Review
Oncology
Regina Wan Ju Wong, Jolynn Zu Lin Ong, Madelaine Skolastika Theardy, Takaomi Sanda
Summary: IRF4 is a crucial transcription factor involved in regulating cell identity and immune responses. It plays essential roles in normal lymphocyte development and immunity by interacting with upstream signaling pathways and binding partners. However, when abnormally expressed, IRF4 can act as an oncogene and induce oncogenic transcription programs. IRF4 and its upstream factor NF-kappa B form a transcriptional regulatory circuit to maintain the oncogenic transcriptional program in malignant lymphoid cells.
Article
Oncology
Ning Huang, Lei Peng, Jiaping Yang, Jinqian Li, Sheng Zhang, Mingjuan Sun
Summary: This study found that FAM111B gene is overexpressed in bladder cancer and is associated with lymphatic metastasis and reduced overall survival. Knockdown of FAM111B gene can inhibit cell proliferation and migration, induce apoptosis, and suppress tumor growth.
Article
Cell Biology
Xiaoling Wang, Peng Jin, Yi Zhang, Kankan Wang
Summary: This study reveals that circSPI1, a circular RNA derived from the SPI1 gene, is highly expressed in AML and acts as an oncogene, promoting AML development through multiple interactions. CircSPI1 contributes to myeloid differentiation, proliferation, and apoptosis in AML cells by interacting with various factors, showcasing the complexity of SPI1 gene regulation involving circSPI1.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Zhaojun Wang, Xinling Liu, Zhanju Wang, Zhenbo Hu
Summary: FOXK2 is a central transcriptional regulator involved in various biological processes, such as genomic stability and cancer development. Its differential expression in different types of cancer suggests its potential role as an oncoprotein or tumor suppressor, although its exact mechanisms in tumorigenesis are still largely unexplored.
Article
Medicine, Research & Experimental
Farah Hasan, Yulun Chiu, Rebecca M. Shaw, Junmei Wang, Cassian Yee
Summary: The combination of hypoxia and TGF-beta(1) can induce the development of a T-RM phenotype in human CD8(+) T cells, leading to specific phenotypic features and enrichment of human T-RM gene signatures. This finding suggests a previously unreported cue for the T-RM differentiation program, offering potential applications in adoptive cellular therapy and basic research.
Article
Plant Sciences
Saddam Hussain, Yuxin Cheng, Yingying Li, Wei Wang, Hainan Tian, Na Zhang, Yating Wang, Yuan Yuan, Hadia Hussain, Rao Lin, Chen Wang, Tianya Wang, Shucai Wang
Summary: The transcription factor AtbZIP62 is involved in regulating plant responses to abiotic stresses and has a role in ABA responses. Overexpression and gene editing experiments showed that AtbZIP62 positively regulates ABA responses in seed germination and cotyledon greening by controlling the expression of ABA-responsive genes.
Article
Oncology
Xiang Wu, Jin Li, Tingyuan Yan, Xueping Ke, Xin Li, Yumin Zhu, Jianrong Yang, Zhongwu Li
Summary: HOXB7 is overexpressed in HNSCC and associated with tumor aggressiveness and poor prognosis, serving as a potential therapeutic target in HNSCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Plant Sciences
Lei Shen, Xin Xia, Longhao Zhang, Shixin Yang, Xu Yang
Summary: Salt stress seriously affects plant growth and yield, and the mechanisms of plant response to salt stress are still unclear. This study found that SmWRKY11, a transcription factor, acts as a positive regulator in eggplant response to salt stress and indirectly regulates salt stress response through forming a positive feedback loop with SmERF1.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Cell Biology
Qiong Wu, Zongwen Liang, Jing Jiang, Xiaoming Feng, Jinming Liu, Zongfeng Zhang, Honglin Wang, Ning Wang, Yanling Gou, Zhi Li, Yingying Cao
Summary: IL-33 secreted from macrophages regulates ferroptosis in eESCs through the P38/JNK/ATF3 pathway, ultimately protecting eESCs from iron-induced cell death.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Yingdong Deng, Simin Tang, Jiurong Cheng, Xiangsheng Zhang, Danqin Jing, Ziqiang Lin, Jun Zhou
Summary: The dorsal root ganglion (DRG) plays an active role in the development of neuropathic pain (NP), but its mechanism in NP regulation is not fully understood. The immune system has been increasingly recognized as important in the pathogenesis of NP, particularly through immune-related genes (IRGs) and specific immune cells. However, the involvement of IRGs in DRG and their regulation of NP action has not been fully elucidated.
Article
Immunology
Ruihan Tang, Nandini Acharya, Ayshwarya Subramanian, Vinee Purohit, Marcin Tabaka, Yu Hou, Danyang He, Karen O. Dixon, Connor Lambden, Junrong Xia, Orit Rozenblatt-Rosen, Raymond A. Sobel, Chao Wang, Aviv Regev, Ana C. Anderson, Vijay K. Kuchroo
Summary: Dendritic cells (DCs) play a crucial role in modulating the immune response by sensing environmental cues. This study identifies Bat3 as an endogenous regulator of DC function, showing that loss of Bat3 expression alters the T cell compartment, resulting in the attenuation of autoimmunity and acceleration of tumor growth.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
Yuzhang Du, Zhihui Ma, Juanjuan Zheng, Shu Huang, Xiaobao Yang, Yue Song, Danfeng Dong, Liyun Shi, Dakang Xu
Summary: The severity of Staphylococcus aureus respiratory infection is correlated with antibacterial gene signature, and ATF3 plays a protective role by enhancing macrophage function and regulating antibacterial genes and actin cytoskeleton for bacterial killing and macrophage migration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Jihu Li, Lina Xie, Xiuling Tian, Siyang Liu, Dengan Xu, Hui Jin, Jie Song, Yan Dong, Dehui Zhao, Genying Li, Yulian Li, Yan Zhang, Yong Zhang, Xianchun Xia, Zhonghu He, Shuanghe Cao
Summary: In this study, TaNAC100 was identified as a key regulator controlling seed protein and starch synthesis in wheat. Overexpression of TaNAC100 led to reduced HMW-GS and other SSP contents, increased seed starch contents, and altered plant phenotypes. This research provides insights into the regulatory mechanisms of seed storage product metabolism in wheat.
Article
Biochemistry & Molecular Biology
Qing Hu, Tian Tian, Yahui Leng, Yuanhui Tang, Shuang Chen, Yueyao Lv, Jingyin Liang, Yanni Liu, Tianhui Liu, Li Shen, Xiaoxia Dong
Summary: Among the GALNT family members, only GALNT2 was frequently overexpressed in NSCLC tissues and was positively correlated with poor prognosis. In vitro experiments showed that GALNT2 knockdown inhibited NSCLC cell proliferation, migration, and invasion, but induced apoptosis and cell cycle arrest. In vivo experiments demonstrated that knockdown of GALNT2 suppressed tumor formation in nude mice. Mechanistic investigations revealed that GALNT2 modified the O-glycosylation of ITGA5 and affected the activation of the PI3K/Akt and MAPK/ERK pathways. Further studies showed that miR-30d was a negative regulator of GALNT2.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Agronomy
Zheng-Ting Yang, Zi-Qiang Guo, Shun-Sha Wang, Yin An, Si-Xian Fan, Yan Jian, Kun Li, Yin Yi
Summary: This study demonstrates that NAC062 acts as an upstream regulator in the ER stress pathway in Arabidopsis, directly regulating the expression of NAC103. Both NAC062 and NAC103 are upregulated in biotic and abiotic stress pathways, and studying their relationship helps to understand their function in enhancing plant tolerance to environmental stresses.
Review
Oncology
Tabish Hussain, Bin Liu, Morgan S. Shrock, Terence Williams, C. Marcelo Aldaz
GENES CHROMOSOMES & CANCER
(2019)
Article
Neurosciences
Tabish Hussain, Hyunsuk Kil, Bharathi Hattiangady, Jaeho Lee, Maheedhar Kodali, Bing Shuai, Sahithi Attaluri, Yoko Takata, Jianjun Shen, Martin C. Abba, Ashok K. Shetty, C. Marcelo Aldaz
NEUROBIOLOGY OF DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Zhenguo Zeng, Weiguo Chen, Alexander Moshensky, Zaid Shakir, Raheel Khan, Laura E. Crotty Alexander, Lorraine B. Ware, C. M. Aldaz, Jeffrey R. Jacobson, Steven M. Dudek, Viswanathan Natarajan, Roberto F. Machado, Sunit Singla
Summary: Chronic cigarette smoking is known to increase risk for ARDS, but the risks associated with chronic e-cigarette use are largely unknown. The WWOX gene is highly susceptible to genotoxic stress from environmental exposures and exposure to nicotine-containing e-cigarette vapor resulted in a decrease in WWOX mRNA levels. The downregulation of WWOX may play a role in the increased risk for ARDS in chronic smokers and potentially in chronic e-cigarette users in the future.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Martin C. Abba, Romina Canzoneri, Agustina Gurruchaga, Jaeho Lee, Pradeep Tatineni, Hyunsuk Kil, Ezequiel Lacunza, C. Marcelo Aldaz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
C. Marcelo Aldaz, Tabish Hussain
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Anne Trinh, Carlos R. Gil Del Alcazar, Sachet A. Shukla, Koei Chin, Young Hwan Chang, Guillaume Thibault, Jennifer Eng, Bojana Jovanovic, C. Marcelo Aldaz, So Yeon Park, Joon Jeong, Catherine Wu, Joe Gray, Kornelia Polyak
Summary: The transition from DCIS to IDC involves genetic correlations despite long latency periods and therapeutic interventions. Immune hot and cold tumors can arise early in DCIS, with different degrees of immune cell mixing between DCIS and IDC. Tumor-specific copy-number aberrations and mutations are associated with differences in immune signaling in IDC, potentially modulating immune function and driving the transition to IDC.
MOLECULAR CANCER RESEARCH
(2021)
Article
Oncology
Valeria Alejandra Ferretti, Romina Canzoneri, Sabina Palma, Ezequiel Lacunza, Claudio Marcelo Aldaz, Martin Carlos Abba
Summary: Rhomboid pseudoproteases such as RHBDD2 play a role in regulating the activity of target proteins in mammary gland development and breast cancer. Interaction studies showed a physical association between RHBDD2 and WWOX in normal and cancer cells, suggesting a potential involvement in breast epithelial cell proliferation and differentiation. WWOX, as a novel target of RHBDD2, may modulate gene expression in breast cells through the TGF beta/SMAD3 signaling pathway.
Article
Genetics & Heredity
Dongju Park, Mehdi Gharghabi, Morgan S. Schrock, Rebecca Plow, Teresa Druck, Charles Yungvirt, C. Marcelo Aldaz, Kay Huebner
Summary: Down regulation of Wwox protein expression occurs in many cancers, contributing to insensitivity to ionizing radiation (IR) and platinum drug treatments. Patients with reduced Wwox expression in their cancer tissue show decreased overall survival following these treatments, in accord with our earlier finding that reduced Wwox protein expression in cancers is associated with changes in choice of DNA double-strand break (DSB) repair pathway.
Article
Oncology
Martin C. Abba, Maria Laura Fabre, Jaeho Lee, Pradeep Tatineni, Hyunsuk Kil, C. Marcelo Aldaz
Summary: The long-non-coding HOX transcript antisense intergenic RNA (HOTAIR) is significantly upregulated in breast ductal carcinoma in situ (DCIS), promoting the progression of early-stage breast cancer by modulating multiple signaling pathways to induce premalignant phenotypic changes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dongju Park, Mehdi Gharghabi, Colleen R. Reczek, Rebecca Plow, Charles Yungvirt, C. Marcelo Aldaz, Kay Huebner
Summary: Wwox-deficient cells in both humans and mice exhibit elevated homologous recombination. The binding of human Wwox to Brca1 inhibits its phosphorylation, while the binding of murine Wwox to Brca1 affects the DNA break repair pathway through the activation of related proteins. The restoration of sensitivity to ionizing radiation and platinum drugs in Wwox-deficient cells is crucial for cancer treatment research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Maria Laura Fabre, Romina Canzoneri, Agustina Gurruchaga, Jaeho Lee, Pradeep Tatineni, Hyunsuk Kil, Ezequiel Lacunza, C. Marcelo Aldaz, Martin Carlos Abba
Summary: This study characterizes the phenotypic and molecular effects of MALINC1, a long non-coding RNA (lncRNA) that is upregulated in premalignant ductal carcinoma in-situ lesions. MALINC1 is found to behave as an oncogenic and immune-related lncRNA involved in early-stage breast cancer progression. High expression of MALINC1 is associated with a pro-tumorigenic immune environment and a favorable predicted response to immunotherapy.
Article
Neurosciences
Tabish Hussain, Kevin Sanchez, Jennifer Crayton, Dhurjhoti Saha, Collene Jeter, Yue Lu, Martin Abba, Ryan Seo, Jeffrey L. Noebels, Laura Fonken, C. Marcelo Aldaz
Summary: WWOX gene loss-of-function (LoF) is associated with neuropathologies causing developmental, epileptic, and ataxic phenotypes. A specific variant of the WWOX gene, p.Pro47Thr, has been linked to a new form of autosomal recessive cerebellar ataxia with epilepsy and intellectual disability. A mutant knock-in mouse model of the Wwox P47T mutation was generated, which mimics the human SCAR12 phenotype. The mice exhibited epilepsy, social and cognitive deficits, poor motor coordination, and signs of progressive cerebellar dysfunction.
PROGRESS IN NEUROBIOLOGY
(2023)
Meeting Abstract
Oncology
Seyed Javad Moghaddam, Tabish Hussain, Melody Zarghooni, Walter V. Velasco, Linda Phan, Michelle I. Savage, Jennifer T. Fox, Shizuko Sei, Powel H. Brown, C. Marcelo Aldaz
CANCER PREVENTION RESEARCH
(2022)
Meeting Abstract
Oncology
Seyed Javad Moghaddam, Tabish Hussain, Melody Zarghooni, Walter V. Velasco, Linda Phan, Michelle I. Savage, Jennifer T. Fox, Shizuko Sei, Powel H. Brown, C. Marcelo Aldaz
CANCER PREVENTION RESEARCH
(2022)
Meeting Abstract
Oncology
Anne Trinh, Carlos R. Gil Del Alcazar, Sachet A. Shukla, Koei Chin, Young Hwan Chen, Guillaume Thibault, Jennifer Eng, Bojana Jovanovic, C. Marcelo Aldaz, So Yeon Park, Joon Jong, Catherine Wu, Joe Gray, Kornelia Polyak