Article
Medicine, General & Internal
Casper P. Hagen, Margit Bistrup Fischer, Christine Wohlfahrt-Veje, Maria Assens, Alexander S. Busch, Anette Tonnes Pedersen, Anders Juul, Katharina M. Main
Summary: This study indicates that ovarian activity in healthy girls remains remarkably stable from small growing follicles, suggesting that AMH concentrations in early life can serve as a useful clinical tool to predict future ovarian activity.
Article
Endocrinology & Metabolism
Tess Clendenen, Wenzhen Ge, Karen L. Koenig, Yelena Afanasyeva, Claudia Agnoli, Elizabeth Bertone-Johnson, Louise A. Brinton, Farbod Darvishian, Joanne F. Dorgan, A. Heather Eliassen, Roni T. Falk, Goran Hallmans, Susan E. Hankinson, Judith Hoffman-Bolton, Timothy J. Key, Vittorio Krogh, Hazel B. Nichols, Dale P. Sandler, Minouk J. Schoemaker, Patrick M. Sluss, Malin Sund, Anthony J. Swerdlow, Kala Visvanathan, Mengling Liu, Anne Zeleniuch-Jacquotte
Summary: This study found positive associations between AMH and age at menarche and parity, and negative associations with hysterectomy/partial oophorectomy. Women who were obese, currently used oral contraceptives, or were current/former smokers had lower AMH concentrations. Interestingly, higher AMH concentrations were observed in women who had a benign breast biopsy, especially in women over 40 years old.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Obstetrics & Gynecology
Fisun Vural, Birol Vural, Eyupcan Kardas, Ayse Deniz Erturk Coskun, Irem Yildirim
Summary: This study investigated the utilization of Anti-Mullerian hormone (AMH) alone or replacing polycystic ovarian morphology (PCOM) in the PCOS diagnostic criteria. The results showed that AMH can be used with high diagnostic accuracy instead of PCOM in Rotterdam criteria, especially for phenotype A and D.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Acoustics
Bilgi Kip, Omer Aydin, Cansu Umran Tunc
Summary: This study utilized the ultrasound-active property of gold nanocones (AuNCs) to overcome drug resistance by combining them with cisplatin (Cis). The triple combination therapy of ultrasound, AuNCs, and low-dose Cis showed significant effects in suppressing the growth of drug-resistant ovarian cancer cells in both 2D and 3D models. This novel therapy has the potential to be effective in vivo and in clinical settings, and it can reduce the side effects of chemotherapy.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Obstetrics & Gynecology
Jenny S. George, Monica W. Rosen, Nicole Curci, Maria Ladino Torres, Ashish P. Wasnik, Yolanda R. Smith, Elisabeth H. Quint
Summary: A retrospective case-control study was conducted on 32 premenarchal girls to identify preoperative transabdominal sonographic predictors of ovarian torsion (OT). The study found that several sonographic variables were significantly associated with OT, including simple cysts, ovarian heterogeneity, peripheralized follicles, and asymmetry of color Doppler. However, only the presence of peripheralized follicles was unique to girls with OT.
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2023)
Article
Nutrition & Dietetics
Amir Pejman Hashemi Taheri, Behnaz Moradi, Amir Reza Radmard, Milad Sanginabadi, Mostafa Qorbani, Mohammad Reza Mohajeri-Tehrani, Nooshin Shirzad, Saeed Hosseini, Azita Hekmatdoost, Sedigheh Asadi, Majid Samadi, Asieh Mansour
Summary: Intake of resveratrol has been associated with improved ovarian morphology, as evidenced by a significantly higher rate of improvement in ovarian morphology and a more dominant follicle in women with polycystic ovary syndrome (PCOS). However, other factors like follicle count per ovary, stromal area, ovarian echogenicity, and distribution of follicles were not significantly altered.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Chemistry, Physical
Maryam Aghaee, Khosro Mohammadi, Payam Hayati, Sara Ahmadi, Fatemeh Yazdian, Angel Gutierrez, Shamila Rouhani, Titus A. M. Msagati
Summary: The nano-structures of K metal-organic coordination polymer compound were synthesized using different experimental methods, and characterized using various techniques. Factors influencing morphology and particle size were extensively analyzed, and the structure was optimized to rationalize electronic properties and study antibacterial properties.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Sport Sciences
Sarah Tenberg, Kazunori Nosaka, Jan Wilke
Summary: The study found that eccentric elbow flexor exercise can lead to an increase in biceps brachii ECT thickness, which correlates positively with palpation pain, affecting delayed onset muscle soreness.
SPORTS MEDICINE-OPEN
(2022)
Article
Multidisciplinary Sciences
Audrey Jing Ting Ng, Ramya Chandrasekaran, Ashutosh Prakash, Sreenivasulu Reddy Mogali
Summary: This systematic review investigated the normative values of median nerve cross-sectional area (CSA) at different landmarks of the upper limb based on ultrasonography. The study found that median nerve CSA varies with age, geographical location, and sex at all landmarks.
SCIENTIFIC REPORTS
(2022)
Article
Anatomy & Morphology
Britta Hanssen, Nicky Peeters, Tijl Dewit, Ester Huyghe, Bernard Dan, Guy Molenaers, Anja Van Campenhout, Lynn Bar-On, Christine Van den Broeck, Patrick Calders, Kaat Desloovere
Summary: This study examined the reliability of 3-dimensional freehand ultrasound (3DfUS) for measuring muscle size, length, and echo-intensity in children with spastic cerebral palsy (SCP) and typical development (TD). The results showed high reliability for muscle size and length measures, with some variation depending on the muscle, rater, and session. Echo-intensity measures had lower reliability, but absolute reliability was better for distal muscles compared to proximal muscles. Overall, 3DfUS appears to be a reliable tool for assessing muscle morphology in children with SCP and TD, but further investigation is needed for certain parameters.
JOURNAL OF ANATOMY
(2023)
Proceedings Paper
Engineering, Biomedical
Saumya Gupta, Venkata K. Suryanarayana, Srinivas Rao Kudavelly, G. A. Ramaraju
Summary: This paper presents a deep learning approach to improve the accuracy of ovarian volume computation and enhance the quality of 3D rendering of the ovary, demonstrating the feasibility of the method for clinical diagnostic assessment.
MEDICAL IMAGING 2021: COMPUTER-AIDED DIAGNOSIS
(2021)
Article
Ophthalmology
Diana C. Schmidt, Line Kessel, Daniella Bach-Holm, Katharina M. Main, Dorte A. Larsen, Regitze Bangsgaard
Summary: This study aimed to investigate the prevalence and risk factors of hypothalamus-pituitary-adrenal axis suppression in infants receiving glucocorticoid eye drops. The results showed that high daily glucocorticoid doses per weight were associated with HPA axis suppression in infants. Monitoring is necessary for infants receiving glucocorticoids after ocular surgery.
ACTA OPHTHALMOLOGICA
(2023)
Article
Andrology
Nina Morup, Ailsa Maria Main, Niels Jorgensen, Gedske Daugaard, Anders Juul, Kristian Almstrup
Summary: This study is the first to report the identification of microbiome species in the seminal plasma of men with TGCT and GCNIS-only, and has found some species differences that may be involved in the pathogenesis of TGCTs. Further studies are needed to confirm these findings.
Review
Endocrinology & Metabolism
Marie Lindhardt Ljubicic, Trine Holm Johannsen, Margit Bistrup Fischer, Emmie N. Upners, Alexander S. Busch, Katharina M. Main, Anna-Maria Andersson, Casper P. Hagen, Anders Juul
Summary: The ratio between luteinizing hormone (LH) and follicle-stimulating hormone (FSH) has been found to be a reliable marker for sex determination in healthy infants. However, its role in patients with differences of sex development (DSD) remains unclear. This retrospective study aimed to describe LH/FSH in infants with DSD and found that the ratio sometimes corresponds to the assigned sex, but not in all cases.
ENDOCRINE CONNECTIONS
(2023)
Article
Medicine, General & Internal
Casper P. Hagen, Margit Bistrup Fischer, Christine Wohlfahrt-Veje, Maria Assens, Alexander S. Busch, Anette Tonnes Pedersen, Anders Juul, Katharina M. Main
Summary: This study indicates that ovarian activity in healthy girls remains remarkably stable from small growing follicles, suggesting that AMH concentrations in early life can serve as a useful clinical tool to predict future ovarian activity.
Article
Obstetrics & Gynecology
Ann-Kristin Dicke, Jakob Albrethsen, Bradley L. Hoare, Margot J. Wyrwoll, Alexander S. Busch, Daniela Fietz, Adrian Pilatz, Clara Buehlmann, Anders Juul, Sabine Kliesch, Joerg Gromoll, Ross A. D. Bathgate, Frank Tuettelmann, Birgit Stallmeyer
Summary: This study reveals that bi-allelic loss-of-function variants in the INSL3 and RXFP2 genes are associated with bilateral cryptorchidism and male infertility, while heterozygous variant carriers are unaffected phenotypically. These findings have diagnostic value for patients with familial/bilateral cryptorchidism and shed light on the importance of INSL3 and RXFP2 in testicular descent and fertility.
HUMAN REPRODUCTION
(2023)
Article
Public, Environmental & Occupational Health
Matilde Laerkeholm Mueller, Alexander Siegfried Busch, Marie Lindhardt Ljubicic, Emmie N. Upners, Margit B. Fischer, Casper P. Hagen, Jakob Albrethsen, Hanne Frederiksen, Anders Juul, Anna-Maria Andersson
Summary: The concentrations of potentially endocrine disrupting chemicals (EDCs) in the urine of infant boys were found to be associated with their serum reproductive hormone concentrations, suggesting that minipuberty is a critical developmental period highly sensitive to endocrine disruption.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Review
Endocrinology & Metabolism
Anders Juul, Claus H. Gravholt, Michel De Vos, Ekaterina Koledova, Martine Cools
Summary: Diagnosis and management of individuals with differences of sex development (DSD) due to numerical or structural variations of sex chromosomes (NSVSC) is challenging. Girls with Turner syndrome (45X) may have varying phenotypic features. Individuals with 45,X/46,XY chromosomal mosaicism may have Turner syndrome-like features and short stature. Newborn screening for sex chromosome variations could be possible but requires further analysis. Comprehensive healthcare and fertility assessment are important for individuals with NSVSC.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Trine Holm Johannsen, Jakob Albrethsen, Vassos Neocleous, Federico Baronio, Martine Cools, Lise Aksglaede, Niels Jorgensen, Peter Christiansen, Meropi Toumba, Pavlos Fanis, Marie Lindhardt Ljubicic, Anders Juul
Summary: Congenital adrenal hyperplasia (CAH) is a recessive condition that affects the adrenal glands. Adult males with CAH, despite hormone replacement therapy, exhibit reduced levels of Leydig and Sertoli cell-derived hormones, including insulin-like factor 3 (INSL3) and testosterone. This study suggests that circulating INSL3 may serve as a biomarker to monitor Leydig cell function in CAH patients, particularly those with testicular adrenal rest tumors.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Hans Valdemar Lopez Krabbe, Jorgen Holm Petersen, Louise Laub Asserhoj, Trine Holm Johannsen, Peter Christiansen, Rikke Beck Jensen, Line Hartvig Cleemann, Casper P. Hagen, Laerke Priskorn, Niels Jorgensen, Katharina M. Main, Anders Juul, Lise Aksglaede
Summary: Adult patients with Klinefelter syndrome (KS) exhibit variable phenotypes and a high risk of metabolic disorders. Most adults require testosterone replacement therapy (TRT), but its use during puberty is debated. This study found that patients with KS have unfavorable body composition and impaired bone mineral status already during childhood and adolescence. Further research is needed to evaluate the effects of TRT during puberty on these parameters.
ENDOCRINE CONNECTIONS
(2023)
Article
Health Care Sciences & Services
Agnethe Berglund, Marie J. Ornstrup, Marie Lind-Holst, Morten Duno, Marie Baekvad-Hansen, Anders Juul, Luise Borch, Niels Jorgensen, Ase K. Rasmussen, Marianne Andersen, Katharina M. Main, Dorte Hansen, Claus H. Gravholt
Summary: This study aimed to describe diagnostic trends for all patients with CAH in Denmark. The prevalence of CAH combined was 15.1 and 9.0 per 100,000 newborn females and males, respectively. Diagnosis of NC-CAH increased significantly during the course of the study.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Oncology
Astrid L. Beck, Cecilie S. Uldbjerg, Youn-Hee Lim, Brent A. Coull, Karina M. Sorensen, Magdalena M. Utko, Bartlomiej Wilkowski, Panu Rantakokko, Marie Bengtsson, Christian Lindh, Jorgen H. Petersen, Niels E. Skakkebaek, Russ Hauser, Anders Juul, Elvira V. Brauner
Summary: Maternal smoking during pregnancy does not appear to be significantly associated with the risk of testicular germ cell cancer (TGCC) in offspring, based on a study using cotinine measurements as a biomarker for tobacco exposure. The study found comparable cotinine levels in maternal serum and amniotic fluid, but no significant association between active tobacco use and TGCC risk. However, different risks were observed for different types of TGCC, although they were not statistically significant.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Endocrinology & Metabolism
Amanda Cleemann Wang, Casper P. Hagen, Trine Holm Johannsen, Andre Greger Madsen, Line Hartvig Cleemann, Peter Christiansen, Katharina M. Main, Anders Juul, Rikke Beck Jensen
Summary: Differentiation between girls with ICPP and PT can be supported by individual clinical and biochemical parameters. However, dimension reduction of clinical and hormonal profiles by PCA improved the diagnostic value, which in the future may support the diagnostic process as a supplement to the GnRH test in evaluation of pubertal disorders.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Andrology
Rune Holt, Sam Kafai Yahyavi, Ireen Kooij, Nadia Nicholine Poulsen, Anders Juul, Niels Jorgensen, Martin Blomberg Jensen
Summary: This study aimed to investigate whether vitamin D supplementation has an impact on sex steroid production in infertile men with vitamin D insufficiency. The results showed that vitamin D supplementation did not alter sex steroid production in infertile men overall, but in men with vitamin D insufficiency, it significantly increased testosterone/luteinizing hormone ratio.
Article
Andrology
Mette Petri Lauritsen, Thomas Leineweber Kristensen, Christine Bo Hansen, Uffe Vest Schneider, Anna Lando Talbot, Anne-Bine Skytte, Jorgen Holm Petersen, Trine Holm Johannsen, Anne Zedeler, Jakob Albrethsen, Anders Juul, Laerke Priskorn, Niels Jorgensen, Henrik Westh, Nina la Cour Freiesleben, Henriette Svarre Nielsen
Summary: This study assessed the impact of mild COVID-19 infection on testicular function and found lower reproductive hormone levels and semen parameters during acute infection, with improvement at follow-up. The study also showed a low risk of SARS-CoV-2 transmission through semen.
Correction
Endocrinology & Metabolism
Anders Juul, Philippe Backeljauw, Michael Hojby, Masanobu Kawai, Rasmus Juul Kildemoes, Agnes Linglart, Nehama Zuckerman-Levin, Reiko Horikawa
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)