Review
Biochemistry & Molecular Biology
Xiaohui Ji, Wenqian Zhang, Liqin Yin, Zunhan Shi, Jinwen Luan, Linshan Chen, Longhua Liu
Summary: The number of patients with type 2 diabetes is increasing, posing challenges to public health and economic development. Peroxisome proliferator-activated receptor gamma (PPAR gamma) has been identified as a potential drug target for the treatment of type 2 diabetes. Post-translational modifications (PTMs) of PPAR gamma offer a promising approach to develop safer compounds for diabetes treatment.
Article
Endocrinology & Metabolism
Peng-Long Li, Mei Li, Zhenya Wang, Xiao-Ming Wang, Shuai-Yang Liu, Song Tian, Zhou-Xiang Wang, Xu Cheng, Yufeng Hu, Peng Zhang, Zhi-Gang She, Hailong Yang, Hongliang Li, Xiao-Jing Zhang
Summary: This study aims to identify promising drug candidates by targeting PPAR gamma for adipogenesis-based metabolic homeostasis and clarify the detailed mechanisms. Magnolol was identified as a potent adipogenesis activator by stabilizing PPAR gamma, providing a new avenue for the therapy of adipogenesis-related metabolic disorder.
Article
Biochemistry & Molecular Biology
Suresh Pola, Shailesh R. Shah, Harikishore Pingali, Pandurang Zaware, Baban Thube, Pankaj Makadia, Hoshang Patel, Debdutta Bandyopadhyay, Akshyaya Rath, Suresh Giri, Jitendra H. Patel, R. K. Ranvir, S. R. Sundar, Harilal Patel, Jeevan Kumar, Mukul R. Jain
Summary: This research aims at finding an effective oral GPR 119 agonist, which showed good results in cell-based assays and animal models without displaying toxicity.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Physiology
Zhenguo Wang, Xiaojing Gao, Qingrun Li, Hongwen Zhu, Xiangjie Zhao, Minerva Garcia-Barrio, Jifeng Zhang, Yanhong Guo, Y. Eugene Chen, Rong Zeng, Jia-Rui Wu, Lin Chang
Summary: This study highlights the critical role of CLK1 in regulating browning of adipose tissue and insulin sensitivity, with the CLK1-THRAP3-PPARγ axis identified as a key mechanism involved in controlling energy expenditure.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cell Biology
Chunhua Yang, Mengna Wei, Yanpu Zhao, Zhanyi Yang, Mengyao Song, Jia Mi, Xiaoyong Yang, Geng Tian
Summary: Post-translational modifications (PTMs) in pancreatic beta cells play crucial roles in insulin secretion and have significant implications for diabetes mellitus development. This article summarizes the major PTMs occurring in beta cells and their impact on insulin secretion, providing valuable insights into the understanding of insulin secretion mechanisms and potential therapeutic targets for diabetes from the perspective of protein PTMs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Robert A. DiSilvestro, Susan Olivo Marston, Autumn Zimmerman, Elizabeth Joseph, Carolynn Boeh McCarty
Summary: Research suggests that GLA may affect resting metabolic rate and help with weight control. However, in overweight young adults with a family history of obesity, borage oil did not affect resting metabolic rate but could improve blood lipid measures.
Article
Biochemistry & Molecular Biology
Cherng-Shyang Chang, Shang-Shiuan Yu, Li-Chun Ho, Shu-Hsin Chao, Ting-Yu Chou, Ai-Ning Shao, Ling-Zhen Kao, Chia-Yu Chang, Yu-Hsin Chen, Ming-Shan Wu, Pei-Jane Tsai, Nobuyo Maeda, Yau-Sheng Tsai
Summary: Mutations in the PPAR gamma gene lead to insulin resistance and lipodystrophy. We analyzed the insulin response and expression of metabolic genes in the preserved fat depots of a lipodystrophy mouse model. The results showed that inguinal fat plays a compensatory role in combating perigonadal fat abnormalities in lipodystrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Organic
Ajay Kumar, Salahuddin, Rajnish Kumar, Rakesh Sahu, Shivali Mishra, Chanchal Singh, Devleena Tiglani
Summary: This article discusses the synthesis of thiazolidinediones and their potential therapeutic effects on diabetes.
MINI-REVIEWS IN ORGANIC CHEMISTRY
(2022)
Article
Cell Biology
Edgar Sanchez-Ramirez, Thi Phuong Lien Ung, Alejandro Alarcon del Carmen, Ximena del Toro-Rios, Guadalupe R. Fajardo-Orduna, Lilia G. Noriega, Victor A. Cortes-Morales, Armando R. Tovar, Juan Jose Montesinos, Ricardo Orozco-Solis, Chiara Stringari, Lorena Aguilar-Arnal
Summary: This study reveals the role of NAD(+) and SIRT1 in adipogenic differentiation, demonstrating that NAD(+) inhibits adipocyte commitment while SIRT1 is essential for terminal differentiation of pre-adipocytes and regulates subcellular compartmentalization of redox metabolism.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Samuel M. Lee, Jose Muratalla, Alberto Diaz-Ruiz, Pablo Remon-Ruiz, Maximilian McCann, Chong W. Liew, Rhonda D. Kineman, Jose Cordoba-Chacon
Summary: Short-term rosiglitazone maleate treatment can enhance insulin sensitivity but may increase hepatic triglyceride content; in mice with severe obesity, hepatocyte PPAR gamma expression may offset the antisteatogenic actions of TZD.
Article
Pharmacology & Pharmacy
Yi Chen, Qi Li, Shiwei Zhao, Lei Sun, Zequn Yin, Xiaolin Wang, Xiaoju Li, Yasuko Iwakiri, Jihong Han, Yajun Duan
Summary: This study found that berberine (BBR) improved the treatment of type 2 diabetes (T2D) by activating the PPARγ-FGF21-GLUT2 signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Samuel M. Lee, Jose Muratalla, Alberto Diaz-Ruiz, Pablo Remon-Ruiz, Maximilian McCann, Chong W. Liew, Rhonda D. Kineman, Jose Cordoba-Chacon
Summary: Short-term treatment with TZD improves insulin sensitivity but may increase hepatic triglyceride content in severely obese mice, while hepatocyte-specific PPARγ knockout can reduce steatosis. These findings suggest that hepatocyte PPARγ expression may counteract the anti-steatogenic effects of TZD in severe obesity.
Article
Food Science & Technology
Xitong Zhang, Lin Du, Weimin Zhang, Mi Yang, Li Chen, Chen Hou, Jianke Li
Summary: This study investigated the potential of pomegranate peel polyphenols (PPPs) in preventing the development of metabolic syndrome (MetS) by improving insulin resistance (IR). The results showed that PPPs treatment reversed the negative effects of high fat diet-induced insulin resistance, including disordered glucose and lipid metabolism, and muscle fiber morphology. PPPs treatment increased the protein expressions of insulin receptor (InsR) and phosphorylated insulin receptor substrate 1 (IRS-1), stimulated peroxisome proliferator activated receptor gamma (PPAR gamma) and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT/PKB) signaling pathway, as well as increased the protein levels of phosphorylated glycogen synthase kinase-3 beta (GSK-3 beta) and glucose transporter 4 (GLUT4). These findings suggest that PPPs have beneficial effects in alleviating insulin resistance by enhancing insulin sensitivity and regulating glucose metabolism.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Editorial Material
Endocrinology & Metabolism
Nils B. Kroemer
Summary: As most studies have mainly focused on the effects of insulin in the brain on men, there is limited understanding of metabolic changes during the menstrual cycle in women. Hummel et al. found that insulin sensitivity is reduced during the luteal phase through intranasal insulin administration and functional MRI.
Article
Endocrinology & Metabolism
Jose E. Galgani, Rodrigo Fernandez-Verdejo
Summary: Glucose, fatty acids, and amino acids are oxidized to produce ATP for energy, and the complex adaptive systems in the body adjust fuel oxidation rates based on fuel availability. Metabolic flexibility refers to the ability of cells, tissues, or organisms to adapt fuel oxidation to fuel availability, which can be impaired in conditions like insulin resistance, diabetes, and obesity. Mitochondrial dysfunction in these conditions has been linked to metabolic inflexibility and overall metabolic health.
Article
Cell Biology
Sunsil Choi, Ji-Eun Jung, Yong Ryoul Yang, Eun-Sun Kim, Hyun-Jun Jang, Eung-Kyun Kim, Il Shin Kim, Joo-Young Lee, Joong Kwan Kim, Jeong Kon Seo, Jung-Min Kim, Jiyoung Park, Pann-Ghill Suh, Jang Hyun Choi
CELLULAR SIGNALLING
(2015)
Article
Endocrinology & Metabolism
Sun-Sil Choi, Eun-Sun Kim, Ji-Eun Jung, David P. Marciano, Ala Jo, Ja Young Koo, Soo Youn Choi, Yong Ryoul Yang, Hyun-Jun Jang, Eung-Kyun Kim, Jiyoung Park, Hyug Moo Kwon, In Hee Lee, Seung Bum Park, Kyung-Jae Myung, Pann-Ghill Suh, Patrick R. Griffin, Jang Hyun Choi
Article
Endocrinology & Metabolism
Kai Sun, Jiyoung Park, Min Kim, Philipp E. Scherer
Article
Gastroenterology & Hepatology
Jun Ho Lee, Jae Hee Suh, Soo Youn Choi, Hyun Je Kang, Hwan Hee Lee, Byeong Jin Ye, Gap Ryol Lee, Seok Won Jung, Chang Jae Kim, Whaseon Lee-Kwon, Jiyoung Park, Kyungjae Myung, Neung Hwa Park, Hyug Moo Kwon
Meeting Abstract
Oncology
Jun Ho Lee, Jae Hee Suh, Soo Youn Choi, Hyun Je Kang, Hwan Hee Lee, Whaseon Lee-Kwon, Jiyoung Park, Kyungjae Myung, Neung Hwa Park, Hyug Moo Kwon
Article
Oncology
Changhu Lee, Min Kim, Jun Ho Lee, Jiyoung Oh, Hyun-Hee Shin, Sang Min Lee, Philipp E. Scherer, Hyug Moo Kwon, Jang Hyun Choi, Jiyoung Park
JOURNAL OF PATHOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Sora Yoon, Hai C. T. Nguyen, Woobeen Jo, Jinhwan Kim, Sang-Mun Chi, Jiyoung Park, Seon-Young Kim, Dougu Nam
NUCLEIC ACIDS RESEARCH
(2019)
Article
Oncology
Anbok Lee, Sunmi Jo, Changhu Lee, Hyun-Hee Shin, Tae Hyun Kim, Ki Jung Ahn, Sung-Kwang Park, Heunglae Cho, Hye-Kyoung Yoon, Woo Gyeong Kim, Jiyoung Park, Yunseon Choi
Article
Cell Biology
Jeu Park, Jin Young Huh, Jiyoung Oh, Jong In Kim, Sang Mun Han, Kyung Cheul Shin, Yong Geun Jeon, Sung Sik Choe, Jiyoung Park, Jae Bum Kim
GENES & DEVELOPMENT
(2019)
Article
Multidisciplinary Sciences
Hwan Hee Lee, Seung Min An, Byeong Jin Ye, Jun Ho Lee, Eun Jin Yoo, Gyu Won Jeong, Hyun Je Kang, Assim A. Alfadda, Sun Woo Lim, Jiyoung Park, Whaseon Lee-Kwon, Jae Bum Kim, Soo Youn Choi, Hyug Moo Kwon
NATURE COMMUNICATIONS
(2019)
Article
Nutrition & Dietetics
Jae Min Lee, Sun Sil Choi, Mi Hyeon Park, Hyunduk Jang, Yo Han Lee, Keon Woo Khim, Sei Ryang Oh, Jiyoung Park, Hyung Won Ryu, Jang Hyun Choi
Editorial Material
Endocrinology & Metabolism
Assim A. Alfadda, Reem M. Sallam, Jiyoung Park
JOURNAL OF OBESITY
(2019)
Article
Medicine, Research & Experimental
Dawei Bu, Clair Crewe, Christine M. Kusminski, Ruth Gordillo, Alexandra L. Ghaben, Min Kim, Jiyoung Park, Hui Deng, Wei Xiong, Xiao-Zheng Liu, Per Eystein Lonning, Nils Halberg, Adan Rios, Yujun Chang, Anneliese Gonzalez, Ningyan Zhang, Zhiqiang An, Philipp E. Scherer
Article
Endocrinology & Metabolism
Jiyoung Park, Min Kim, Kai Sun, Yu Aaron An, Xue Gu, Philipp E. Scherer
Review
Biochemistry & Molecular Biology
Changhu Lee, Dohyeon An, Jiyoung Park
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2016)