Article
Genetics & Heredity
Niloufar Salimian, Maryam Peymani, Kamran Ghaedi, Mehrdad Hashemi, Ebrahim Rahimi
Summary: This study evaluated changes in the expression levels of collagen family genes related to EMT and metastasis in gastric, breast, and colorectal cancers, identifying COL11A1 and COL1A1 as common diagnostic biomarkers for these three types of cancer.
Article
Cell Biology
Yang Liu, Lanlan Chen, Xiangbo Meng, Shujun Ye, Lianjun Ma
Summary: This study identified hub genes associated with colorectal adenocarcinoma and constructed a 3-gene signature to predict the prognosis of patients. The findings provide valuable insights into the molecular mechanisms and potential prognosis factors of colorectal adenocarcinoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Michael Rohr, Jordan Beardsley, Sai Preethi Nakkina, Xiang Zhu, Jihad Aljabban, Dexter Hadley, Deborah Altomare
Summary: The study developed a meta-dataset comprising healthy, adenoma, and CRC tissue samples from multiple independent studies, providing a robust platform for investigating colorectal adenoma formation and malignant transformation through integrated analysis and functional validation.
Article
Biochemistry & Molecular Biology
Olaia Martinez-Iglesias, Vinogran Naidoo, Juan Carlos Carril, Silvia Seoane, Natalia Cacabelos, Ramon Cacabelos
Summary: There is a lack of effective diagnostic biomarkers for neurodegenerative disorders (NDDs). Gene expression analysis can provide diagnostic value for NDDs and offers an alternative to current diagnostic methods. This study identified specific gene expressions associated with Alzheimer's disease (AD), Parkinson's disease (PD), and vascular/mixed dementia (VaD). APOE, PSEN1, ABCA7, and SNCA mRNA levels showed high diagnostic accuracy for AD and PD, while PICALM had less accuracy as a biomarker for AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Chang Woo Kim, Jae Myung Cha, Min Seob Kwak
Summary: In colorectal cancer, patients with mucinous adenocarcinoma (MAC) have a poorer prognosis compared to those with traditional adenocarcinoma (TAC), especially in Stage II. The study findings suggest that identifying potential biomarkers and biological pathways can be useful in predicting the prognosis of colorectal cancer.
Article
Gastroenterology & Hepatology
Jessica Roelands, Manon Van der Ploeg, Marieke E. Ijsselsteijn, Hao Dang, Jurjen J. Boonstra, James C. H. Hardwick, Lukas J. A. C. Hawinkels, Hans Morreau, Noel F. C. C. de Miranda
Summary: Spatial profiling of pT1 CRC samples revealed the molecular and immunological landscape of early-stage colorectal cancer, identifying biomarkers associated with disease progression and targetable immune processes applicable in a clinical setting.
Article
Oncology
Qiu Lin, Li Luo, Hua Wang
Summary: This study establishes a signature based on four oxaliplatin resistance-related genes for predicting survival in colon cancer patients. The signature shows high accuracy in prognostic prediction for colon cancer, helping identify cases with poor prognostic outcomes and shedding light on mechanisms of oxaliplatin resistance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Yun Li, Haixiang Zhou, Qian Huang, Wei Tan, Yuting Cai, Zicong Wang, Jingling Zou, Bingyan Li, Shigeo Yoshida, Yedi Zhou
Summary: This study reveals the altered expression profiles of circular RNAs in the peripheral blood mononuclear cells of patients with retinopathy of prematurity and identifies potential biomarkers for ROP diagnosis. The findings suggest that circRNAs could be used as diagnostic biomarkers and therapeutic targets for ROP.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Wenjing Song, Xin He, Pengju Gong, Yan Yang, Sirui Huang, Yifan Zeng, Lei Wei, Jingwei Zhang
Summary: This study identified novel prognostic genes related to glycolysis in PDAC and developed a risk prediction model based on these genes. The high-risk group patients showed worse prognosis and immunosuppressed status, with more macrophage infiltration. Internal and external validations confirmed the predictive ability of the model for PDAC prognosis.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Zheying Zhang, Huijie Jia, Yuhang Wang, Baoshun Du, Jiateng Zhong
Summary: The study found that increased MACC1 levels may be associated with lymphatic metastasis in colorectal cancer patients, especially in the middle-aged group of 64-75 years old.
Article
Environmental Sciences
Bongkyun Park, Musun Park, Kyuhyung Jo, Chan-Sik Kim, Su-Jin Baek
Summary: By analyzing the transcriptome of mouse nasal tissues, significant gene expression differences related to nasal inflammation caused by exposure to Korean diesel particulate matter 20 (KDP20) were identified. Potential predictive biomarkers and binding analysis between metal ions and genes were also discovered.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, General & Internal
Yuan Yuan, Weimin Ren, Jinchao Zhu, Saiyan Ji, Qingyuan Yang
Summary: Lymph node metastasis, perineural/venous invasion, TNM stage, local recurrence or distant metastasis after surgery, and the expression of Ki-67 and KRAS mutation are independent prognostic biomarkers for predicting the 2-year survival rate of CRC patients. These markers show differential prognosis in different subgroups based on age, tumor site, differentiation, histological type, lymph node metastasis, TNM stage, and recurrence/metastasis.
ANNALS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jiamin Zhou, Weiqi Xu, Yibin Wu, Miao Wang, Ning Zhang, Longrong Wang, Yun Feng, Ti Zhang, Lu Wang, Anrong Mao
Summary: Liver metastases are commonly found in colorectal cancer patients and are associated with poor prognosis. The expression of GPR37 is significantly elevated in liver metastases of colorectal cancer. In mouse models, depletion of GPR37 suppresses liver metastasis. It has been shown that GPR37 knockdown inhibits tumor growth by reducing glycolysis and prevents neutrophil recruitment in the tumor microenvironment. Mechanistically, GPR37 activates the hippo pathway, leading to increased LDHA expression and glycolysis, resulting in changes in the tumor metabolism and microenvironment.
Article
Endocrinology & Metabolism
Yunjin Yao, Peiwei Xu, Tianxing Ying, Yue Wang, Xumeng Wang, Liqi Shu, Zhe Mo, Zhijian Chen, Xiaofeng Wang, Weibin Wang, Lisong Teng, Xiaoming Lou
Summary: This study conducted an integrative analysis of DNA methylation and RNA array data to identify thyroid cancer-specific DNA methylation markers, providing potential molecular markers for early diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pathology
Chan Xiang, Chunyu Ji, Yiran Cai, Haohua Teng, Yulu Wang, Ruiying Zhao, Zhanxian Shang, Lianying Guo, Shengnan Chen, Analyn Lizaso, Jing Lin, Haozhe Wang, Bing Li, Zhou Zhang, Jikai Zhao, Jinzhi Wei, Jiaxin Liu, Lei Zhu, Wentao Fang, Yuchen Han
Summary: This study analyzed the clinical, histopathological, and molecular data of Chinese patients with preinvasive to invasive lung adenocarcinoma (LUAD). The findings revealed distinct molecular features between preinvasive lesions and invasive tumors, including specific gene mutations. The study also demonstrated different mutational features for subtypes of oncogene mutations favored by different invasion patterns in adenocarcinomas.
Article
Oncology
Ronald McDowell, Sarah Perrott, Peter Murchie, Christopher Cardwell, Carmel Hughes, Leslie Samuel
Summary: The study found that antibiotics may be associated with colon tumor formation across all age groups, while they were not associated with rectal cancer.
BRITISH JOURNAL OF CANCER
(2022)
Article
Medicine, Research & Experimental
Louise C. Brown, Janet Graham, David Fisher, Richard Adams, Jenny Seligmann, Matthew Seymour, Richard Kaplan, Emma Yates, Mahesh Parmar, Susan D. Richman, Philip Quirke, Rachel Butler, Kaikeen Shiu, Gary Middleton, Leslie Samuel, Richard H. Wilson, Timothy S. Maughan
Summary: FOCUS4 is a molecularly stratified umbrella trial in metastatic colorectal cancer, using adaptive statistical methodology to close sub-trials and add new therapies. Feedback from investigators at the close of the trial was consolidated into recommendations and lessons learned for similar future trials.
Article
Oncology
Alexandra Roux, Rachel Cholerton, Jonathan Sicsic, Nora Moumjid, David P. French, Paolo Giorgi Rossi, Corinne Balleyguier, Michal Guindy, Fiona J. Gilbert, Jean-Benoit Burrion, Xavier Castells, David Ritchie, Debbie Keatley, Camille Baron, Suzette Delaloge, Sandrine de Montgolfier
Summary: The MyPeBS study is a randomized controlled trial testing the effectiveness of a risk-stratified breast cancer screening strategy compared to age-based screening. It aims to explore the psychological, socio-economic, and ethical aspects of this new strategy. Data is collected through online questionnaires and qualitative interviews, and will be analyzed to assess differences and outcomes between the two screening arms.
Article
Oncology
Andrew D. James, Theresa K. Leslie, Joshua D. Kaggie, Laura Wiggins, Lewis Patten, John Murphy O'Duinn, Swen Langer, Marie-Christine Labarthe, Frank Riemer, Gabrielle Baxter, Mary A. McLean, Fiona J. Gilbert, Aneurin J. Kennerley, William J. Brackenbury
Summary: In this study, the diagnostic and treatment-monitoring potential of sodium (Na-23) MRI in breast cancer was demonstrated. The researchers found elevated sodium concentration in tumor regions compared to non-tumor regions, and combining Na-23 MRI with other imaging measurements improved the accuracy of tumor classification. This novel MRI method also showed superior sensitivity in assessing treatment response compared to traditional methods.
BRITISH JOURNAL OF CANCER
(2022)
Article
Critical Care Medicine
Jonathan R. Weir-McCall, Elise Debruyn, Scott Harris, Nagmi R. Qureshi, Robert C. Rintoul, Fergus Gleeson, Fiona J. Gilbert
Summary: A lung cancer prediction convolutional neural network (LCP-CNN) demonstrates diagnostic performance comparable to PET with CT imaging in the diagnosis of solitary pulmonary nodules. The LCP-CNN outperforms dynamic contrast-enhanced (DCE) CT imaging in accuracy, while being equal to PET with CT imaging.
Article
Rheumatology
Fraser L. Collins, Anke J. Roelofs, Rebecca A. Symons, Karolina Kania, Ewan Campbell, Elaina S. R. Collie-duguid, Anna H. K. Riemen, Susan M. Clark, Cosimo De Bari
Summary: This study provides a detailed characterization of synovial fibroblasts and progenitors in mouse knees, both in healthy and injured conditions. The findings shed light on the cellular and molecular principles underlying the organization and maintenance of adult synovial joints.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Biographical-Item
Radiology, Nuclear Medicine & Medical Imaging
Gordon D. Waiter, Fiona J. Gilbert, Alison Murray, Beverly MacLennan
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Andrej Corovic, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T. Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R. Jayne, Stephen P. Hoole, Patrick A. Calvert, Andrew F. Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D. Fryer, Luigi Aloj, Martin J. Graves, Fiona J. Gilbert, Marc R. Dweck, David E. Newby, Zahi A. Fayad, Gary Reynolds, Ann W. Morgan, Eric O. Aboagye, Anthony P. Davenport, Helle F. Jorgensen, Ziad Mallat, Martin R. Bennett, James E. Peters, James H. F. Rudd, Justin C. Mason, Jason M. Tarkin
Summary: This study investigates the feasibility of using somatostatin receptor 2 (SST2) as a molecular imaging target for inflammation in large vessel vasculitis (LVV), and provides evidence for its potential in the diagnosis and therapeutic monitoring of LVV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jung Hyun Yoon, Fredrik Strand, Pascal A. T. Baltzer, Emily F. Conant, Fiona J. Gilbert, Constance D. Lehman, Elizabeth A. Morris, Lisa A. Mullen, Robert M. Nishikawa, Nisha Sharma, Ilse Vejborg, Linda Moy, Ritse M. Mann
Summary: This study evaluated the performance of artificial intelligence (AI) in the interpretation of digital mammography and digital breast tomosynthesis (DBT). The results showed that standalone AI performed as well as or better than radiologists in digital mammography, but there were insufficient studies to assess its performance in DBT interpretation.
Editorial Material
Biochemistry & Molecular Biology
Fiona Gilbert
Summary: Combining artificial intelligence with human expertise can be the best approach to enhance diagnostic accuracy in clinical imaging while ensuring safety.
Article
Acoustics
Hisham Assi, Rui Cao, Madhura Castelino, Ben Cox, Fiona J. Gilbert, Janek Gro, Kurinchi Gurusamy, Lina Hacker, Aoife M. Ivory, James Joseph, Ferdinand Knieling, Martin J. Leahy, Ledia Lilaj, Srirang Manohar, Igor Meglinski, Carmel Moran, Andrea Murray, Alexander A. Oraevsky, Mark D. Pagel, Manojit Pramanik, Jason Raymond, Mithun Kuniyil Ajith Singh, William C. Vogt, Lihong Wang, Shufan Yang, Sarah E. Bohndiek
Summary: Photoacoustic imaging has a promising potential in clinical trials, but its adoption in healthcare systems for clinical decision making faces barriers such as education, training, and data interpretation. The International Photoacoustic Standardisation Consortium identified these barriers and developed plans to address them.
Article
Radiology, Nuclear Medicine & Medical Imaging
Simone Schiaffino, Katja Pinker, Andrea Cozzi, Veronica Magni, Alexandra Athanasiou, Pascal A. T. Baltzer, Julia Camps Herrero, Paola Clauser, Eva M. Fallenberg, Gabor Forrai, Michael H. Fuchsjaeger, Fiona J. Gilbert, Thomas Helbich, Fleur Kilburn-Toppin, Christiane K. Kuhl, Mihai Lesaru, Ritse M. Mann, Pietro Panizza, Federica Pediconi, Francesco Sardanelli, Tamar Sella, Isabelle Thomassin-Naggara, Sophia Zackrisson, Ruud M. Pijnappel
Summary: New evidence has led to updates in recommendations by EUSOBI regarding breast imaging examinations after COVID-19 vaccination. For asymptomatic patients with unilateral lymphadenopathy and no suspicious breast findings, no further work-up is needed. Other recommendations issued in 2021 remain valid.
INSIGHTS INTO IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Cozzi, Giovanni Di Leo, Nehmat Houssami, Fiona J. Gilbert, Thomas H. Helbich, Marina Alvarez Benito, Corinne Balleyguier, Massimo Bazzocchi, Peter Bult, Massimo Calabrese, Julia Camps Herrero, Francesco Cartia, Enrico Cassano, Paola Clauser, Marcos de Lima F. Docema, Catherine Depretto, Valeria Dominelli, Gabor Forrai, Rossano Girometti, Steven E. Harms, Sarah Hilborne, Raffaele Ienzi, Marc B. I. Lobbes, Claudio Losio, Ritse M. Mann, Stefania Montemezzi, Inge-Marie Obdeijn, Umit A. Ozcan, Federica Pediconi, Katja Pinker, Heike Preibsch, Jose L. Raya Povedano, Carolina Rossi Saccarelli, Daniela Sacchetto, Gianfranco P. Scaperrotta, Margrethe Schlooz, Botond K. Szabo, Donna B. Taylor, Ozden S. Ulus, Mireille Van Goethem, Jeroen Veltman, Stefanie Weigel, Evelyn Wenkel, Chiara Zuiani, Francesco Sardanelli
Summary: This study aimed to investigate the mastectomy and reoperation rates in breast cancer patients who underwent MRI for screening or diagnostic purposes. The results showed that patients who had MRI for screening had higher mastectomy rates and lower reoperation rates compared to those who had MRI for diagnostic purposes.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia C. Carmona-Bozo, Roido Manavaki, Jodi L. Miller, Cara Brodie, Corradina Caraco, Ramona Woitek, Gabrielle C. Baxter, Martin J. Graves, Tim D. Fryer, Elena Provenzano, Fiona J. Gilbert
Summary: This study explores the relationship between indices of hypoxia and vascular function in ER + breast cancer using [F-18]-FMISO PET/MRI and immunohistochemical markers. The results indicate that hypoxia is associated with increased CAIX expression, reduced microvessel density, and smaller vessel diameters in ER + breast cancer, further confirming the link between inadequate vascularity and hypoxia in this type of cancer.
EUROPEAN RADIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Melanie Turner, Romi Carriere, Shona Fielding, George Ramsay, Leslie Samuel, Andrew Maclaren, Peter Murchie
Summary: Limited data exist on the effect of travelling time on post-diagnosis cancer care and mortality. This study analyzed the impact of travel time to cancer treatment center on secondary care contact time and one-year mortality in Scotland. Patients with longer travelling time and island-dwellers had increased secondary care cancer contact time. Longer travel time was not associated with increased secondary care contact time for emergency cancer admissions. Living on an island increased mortality at one-year.