoukian, Bernardo Bonanni, Paolo Radice, Natalia Bogdanova, Natalia Antonenkova, Thilo Doerk, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Peter Devilee, Caroline Seynaeve, Christi J. Van Asperen, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Ute Hamann, Diana Torres, Rita K. Schmutzler, Susan L. Neuhausen, Hoda Anton-Culver, Vessela N. Kristensen, Grethe I. Grenaker Alnaes, Brandon L. Pierce, Peter Kraft, Ulrike Peters, Sara Lindstrom, Daniela Seminara, Stephen Burgess, Habibul Ahsan, Alice S. Whittemore, Esther M. John, Marilie D. Gammon, Kathleen E. Malone, Daniel C. Tessier, Daniel Vincent, Francois Bacot, Craig Luccarini, Caroline Baynes, Shahana Ahmed, Mel Maranian, Catherine S. Healey, Anna Gonzalez-Neira, Guillermo Pita, M. Rosario Alonso, Nuria Alvarez, Daniel Herrero, Paul D. P. Pharoah, Jacques Simard, Per Hall, David J. Hunter, Douglas F. Easton, Wei Zheng

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

添加到收藏夹
Article Genetics & Heredity

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

Kyriaki Michailidou, Jonathan Beesley, Sara Lindstrom, Sander Canisius, Joe Dennis, Michael J. Lush, Mel J. Maranian, Manjeet K. Bolla, Qin Wang, Mitul Shah, Barbara J. Perkins, Kamila Czene, Mikael Eriksson, Hatef Darabi, Judith S. Brand, Stig E. Bojesen, Borge G. Nordestgaard, Henrik Flyger, Sune F. Nielsen, Nazneen Rahman, Clare Turnbull, Olivia Fletcher, Julian Peto, Lorna Gibson, Isabel dos-Santos-Silva, Jenny Chang-Claude, Dieter Flesch-Janys, Anja Rudolph, Ursula Eilber, Sabine Behrens, Heli Nevanlinna, Taru A. Muranen, Kristiina Aittomaki, Carl Blomqvist, Sofia Khan, Kirsimari Aaltonen, Habibul Ahsan, Muhammad G. Kibriya, Alice S. Whittemore, Esther M. John, Kathleen E. Malone, Marilie D. Gammon, Regina M. Santella, Giske Ursin, Enes Makalic, Daniel F. Schmidt, Graham Casey, David J. Hunter, Susan M. Gapstur, Mia M. Gaudet, W. Ryan Diver, Christopher A. Haiman, Fredrick Schumacher, Brian E. Henderson, Loic Le Marchand, Christine D. Berg, Stephen J. Chanock, Jonine Figueroa, Robert N. Hoover, Diether Lambrechts, Patrick Neven, Hans Wildiers, Erik van Limbergen, Marjanka K. Schmidt, Annegien Broeks, Senno Verhoef, Sten Cornelissen, Fergus J. Couch, Janet E. Olson, Emily Hallberg, Celine Vachon, Quinten Waisfisz, Hanne Meijers-Heijboer, Muriel A. Adank, Rob B. van der Luijt, Jingmei Li, Jianjun Liu, Keith Humphreys, Daehee Kang, Ji-Yeob Choi, Sue K. Park, Keun-Young Yoo, Keitaro Matsuo, Hidemi Ito, Hiroji Iwata, Kazuo Tajima, Pascal Guenel, Therese Truong, Claire Mulot, Marie Sanchez, Barbara Burwinkel, Frederik Marme, Harald Surowy, Christof Sohn, Anna H. Wu, Chiu-chen Tseng, David Van den Berg, Daniel O. Stram, Anna Gonzalez-Neira, Javier Benitez, M. Pilar Zamora, Jose Ignacio Arias Perez, Xiao-Ou Shu, Wei Lu, Yu-Tang Gao, Hui Cai, Angela Cox, Simon S. Cross, Malcolm W. R. Reed, Irene L. Andrulis, Julia A. Knight, Gord Glendon, Anna Marie Mulligan, Elinor J. Sawyer, Ian Tomlinson, Michael J. Kerin, Nicola Miller, Annika Lindblom, Sara Margolin, Soo Hwang Teo, Cheng Har Yip, Nur Aishah Mohd Taib, Gie-Hooi Tan, Maartje J. Hooning, Antoinette Hollestelle, John W. M. Martens, J. Margriet Collee, William Blot, Lisa B. Signorello, Qiuyin Cai, John L. Hopper, Melissa C. Southey, Helen Tsimiklis, Carmel Apicella, Chen-Yang Shen, Chia-Ni Hsiung, Pei-Ei Wu, Ming-Feng Hou, Vessela N. Kristensen, Silje Nord, Grethe I. Grenaker Alnaes, Graham G. Giles, Roger L. Milne, Catriona McLean, Federico Canzian, Dimitrios Trichopoulos, Petra Peeters, Eiliv Lund, Malin Sund, Kay-Tee Khaw, Marc J. Gunter, Domenico Palli, Lotte Maxild Mortensen, Laure Dossus, Jose-Maria Huerta, Alfons Meindl, Rita K. Schmutzler, Christian Sutter, Rongxi Yang, Kenneth Muir, Artitaya Lophatananon, Sarah Stewart-Brown, Pornthep Siriwanarangsan, Mikael Hartman, Hui Miao, Kee Seng Chia, Ching Wan Chan, Peter A. Fasching, Alexander Hein, Matthias W. Beckmann, Lothar Haeberle, Hermann Brenner, Aida Karina Dieffenbach, Volker Arndt, Christa Stegmaier, Alan Ashworth, Nick Orr, Minouk J. Schoemaker, Anthony J. Swerdlow, Louise Brinton, Montserrat Garcia-Closas, Wei Zheng, Sandra L. Halverson, Martha Shrubsole, Jirong Long, Mark S. Goldberg, France Labreche, Martine Dumont, Robert Winqvist, Katri Pylkas, Arja Jukkola-Vuorinen, Mervi Grip, Hiltrud Brauch, Ute Hamann, Thomas Bruening, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Loris Bernard, Natalia V. Bogdanova, Thilo Doerk, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Peter Devilee, Robert A. E. M. Tollenaar, Caroline Seynaeve, Christi J. Van Asperen, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska, Tomasz Huzarski, Suleeporn Sangrajrang, Valerie Gaborieau, Paul Brennan, James Mckay, Susan Slager, Amanda E. Toland, Christine B. Ambrosone, Drakoulis Yannoukakos, Maria Kabisch, Diana Torres, Susan L. Neuhausen, Hoda Anton-Culver, Craig Luccarini, Caroline Baynes, Shahana Ahmed, Catherine S. Healey, Daniel C. Tessier, Daniel Vincent, Francois Bacot, Guillermo Pita, M. Rosario Alonso, Nuria Alvarez, Daniel Herrero, Jacques Simard, Paul P. D. P. Pharoah, Peter Kraft, Alison M. Dunning, Georgia Chenevix-Trench, Per Hall, Douglas F. Easton

NATURE GENETICS (2015)

添加到收藏夹
Meeting Abstract Economics

TREATMENT COSTS IN PRIMARY AND SECONDARY HEALTHCARE IN FINLAND

T. Purmonen, V Tyrvainen, T. Purmonen, A. Rytkonen, V Kataja

VALUE IN HEALTH (2015)

添加到收藏夹
Review Oncology

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

Antoinette Hollestelle, Frederieke H. van der Baan, Andrew Berchuck, Sharon E. Johnatty, Katja K. Aben, Bjarni A. Agnarsson, Kristiina Aittomaki, Elisa Alducci, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Antonis C. Antoniou, Carmel Apicella, Volker Arndt, Norbert Arnold, Banu K. Arun, Brita Arver, Alan Ashworth, Laura Baglietto, Rosemary Balleine, Elisa V. Bandera, Daniel Barrowdale, Yukie T. Bean, Lars Beckmann, Matthias W. Beckmann, Javier Benitez, Andreas Berger, Raanan Berger, Benoit Beuselinck, Maria Bisogna, Line Bjorge, Carl Blomqvist, Natalia V. Bogdanova, Anders Bojesen, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Louise Brinton, Angela Brooks-Wilson, Fiona Bruinsma, Joan Brunet, Thomas Bruning, Agnieszka Budzilowska, Clareann H. Bunker, Barbara Burwinkel, Ralf Butzow, Saundra S. Buys, Maria A. Caligo, Ian Campbell, Jonathan Carter, Jenny Chang-Claude, Stephen J. Chanock, Kathleen B. M. Claes, J. Margriet Collee, Linda S. Cook, Fergus J. Couch, Angela Cox, Daniel Cramer, Simon S. Cross, Julie M. Cunningham, Cezary Cybulski, Kamila Czene, Francesca Damiola, Agnieszka Dansonka-Mieszkowska, Hatef Darabi, Miguel de la Hoya, Anna deFazio, Joseph Dennis, Peter Devilee, Ed M. Dicks, Orland Diez, Jennifer A. Doherty, Susan M. Domchek, Cecilia M. Dorfling, Thilo Dork, Isabel Dos Santos Silva, Andreas du Bois, Martine Dumont, Alison M. Dunning, Mercedes Duran, Douglas F. Easton, Diana Eccles, Robert P. Edwards, Hans Ehrencrona, Bent Ejlertsen, Arif B. Ekici, Steve D. Ellis, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Lidia Feliubadalo, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Annette Fontaine, Stefano Fortuzzi, Florentia Fostira, Brooke L. Fridley, Tara Friebel, Eitan Friedman, Grace Friel, Debra Frost, Judy Garber, Montserrat Garcia-Closas, Simon A. Gayther, Aleksandra Gentry-Maharaj, Anne-Marie Gerdes, Graham G. Giles, Rosalind Glasspool, Gord Glendon, Andrew K. Godwin, Marc T. Goodman, Martin Gore, Mark H. Greene, Mervi Grip, Jacek Gronwald, Daphne Gschwantler Kaulich, Pascal Guenel, Starr R. Guzman, Lothar Haeberle, Christopher A. Haiman, Per Hall, Sandra L. Halverson, Ute Hamann, Thomas V. O. Hansen, Philipp Harter, Jaana M. Hartikainen, Sue Healey, Alexander Hein, Florian Heitz, Brian E. Henderson, Josef Herzog, Michelle A. T. Hildebrandt, Claus K. Bogdan, Estrid Hogdall, Frans B. L. Hogervorst, John L. Hopper, Keith Humphreys, Tomasz Huzarski, Evgeny N. Imyanitov, Claudine Isaacs, Anna Jakubowska, Ramunas Janavicius, Katarzyna Jaworska, Allan Jensen, Uffe Birk Jensen, Nichola Johnson, Arja Jukkola-Vuorinen, Maria Kabisch, Beth Y. Karlan, Vesa Kataja, Noah Kauff, Linda E. Kelemen, Michael J. Kerin, Lambertus A. Kiemeney, Susanne K. Kjaer, Julia A. Knight, Jacoba P. Knol-Bout, Irene Konstantopoulou, Veli-Matti Kosma, Camilla Krakstad, Vessela Kristensen, Karoline B. Kuchenbaecker, Jolanta Kupryjanczyk, Yael Laitman, Diether Lambrechts, Sandrina Lambrechts, Melissa C. Larson, Adriana Lasa, Pierre Laurent-Puig, Conxi Lazaro, Nhu D. Le, Loic Le Marchand, Arto Leminen, Jenny Lester, Douglas A. Levine, Jingmei Li, Dong Liang, Annika Lindblom, Noralane Lindor, Jolanta Lissowska, Jirong Long, Karen H. Lu, Jan Lubinski, Lene Lundvall, Galina Lurie, Phuong L. Mai, Arto Mannermaa, Sara Margolin, Frederique Mariette, Frederik Marme, John W. M. Martens, Leon F. A. G. Massuger, Christine Maugard, Sylvie Mazoyer, Lesley McGuffog, Valerie McGuire, Catriona McLean, Lain McNeish, Alfons Meindi, Florence Menegaux, Primitiva Menendez, Janusz Menkiszak, Usha Menon, Arjen R. Mensenkamp, Nicola Miller, Roger L. Milne, Francesmary Modugno, Marco Montagna, Kirsten B. Moysich, Heiko Mueller, Anna Marie Mulligan, Taru A. Muranen, Steven A. Narod, Katherine L. Nathanson, Roberta B. Ness, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Finn C. Nielsen, Sune F. Nielsen, Berge G. Nordestgaard, Robert L. Nussbaum, Kunle Odunsi, Kenneth Offit, Edith Olah, Olufunmilayo I. Olopade, Janet E. Olson, Sara H. Olson, Jan C. Oosterwijk, Irene Orlow, Nick Orr, Sandra Orsulic, Ana Osorio, Laura Ottini, James Paul, Celeste L. Pearce, Inge Sokilde Pedersen, Bernard Peissel, Tanja Pejovic, Liisa M. Pelttari, Jo Perkins, Jenny Permuth-Wey, Paolo Peterlongo, Julian Peto, Catherine M. Phelan, Kelly-Anne Phillips, Marion Piedmonte, Malcolm C. Pike, Radka Platte, Joanna Plisiecka-Halasa, Elizabeth M. Poole, Bruce Poppe, Katri Pylkas, Paolo Radice, Susan J. Ramus, Timothy R. Rebbeck, Malcolm W. R. Reed, Gad Rennert, Harvey A. Risch, Mark Robson, Gustavo C. Rodriguez, Atocha Romero, Mary Anne Rossing, Joseph H. Rothstein, Anja Rudolph, Ingo Runnebaum, Ritu Salani, Helga B. Salvesen, Elinor J. Sawyer, Joellen M. Schildkraut, Marjanka K. Schmidt, Rita K. Schmutzler, Andreas Schneeweiss, Minouk J. Schoemaker, Michael G. Schrauder, Fredrick Schumacher, Ira Schwaab, Giulietta Scuvera, Thomas A. Sellers, Gianluca Severi, Caroline M. Seynaeve, Mitul Shah, Martha Shrubsole, Nadeem Siddiqui, Weiva Sieh, Jacques Simard, Christian F. Singer, Olga M. Sinilnikova, Dominiek Smeets, Christof Sohn, Maria Soller, Honglin Song, Penny Soucy, Melissa C. Southey, Christa Stegmaier, Dominique Stoppa-Lyonnet, Lara Sucheston, Anthony Swerdlow, Ingvild L. Tangen, Muy-Kheng Tea, Manuel R. Teixeira, Kathryn L. Terry, Mary Beth Terry, Mads Thomassen, Pamela J. Thompson, Laima Tihomirova, Marc Tischkowitz, Amanda Ewart Toland, Rob A. E. M. Tollenaar, Ian Tomlinson, Diana Torres, Therese Truong, Helen Tsimiklis, Nadine Tung, Shelley S. Tworoger, Jonathan P. Tyrer, Celine M. Vachon, Laura J. Van 't Veer, Anne M. van Altena, C. J. Van Asperen, David van den Berg, Ans M. W. van den Ouweland, Helena C. van Doom, Els Van Nieuwenhuysen, Elizabeth J. van Rensburg, Ignace Vergote, Senno Verhoef, Robert A. Vierkant, Joseph Vijai, Allison F. Vitonis, Anna von Wachenfeldt, Christine Walsh, Qin Wang, Shan Wang-Gohrke, Barbara Wappenschmidt, Maren Weischer, Jeffrey N. Weitzel, Caroline Weltens, Nicolas Wentzensen, Alice S. Whittemore, Lynne R. Wilkens, Robert Winqvist, Anna H. Wu, Xifeng Wu, Hannah P. Yang, Daniela Zaffaroni, M. Pilar Zamora, Wei Zheng, Argyrios Ziogas, Georgia Chenevix-Trench, Paul D. P. Pharoah, Matti A. Rookus, Maartje J. Hooning, Ellen L. Goode

GYNECOLOGIC ONCOLOGY (2016)

添加到收藏夹
Article Genetics & Heredity

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS

Melissa C. Southey, David E. Goldgar, Robert Winqvist, Katri Pylkas, Fergus Couch, Marc Tischkowitz, William D. Foulkes, Joe Dennis, Kyriaki Michailidou, Elizabeth J. van Rensburg, Tuomas Heikkinen, Heli Nevanlinna, John L. Hopper, Thilo Doerk, Kathleen B. M. Claes, Jorge Reis-Filho, Zhi Ling Teo, Paolo Radice, Irene Catucci, Paolo Peterlongo, Helen Tsimiklis, Fabrice A. Odefrey, James G. Dowty, Marjanka K. Schmidt, Annegien Broeks, Frans B. Hogervorst, Senno Verhoef, Jane Carpenter, Christine Clarke, Rodney J. Scott, Peter A. Fasching, Lothar Haeberle, Arif B. Ekici, Matthias W. Beckmann, Julian Peto, Isabel dos-Santos-Silva, Olivia Fletcher, Nichola Johnson, Manjeet K. Bolla, Elinor J. Sawyer, Ian Tomlinson, Michael J. Kerin, Nicola Miller, Federik Marme, Barbara Burwinkel, Rongxi Yang, Pascal Guenel, Therese Truong, Florence Menegaux, Marie Sanchez, Stig Bojesen, Sune F. Nielsen, Henrik Flyger, Javier Benitez, M. Pilar Zamora, Jose Ignacio Arias Perez, Primitiva Menendez, Hoda Anton-Culver, Susan Neuhausen, Argyrios Ziogas, Christina A. Clarke, Hermann Brenner, Volker Arndt, Christa Stegmaier, Hiltrud Brauch, Thomas Bruening, Yon-Dschun Ko, Taru A. Muranen, Kristiina Aittomaki, Carl Blomqvist, Natalia V. Bogdanova, Natalia N. Antonenkova, Annika Lindblom, Sara Margolin, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Amanda B. Spurdle, Els Wauters, Dominiek Smeets, Benoit Beuselinck, Giuseppe Floris, Jenny Chang-Claude, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Janet E. Olson, Celine Vachon, Vernon S. Pankratz, Catriona McLean, Christopher A. Haiman, Brian E. Henderson, Fredrick Schumacher, Loic Le Marchand, Vessela Kristensen, Grethe Grenaker Alnaes, Wei Zheng, David J. Hunter, Sara Lindstrom, Susan E. Hankinson, Peter Kraft, Irene Andrulis, Julia A. Knight, Gord Glendon, Anna Marie Mulligan, Arja Jukkola-Vuorinen, Mervi Grip, Saila Kauppila, Peter Devilee, Robert A. E. M. Tollenaar, Caroline Seynaeve, Antoinette Hollestelle, Montserrat Garcia-Closas, Jonine Figueroa, Stephen J. Chanock, Jolanta Lissowska, Kamila Czene, Hatef Darabi, Mikael Eriksson, Diana M. Eccles, Sajjad Rafiq, William J. Tapper, Sue M. Gerty, Maartje J. Hooning, John W. M. Martens, J. Margriet Collee, Madeleine Tilanus-Linthorst, Per Hall, Jingmei Li, Judith S. Brand, Keith Humphreys, Angela Cox, Malcolm W. R. Reed, Craig Luccarini, Caroline Baynes, Alison M. Dunning, Ute Hamann, Diana Torres, Hans Ulrich Ulmer, Thomas Ruediger, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska, Katarzyna Durda, Susan Slager, Amanda E. Toland, Christine B. Ambrosone, Drakoulis Yannoukakos, Anthony Swerdlow, Alan Ashworth, Nick Orr, Michael Jones, Anna Gonzalez-Neira, Guillermo Pita, M. Rosario Alonso, Nuria Alvarez, Daniel Herrero, Daniel C. Tessier, Daniel Vincent, Francois Bacot, Jacques Simard, Martine Dumont, Penny Soucy, Rosalind Eeles, Kenneth Muir, Fredrik Wiklund, Henrik Gronberg, Johanna Schleutker, Borge G. Nordestgaard, Maren Weischer, Ruth C. Travis, David Neal, Jenny L. Donovan, Freddie C. Hamdy, Kay-Tee Khaw, Janet L. Stanford, William J. Blot, Stephen Thibodeau, Daniel J. Schaid, Joseph L. Kelley, Christiane Maier, Adam S. Kibel, Cezary Cybulski, Lisa Cannon-Albright, Katja Butterbach, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R. Teixeira, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Stefan P. Renner, Arndt Hartmann, Alexander Hein, Matthias Ruebner, Diether Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Sandrina Lambretchs, Jennifer A. Doherty, Mary Anne Rossing, Stefan Nickels, Ursula Eilber, Shan Wang-Gohrke, Kunle Odunsi, Lara E. Sucheston-Campbell, Grace Friel, Galina Lurie, Jeffrey L. Killeen, Lynne R. Wilkens, Marc T. Goodman, Ingo Runnebaum, Peter A. Hillemanns, Liisa M. Pelttari, Ralf Butzow, Francesmary Modugno, Robert P. Edwards, Roberta B. Ness, Kirsten B. Moysich, Andreas du Bois, Florian Heitz, Philipp Harter, Stefan Kommoss, Beth Y. Karlan, Christine Walsh, Jenny Lester, Allan Jensen, Susanne Kruger Kjaer, Estrid Hogdall, Bernard Peissel, Bernardo Bonanni, Loris Bernard, Ellen L. Goode, Brooke L. Fridley, Robert A. Vierkant, Julie M. Cunningham, Melissa C. Larson, Zachary C. Fogarty, Kimberly R. Kalli, Dong Liang, Karen H. Lu, Michelle A. T. Hildebrandt, Xifeng Wu, Douglas A. Levine, Fanny Dao, Maria Bisogna, Andrew Berchuck, Edwin S. Iversen, Jeffrey R. Marks, Lucy Akushevich, Daniel W. Cramer, Joellen Schildkraut, Kathryn L. Terry, Elizabeth M. Poole, Meir Stampfer, Shelley S. Tworoger, Elisa V. Bandera, Irene Orlow, Sara H. Olson, Line Bjorge, Helga B. Salvesen, Anne M. van Altena, Katja K. H. Aben, Lambertus A. Kiemeney, Leon F. A. G. Massuger, Tanja Pejovic, Yukie Bean, Angela Brooks-Wilson, Linda E. Kelemen, Linda S. Cook, Nhu D. Le, Bohdan Grski, Jacek Gronwald, Janusz Menkiszak, Claus K. Hogdall, Lene Lundvall, Lotte Nedergaard, Svend Aage Engelholm, Ed Dicks, Jonathan Tyrer, Ian Campbell, Iain McNeish, James Paul, Nadeem Siddiqui, Rosalind Glasspool, Alice S. Whittemore, Joseph H. Rothstein, Valerie McGuire, Weiva Sieh, Hui Cai, Xiao-Ou Shu, Rachel T. Teten, Rebecca Sutphen, John R. McLaughlin, Steven A. Narod, Catherine M. Phelan, Alvaro N. Monteiro, David Fenstermacher, Hui-Yi Lin, Jennifer B. Permuth, Thomas A. Sellers, Y. Ann Chen, Ya-Yu Tsai, Zhihua Chen, Aleksandra Gentry-Maharaj, Simon A. Gayther, Susan J. Ramus, Usha Menon, Anna H. Wu, Celeste L. Pearce, David Van den Berg, Malcolm C. Pike, Agnieszka Dansonka-Mieszkowska, Joanna Plisiecka-Halasa, Joanna Moes-Sosnowska, Jolanta Kupryjanczyk, Paul D. P. Pharoah, Honglin Song, Ingrid Winship, Georgia Chenevix-Trench, Graham G. Giles, Sean V. Tavtigian, Doug F. Easton, Roger L. Milne

JOURNAL OF MEDICAL GENETICS (2016)

添加到收藏夹
Article Oncology

Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21

Yosr Hamdi, Penny Soucy, Veronique Adoue, Kyriaki Michailidou, Sander Canisius, Audrey Lemacon, Arnaud Droit, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Caroline Baynes, Carl Blomqvist, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Anne-Lise Borresen-Dale, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Jenny Chang-Claude, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Peter Devilee, Thilo Doerk, Isabel Dos-Santos-Silva, Mikael Eriksson, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Montserrat Garcia-Closas, Graham G. Giles, Mark S. Goldberg, Anna Gonzalez-Neira, Grethe Grenaker-Alnaes, Pascal Guenel, Lothar Haeberle, Christopher A. Haiman, Ute Hamann, Emily Hallberg, Maartje J. Hooning, John L. Hopper, Anna Jakubowska, Michael Jones, Maria Kabisch, Vesa Kataja, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Jan Lubinski, Arto Mannermaa, Mel Maranian, Sara Margolin, Frederik Marme, Roger L. Milne, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Curtis Olswold, Julian Peto, Dijana Plaseska-Karanfilska, Katri Pylkaes, Paolo Radice, Anja Rudolph, Elinor J. Sawyer, Marjanka K. Schmidt, Xiao-Ou Shu, Melissa C. Southey, Anthony Swerdlow, Rob A. E. M. Tollenaar, Ian Tomlinson, Diana Torres, Therese Truong, Celine Vachon, Ans M. W. Van Den Ouweland, Qin Wang, Robert Winqvist, Wei Zheng, Javier Benitez, Georgia Chenevix-Trench, Alison M. Dunning, Paul D. P. Pharoah, Vessela Kristensen, Per Hall, Douglas F. Easton, Tomi Pastinen, Silje Nord, Jacques Simard

ONCOTARGET (2016)

添加到收藏夹
Article Oncology

Adjuvant Capecitabine in Combination With Docetaxel, Epirubicin, and Cyclophosphamide for Early Breast Cancer The Randomized Clinical FinXX Trial

Heikki Joensuu, Pirkko-Liisa Kellokumpu-Lehtinen, Riikka Huovinen, Arja Jukkola-Vuorinen, Minna Tanner, Riitta Kokko, Johan Ahlgren, Paivi Auvinen, Outi Lahdenpera, Sanna Kosonen, Kenneth Villman, Paul Nyandoto, Greger Nilsson, Paula Poikonen-Saksela, Vesa Kataja, Jouni Junnila, Petri Bono, Henrik Lindman

JAMA ONCOLOGY (2017)

添加到收藏夹
Article Chemistry, Multidisciplinary

Predicting Objective Response Rate (ORR) in Immune Checkpoint Inhibitor (ICI) Therapies with Machine Learning (ML) by Combining Clinical and Patient-Reported Data

Sanna Iivanainen, Jussi Ekstrom, Henri Virtanen, Vesa V. Kataja, Jussi P. Koivunen

Summary: In this study, a machine learning-based model was built to predict the overall response rate (ORR) of ICIs in cancer patients. The model utilized patient-reported symptom data and other clinical data as inputs, and achieved promising performance in predicting ORR with a high accuracy, AUC, F1 score, and MCC. It was found that itching and fatigue were the two most important symptoms for predicting ORR.

APPLIED SCIENCES-BASEL (2022)

添加到收藏夹
Article Oncology

Cancer costs and outcomes in the Finnish population 2004-2014

Paulus Torkki, Riikka-Leena Leskela, Miika Linna, Suvi Maklin, Jukka-Pekka Mecklin, Petri Bono, Vesa Kataja, Sakari Karjalainen

ACTA ONCOLOGICA (2018)

添加到收藏夹
Article Urology & Nephrology

Safety and Antitumour Activity of ODM-201 (BAY-1841788) in Castration-resistant, CYP17 Inhibitor-naive Prostate Cancer: Results from Extended Follow-up of the ARADES Trial

Karim Fizazi, Christophe Massard, Petri Bono, Vesa Kataja, Nicholas James, Teuvo L. Tammela, Heikki Joensuu, John Aspegren, Mika Mustonen

EUROPEAN UROLOGY FOCUS (2017)

添加到收藏夹
Article Oncology

Hypofractionated stereotactic body radiotherapy for localized prostate cancer - first Nordic clinical experience

Kristiina Koskela, Jan-Erik Palmgren, Janne Heikkila, Heli Virsunen, Liisa Sailas, Paivi Auvinen, Jan Seppala, Vesa Kataja

ACTA ONCOLOGICA (2017)

添加到收藏夹
Article Oncology

Patient survival and tumor characteristics associated with CHEK2:p.I157T-findings from the Breast Cancer Association Consortium

Taru A. Muranen, Carl Blomqvist, Thilo Doerk, Anna Jakubowska, Paivi Heikkila, Rainer Fagerholm, Dario Greco, Kristiina Aittomaki, Stig E. Bojesen, Mitul Shah, Alison M. Dunning, Valerie Rhenius, Per Hall, Kamila Czene, Judith S. Brand, Hatef Darabi, Jenny Chang-Claude, Anja Rudolph, Borge G. Nordestgaard, Fergus J. Couch, Steven N. Hart, Jonine Figueroa, Montserrat Garcia-Closas, Peter A. Fasching, Matthias W. Beckmann, Jingmei Li, Jianjun Liu, Irene L. Andrulis, Robert Winqvist, Katri Pylkas, Arto Mannermaa, Vesa Kataja, Annika Lindblom, Sara Margolin, Jan Lubinski, Natalia Dubrowinskaja, Manjeet K. Bolla, Joe Dennis, Kyriaki Michailidou, Qin Wang, Douglas F. Easton, Paul D. P. Pharoah, Marjanka K. Schmidt, Heli Nevanlinna

BREAST CANCER RESEARCH (2016)

添加到收藏夹
Article Oncology

Common germline polymorphisms associated with breast cancer-specific survival

Ailith Pirie, Qi Guo, Peter Kraft, Sander Canisius, Diana M. Eccles, Nazneen Rahman, Heli Nevanlinna, Constance Chen, Sofia Khan, Jonathan Tyrer, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Alison M. Dunning, Mitul Shah, Kamila Czene, Hatef Darabi, Mikael Eriksson, Dieter Lambrechts, Caroline Weltens, Karin Leunen, Chantal van Ongeval, Borge G. Nordestgaard, Sune F. Nielsen, Henrik Flyger, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Carl Blomqvist, Kristiina Aittomaki, Rainer Fagerholm, Taru A. Muranen, Janet E. Olsen, Emily Hallberg, Celine Vachon, Julia A. Knight, Gord Glendon, Anna Marie Mulligan, Annegien Broeks, Sten Cornelissen, Christopher A. Haiman, Brian E. Henderson, Frederick Schumacher, Loic Le Marchand, John L. Hopper, Helen Tsimiklis, Carmel Apicella, Melissa C. Southey, Simon S. Cross, Malcolm W. R. Reed, Graham G. Giles, Roger L. Milne, Catriona McLean, Robert Winqvist, Katri Pylkas, Arja Jukkola-Vuorinen, Mervi Grip, Maartje J. Hooning, Antoinette Hollestelle, John W. M. Martens, Ans M. W. van den Ouweland, Federick Marme, Andreas Schneeweiss, Rongxi Yang, Barbara Burwinkel, Jonine Figueroa, Stephen J. Chanock, Jolanta Lissowska, Elinor J. Sawyer, Ian Tomlinson, Michael J. Kerin, Nicola Miller, Hermann Brenner, Katja Butterbach, Bernd Holleczek, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Jingmei Li, Judith S. Brand, Keith Humphreys, Peter Devilee, Robert A. E. M. Tollenaar, Caroline Seynaeve, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Filomena Ficarazzi, Matthias W. Beckmann, Alexander Hein, Arif B. Ekici, Rosemary Balleine, Kelly-Anne Phillips, Javier Benitez, M. Pilar Zamora, Jose Ignacio Arias Perez, Primitiva Menendez, Anna Jakubowska, Jan Lubinski, Jacek Gronwald, Katarzyna Durda, Ute Hamann, Maria Kabisch, Hans Ulrich Ulmer, Thomas Ruediger, Sara Margolin, Vessela Kristensen, Siljie Nord, D. Gareth Evans, Jean Abraham, Helena Earl, Christopher J. Poole, Louise Hiller, Janet A. Dunn, Sarah Bowden, Rose Yang, Daniele Campa, W. Ryan Diver, Susan M. Gapstur, Mia M. Gaudet, Susan Hankinson, Robert N. Hoover, Anika Husing, Rudolf Kaaks, Mitchell J. Machiela, Walter Willett, Myrto Barrdahl, Federico Canzian, Suet-Feung Chin, Carlos Caldas, David J. Hunter, Sara Lindstrom, Montserrat Garcia-Closas, Fergus J. Couch, Georgia Chenevix-Trench, Arto Mannermaa, Irene L. Andrulis, Per Hall, Jenny Chang-Claude, Douglas F. Easton, Stig E. Bojesen, Angela Cox, Peter A. Fasching, Paul D. P. Pharoah, Marjanka K. Schmidt

BREAST CANCER RESEARCH (2015)

添加到收藏夹
Article Oncology

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy

Jieping Lei, Anja Rudolph, Kirsten B. Moysich, Sajjad Rafiq, Sabine Behrens, Ellen L. Goode, Paul Pd Pharoah, Petra Seibold, Peter A. Fasching, Irene L. Andrulis, Vessela N. Kristensen, Fergus J. Couch, Ute Hamann, Maartje J. Hooning, Heli Nevanlinna, Ursula Eilber, Manjeet K. Bolla, Joe Dennis, Qin Wang, Annika Lindblom, Arto Mannermaa, Diether Lambrechts, Montserrat Garcia-Closas, Per Hall, Georgia Chenevix-Trench, Mitul Shah, Robert Luben, Lothar Haeberle, Arif B. Ekici, Matthias W. Beckmann, Julia A. Knight, Gord Glendon, Sandrine Tchatchou, Grethe I. Grenaker Alnaes, Anne-Lise Borresen-Dale, Silje Nord, Janet E. Olson, Emily Hallberg, Celine Vachon, Diana Torres, Hans-Ulrich Ulmer, Thomas Ruediger, Agnes Jager, Carolien Hm van Deurzen, Madeleine Ma Tilanus-Linthorst, Taru A. Muranen, Kristiina Aittomaki, Carl Blomqvist, Sara Margolin, Veli-Matti Kosma, Jaana M. Hartikainen, Vesa Kataja, Sigrid Hatse, Hans Wildiers, Ann Smeets, Jonine Figueroa, Stephen J. Chanock, Jolanta Lissowska, Jingmei Li, Keith Humphreys, Kelly-Anne Phillips, Sabine Linn, Sten Cornelissen, Sandra Alexandra J. van den Broek, Daehee Kang, Ji-Yeob Choi, Sue K. Park, Keun-Young Yoo, Chia-Ni Hsiung, Pei-Ei Wu, Ming-Feng Hou, Chen-Yang Shen, Soo Hwang Teo, Nur Aishah Mohd Taib, Cheng Har Yip, Gwo Fuang Ho, Keitaro Matsuo, Hidemi Ito, Hiroji Iwata, Kazuo Tajima, Alison M. Dunning, Javier Benitez, Kamila Czene, Lara E. Sucheston, Tom Maishman, William J. Tapper, Diana Eccles, Douglas F. Easton, Marjanka K. Schmidt, Jenny Chang-Claude

BREAST CANCER RESEARCH (2015)

添加到收藏夹
暂无数据
研讨会 海报 问题 讨论圈 基金 期刊 论文 科研社交 资讯集成 审稿人 关于我们 常见问题 移动App 隐私条款 使用条款
© Peeref 2019-2024. All rights reserved.