Article
Agronomy
Aisha Almakas, Guoxiang Chen, Fahad Masoud Wattoo, Rashid Mehmood Rana, Muhammad Asif Saleem, Zhiping Gao, Muhammad Waqas Amjid, Muhammad Ishaq Asif Rehmani, Abeer Hashem, Elsayed Fathi Abd Allah
Summary: The study showed that exposure to high light during the yellowing stage led to photooxidation in mutant 812HS leaves, while using a dark cover during the recovery stage restored green color. Additionally, mutant 812HS had decreased net photosynthetic rate and pigment content during the yellowing stage.
Article
Chemistry, Applied
Jie Zhang, John A. Duley, David M. Cowley, Paul N. Shaw, Pieter Koorts, Nidhi Bansal
Summary: This study compared the effects of Holder pasteurization (HoP) and hydrostatic high-pressure (HHP) processing on human milk proteins. The results showed that HHP processing better preserved the protein profile of human milk compared to HoP.
Article
Oncology
Emanuel Goncalves, Rebecca C. Poulos, Zhaoxiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yangxiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip J. Robinson, Qing Zhong, Mathew J. Garnett, Roger R. Reddel
Summary: The study analyzes the proteomes of multiple cancer cell lines through mass spectrometry and reveals thousands of cancer protein biomarkers that are not significant at the transcript level, demonstrating that the proteome has predictive power for drug response similar to the transcriptome.
Article
Multidisciplinary Sciences
Benjamin B. Sun, Joshua Chiou, Matthew Traylor, Christian Benner, Yi-Hsiang Hsu, Tom G. Richardson, Praveen Surendran, Anubha Mahajan, Chloe Robins, Steven G. Vasquez-Grinnell, Liping Hou, Erika M. Kvikstad, Oliver S. Burren, Jonathan Davitte, Kyle L. Ferber, Christopher E. Gillies, Asa K. Hedman, Sile Hu, Tinchi Lin, Rajesh Mikkilineni, Rion K. Pendergrass, Corran Pickering, Bram Prins, Denis Baird, Chia-Yen Chen, Lucas D. Ward, Aimee M. Deaton, Samantha Welsh, Carissa M. Willis, Nick Lehner, Matthias Arnold, Maria A. Woerheide, Karsten Suhre, Gabi Kastenmueller, Anurag Sethi, Madeleine Cule, Anil Raj, Lucy Alnylam Human Genetics, Eugene AstraZeneca Genomics Initiative, Mary Helen Biogen Biobank Team, Eric B. Bristol Myers Squibb, Joanna M. M. Genentech Human Genetics, Hyun Min GlaxoSmithKline Genomic Sci, Mark I. Pfizer Integrative Biology, Paul Population Analytics Janssen Data Sci, Slave Regeneron Genetics Ctr, Lucy Burkitt-Gray, Eugene Melamud, Mary Helen Black, Eric B. Fauman, Joanna M. M. Howson, Hyun Min Kang, Mark I. Mccarthy, Paul Nioi, Slave Petrovski, Robert A. Scott, Erin N. Smith, Sandor Szalma, Dawn M. Waterworth, Lyndon J. Mitnaul, Joseph D. Szustakowski, Bradford W. Gibson, Melissa R. Miller, Christopher D. Whelan
Summary: The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium that characterizes the plasma proteomic profiles of over 54,000 UK Biobank participants. The study provides detailed insights into proteomic disease signatures, genetic associations, and biological mechanisms, offering a valuable resource for drug discovery and biomarker development.
Article
Biochemistry & Molecular Biology
Denise de Abreu Pereira, Vanessa Sandim, Thais F. B. Fernandes, Vitor Hugo Almeida, Murilo Ramos Rocha, Ronaldo J. F. C. do Amaral, Maria Isabel D. Rossi, Dario Eluan Kalume, Russolina B. Zingali
Summary: This study compared the membrane protein composition and abundance differences between HCC-1954 and MCF-7 breast cancer cell lines, and found that proteins involved in cytoskeleton organization were more abundant in HCC-1954. In addition, the membrane expression of beta 1 integrin increased after trastuzumab treatment in the HCC-1954 cell line, highlighting the need to investigate the role of beta 1 integrin modulation in trastuzumab resistance mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Jeremy M. Robbins, Bennet Peterson, Daniela Schranner, Usman A. Tahir, Theresa Rienmueller, Shuliang Deng, Michelle J. Keyes, Daniel H. Katz, Pierre M. Jean Beltran, Jacob L. Barber, Christian Baumgartner, Steven A. Carr, Sujoy Ghosh, Changyu Shen, Lori L. Jennings, Robert Ross, Mark A. Sarzynski, Claude Bouchard, Robert E. Gerszten
Summary: The study analyzed plasma protein levels and identified proteins associated with individual oxygen consumption and increase in oxygen consumption after exercise training, which improved the prediction of individual oxygen consumption. The findings were validated in separate exercise cohorts and linked some proteins to all-cause mortality in a community-based cohort. The study also reproduced the specificity of key findings using antibody-based assays.
Article
Cell Biology
Jerome Salignon, Omid R. Faridani, Tasso Miliotis, Georges E. Janssens, Ping Chen, Bader Zarrouki, Rickard Sandberg, Pia Davidsson, Christian G. Riedel
Summary: By analyzing proteins and small RNAs in human blood plasma samples, it was found that combining protein and miRNA data can result in more accurate age-predictive models, possibly capturing a broader range of age-related physiological changes.
Review
Cardiac & Cardiovascular Systems
Shin-Haw Lee, Da Hye Kim, Uros Kuzmanov, Anthony O. Gramolini
Summary: Cardiovascular diseases are the fastest rising contributing factor to all-cause mortality globally, with membrane proteins playing a crucial role in maintaining the function of cardiomyocytes. Membrane proteins are excellent pharmaceutical targets due to their unique position within the cell, and changes in cardiac membrane proteins are implicated in the progression and pathogenesis of heart diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Haji Gul, Xingyong Chen, Zhaoyu Geng
Summary: Cholesterol concentration in egg yolk significantly affects protein abundance, molecular function, and biological processes related to lipid transport and embryo protection during embryonic development. High cholesterol eggs exhibit increased expression of certain proteins like vitellogenin, ovoinhibitor, immunoglobulin lambda light chain precursor, and beta-2-glycoprotein-1 precursor, while low cholesterol eggs show significant intensities of proteins like haptoglobin protein PIT-54 and vitelline membrane outer layer proteins. Additionally, the ovotransferrin and vitellin membrane outer layer proteins play important roles in regulating biological processes and cellular components in the egg yolk.
Article
Biology
Jennette M. Codjoe, Ryan A. Richardson, Fionn McLoughlin, Richard David Vierstra, Elizabeth S. Haswell
Summary: This study reveals that the Arabidopsis MSL10 channel is associated and functions with proteins at endoplasmic reticulum-plasma membrane contact sites (EPCSs). Mutations in the synaptotagmin genes were identified as suppressors of MSL10 gain-of-function phenotype. In addition, the expansion of EPCSs in msl10-3G plants provides new insights into the function and regulation of this subcellular compartment.
Review
Biochemistry & Molecular Biology
Pierre Dupuy, Claude Gutierrez, Olivier Neyrolles
Summary: Recent research has shown that specific protein clustering occurs within membrane subdomains in bacteria, contradicting the notion that prokaryotes lack these subdomains. This article provides examples of bacterial membrane protein clustering, explaining the advantages of protein assembly in membranes and highlighting how clustering regulates protein activity.
MOLECULAR MICROBIOLOGY
(2023)
Article
Biochemical Research Methods
Adi L. Tarca, Roberto Romero, Gaurav Bhatti, Francesca Gotsch, Bogdan Done, Dereje W. Gudicha, Dahiana M. Gallo, Eunjung Jung, Roger Pique-Regi, Stanley M. Berry, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez
Summary: The human plasma proteome was analyzed using an aptamer-based platform, revealing associations between gestational age and changes in proteins related to growth regulation, angiogenesis, immunity, and inflammation. Machine learning was able to accurately predict gestational age and time to term delivery, indicating the potential of the plasma proteome as a non-invasive tool for investigating obstetrical diseases.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Immunology
Lior Soday, Martin Potts, Leah M. Hunter, Benjamin J. Ravenhill, Jack W. Houghton, James C. Williamson, Robin Antrobus, Mark R. Wills, Nicholas J. Matheson, Michael P. Weekes
Summary: This study reveals the variability of IFN alpha 2a effects among primary human immune cells, with differences in response observed between CD4+ T cells and monocytes. The research provides a comprehensive map of IFN alpha 2a-stimulated primary immune cell surface proteins and highlights the importance of understanding the impact of IFN on plasma membrane proteins for antiviral immunity and therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ruta Navakauskiene, Sandra Baronaite, Dalius Matuzevicius, Natalija Krasovskaja, Grazina Treigyte, Audrone Arlauskiene, Dalius Navakauskas
Summary: Mass spectrometry-based proteomics was used to analyze amniotic fluid samples and identify proteins related to normal and polyhydramnios pregnancies. Quantitative changes in proteins were evaluated through computational analysis and comparison of protein maps. The study found that certain proteins showed increased levels in pathological pregnancies, suggesting their association with immune response, inflammation, and abnormal development. This research provides insights into the mechanisms underlying pathological pregnancies and fetal abnormalities.
Article
Biochemistry & Molecular Biology
Juan Manuel Velazquez-Enriquez, Alma Aurora Ramirez-Hernandez, Luis Manuel Sanchez Navarro, Itayetzi Reyes-Avendano, Karina Gonzalez-Garcia, Cristian Jimenez-Martinez, Luis Castro-Sanchez, Xariss Miryam Sanchez-Chino, Veronica Rocio Vasquez-Garzon, Rafael Baltierrez-Hoyos
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with unknown causes. This study identified differentially expressed proteins (DEPs) related to IPF pathogenesis by comparing IPF lung fibroblast cell lines with normal lung fibroblast cell lines. The results provide valuable information on the role of DEPs in IPF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
