Article
Materials Science, Multidisciplinary
Kangqiang Qiu, Aditya Yadav, Zhiqi Tian, Ziyuan Guo, Donglu Shi, Chayan K. Nandi, Jiajie Diao
Summary: In this study, biocompatible protein-modified noble-metal nanoclusters were used to image lysosomes under structured illumination microscopy. The nanoclusters exhibited excellent performance in pH fluctuation resistance and antiphotobleaching, allowing for the observation of lysosomal events and the interplay between lysosomes and mitochondria. This research opens up new possibilities for long-term bioimaging with nanoclusters.
ACS MATERIALS LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Mary Adebayo, Seema Singh, Ajay Pratap Singh, Santanu Dasgupta
Summary: Mitochondria are dynamic organelles inherited maternally, fulfilling cellular energy demand and playing roles in cell signaling, metabolism, and apoptosis. Maintenance of mitochondrial integrity and homeostasis through fusion and fission is crucial, and imbalance can lead to various diseases.
Article
Cell Biology
Dongjie Zhou, Ming-Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song-Hee Lee, Geun Heo, Jungseok Choi, Kwan-Suk Kim, Xiang-Shun Cui
Summary: In this study, the mRNA level of YME1L1 was knocked down in pig embryos and the expression patterns of YME1L1 and related proteins were examined. It was found that YME1L1 is localized in the punctate structures of mitochondria and highly expressed from the 4-cell stage. Knocking down YME1L1 led to decreased blastocyst rate and quality, mitochondrial fragmentation, excessive ROS production, lower mitochondrial membrane potential and ATP levels. Moreover, YME1L1 knockdown induced OPA1 cleavage and cytochrome c release. These findings demonstrate that YME1L1 is crucial for regulating mitochondrial fission, function, and apoptosis during porcine embryo preimplantation development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Editorial Material
Cell Biology
Tomoyuki Fukuda, Kentaro Furukawa, Tatsuro Maruyama, Nobuo N. Noda, Tomotake Kanki
Summary: Mitophagy is a selective form of autophagy that targets dysfunctional or superfluous mitochondria for degradation. Our recent study has identified Atg44 as a mitochondrial fission factor that generates mitochondrial fragments suitable for phagophore engulfment. We propose the term mitofissin to refer to Atg44 and its homologous proteins that might participate in diverse cellular processes.
Article
Oncology
Fang-Liang Huang, Sheng-Jie Yu, En-Chih Liao, Long-Yuan Li, Pei-Wen Shen, Chia-Ling Li
Summary: Niclosamide exhibits anti-leukemia effects in T-ALL by regulating apoptosis and autophagy to suppress tumor growth.
Article
Oncology
Jyoti B. Kaushal, Rakesh Bhatia, Ranjana K. Kanchan, Pratima Raut, Surya Mallapragada, Quan P. Ly, Surinder K. Batra, Satyanarayana Rachagani
Summary: The study evaluated the therapeutic efficacy of Niclosamide on pancreatic cancer and found that it induced cell death through mitochondrial stress and mTORC1-dependent autophagy. Niclosamide inhibited the Hedgehog (Hh) signaling pathway and promoted cell death through regulation of p-Gsk3 beta.
Article
Oncology
Weipeng Gong, Song Zhang
Summary: Mitochondria play a central role in cell metabolism and other processes. This study found that Y-box binding protein 1 regulates cellular autophagy and mitochondrial activity, and mitochondria-derived RNA can replace certain mRNAs in cells, affecting cell function. This finding has potential implications for breast cancer therapy and the understanding of cellular interactions involving RNA-binding proteins.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Ana Karen Meza-Buendia, Omar Emiliano Aparicio-Trejo, Fernando Diaz, Claudia Caamal-Monsreal, Jose Pedraza-Chaverri, Carolina Alvarez-Delgado, Kurt Paschke, Carlos Rosas
Summary: Mitochondrial respirometry is important for understanding the impact of environmental factors on cellular energy processes. This study developed a method to measure mitochondrial respiration in the hearts of adult Octopus maya, and found that high temperatures may restrict female reproduction due to limited oxygen supply to the body, affecting energy production in other organs.
Article
Environmental Sciences
Jiangyan Li, Xiaoru Chang, Mengting Shang, Shuyan Niu, Wenli Zhang, Bangyong Zhang, Wenyan Huang, Tianshu Wu, Ting Zhang, Meng Tang, Yuying Xue
Summary: The study showed that the cytotoxicity of silver nanoparticles on A549 cells led to apoptosis and mitochondrial injury, triggering autophagy and mitophagy, and also causing lysosomal damage and oxidative/antioxidant imbalance.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Junjie Mou, Jinhui Xu, Zhe Wang, Chuanli Wang, Xueqi Yang, Xingchen Wang, Huiliang Xue, Ming Wu, Laixiang Xu
Summary: Photoperiod influences the morphology and functioning of striped dwarf hamsters' main sex organs, leading to differences in blood melatonin levels and hormone concentrations under different light conditions. Testis and epididymis show distinct changes in size, cell numbers, and protein expression levels in response to short daylight (SD) and long daylight (LD), indicating unique regulatory mechanisms for each organ. Overall, different regulatory mechanisms contribute to degeneration in the testis under SD and maintenance in the epididymis under LD, with a focus on mitochondrial function regulation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Saeed Mehrzadi, Mohammad Yahya Karimi, Alireza Fatemi, Russel J. Reiter, Azam Hosseinzadeh
Summary: Coronaviruses like SARS-CoV-2 target mitochondria to facilitate viral replication, evading the host immune response. In aging patients, COVID-19 infections are more severe, suggesting that melatonin could potentially inhibit cell damage induced by SARS-CoV-2 through regulating mitochondrial physiology.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Mina Gholami, A. Wallace Hayes, Hamidreza Jamaati, Antoni Sureda, Majid Motaghinejad
Summary: This study investigated the neurotoxicity of tramadol and found that it activates apoptosis and autophagy through modulation of TNF-α or IL-1β/JNK/Bcl-2/Beclin1 and Bcl-2/Bax signaling pathways, as well as dysfunction of mitochondrial respiratory chain enzymes.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Environmental Sciences
Xishuai Tong, Xiaohui Fu, Gengsheng Yu, Huayi Qu, Hui Zou, Ruilong Song, Yonggang Ma, Yan Yuan, Jianchun Bian, Jianhong Gu, Zongping Liu
Summary: Cadmium (Cd) is a harmful environmental heavy metal that accumulates in the body and causes various health problems. Polystyrene (PS), a type of microplastic, also has toxic effects. The study aimed to investigate the effects of PS on Cd-induced mitochondrial damage in the lungs of mice.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Xuan Zheng, Jianyun Zhang, Shuangting Li, Xiaolei Gao, Yixin Zhang, Meng Wang, Liying Dong, Liangjie Sun, Na Zhao, Zeyun Ma, Chong Ding, Yixiang Wang
Summary: We developed a new, safe strategy for treating melanoma by using low doses of niclosamide and quinacrine. We found that the combination of these two drugs activates autophagy-mediated p53-dependent apoptosis, leading to an efficient anti-melanoma effect. This novel strategy also showed a universal anti-cancer role in other types of cancer.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Environmental Sciences
Yu-Ting Zhou, Rui Li, Si-Hong Li, Xiang Ma, Lu Liu, Dong Niu, Xing Duan
Summary: Perfluorooctanoic acid (PFOA) exposure during gestation was found to have potential toxic effects on ovarian function and resulted in higher meiotic defects in female offspring. PFOA exposure disrupted early embryonic cleavage and blastocyst formation by impacting spindle assembly and chromosome alignment. Moreover, PFOA exposure caused mitochondrial dysfunction, oxidative stress, DNA damage, autophagy, and apoptosis in 2-cell stage embryos.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Ji Hyun Shin, Pan Soo Kim, Eun Sung Kim, So Jung Park, Yoon Kyung Jo, Jung Jin Hwang, Tae Joo Park, Jong Wook Chang, Jin-Ho Seo, Dong-Hyung Cho
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
So Jung Park, Heejin Lee, Doo Shin Jo, Yoon Kyung Jo, Ji Hyun Shin, Han Byeol Kim, Hae Mi Seo, David C. Rubinsztein, Jae-Young Koh, Eun Kyung Lee, Dong-Hyung Cho
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2015)
Article
Biochemistry & Molecular Biology
Ji Hyun Shin, Dong-Jun Bae, Eun Sung Kim, Han Byeol Kim, So Jung Park, Yoon Kyung Jo, Doo Sin Jo, Dong-Gyu Jo, Sang-Yeob Kim, Dong-Hyung Choi
BIOMOLECULES & THERAPEUTICS
(2015)
Article
Multidisciplinary Sciences
Eun Sung Kim, Hong Bae Jeon, Hoon Lim, Ji Hyun Shin, So Jung Park, Yoon Kyung Jo, Wonil Oh, Yoon Sun Yang, Dong-Hyung Cho, Ju-Yeon Kim
Article
Oncology
So Jung Park, Doo Sin Jo, Se-Young Jo, Dong Woon Shin, Sangmi Shim, Yoon Kyung Jo, Ji Hyun Shin, Ye Jin Ha, Seong-Yun Jeong, Jung Jin Hwang, Young Sam Kim, Young-Ah Suh, Jong Wook Chang, Jin Cheon Kim, Dong-Hyung Cho
Article
Neurosciences
Seung Hyun Baek, So Jung Park, Jae In Jeong, Sung Hyun Kim, Jihoon Han, Jae Won Kyung, Sang-Ha Baik, Yuri Choi, Bo Youn Choi, Jin Su Park, Gahee Bahn, Ji Hyun Shin, Doo Sin Jo, Joo-Yong Lee, Choon-Gon Jang, Thiruma V. Arumugam, Jongpil Kim, Jeung-Whan Han, Jae-Young Koh, Dong-Hyung Cho, Dong-Gyu Jo
JOURNAL OF NEUROSCIENCE
(2017)
Article
Oncology
Yoon Kyung Jo, Na Yeon Park, Ji Hyun Shin, Doo Sin Jo, Ji-Eun Bae, Eun Sun Choi, Sungho Maeng, Hong Bae Jeon, Seon Ae Roh, Jong Wook Chang, Jin Cheon Kim, Dong-Hyung Cho
ANTICANCER RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Pan Soo Kim, Ji Hyun Shin, Doo Sin Jo, Dong Woon Shin, Dong-Hwa Choi, Woo Jung Kim, Kyuhee Park, Jin Kyu Kim, Chul Gue Joo, Jong Suk Lee, Yongmun Choi, Yong Won Shin, Joong Jin Shin, Hong Bae Jeon, Jin-Ho Seo, Dong-Hyung Cho
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Eun Sung Kim, Ji Hyun Shin, So Jung Park, Yoon Kyung Jo, Jae-Sung Kim, Il-Hwan Kang, Jung-Bum Nam, Doo-Young Chung, Yoonchul Cho, EunJoo H. Lee, Jong Wook Chang, Dong-Hyung Cho
Article
Multidisciplinary Sciences
Hyunjung Choi, Ji Hyun Shin, Eun Sung Kim, So Jung Park, Il-Hong Bae, Yoon Kyung Jo, In Young Jeong, Hyoung-June Kim, Youngjin Lee, Hea Chul Park, Hong Bae Jeon, Ki Woo Kim, Tae Ryong Lee, Dong-Hyung Cho
Article
Cell Biology
Ji Hyun Shin, So Jung Park, Doo Sin Jo, Na Yeon Park, Joon Bum Kim, Ji-Eun Bae, Yoon Kyung Jo, Jung Jin Hwang, Jin-A Lee, Dong-Gyu Jo, Jin Cheon Kim, Yong Keun Jung, Jae-Young Koh, Dong-Hyung Cho
Article
Biochemistry & Molecular Biology
Ji Hyun Shin, Dong-Hyung Cho
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Cell Biology
Doo Sin Jo, So Jung Park, Ae-Kyeong Kim, Na Yeon Park, Joon Bum Kim, Ji-Eun Bae, Hyun Jun Park, Ji Hyun Shin, Jong Wook Chang, Peter K. Kim, Yong-Keun Jung, Jae-Young Koh, Seong-Kyu Choe, Kyu-Sun Lee, Dong-Hyung Cho
Review
Biochemistry & Molecular Biology
Ji Hyun Shin, Jinho Lee, Yun Kyung Jung, Kyeong Sik Kim, Jaemin Jeong, Dongho Choi
Summary: The innovative genome editing techniques have revolutionized biomedical research, with liver being the most favored target organ due to its regenerative ability. Liver's regenerative capacity enables ex vivo gene editing, where mutated genes in hepatocytes from animal models of genetic diseases can be repaired. The liver is also considered the easiest target organ for gene editing due to its high absorption capacity. mRNA vaccines have introduced a novel gene editing strategy using Cas mRNA, which has shown promising results in treating genetic liver diseases through a single injection.
Article
Oncology
Yoon Kyung Jo, Seon Ae Roh, Heejin Lee, Na Yeon Park, Eun Sun Choi, Ju-Hee Oh, So Jung Park, Ji Hyun Shin, Young-Ah Suh, Eun Kyung Lee, Dong-Hyung Cho, Jin Cheon Kim