Article
Allergy
Donald T. Gracias, Gurupreet S. Sethi, Amit K. Mehta, Haruka Miki, Rinkesh K. Gupta, Hideo Yagita, Michael Croft
Summary: The study found that memory T-cell responses to complex allergens are controlled by several TNF costimulatory interactions, and targeting these molecules in combination may represent a strategy to reduce the severity of inflammatory reactions following reexposure to allergen.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Wenjing Gu, Suyu Guo, Jiahui Zhang, Xinxing Zhang, Zhichao Sun, Zhengrong Chen, Li Huang
Summary: Asthma is an inflammatory disease in which Th2 differentiation and dendritic cells (DCs) play important roles. Highly expressed March1 can promote Th2 differentiation induced by DCs through facilitating OX40L expression and contribute to the development of asthma. These findings might provide new insights into the treatment of asthma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Masutaka Furue, Mihoko Furue
Summary: The OX40L-OX40 axis plays a crucial role in the sustained activation and expansion of effector T cells, and has shown therapeutic potential in diseases like atopic dermatitis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Qiang Li, Xiaohui Li, Hongkun Quan, Yihui Wang, Guanggang Qu, Zhiqiang Shen, Cheng He
Summary: The study revealed that IL-10(-/-) mice and IL-10 inhibitor mice showed higher survival rates during C. psittaci infection, while mice with DC depletion had lower survival rates. IL-10(-/-) upregulated the function of deficient DCs by activating OX40-OX40L, T cells, and the NLPR3 inflammasome, and inhibiting IDO and regulatory T cells, leading to enhanced clearance of C. psittaci.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Benjamin Hamid, Josephine Schlosser-Brandenburg, Lalita Bechtold, Friederike Ebner, Sebastian Rausch, Susanne Hartmann
Summary: This study examined the early immune response initiation after exposure to Toxoplasma gondii in pigs, revealing that porcine CD3-NKp46+ cells serve as important IL-12 producers following TLR ligation, while IL-18 likely plays a prominent role in early immune response initiation in pigs after T. gondii infection.
Article
Multidisciplinary Sciences
Alice Coillard, Lea Guyonnet, Alba De Juan, Adeline Cros, Elodie Segura
Summary: Monocytes are recruited to inflamed tissues where they encounter a broad range of microbial motifs, leading to differentiation into mo-mac or mo-DC. Viruses promote mo-mac differentiation via TLR signaling, while Mycobacteria favor mo-DC differentiation through NOD signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Biomedical
Lin Lin, Yingying Hu, Zhaopei Guo, Jie Chen, Pingjie Sun, Huayu Tian, Xuesi Chen
Summary: A gene-guided self-killing therapy based on anchoring OX40L to tumor cell membrane was developed to enhance the effectiveness of immune checkpoint blockade therapy. It transformed cold tumors to hot, prevented tumor recurrence and metastasis, and offered a new possibility for immunotherapy of various solid tumors.
BIOACTIVE MATERIALS
(2023)
Article
Cell Biology
Qian Wang, Zhaoyang Chen, Junjie Guo, Xiaoping Peng, Zeqi Zheng, Hang Chen, Haibo Liu, Yuanji Ma, Jianbing Zhu
Summary: Our study found that atorvastatin-induced tDCs have a beneficial effect on post-infarction cardiomyocyte apoptosis and myocardial fibrosis, reducing inflammatory cell infiltration and inhibiting oxidative stress, likely through suppression of TLR-4/NF-kappa B activation.
INFLAMMATION RESEARCH
(2023)
Article
Immunology
Lin Zhao, Wenjie Zhang, Meng Liu, Ruoyu Jia, Juncheng Wang, Fengge Wang, Yuekang Xu
Summary: A well-preserved immune system relies on co-stimulatory molecules like OX40L to ensure efficient immune responses in different conditions. This study demonstrates that OX40L is required for antigen presentation by dendritic cells (DCs) and promotes CD4(+) T cell differentiation while enhancing CD8(+) T cell cytotoxicity. The strong immunogenic roles of OX40L in DCs also lead to better metastasis inhibition in vivo, suggesting its potential as a target in DC-based vaccines for enhanced anti-tumor efficacy.
MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Immunology
Elene A. Clemens, Beth C. Holbrook, Brendan McNeilly, Masaru Kanekiyo, Barney S. Graham, Martha A. Alexander-Miller
Summary: The newborn immune system is weaker, making infants vulnerable to virus-mediated diseases and challenging vaccination. Optimal vaccination strategies for newborns should generate protective antibodies that can combat the variability in virus strains. Administering an inactivated vaccine with R848 can promote the sustained production of specific antibodies.
Article
Immunology
Lina Jing, Xin Zhang, Dong Liu, Yonghong Yang, Huabao Xiong, Guanjun Dong
Summary: This study found that ACK1 is involved in the pathogenesis of inflammation and autoimmune diseases mediated by TLR pathways, presenting a potential target for controlling inflammation and alleviating autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Tadej Fevzer, Primoz Pozenel, Kaja Zajc, Natasa Tesic, Urban Svajger
Summary: This study presents a novel and superior maturation cocktail for dendritic cells (DCs) in the production of DC-based vaccines. The new cocktail, which includes TLR-3 agonist, tumor necrosis factor, interleukin, interferon, and TLR-8 stimulation, enhances the efficacy of the DC vaccines by promoting the expression of co-stimulatory molecules, migratory capacity, and immune response. It demonstrates the potential for improving the manufacturing protocols of next-generation DC vaccines.
Article
Immunology
Chenxue Mei, Fanxiang Meng, Xiao Wang, Siqi Yan, Qianqian Zheng, Xiaoqing Zhang, Wenda Fu, Junxiu Xue, Shengyi Wang, Yan He, Xun Sun, Xuefeng Jiang, Yuanyuan Wang
Summary: The study found that CD30L may promote the inflammatory response by inducing the homing and differentiation of monocytes via the CCL2/CCR2 axis and NF-kappa B signaling pathway. These findings provide a novel target for monocyte-based immunotherapy against inflammatory bowel diseases (IBD).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Yong Du, Marie Dominique Ah Kioon, Paoline Laurent, Vidyanath Chaudhary, Michael Pierides, Chao Yang, David Oliver, Lionel B. Ivashkiv, Franck J. Barrat
Summary: The authors describe a noncanonical role for multiple chemokines to serve as nucleic acid delivery vectors to modulate TLR signaling, with implications for the chronic presence of IFN-I in autoimmune diseases.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Cristiane Secca, Jennifer K. Bando, Jose L. Fachi, Susan Gilfillan, Vincent Peng, Blanda Di Luccia, Marina Cella, Keely G. McDonald, Rodney D. Newberry, Marco Colonna
Summary: LTi-like cells play a crucial role in maintaining gut epithelial integrity and protection against bacterial infections. The retention of LTi-like cells in conventional solitary intestinal lymphoid tissue is controlled by the chemokine receptor CXCR5. Deletion of Cxcr5 leads to uncontrolled activity of LTi-like cells and increased IL-22 production, improving gut barrier integrity in mice infected with Clostridium difficile.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Woo Seok Yang, Young-Jin Son, Mi-Yeon Kim, Soochan Kim, Jong-Hoon Kim, Jae Youl Cho
MEDIATORS OF INFLAMMATION
(2015)
Article
Immunology
Soochan Kim, Sinsuk Han, Hyung Soo Lee, Yong-Sun Kim, Eun-Kyoung Choi, Mi-Yeon Kim
Article
Immunology
Soochan Kim, Sinsuk Han, Ye Eun Lee, Woong-Jae Jung, Hyung Soo Lee, Yong-Sun Kim, Eun-Kyoung Choi, Mi-Yeon Kim
Article
Multidisciplinary Sciences
Dong Hyuk Seo, Xiumei Che, Min Seob Kwak, Soochan Kim, Jae Hyeon Kim, Hyun Woo Ma, Da Hye Kim, Tae Il Kim, Won Ho Kim, Seung Won Kim, Jae Hee Cheon
SCIENTIFIC REPORTS
(2017)
Article
Plant Sciences
Jingyu Bae, Jihye Koo, Soochan Kim, Tae-Yoon Park, Mi-Yeon Kim
JOURNAL OF GINSENG RESEARCH
(2012)
Article
Biochemistry & Molecular Biology
Jae Hyeon Kim, Jae Bum Ahn, Da Hye Kim, Soochan Kim, Hyun Woo Ma, Xiumei Che, Dong Hyuk Seo, Tae Il Kim, Won Ho Kim, Jae Hee Cheon, Seung Won Kim
Article
Microbiology
Da Hye Kim, Soochan Kim, Jae Bum Ahn, Jae Hyeon Kim, Hyun Woo Ma, Dong Hyuk Seo, Xiumei Che, Ki Cheong Park, Jeong Yong Jeon, Sang Yong Kim, Han Cheol Lee, Jae-Young Lee, Tae Il Kim, Won Ho Kim, Seung Won Kim, Jae Hee Cheon
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Seung Won Kim, Soochan Kim, Mijeong Son, Jae Hee Cheon, Young Sook Park
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Dong Hyuk Seo, Xiumei Che, Soochan Kim, Da Hye Kim, Hyun Woo Ma, Jae Hyeon Kim, Tae Il Kim, Won Ho Kim, Seung Won Kim, Jae Hee Cheon
Summary: α-TREM-1 antibody alleviates colitis by modulating neutrophil function, clearing pathogens, protecting the intestinal barrier, and rebalancing the microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Da Hye Kim, Jihye Park, Soochan Kim, Young Mi Yoon, Hyun Woo Ma, I. Seul Park, Mijeong Son, Ji Hyung Kim, Tae Il Kim, Won Ho Kim, Sang Sun Yoon, Seung Won Kim, Jae Hee Cheon
Summary: The study found that the atypical Escherichia coli strain could restore body weight, reduce disease activity score, decrease hydrogen peroxide levels, and increase regulatory T cell numbers in mice with colitis. By controlling immune responses and microbial composition, atEc can alleviate colonic inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jihye Park, Da Hye Kim, Soochan Kim, Hyun Woo Ma, I. Seul Park, Mijeong Son, Ji Hyung Kim, Yoojin Shin, Seung Won Kim, Jae Hee Cheon
INTESTINAL RESEARCH
(2021)
Article
Immunology
Mijeong Son, I. Seul Park, Soochan Kim, Hyun Woo Ma, Ji Hyung Kim, Tae Il Kim, Won Ho Kim, Jaeyong Han, Seung Won Kim, Jae Hee Cheon
Summary: Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder. The use of proton pump inhibitors (PPIs) may worsen IBD. However, tegoprazan can improve IBD and enhance intestinal epithelial barrier function without causing gut dysbiosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
J. H. Kim, J. B. Ahn, D. H. Kim, S. Kim, H. W. Ma, X. Che, D. H. Seo, T. I. Kim, W. H. Kim, J. H. Cheon, S. W. Kim
JOURNAL OF CROHNS & COLITIS
(2020)
Article
Biochemistry & Molecular Biology
Soochan Kim, Sinsuk Han, Taehyun Kim, Jeehoon Nam, Yong-Sun Kim, Eun-Kyoung Choi, Mi-Yeon Kim