期刊
BMC CANCER
卷 10, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1471-2407-10-523
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资金
- 863 Program [2009AA022701, 2006AA02A407]
- S973 Program [2010CB529600, 2007CB914703, 2007CB947300]
- National Key Project for Investigational New Drug [2008ZX09312-003]
- Shanghai Municipal Commission of Science and Technology Program [09DJ1400601]
- National Nature Science Foundation of China [30700457]
- Shanghai Leading Academic Discipline Project [B205]
Background: Genetic factors related to the regulation of apoptosis in schizophrenia patients may be involved in a reduced vulnerability to cancer. XRCC4 is one of the potential candidate genes associated with schizophrenia which might induce colorectal cancer resistance. Methods: To examine the genetic association between colorectal cancer and schizophrenia, we analyzed five SNPs (rs6452526, rs2662238, rs963248, rs35268, rs2386275) covering similar to 205.7 kb in the region of XRCC4. Results: We observed that two of the five genetic polymorphisms showed statistically significant differences between 312 colorectal cancer subjects without schizophrenia and 270 schizophrenia subjects (rs6452536, p = 0.004, OR 0.61, 95% CI 0.44-0.86; rs35268, p = 0.028, OR 1.54, 95% CI 1.05-2.26). Moreover, the haplotype which combined all five markers was the most significant, giving a global p = 0.0005. Conclusions: Our data firstly indicate that XRCC4 may be a potential protective gene towards schizophrenia, conferring reduced susceptibility to colorectal cancer in the Han Chinese population.
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