Article
Gastroenterology & Hepatology
Prashant Singh, Eric J. Alm, John M. Kelley, Vivian Cheng, Mark Smith, Zain Kassam, Judy Nee, Johanna Iturrino, Anthony Lembo
Summary: Fecal microbiota transplantation is an effective strategy to correct microbial dysbiosis in diarrhea-predominant irritable bowel syndrome. For patients with IBS-D, FMT with antibiotic pretreatment significantly reduces bacterial engraftment.
Review
Chemistry, Multidisciplinary
You Yu, Weihong Wang, Faming Zhang
Summary: Fecal microbiota transplantation (FMT) has emerged as a promising approach for dysbiosis-related diseases. Advanced methods, such as washed microbiota transplantation, bacteria spores treatment, and fecal virome transplantation, provide more acceptable options for patients and minimize research heterogeneity.
Article
Multidisciplinary Sciences
Erez N. Baruch, Ilan Youngster, Guy Ben-Betzalel, Rona Ortenberg, Adi Lahat, Lior Katz, Katerina Adler, Daniela Dick-Necula, Stephen Raskin, Naamah Bloch, Daniil Rotin, Liat Anafi, Camila Avivi, Jenny Melnichenko, Yael Steinberg-Silman, Ronac Mamtani, Hagit Harati, Nethanel Asher, Ronnie Shapira-Frommer, Tal Brosh-Nissimov, Yael Eshet, Shira Ben-Simon, Oren Ziv, Md Abdul Wadud Khan, Moran Amit, Nadim J. Ajami, Iris Barshack, Jacob Schachter, Jennifer A. Wargo, Omry Koren, Gal Markel, Ben Boursi
Summary: This study conducted a phase 1 clinical trial and found that FMT treatment in patients with anti-PD-1-refractory metastatic melanoma, along with reinduction of anti-PD-1 immunotherapy, resulted in clinical responses in some patients. This suggests that modulating the gut microbiota could be a promising approach in cancer treatment.
Article
Gastroenterology & Hepatology
Jasmohan S. Bajaj, Edith A. Gavis, Andrew Fagan, James B. Wade, Leroy R. Thacker, Michael Fuchs, Samarth Patel, Brian Davis, Jill Meador, Puneet Puri, Masoumeh Sikaroodi, Patrick M. Gillevet
Summary: This study suggests that FMT may be a safe and effective treatment for patients with alcohol-related cirrhosis, reducing alcohol craving and consumption while improving cognition and quality of life.
Article
Medicine, General & Internal
Soumaya Kouidhi, Oumaima Zidi, Muhanad Alhujaily, Nessrine Souai, Amor Mosbah, Tareg M. Belali, Kais Ghedira, Imene El Kossai, Jamelddine El Manaa, Wissem Mnif, Ameur Cherif
Summary: This study found significant differences in fecal metabolites between kidney transplant recipients and healthy individuals, particularly in lipids. Changes in metabolic pathways also provide potential biomarkers for transplant recipients. Therefore, metabolomics may play a crucial role in monitoring kidney transplants.
Article
Immunology
Caroline Zellmer, Mohamad R. A. Sater, Miriam H. Huntley, Majdi Osman, Scott W. Olesen, Bharat Ramakrishna
Summary: Fecal microbiota transplantation is recommended for multiply recurrent Clostridioides difficile infection, but transmission of Shiga toxin-producing Escherichia coli from donors can lead to adverse events. Improved screening can help prevent future transmission.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biology
Zhao-Bo Luo, Shengzhong Han, Xi-Jun Yin, Hongye Liu, Junxia Wang, Meifu Xuan, Chunyun Hao, Danqi Wang, Yize Liu, Shuangyan Chang, Dongxu Li, Kai Gao, Huiling Li, Biaohu Quan, Lin-Hu Quan, Jin-Dan Kang
Summary: The host genome and intestinal microbiota have mutual influences on each other. Deletion of the myostatin (MSTN) gene in pigs positively regulates the expression of tight junction-related genes in the intestine, leading to changes in the structure of the intestinal microbiota. Transplantation of the intestinal microbiota from MSTN-deficient pigs into mice resulted in increased muscle growth and higher levels of short-chain fatty acids.
Review
Biology
Justine Keathley, Jessica White, Gregor Reid
Summary: The recognition of the importance of microbes in human life has led to research on manipulating them for better health outcomes. However, there is currently no consensus on dietary recommendations to complement ingested organisms for improved health. This review aims to discuss the use of beneficial microbes, such as probiotics, fermented foods, and donor feces, in managing health, and explores the rationale for selecting specific microbial strains and aligning diets to support their growth in the gut.
Review
Oncology
Maroun Bou Zerdan, Stephanie Niforatos, Sandy Nasr, Dayana Nasr, Mulham Ombada, Savio John, Dibyendu Dutta, Seah H. Lim
Summary: Fecal microbiota transplant (FMT) is a therapeutic approach that involves transferring a normal intestinal microbial community from healthy donors to patients with various diseases, particularly for treating recurrent or refractory CDI. Patients with hematologic and oncologic diseases are particularly susceptible to complications related to altered intestinal microbial composition, making them an ideal population for exploring FMT as a therapeutic approach. However, there are inherent obstacles in applying FMT to these patients.
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Olga Brusnic, Danusia Maria Onisor, Amedeo Amedei, Ryota Niikura
Summary: Imbalances in the gut microbiota play a crucial role in the development of liver diseases, and fecal microbiota transplantation has shown promise as an effective treatment for chronic liver diseases and cirrhosis.
Review
Gastroenterology & Hepatology
Shaghayegh Habibi, Armin Rashidi
Summary: Disruptions to the gut microbiota have been linked to adverse outcomes after hematopoietic cell transplantation and cellular therapy. Fecal microbiota transplantation (FMT) is a potential therapeutic intervention, but more research is needed before it can be considered a standard treatment. This review examines the evidence for microbiota-outcome associations, highlights the main FMT trials, and suggests future paths for research.
Review
Microbiology
Zahra Dossaji, Adam Khattak, Kyaw Min Tun, Mark Hsu, Kavita Batra, Annie S. S. Hong
Summary: There is a high prevalence of gastrointestinal-related symptoms among children with autism spectrum disorder (ASD), and these symptoms are associated with the severity of behavioral symptoms. Fecal microbiota transplantation (FMT) is a potential therapeutic strategy for addressing gut microbiome dysregulation in pediatric patients with ASD. A systematic review found that FMT led to significant improvements in both behavioral and gastrointestinal symptoms in these patients. These findings suggest that FMT holds promise as an intervention for treating pediatric patients with autism.
Article
Biochemistry & Molecular Biology
Kan Gao, Aitak Farzi, Xueqin Ke, Yunxia Yu, Cailin Chen, Su Chen, Tengfei Yu, Haifeng Wang, Yanjun Li
Summary: Depression, associated with abnormalities in 5-HT metabolism, can be improved by certain probiotics. The L. lactis strain WHH2078 demonstrated antidepressant effects in mice with induced chronic unpredictable mild stress, through enhancing 5-HT metabolism and modulating gut microbiome composition.
Review
Gastroenterology & Hepatology
Simone Baldi, Tiziana Mundula, Giulia Nannini, Amedeo Amedei
Summary: Probiotic supplementation and FMT have shown to improve cognitive function, while prebiotic supplementation did not provide significant cognitive improvements. Studies indicate that these interventions have positive effects in healthy individuals and patients with neurological disorders, with FMT and probiotics showing beneficial effects on different cognitive functions.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Haiming Fang, Lian Fu, Xuejun Li, Chunxia Lu, Yuan Su, Kangwei Xiong, Lijiu Zhang
Summary: The study demonstrates that monotherapy with a single fresh FMT is an effective and safe strategy for inducing long-term remission in patients with active UC, providing a potential alternative to drug therapy for recurrent or primary UC.
MICROBIAL CELL FACTORIES
(2021)
