Review
Biochemistry & Molecular Biology
Benjamin Linard, Ingo Ebersberger, Shawn E. McGlynn, Natasha Glover, Tomohiro Mochizuki, Mateus Patricio, Odile Lecompte, Yannis Nevers, Paul D. Thomas, Toni Gabaldon, Erik Sonnhammer, Christophe Dessimoz, Ikuo Uchiyama
Summary: Accurate determination of evolutionary relationships between genes is crucial in biology, with homology often determined by sequence similarity analysis. However, distinguishing between orthologs and paralogs presents challenges. The recent QFO meeting in Japan highlighted progress in standardizing orthology methods and integrating orthology across different biological levels, while also revealing challenges in leveraging orthology computations and adapting methods to genomic diversity.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Chemistry, Multidisciplinary
Michael Naguib, Michel W. Barsoum, Yury Gogotsi
Summary: Since their discovery in 2011, the number of 2D transition metal carbides and nitrides (MXenes) has steadily increased to over 40 compositions, potentially becoming the largest family of 2D materials. MXenes exhibit unique properties such as high electrical conductivity, which make them useful in various applications like energy storage and optoelectronics. The production of MXenes using methods like selective etching has led to rapid growth in research publications and patents, indicating promising commercialization potential.
ADVANCED MATERIALS
(2021)
Article
Oncology
Daniel G. Coit, Charlotte E. Ariyan
Summary: This paper outlines the scientific and clinical advances in the treatment of melanoma over the past 50 years, including reduction in surgical procedures, introduction of targeted therapy, and immune checkpoint blockade.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Daniel G. Coit, Vivian E. Strong
Summary: This article summarizes the important changes in gastric cancer management and the supporting data. These changes have been derived from randomized controlled trials, prospective databases, and in-depth analysis of individual patients.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Lucia Monaco, Galliano Zanello, Gareth Baynam, Anneliene H. Jonker, Daria Julkowska, Adam L. Hartman, Daniel O'Connor, Chiuhui Mary Wang, Durhane Wong-Rieger, David A. Pearce
Summary: The International Rare Diseases Research Consortium (IRDiRC) is a global collaborative initiative launched in 2011 with the aim of tackling rare diseases through research. This article provides a summary of IRDiRC's vision, goals, achievements, and prospects after its first decade.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Review
Polymer Science
Zeping Zhou, Zhen Jiang, Feng Chen, Tairong Kuang, Dapeng Zhou, Fuliang Meng
Summary: With the rapid development of electronic devices, the corresponding energy storage equipment has also been continuously developed. Polyphosphazene polymers are widely used in various fields due to their unique properties. This article briefly introduces the research progress in energy based on polyphosphazene materials in the past ten years, focusing on the defects of different types of batteries and introducing different functional group modification.
Review
Oncology
Arne Bartol, Katrin Dressler, Peter Kaskel, Christiane Landsberg, Cornelia Lechner, Marco Petschulies
Summary: The AMNOG process has shown significant improvements in the pharmaceutical field as a constantly evolving system, but there are still areas that need improvement, especially in patient-relevant outcomes, real-world data application, and evidence transfer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Pawan Kumar Singh, Soumalya Kundu, Titir Adhikary, Ram Sarkar, Debotosh Bhattacharjee
Summary: This survey provides an overview of the various approaches proposed for Human Action Recognition (HAR) in the past decade, focusing mainly on the development of methods for unimodal HAR using concepts of machine learning and deep learning models. It also includes discussions on different feature extractors, majorly used video and still-image datasets, and offers insights into future work scope.
ARCHIVES OF COMPUTATIONAL METHODS IN ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Alejandra Gonzalez-Urias, Angel Licea-Claverie, J. Adriana Sanudo-Barajas, Mirian A. Gonzalez-Ayon
Summary: Hydrogels are three-dimensionally crosslinked polymeric chains with the ability to absorb other molecules and improve their properties. Among them, hydrogels based on the thermosensitive polymer PNVCL have great potential in various biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Junli Pu, Hongwei Wang, Chao Huang, Chunmiao Bo, Bolin Gong, Junjie Ou
Summary: Chiral compounds are common in the field of medicine, and the separation of racemic drugs is crucial for their safe use. Molecularly imprinted technique (MIT) has gained attention as a method for separating chiral drugs due to its simplicity and specific recognition ability. Molecularly imprinted polymers (MIPs) have been successfully used in various analytical techniques to separate chiral drugs. This paper reviews the recent advances in MIT for drug separation, discussing different chromatographic techniques and the contributions of surface molecularly imprinted technique (SMIT) and molecularly imprinted membrane (MIM) technology. The challenges and future development directions of chiral MIT are also briefly discussed.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Review
Chemistry, Multidisciplinary
Siyu Wei, Junxian Tao, Jing Xu, Xingyu Chen, Zhaoyang Wang, Nan Zhang, Lijiao Zuo, Zhe Jia, Haiyan Chen, Hongmei Sun, Yubo Yan, Mingming Zhang, Hongchao Lv, Fanwu Kong, Lian Duan, Ye Ma, Mingzhi Liao, Liangde Xu, Rennan Feng, Guiyou Liu, Yongshuai Jiang
Summary: EWAS has been utilized for a decade to analyze DNA methylation variation in complex diseases, and has gradually become a hot topic of current studies. The progress of EWAS research, contributions to clinical applications, achievements in typical diseases, challenges encountered, and bold predictions for future development are all discussed.
Review
Oncology
Bo Qiu, Cassie Kline, Sabine Mueller
Summary: Pediatric brain tumors are the most common solid tumors in children, with some high-risk diagnoses remaining incurable. There is ongoing development of therapy options for CNS tumors, but for most high-risk patients, single agent treatments may not be sufficient.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Qian Yu, Chenyu Liu, Anjana Pillai, Osman Ahmed
Summary: Both EBRT and SIRT were found to be safe and effective in treating unresectable iCCA patients, with improved median survival time and overall survival rate. Both radiation therapies were effective in downstaging the disease for potential surgery. However, SIRT group had more common side effects, while EBRT group had higher rates of anemia and neutropenia.
Article
Plant Sciences
Gian Marco Ludovici, Andrea Chierici, Susana Oliveira de Souza, Francesco d'Errico, Alba Iannotti, Andrea Malizia
Summary: This study analyzes the effects of ionizing radiation and radionuclides on higher plants around the Fukushima nuclear power plant, finding that plants have certain radiation adaptive ability and that radiation affects the genetic structure of plants.
Article
Geosciences, Multidisciplinary
Wouter B. Mol, Wouter H. Knap, Chiel C. van Heerwaarden
Summary: This article presents an observational dataset of global, direct, and diffuse solar irradiance collected over a 10-year period from the BSRN station in Cabauw, the Netherlands. The dataset includes detailed information on variability, cloud effects, aerosol analysis, solar position, cloud observations, sky type, and wind measurements. These observations contribute to research on the impact of clouds and atmospheric composition on solar irradiance variability and help validate models.
EARTH SYSTEM SCIENCE DATA
(2023)
