Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Tae Sung M. Kim, Lakmali Silva, Vasileios Ionas Theofilou, Teresa Greenwell-Wild, Lu Li, Drake Winslow Williams, Tomoko Ikeuchi, Laurie H. Brenchley, Thomas I. Bugge, Patricia J. Diaz, Mariana Kaplan, Carmelo M. Carmona-Rivera, Niki Moutsopoulos
Summary: Neutrophil extracellular traps (NETs) are early triggers of pathogenic inflammation in periodontitis, a prevalent oral inflammatory disease. NETs promote IL-17/Th17 immune response and contribute to bone destruction. Human findings support the role of NET-mediated pathology in periodontitis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
J. Zhang, L. Sun, M. H. H. Withanage, S. M. Ganesan, M. A. Williamson, J. T. Marchesan, Y. Jiao, F. R. Teles, N. Yu, Y. Liu, D. Wu, K. L. Moss, A. K. Mangalam, E. Zeng, Y. L. Lei, S. Zhang
Summary: This study identified a risk locus TRAF3IP2 associated with periodontitis and investigated its underlying mechanism in the development of periodontitis. The results showed that TRAF3IP2 plays a significant role in the production of chemokines mediated by IL-17 and in host defense against periodontal pathogens.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Medical Laboratory Technology
Ruth Rodriguez-Montano, Ana Guilaisne Bernard-Medina, Edith Oregon-Romero, Vianeth Maria del Carmen Martinez-Rodriguez, Maria Luisa Pita-Lopez, Belinda Claudia Gomez-Meda, Celia Guerrero-Velazquez
Summary: The study found that the expression patterns of IL-23 and IL-17A tend to be downregulated when patients have both rheumatoid arthritis and periodontitis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Immunology
Andre Lopes Saraiva, Raphael Sanches Peres, Flavio Protasio Veras, Jhimmy Talbot, Kalil Alves de Lima, Joao Paulo Mesquita Luiz, Thiago Mattar Cunha, Paulo Louzada-Junior, Fernando Queiroz Cunha, Jose Carlos Alves-Filho
Summary: The experimental arthritis model established using citrullinated human plasma fibrinogen revealed the importance of IL-23/IL-17 immune axis-mediated inflammatory responses in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Giovanni Adami, Angelo Fassio, Maurizio Rossini, Camilla Benini, Riccardo Bixio, Denise Rotta, Ombretta Viapiana, Davide Gatti
Summary: The study uncovered unique bone profile in RA, including lower bone density and distinct biomarker patterns compared to controls. Association between bone biomarkers and clinical variables were revealed, and machine learning models and principal component analysis successfully differentiated RA patients based on bone biomarker profiles.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Dong Mao, Hong Jiang, Fei Zhang, Haoyu Yang, Xiaodong Fang, Qian Zhang, Gang Zhao
Summary: This study found that HDAC2 is highly expressed in synovial tissue of rheumatoid arthritis (RA) patients and exacerbates the progression of RA by regulating the IL-17-CCL7 signaling pathway. This suggests that HDAC2 may be a promising therapeutic target for RA treatment.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Jonas Nogueira Ferreira Maciel Gusmao, Khetyma Moreira Fonseca, Bruno Sousa Pinto Ferreira, Bruno Wesley de Freitas Alves, Howard Lopes Ribeiro Junior, Mario Roberto Pontes Lisboa, Karuza Maria Alves Pereira, Mariana Lima Vale, Delane Viana Gondim
Summary: Electroacupuncture (EA) has shown anti-inflammatory and anti-resorptive effects in experimental studies. In this rat study involving periodontitis and rheumatoid arthritis (RA), EA reduced pain intensity and inflammation related to periodontitis in arthritic rats, but did not prevent alveolar bone loss (ABL). EA was more effective in reducing ABL and bone radiographic density (BRD) in the presence of periodontitis.
Article
Endocrinology & Metabolism
Tomoko Ikeuchi, Niki M. Moutsopoulos
Summary: This review focuses on the mechanisms of induction, amplification, and pathogenicity of Th17 cells in periodontitis.
Article
Medicine, Research & Experimental
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: Patients with rheumatoid arthritis (RA) have higher levels of interleukin-18 (IL-18) and lower levels of IL-18 binding protein (IL-18BP) in their serum and synovial fluid compared to those with osteoarthritis (OA) or healthy controls. In vitro studies show that IL-18BP can correct the Th17/Treg imbalance in CD4(+) T cells of RA patients and reduce IL-17-induced osteoclastogenesis, suggesting therapeutic potential for RA treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Jiexin Wang, Linxi He, Weihong Li, Shangbin Lv
Summary: Rheumatoid arthritis (RA) is caused by joint inflammation and significantly increases the occurrence of cardiovascular disease. Mortality of RA patients with cardiovascular disease is 1.5-3 times higher than that of RA patients alone. Atherosclerosis is more prevalent and develops rapidly in RA patients, which is a major cause of death in RA. Recent studies have shown that IL-17 expression is upregulated in patients with RA and atherosclerosis, and it plays a role in the development of atherosclerosis through various ways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Benita Buragaite-Staponkiene, Adomas Rovas, Alina Puriene, Kristina Snipaitiene, Egle Punceviciene, Arunas Rimkevicius, Irena Butrimiene, Sonata Jarmalaite
Summary: This study aimed to identify specific miRNAs associated with periodontitis (PD) in gingival tissues and evaluate their levels in saliva and blood plasma among participants with and without rheumatoid arthritis (RA). Genome-wide miRNA expression analysis revealed 177 deregulated miRNAs in 16 gingival tissue samples. Validation in 80 samples confirmed higher expression of miR-140-3p and -145-5p and lower expression of miR-125a-3p in PD-affected tissues. Further analysis in a larger sample showed increased salivary levels of miR-145-5p associated with PD severity and higher plasma levels of miR-140-3p in PD participants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Elisa Gremese, Barbara Tolusso, Dario Bruno, Simone Perniola, Gianfranco Ferraccioli, Stefano Alivernini
Summary: Despite advances in understanding the molecular and cellular taxonomy of synovial membranes in rheumatoid arthritis (RA), a proportion of patients do not respond to current treatments. In this review, we discuss the role of IL-8 and IL-17 in promoting inflammation in multiple biological compartments and how targeting them could improve treatment resistance.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Zhimeng Lv, Ming Guo, Xuelin Zhao, Yina Shao, Weiwei Zhang, Chenghua Li
Summary: This study provides functional evidence that IL-17 is a conserved cytokine in invertebrates, specifically in the sea cucumber Apostichopus japonicus. The expression of A. japonicus IL-17 (AjIL-17) was positively correlated with the development of inflammation, and the administration of purified recombinant AjIL-17 protein directly promoted inflammation. A novel IL-17R counterpart was identified in the sea cucumber genome and shown to bind AjIL-17. AjIL-17/AjIL-17R regulated inflammatory responses by promoting TRAF6 ubiquitination, p65 nuclear translocation, and coelomocyte proliferation and migration.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Longjie Huangfu, Ruiying Li, Yamei Huang, Shan Wang
Summary: This review discusses the recent progress in understanding the IL-17 signaling pathway and its physiological roles, as well as the mechanism underlying IL-17's role in various pathologies. Additionally, promising developments in the diagnosis and treatment of autoimmune diseases and tumors are briefly discussed.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
