Article
Endocrinology & Metabolism
Eva S. van Walree, Iris E. Jansen, Nathaniel Y. Bell, Jeanne E. Savage, Christiaan de Leeuw, Max Nieuwdorp, Sophie van der Sluis, Danielle Posthuma
Summary: A quarter of the world's population is estimated to have metabolic syndrome (MetS), which is associated with increased risk of coronary artery disease and type 2 diabetes. This study found that the genetic correlations of MetS components can be best captured by a genetic one factor model. A genome-wide association study detected 235 associated loci, with 53 loci overlapping with loci for multiple MetS components. These findings provide insights into the genetics of MetS and suggest potential drug targets.
Article
Endocrinology & Metabolism
Emanuela Orsi, Anna Solini, Enzo Bonora, Martina Vitale, Monia Garofolo, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Gianpaolo Zerbini, Antonio Nicolucci, Giuseppe Pugliese
Summary: The presence and grade of diabetic retinopathy (DR) can predict all-cause mortality in individuals with type 2 diabetes mellitus, independent of cardiovascular disease (CVD) and other complications. The risk of death is higher in patients with advanced DR, especially proliferative DR. However, the impact of DR is more significant in patients without diabetic kidney disease (DKD) or CVD.
DIABETES & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Qin Zhang, Shucai Xiao, Xiaojuan Jiao, Yunfeng Shen
Summary: A U-shaped association was observed between the baseline TyG index and cardiovascular (CV) and all-cause mortality in CVD patients with diabetes or pre-diabetes in the American population.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Multidisciplinary Sciences
Naomi Azulay, Roy Bjorkholt Olsen, Christopher Sivert Nielsen, Audun Stubhaug, Trond Geir Jenssen, Henrik Schirmer, Arnoldo Frigessi, Leiv Arne Rosseland, Christian Tronstad
Summary: This study investigates the differences in heart rate variability (HRV) among healthy individuals, individuals with metabolic syndrome (MetS), and individuals with diabetes. The study finds a significant negative association between the number of MetS components and HRV, with the decrease in HRV leveling off after the third component. Additionally, there is a significant negative association between HbA1c and HRV. It suggests that both MetS and diabetes populations have impaired autonomic nervous system function compared to healthy controls.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Tingting Geng, Jun-Xiang Chen, Yan-Feng Zhou, Qi Lu, Zhenzhen Wan, Liegang Liu, An Pan, Gang Liu
Summary: Based on data from the UK Biobank study, researchers found a significant association between proton pump inhibitor (PPI) use and increased risks of cardiovascular disease events and all-cause mortality in patients with type 2 diabetes. The study suggests that monitoring of adverse cardiovascular events and careful consideration of the benefits and risks of PPI use should be implemented in patients with type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Sadiya S. Khan, Hongyan Ning, Arjun Sinha, John Wilkins, Norrina B. Allen, Thanh Huyen T. Vu, Jarett D. Berry, Donald M. Lloyd-Jones, Ranya Sweis
Summary: This study found that smoking is significantly associated with premature death, whether related to cardiovascular disease or not. Smoking not only increases the risk of cardiovascular disease, but also leads to an earlier onset of cardiovascular disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Rieko Bessho, Kazuhiro Kashiwagi, Akihiko Ikura, Karin Yamataka, Jun Inaishi, Hiromasa Takaishi, Takanori Kanai
Summary: This study investigated the association between subclinical atherosclerosis and metabolic dysfunction-associated fatty liver disease (MAFLD) or non-alcoholic fatty liver disease (NAFLD), as well as the synergistic effect of diabetes mellitus (DM) and MAFLD on subclinical atherosclerosis. The results showed that MAFLD was significantly associated with subclinical atherosclerosis in the general population, and DM-MAFLD could be a significant risk factor for cardiovascular disease through insulin resistance and low-grade inflammation.
Article
Cardiac & Cardiovascular Systems
Iram Faqir Muhammad, Xue Bao, Peter M. Nilsson, Suneela Zaigham
Summary: This study found an association between the TyG index and arterial stiffness, incidence of diabetes, adverse cardiovascular outcomes, and all-cause and cardiovascular mortality. The results suggest that the TyG index may have potential utility in identifying individuals at increased long-term risk of adverse health outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Di He, Jun Li, Yuhao Li, Jinghan Zhu, Tianjing Zhou, Yuying Xu, Qiong Wu, Zongxue Cheng, Qing Chen, Zuyun Liu, Yimin Zhu
Summary: This study found that frailty is associated with the progression of prediabetes to diabetes and elevated risks of cardiovascular disease (CVD) and all-cause mortality in individuals with prediabetes and diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Cardiac & Cardiovascular Systems
Lin Liu, Xiaofeng Su, Zhe Zhao, Jiming Han, Jianhua Li, Weihao Xu, Zijun He, Yinghui Gao, Kaibing Chen, Libo Zhao, Yan Gao, Huanhuan Wang, JingJing Guo, Junling Lin, Tianzhi Li, Xiangqun Fang
Summary: The presence of metabolic syndrome (MetS) in elderly patients with obstructive sleep apnea (OSA) is associated with an increased risk of major adverse cardiac events (MACE) and all-cause mortality. The risk of MACE gradually increases in individuals with three or more MetS components. Male, younger age, overweight and obese individuals, and those with moderate-severe OSA combined with MetS have a higher risk of MACE.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Multidisciplinary
Zhou-Zheng Tu, Qi Lu, Yan-Bo Zhang, Zhe Shu, Yu -Wei Lai, Meng -Nan Ma, Peng-Fei Xia, Ting -Ting Geng, Jun -Xiang Chen, Yue Li, Lin-Jing Wu, Jing Ouyang, Zhi Rong, Xiong Ding, Xu Han, Shuo-Hua Chen, Mei-An He, Xiao-Min Zhang, Lie -Gang Liu, Tang -Chun Wu, Shou-Ling Wu, Gang Liu, An Pan
Summary: This study investigates the associations between healthy lifestyle factors and the risks of cardiovascular disease, cancer, and mortality among individuals with prediabetes. The results show that individuals with a healthier lifestyle have significantly reduced risks of these health outcomes compared to those with an unhealthy lifestyle.
Article
Urology & Nephrology
Glen James, Jennifer Kim, Carl Mellstrom, Kerrie L. Ford, Nia C. Jenkins, Carmen Tsang, Marc Evans, Phil McEwan
Summary: This study investigated the impact of time and variability of serum potassium on adverse clinical outcomes in patients with chronic kidney disease, resistant hypertension, heart failure, and diabetes. The results suggest that patterns of hyperkalaemia are associated with adverse clinical outcomes, and regular monitoring can help manage hyperkalaemia and prevent adverse events.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Di He, Xuhui Zhang, Shuohua Chen, Chen Dai, Qiong Wu, Yaohan Zhou, Ziqi Jin, Shouling Wu, Yimin Zhu
Summary: Dynamic changes in MetS were found to alter the risks of CVD and all-cause mortality, particularly in individuals with early onset age. The study highlights the importance of dynamic changes in MetS and onset age in the prevention and control of CVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ji Hye Huh, Eun Roh, Seong Jin Lee, Sung-Hee Ihm, Kyung-Do Han, Jun Goo Kang
Summary: This retrospective, longitudinal study demonstrated that high levels of remnant cholesterol are associated with an increased risk of incident type 2 diabetes (T2D), particularly in individuals without traditional T2D risk factors and metabolic abnormalities. These findings suggest that remnant cholesterol profiles provide additional information in predicting future progression of T2D, independent of conventional lipid parameters.
Review
Physiology
Liliana Espinoza, Stephanie Fedorchak, Carie R. Boychuk
Summary: There is a consensus that the heart is regulated by both the parasympathetic and sympathetic nervous system, with recent interest focusing on the potential of parasympathetic motor output in treating cardiovascular diseases. Understanding how vagal motor output is generated and regulated is crucial due to its links to cardiovascular and metabolic diseases. Vagal brainstem circuits provide an integrative network that responds to metabolic cues to control cardiac function.
FRONTIERS IN PHYSIOLOGY
(2021)