期刊
BMB REPORTS
卷 45, 期 2, 页码 108-113出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2012.45.2.108
关键词
Cyclooxygenase-2; Cytokine; Inflammation; Macrophage; Nitric oxide; Protopine
资金
- Chungbuk National University
- National Research Council of Science & Technology (NST), Republic of Korea [2Z0356] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Protopine is an isoquinoline alkaloid contained in plants in northeast Asia. In this study, we investigated whether protopine derived from Hypecoum erectum L could suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages (Raw 264.7 cells). Protopine was found to reduce nitric oxide (NO), cyclooxygenase-2 (COX-2), and prostaglandin E-2 (PGE(2)) production by U'S-stimulated Raw 264.7 cells, without a cytotoxic effect. Pm-treatment of Raw 264.7 cells with protopine reduced the production of pro-inflammatory cytokines. These inhibitory effects were caused by blocking phosphorylation of mitogen-activated protein kinases (MAP kinases) and also blocking activation of a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B). [BMB reports 2012; 45(2): 108-113]
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