Article
Oncology
Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang, Jianxin Qiu
Summary: ROC1 is up-regulated in BCa tissues and cell lines, with high levels correlated with higher tumor grade, metastasis, and poor prognosis. It promotes BCa invasion and migration by activating NF-κB signaling through enhancing p-IκBα ubiquitination, leading to p65 nuclear translocation and transcription of metastasis-related genes.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, ubiquitination was identified as a post-translational modification on Tollip, and RNF167 was found to be the potential E3 ligase for Tollip. Tollip's ubiquitination plays a crucial role in TNF-a signaling.
Article
Cell Biology
Tingjuan Deng, Boli Hu, Xingbo Wang, Shuxiang Ding, Lulu Lin, Yan Yan, Xiran Peng, Xiaojuan Zheng, Min Liao, Yulan Jin, Weiren Dong, Jinyan Gu, Jiyong Zhou
Summary: This study found that the Avibirnavirus VP3 protein is ubiquitinated during infection, enhancing virus replication. VP3 inhibits the immune response and evades the host immune system by autophagy. These findings provide insights into potential drug targets for controlling virus infection.
Article
Fisheries
Yang Chen, Ya Chen, Xiaolong Yan, Qi Li, Pengfei Wang, Yuena Sun, Tianjun Xu
Summary: This study reveals that hnRNPub inhibits the NF-kappa B signaling pathway by targeting TRAF6, thereby limiting LPS-induced innate activation.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shusuke Yasuda, Mano Horinaka, Yosuke Iizumi, Wakana Goi, Mamiko Sukeno, Toshiyuki Sakai
Summary: Cellular senescence is a state of irreversible cell growth arrest that triggers the production of pro-inflammatory cytokines, known as SASP. Oridonin has been identified as a potential inhibitor of SASP, potentially through modulation of the NF-kappa B and p38 pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Plant Sciences
Tianle Zhan, Baoli Wang, Jiayao Fu, Yanxiong Shao, Lei Ye, Huan Shi, Lingyan Zheng
Summary: The study demonstrated that artesunate (ART) can attenuate BAFF-induced B cell hyperactivation and Sjogren's syndrome (SS)-like symptoms in NOD/Ltj mice. ART inhibited lymphocytic foci formation, B cell infiltration and autoantibody secretion in mice, while also targeting BAFF-activated NF kappa B pathway by regulating TRAF6 degradation to determine B cell survival and proliferation.
Article
Biochemistry & Molecular Biology
Haijun Zhao, Weijie Zhu, Wude Mao, Chengkai Shen
Summary: The study demonstrates that PRP can protect chondrocytes from doxorubicin-induced damage, inhibiting apoptosis and inflammation, and improving cartilage destruction. This research provides a new theoretical basis for the clinical treatment of osteoarthritis caused by doxorubicin.
MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Zhi Cui, Shiqun Sun, Jia Li, Jianing Li, Tong Sha, Jie He, Linjing Zuo
Summary: This study found that UBE2L3 is overexpressed in HNSCC and its overexpression is associated with poor prognosis. In vitro experiments further demonstrated that UBE2L3 overexpression promotes proliferation, invasion, migration, and tumor growth in HNSCC cells. The study also revealed that UBE2L3 activates the NF-κB signaling pathway and is negatively regulated by miR-378a-5p. Therefore, UBE2L3 may be a potential therapeutic target for the treatment of HNSCC.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Immunology
Huanhuan Xu, Titi Liu, Yuankan Jia, Jin Li, Li Jiang, Caijiang Hu, Xuanjun Wang, Jun Sheng
Summary: EGCG in green tea can inhibit osteoclastogenesis by interfering with the interaction between RANK and RANKL, suppressing the phosphorylation of key regulatory factors, and negatively regulating NF-kappa B and MAPK signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Huanhuan Xu, Yuankan Jia, Jin Li, Xueqin Huang, Li Jiang, Ting Xiang, Yuanhao Xie, Xiaomei Yang, Titi Liu
Summary: This study found that niloticin can inhibit osteoclastogenesis by blocking the interaction between RANKL and RANK, reducing the expression of key osteoclast differentiation-related regulatory factors. It suggests that niloticin could be a novel drug for inhibiting osteoclastogenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Orthopedics
Changqi Sun, Can Cao, Ting Zhao, Hailing Guo, Braden C. Fleming, Brett Owens, Jillian Beveridge, Scott McAllister, Lei Wei
Summary: Alpha 2-macroglobulin (A2M) is able to bind and neutralize interleukin-1 beta (IL-1 beta), thereby blocking the inflammatory response induced by nuclear factor kappa B (NF-kappa B). A2M reduces inflammatory catabolic activity and protects cartilage. Further research is needed to fully understand the potential of A2M as a therapy for posttraumatic osteoarthritis (PTOA).
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Lluis Espinosa, Laura Marruecos
Summary: I kappa B alpha is known for inhibiting the NF-kappa B signaling pathway, but alterations found in cancer may be associated with either NF-kappa B-dependent or NF-kappa B-independent activities of the protein.
Article
Biochemistry & Molecular Biology
Valentine Spagnol, Caio A. B. Oliveira, Suzanne J. Randle, Patricia M. S. Passos, Camila R. S. T. B. Correia, Natalia B. Simaroli, Joice S. Oliveira, Tycho E. T. Mevissen, Ana Carla Medeiros, Marcelo D. Gomes, David Komander, Heike Laman, Felipe Roberti Teixeira
Summary: The study reveals that Fbxo7 interacts with UXT-V2, leading to its ubiquitination and subsequent proteasomal degradation, ultimately inhibiting the NF-kappa B signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Oncology
Khalid Amine Timani, Sahar Rezaei, Amanda Whitmill, Ying Liu, Johnny J. He
Summary: Tip110 is a nuclear protein that plays a role in NF-kappa B signaling by regulating I kappa B alpha stability and altering the expression of NF-kappa B-dependent proinflammatory cytokines.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Buyun Kim, Ki Yong Lee, Byoungduck Park
Summary: Alzheimer's disease is a severe neurodegenerative disorder characterized by distinct pathological features. The nuclear factor-κB plays a crucial role in neuronal inflammation. Isoorientin (ISO) shows potential as a promising therapeutic drug candidate for the treatment and prevention of AD.