Article
Oncology
Zhining Yang, Zeman Cai, Qingxin Cai, Yingji Hong, Cuidai Zhang, Kaichun Huang, Zhixiong Lin, Mei Li
Summary: The study compared the efficacy and safety of induction chemotherapy followed by intensity-modulated radiotherapy versus concurrent chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma. The results showed similar outcomes in terms of PFS, OS, LRRFS, and DMFS between the two treatment arms, but the IC plus IMRT arm had lower incidences of leukopenia and anemia.
Article
Oncology
Wei-Jie Luo, Wen-Qing Zou, Shao-Bo Liang, Lei Chen, Guan-Qun Zhou, Hao Peng, Wen-Fei Li, Xu Liu, Ying Sun, Ai-Hua Lin, Jun Ma, Yan-Ping Mao
Summary: In this study, the role of concurrent chemoradiotherapy (CCRT) after induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (LANPC) patients was investigated. Results showed that favorable responders to IC benefited from IC + CCRT with superior 5-year disease-free survival and overall survival compared to IC + IMRT. High-risk patients benefited from CCRT after IC regarding disease-free survival, overall survival, and distant metastasis-free survival.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, General & Internal
Peirong Wang, Feng Dong, Chuanshu Cai, Chunlin Ke
Summary: The study evaluated the efficacy of a combinatorial treatment strategy involving IC, IMRT, and AC for locoregionally advanced NPC. Results showed that a total of 4 cycles of IC and AC were more beneficial compared to 3 cycles, as well as a total of 6 chemotherapy cycles compared to 4 in terms of DFFR and PFS.
Article
Oncology
Ziyi Zeng, Chen Chen, Lanlan Guo, Cheng Zhang, Lei Chen, Chuanping Yuan, Lixia Lu
Summary: The study suggests that receiving two courses of platinum-based induction chemotherapy may be the optimal strategy to reduce the risk of death and progression in patients with high levels of pEBV-DNA in the era of intensity modulated radiation therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Li Xiang, Jin-Feng Rong, Xiao-Yue Li, Yun Zheng, Pei-Rong Ren, Sheng Lin, Qing-Lian Wen, Li-Jia He, Jian-Wen Zhang, Chang-Ling Shang, Hong-Ru Yang, Juan Fan, Hao-Wen Pang, Jing Zhang, Bang-Xian Tan, Ling Zhang, Xiao-Bo Du, Shi-Min Wen, Liang Jiang, Gang Qin, Jing-Bo Wu
Summary: The purpose of this study was to evaluate the long-term survival, late toxicity profile, and quality of life of patients with advanced nasopharyngeal carcinoma who received combined induction chemotherapy and concurrent chemoradiotherapy. The results showed that reducing the target volumes of intensity modulated radiation therapy after induction chemotherapy did not increase the risk of locoregional relapse and may improve quality of life and reduce late toxicity.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Weiling Qu, Xuan Wang, Qiao Qiao, Yanli Wang
Summary: This study aimed to explore the benefit of chemotherapy in patients with locally advanced nasopharyngeal carcinoma (NPC), especially those with negative lymph nodes. The results showed that chemotherapy could significantly improve survival rates in patients with positive lymph nodes, but did not provide additional benefit for those with negative lymph nodes. For T3-4N0M0 NPC, radiotherapy alone improved overall survival and cancer-specific survival compared to no radiotherapy, while chemotherapy did not show significant survival benefit compared to no chemotherapy.
Article
Cell Biology
Kaixuan Yang, Wenji Xie, Xiangbin Zhang, Yu Wang, Arthur Shou, Qiang Wang, Jiangfang Tian, Jiangping Yang, Guangjun Li
Summary: This study aimed to predict late radiation xerostomia and successfully developed a predictive model, which can effectively improve patients' quality of life.
Article
Oncology
Longjiang She, Kun Tian, Jiaqi Han, Weihan Zuo, Zhu Wang, Ning Zhang
Summary: Adding metronomic capecitabine to concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma patients has been shown to be a cost-effective strategy, resulting in additional quality-adjusted life years and a favorable incremental cost-effective ratio at a willingness-to-pay threshold of $33,585 per QALY.
FRONTIERS IN ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Jia Kou, Lu-Lu Zhang, Xing-Li Yang, Dan-Wan Wen, Guan-Qun Zhou, Chen-Fei Wu, Si-Si Xu, Wei-Hong Zheng, Zhen-Yu Qi, Ying Sun, Li Lin
Summary: This study aims to explore risk-adapted treatment for elderly patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC) according to their pretreatment risk stratification and the degree of comorbidity. By constructing a prognostic nomogram for disease-free survival and dividing patients into different risk groups, it was found that combining risk stratification and the degree of comorbidities can guide risk-adapted treatment for elderly LA-NPC patients and improve prognosis.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Oncology
Bi-Cheng Wang, Bo-Hua Kuang, Xin-Xiu Liu, Guo-He Lin, Quentin Liu
Summary: Different induction chemotherapeutic strategies have varying effects and risks on the survival outcomes of patients with locoregionally advanced nasopharyngeal carcinoma. Gemcitabine plus platinum and docetaxel combined with 5-fluorouracil plus platinum strategies were associated with the highest rates of overall survival. The objective response and disease control rates were high after the completion of induction chemotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ying Li, Jianping Bi, Guoliang Pi, Hanping He, Yanping Li, Dandan Zheng, Zecheng Wei, Guang Han
Summary: This study aimed to evaluate the optimal number of cycles of induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (LANPC) by quantifying the changes in tumor volumes. The results showed that the effects of IC cycles on tumor volume reduction varied for different tumor and lymph node types. Two cycles of IC were sufficient for tumor and retropharyngeal lymph node volume reduction, while three cycles were recommended for further reduction of cervical lymph node volume.
Article
Oncology
Yu-Ting Jiang, Kai-Hua Chen, Jie Yang, Zhong-Guo Liang, Ling Li, Song Qu, Xiao-Dong Zhu
Summary: This study revealed that for locoregionally advanced nasopharyngeal carcinoma, high-risk patients could benefit from a higher cumulative cisplatin dose in terms of 3-year progression-free survival and distant metastasis-free survival, while low-risk patients did not show significant survival advantages. A high cisplatin dose increased treatment-related acute toxicities.
Article
Oncology
Rui Zou, Jing-Jing Yuan, Qiang Li, Jian-Wu Ding, Bing Liao, Zi-Wei Tu, Rong-Huan Hu, Dan Gong, Jia-Li Hu, Lei Zeng
Summary: The study analyzed the outcomes and toxicities of ICT followed by CCRT plus ACT in LA-NPC patients, and found that this treatment approach did not significantly improve DFS and OS compared to adding ICT to CCRT, with more acute adverse events. Longer-term clinical studies are needed to evaluate treatment outcomes and late toxicities.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Zhang, Xiangjun Wu, Jing Liu, Bin Zhang, Xiaokai Mo, Qiuying Chen, Jin Fang, Fei Wang, Minmin Li, Zhuozhi Chen, Shuyi Liu, Luyan Chen, Jingjing You, Zhe Jin, Binghang Tang, Di Dong, Shuixing Zhang
Summary: A deep-learning model based on MRI features and clinical variables was developed to predict distant metastasis-free survival in locoregionally advanced nasopharyngeal carcinoma patients. The model showed good performance in training, validation, and testing cohorts. Patients in low-risk groups treated with concurrent chemoradiotherapy alone had better outcomes compared to those who received additional chemotherapy.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Oncology
Horace Cheuk-Wai Choi, Sik-Kwan Chan, Ka-On Lam, Sum-Yin Chan, Sze-Chun Chau, Dora Lai-Wan Kwong, To-Wai Leung, Mai-Yee Luk, Anne Wing-Mui Lee, Victor Ho-Fun Lee
Summary: This study aimed to compare the survival benefits of all available induction chemotherapy (IC) regimens followed by concurrent chemoradiotherapy (CCRT) in non-metastatic locoregionally advanced nasopharyngeal carcinoma (NPC) through a network meta-analysis. The results showed that DC, GP, and PX were the most efficacious IC regimens, with doublet and gemcitabine-based regimens demonstrating better survival benefits compared to triplet and taxane-based regimens.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guang Ma, Bingxin Gu, Jiyi Hu, Lin Kong, Jiangang Zhang, Zili Li, Yangbo Xue, Jiade Lu, Junning Cao, Jingyi Cheng, Yingjian Zhang, Shaoli Song, Zhongyi Yang
Summary: The study examined the value of pretreatment F-18-FDG uptake heterogeneity in predicting the prognosis of locally recurrent nasopharyngeal carcinoma (LRNPC) patients treated with carbon ion radiotherapy (CIRT). Results showed that F-18-FDG uptake heterogeneity, particularly with a HI>=0.81, was significantly associated with poorer LRFS and PFS outcomes, indicating its potential as an independent predictor for LRNPC patients undergoing CIRT.
ANNALS OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Wanzun Lin, Xianxin Qiu, Pian Sun, Yuling Ye, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: While successful clinical trials of immunotherapy have shown promising strategies for many cancers, its application in glioma has lagged behind compared to other cancers. This study focused on the molecular alterations affecting therapeutic response in lower-grade glioma (LGG) and characterized the immunological phenotypes with different molecular subtypes to improve our understanding and application of immunotherapies in LGG. The research collected data from 1,052 patients, stratified them into three genetic subgroups, and discovered distinct immunological tumor microenvironments associated with IDH mutations and 1p/19q codeletions in LGG, ultimately leading to the construction of an immune-related prognostic signature that predicts overall survival time in LGG.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Review
Cell Biology
Vivek Kumar, Mohit Vashishta, Lin Kong, Xiaodong Wu, Jiade J. Lu, Chandan Guha, B. S. Dwarakanath
Summary: Resistance to therapy is a major challenge in cancer management, with cancer cells rewiring their cellular processes to resist the deleterious effects of various therapeutic approaches. Understanding the role of developmental pathways in cancer and their contribution to resistance can lead to insights for developing novel therapeutic approaches. Recognizing the importance of molecular networks in overcoming drug resistance can provide a rational basis for improving cancer treatment with safer and more effective combined therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Wanzun Lin, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: The study found that high expression of VMP1 in glioma patients is associated with faster disease progression and poorer prognosis. Depletion of VMP1 by CRISPR-Cas9 gene editing significantly inhibits cell proliferation, increases cell death, and induces cell cycle arrest. Knockout of VMP1 blocks autophagic flux and sensitizes glioma cells to radiotherapy and chemotherapy.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Oncology
Jiyi Hu, Qingting Huang, Jing Gao, Weixu Hu, Jing Yang, Xiyin Guan, Xianxin Qiu, Wenna Zhang, Lin Kong, Jiade J. Lu
Summary: The study demonstrated that the combination of IMRT with CIRT boost therapy provides excellent disease control and favorable toxicity profile for patients with non-metastatic nasopharyngeal carcinoma. The results suggest that this mixed treatment strategy is safe and well-tolerated, with promising outcomes in terms of disease control.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shubing Jia, Jian Chen, Ningyi Ma, Jingfang Zhao, Jingfang Mao, Guoliang Jiang, Jiade Lu, Kailiang Wu
Summary: This study demonstrates the dosimetric benefits of adaptive carbon ion radiotherapy (CIRT) for locally advanced non-small cell lung cancer (LANSCLC) and compares the differences between patients with and without adaptive plans. The results show that adaptive plans can ensure target coverage and reduce spinal cord dose. Patients with adaptive plans have larger tumor volumes and greater volume changes. iGTV volume changes and iGTV center movements are the main factors influencing adaptive planning.
Article
Immunology
Wanzun Lin, Yanyan Xu, Jing Gao, Haojiong Zhang, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: The study identifies B7-H3 as a novel biomarker for head and neck squamous cell carcinoma (HNSCC), predicting prognosis and response to immunotherapy; high expression of B7-H3 is associated with poor prognosis, immunotherapy resistance, and contributes to an immunosuppressive microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Ning-Yi Ma, Jian Chen, Xue Ming, Guo-Liang Jiang, Jiade J. Lu, Kai-Liang Wu, Jingfang Mao
Summary: The study found that proton plus carbon-ion radiotherapy combined with chemotherapy has good tolerability and promising survival rates in patients with limited-stage small cell lung cancer. Acute toxicities, both hematologically and non-hematologically related, were well managed, with some cases of late side effects observed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fangzhu Wan, Haojiong Zhang, Jiyi Hu, Li Chen, Shikai Geng, Lin Kong, Jiade J. Lu
Summary: This study identified miR-125a as highly expressed in normal nasopharyngeal epithelial tissue compared to nasopharyngeal carcinoma. It demonstrated that miR-125a inhibits the migration and vasculogenic mimicry (VM) formation in nasopharyngeal carcinoma cells, targeting TAZ. Additionally, artificial engineering of mesenchymal stem cells (MSCs) allowed the generation of miR-125a-overexpressing exosomes which attenuated VM formation and migration in nasopharyngeal carcinoma, providing a potential therapeutic approach.
FRONTIERS IN ONCOLOGY
(2022)
Article
Ophthalmology
Jingli Guo, Xianxin Qiu, Wenyi Tang, Gezhi Xu, Michael F. Moyers, Wei Ren, Ying Xing, Jin Gao, Jiayao Sun, Jiade Lu, Lin Kong, Wei Liu
Summary: The study demonstrates that PBI combined with IVC may help promote regression and closure of polyps in PCV, reduce central macular thickness, and improve BCVA with good safety profile after 12 months. Hence, PBI may be a useful adjuvant therapy for patients with refractory or recurrent PCV.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Oncology
Dong Yang, Weiwei Wang, Jiyi Hu, Weixu Hu, Xiyu Zhang, Xiaodong Wu, Jiade J. Lu, Lin Kong
Summary: This study investigated the feasibility of lattice radiotherapy (LRT) using proton or carbon-ion beams in the treatment of sinonasal malignancies. The results showed that proton and carbon-ion LRT plans can better protect critical organs compared to photon LRT plans, despite minimal differences in PVDR.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Robert L. Foote, Hirohiko Tsujii, Reiko Imai, Hiroshi Tsuji, Eugen B. Hug, Tatsuaki Kanai, Jiade J. Lu, Juergen Debus, Rita Engenhart-Cabillic, Anita Mahajan
Summary: As of December 31, 2020, there were 12 facilities in Asia and Europe providing carbon ion radiotherapy (CIRT) for cancer patients, with a total of 37,548 patients treated worldwide. The absence of CIRT facilities in the U.S. limits access to this treatment for American cancer patients and prevents their inclusion in phase III clinical trials, which are essential for FDA approval and insurance coverage. Overcoming this barrier would require establishing a limited number of CIRT facilities in the U.S.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Wanzun Lin, Jing Gao, Haojiong Zhang, Li Chen, Xianxin Qiu, Qingting Huang, Jiyi Hu, Lin Kong, Jiade J. Lu
Summary: This study classified lower-grade glioma (LGG) into inflammation-, low, -mid, and -high subtypes based on the inflammatory response, which have distinct clinicopathologic features, prognosis, and tumor microenvironment. An inflammation-related prognostic model was also established with strong predictive power for prognosis assessment.
INFLAMMATION AND REGENERATION
(2022)
Review
Oncology
Anna Lee, Sarin Kitpanit, Marina Chilov, Johannes A. Langendijk, Jiade Lu, Nancy Y. Lee
Summary: This study systematically reviewed the literature on proton therapy in nasopharyngeal cancer patients, finding that proton therapy can maintain good treatment outcomes while reducing toxic dose to normal tissues. Compared with intensity-modulated radiation therapy, proton therapy showed lower rates of feeding tube and mucositis, indicating an improved toxicity profile in NPC patients.
INTERNATIONAL JOURNAL OF PARTICLE THERAPY
(2021)
Article
Oncology
Cihang Bao, Yun Sun, Bilikere Dwarakanath, Yuanli Dong, Yangle Huang, Xiaodong Wu, Chandan Guha, Lin Kong, Jiade J. Lu
Summary: This study revealed that carbon ion could induce necroptosis in nasopharyngeal carcinoma cells, especially in photon-resistant cells, and the mechanisms involve the regulation of BCL-x.