Review
Cell Biology
Maoduo Zhang, Ying Yi Zhang, Yongze Chen, Jia Wang, Qiang Wang, Hezhe Lu
Summary: The TGF-beta pathway in cancer has dual roles and is considered a potential new avenue for cancer therapy, but its functions and mechanisms of action require further investigation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jeff Yat-Fai Chung, Max Kam-Kwan Chan, Jane Siu-Fan Li, Alex Siu-Wing Chan, Philip Chiu-Tsun Tang, Kam-Tong Leung, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: TGF-beta signaling plays crucial roles in inflammatory diseases by regulating immunocytes in tissue fibrosis and accelerating tumor development in cancer. The pleiotropic nature of TGF-beta signaling in generating fibrotic TME, containing CAFs and matrix proteins, remains largely unclear, despite recent studies demonstrating its clinical implications in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Li-Li Ren, Xiao-Jun Li, Ting-Ting Duan, Zheng-Hai Li, Jun-Zheng Yang, Ya-Mei Zhang, Liang Zou, Hua Miao, Ying-Yong Zhao
Summary: Fibrosis is the excessive deposition of extracellular matrix components in the processes of tissue repair, causing organ structural integrity and functional impairment. Transforming growth factor-beta (TGF-beta) is a key factor in promoting fibrosis by activating profibrotic signals. This review discusses the role of TGF-beta signaling in fibrotic organs, as well as potential therapeutic options for targeting tissue fibrosis through modulating TGF-beta signaling.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Medicine, Research & Experimental
Shuping Yin, Han Cui, Shuang Qin, Shengnan Yu
Summary: Cervical cancer is a serious global threat to women's health, and identifying key molecules associated with its progression is crucial for drug development, disease monitoring, and precision therapy. TGF-beta has recently emerged as a promising target for cervical cancer treatment, particularly in the field of immunotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Immunology
Hua Cao, Chungang Xiao, Zhangxiu He, Hong Huang, Huifang Tang
Summary: Cardiac remodeling is influenced by IgE and its receptor Fc epsilon R1, which directly promote pathological myocardial remodeling and dysfunction. Blocking this pathway can suppress cardiac hypertrophy and fibrosis, suggesting IgE-Fc epsilon R1 as potentially therapeutic targets for heart failure.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Wookbong Kwon, Seong-Kyoon Choi, Daehwan Kim, Hyeon-Gyeom Kim, Jin-Kyu Park, Jee Eun Han, Gil-Jae Cho, Sungho Yun, Wookyung Yu, Se-Hyeon Han, Yun-Sok Ha, Jun Nyung Lee, Tae Gyun Kwon, Dong-Hyung Cho, Jun-Koo Yi, Myoung Ok Kim, Zae Young Ryoo, Song Park
Summary: The study identified ZNF507 as a key regulator in the progression of prostate cancer to an aggressive state by upregulating the TGF-beta signaling pathway. ZNF507 was found to promote cell growth, survival, proliferation, and metastasis properties of prostate cancer, and positively regulated the transcription of genes such as TGFBR1, MAP3K8, and FURIN. These findings suggest that ZNF507 could be a promising target for studying the development of advanced metastatic prostate cancers.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Max Kam-Kwan Chan, Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Alex Siu-Wing Chan, Johnny Yuk-Yeung Ho, Tony Pak-Tik Lin, Jiaoyi Chen, Kam-Tong Leung, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: Transforming growth factor-beta (TGF-beta) signaling plays important roles in cancer, both as a suppressor and a promoter. Disruption of TGF-beta signaling leads to complex anti-cancer and pro-tumoral outcomes, highlighting the need for a better understanding of its molecular mechanisms for the development of effective cancer therapies.
Article
Biochemistry & Molecular Biology
Su Woong Jung, Su-Mi Kim, Arum Kim, Seon Hwa Park, Ju-Young Moon, Sang-Ho Lee
Summary: The midbody plays a crucial role in the transition of fibroblasts into myofibroblasts by mediating TGF-beta/Smad signaling. The pathway related to microtubules is implicated in kidney fibrosis, and blocking microtubule dynamics can improve kidney fibrosis.
Article
Biology
Jifan Feng, Xia Han, Yuan Yuan, Courtney Kyeong Cho, Eva Janeckova, Tingwei Guo, Siddhika Pareek, Md Shaifur Rahman, Banghong Zheng, Jing Bi, Junjun Jing, Mingyi Zhang, Jian Xu, Thach-Vu Ho, Yang Chai
Summary: This study investigates the role of TGF-beta signaling in the regulation of pharyngeal muscle development in mice, revealing that TGF-beta signaling activates the Fgf18 pathway to regulate communication between perimysial fibroblasts and myogenic cells.
Review
Oncology
Reinofke A. J. van de Vis, Aristidis Moustakas, Lars P. van der Heide
Summary: TGF-beta signaling is crucial for regulating various cellular processes and is often implicated in tumor formation and progression. NUAK1 and NUAK2 play important roles in regulating TGF-beta signaling, enhancing or attenuating the cellular response to steer towards a specific output. Understanding the mechanisms of TGF-beta signaling and the role of NUAK kinases can provide insights into developing targeted therapies for TGF-beta-dependent diseases.
Article
Medicine, Research & Experimental
Qian Wu, Xuemeng Miao, Jingjing Zhang, Ludan Xiang, Xiuchun Li, Xiaomei Bao, Siyu Du, Mianxian Wang, Shuangda Miao, Yiren Fan, Wei Wang, Xingxing Xu, Xiya Shen, Danlu Yang, Xiwu Wang, Yuanyuan Fang, Lixin Hu, Xuyi Pan, Haoru Dong, Hui Wang, Ying Wang, Jia Li, Zhihui Huang
Summary: The study showed that YAP was significantly upregulated and activated in astrocytes of optic nerve in EAE mice. Conditional knockout of YAP in astrocytes resulted in more severe inflammatory infiltration and demyelination in the optic nerve, as well as promoted activation of astrocytes and microglia while inhibiting astrocyte proliferation. The downregulation of the TGF-beta signaling pathway after YAP deletion in astrocytes was also observed, with potential therapeutic agents like SRI-011381 and XMU-MP-1 showing promising effects in rescuing optic nerve deficits and relieving neuroinflammation in EAE mice.
Article
Virology
Gabrielly Sbano Teixeira, Audrien Alves Andrade, Lauana Ribas Torres, Dinair Couto-Lima, Otacilio C. Moreira, Rayane Abreu, Mariana Caldas Waghabi, Elen Mello de Souza
Summary: The study found that TGF-beta 1 plays a significant role in the replication of dengue virus in macrophages, and targeting TGF-beta 1 may represent an alternative therapeutic strategy to be explored in dengue infection.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Cell Biology
Simon I. Dreher, Selina Hoeckele, Peter Huypens, Martin Irmler, Christoph Hoffmann, Tim Jeske, Maximilian Hastreiter, Anja Moller, Andreas L. Birkenfeld, Hans-Ulrich Haering, Andreas Peter, Johannes Beckers, Martin Hrabe de Angelis, Cora Weigert
Summary: This study investigated the impact of TGF-beta on individual exercise response, revealing its role in regulating miRNA and observing significant induction of TGF-beta signaling and the miR-143/145 cluster in non-responders. The findings suggested that elevated TGF-beta signaling and miR-143/145 cluster induction in skeletal muscle of non-responders may hinder improvements in insulin sensitivity by affecting muscle cell fusion, myofiber functionality, and insulin signaling components.
Article
Cell Biology
Ran Zhang, Jingting Lin, Yang Liu, Shurong Yang, Qi He, Liang Zhu, Xiao Yang, Guan Yang
Summary: Proper differentiation of odontoblasts is crucial for the development of tooth roots. Disruption of TGF-beta signaling in root pre-odontoblasts leads to abnormal formation of root osteodentin and ectopic osteogenic differentiation of odontoblasts. Upregulation of Wnt signaling is observed when TGF-beta signaling is disrupted, and inhibiting Wnt signaling can reduce ectopic osteogenic differentiation and halt odontoblast differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yan-Long Han, Dan Luo, Kakeng Habaxi, Julaiti Tayierjiang, Wei Zhao, Wei Wang, Wumaierjiang Aikebaier, Li Wang
Summary: In this study, we identified COL5A2 as a prognostic gene for osteosarcoma through bioinformatics analysis, and showed that COL5A2 inhibits invasion and metastasis of osteosarcoma by suppressing the TGF-beta and Wnt/β-Catenin signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)