Review
Biochemistry & Molecular Biology
Jorrit M. Enserink, Pierre Chymkowitch
Summary: Cdk1 is a master regulator of the cell cycle, controlling progression through different phases. It also directly regulates RNA polymerase activity, which is important for protein synthesis and meeting cellular demands. This regulation promotes cell cycle entry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Zongren Wan, Lixin Wang, Dan Yang, Pengling Li, Qing Liu, Baolan Wang
Summary: The study revealed that CKS2 is upregulated in NSCLC tissues and cells, promoting cell growth and cell cycle progression, while its knockdown suppresses tumorigenesis. CKS2 could potentially serve as a biomarker in NSCLC progression and prognosis.
Review
Biochemistry & Molecular Biology
Pawel Lukasik, Michal Zaluski, Izabela Gutowska
Summary: Cyclin-dependent kinases are crucial in various cellular processes and their dysregulation can lead to diseases, making them potential drug targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Riham R. E. Abouleisa, Jessica M. Miller, Ahmad Gebreil, Abou Bakr M. Salama, Marc Dwenger, Hania Abdelhafez, Reham M. Wahid, Adeniyi T. Adewumi, Mahmoud E. S. Soliman, Nader E. Abo-Dya, Tamer M. A. Mohamed
Summary: This study identified a small molecule called NDPPC, which can enhance the cell cycle progression of cardiomyocytes and has the potential to be a drug for heart failure treatment.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Microbiology
Juri Kim, Eun-Ah Park, Mee Young Shin, Soon-Jung Park
Summary: This study investigated the functional roles of Giardia lamblia CDKs (GlCDKs) and their cognate cyclins. Using morpholino-mediated knockdown and coimmunoprecipitation, the functions of GlCDK1 and GlCDK2 were distinguished. GlCDK1 with Glcyclin 3977 plays a crucial role in flagellum formation and cell cycle control of G. lamblia, while GlCDK2 with Glcyclin 22394/6584 is involved in cell cycle control.
MICROBIOLOGY SPECTRUM
(2023)
Review
Cell Biology
Aleksandra J. Pluta, Cecilia Studniarek, Shona Murphy, Chris J. Norbury
Summary: This article discusses the important roles of structurally related cyclin-dependent protein kinases (CDKs) in eukaryotic cell function, highlighting their roles in cell cycle regulation and transcriptional regulation, and the overlap between these processes.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Forestry
Yijie Li, Song Chen, Yuhang Liu, Haijiao Huang
Summary: This study identified 59 cell cycle gene models in the genome of Betula pendula, with 17 highly expressed genes among them. These findings provide a foundation for further research on the function of cell cycles in Betula pendula.
Article
Microbiology
Yanfei Zhang, Matteo Barberis
Summary: Coordination between cell cycle and metabolism is important for cell division and new cell construction. Cyclin-dependent kinases (Cdks) play a crucial role in this coordination, regulating cell division. This study reveals the possible impact of cell cycle mechanisms on cellular metabolism, finding that certain metabolic enzymes may be phosphorylated by Cdks, affecting their activities and metabolic regulation.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Pawel Lukasik, Irena Baranowska-Bosiacka, Katarzyna Kulczycka, Izabela Gutowska
Summary: Recent studies have shown that small molecule drugs targeting CDK inhibitors have become attractive options for treating cancer and neurodegenerative disorders. Most CDK inhibitors target the ATP binding pocket, but the similarity in structure among CDK kinases makes achieving selectivity challenging. Therefore, inhibitors binding outside the ATP binding site have attracted great interest for their potential applications in the biomedical field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Minhui Yang, Changxiao Hu, Yibo Cao, Wanling Liang, Xiangdong Yang, Tianbao Xiao
Summary: The study explores the biological functions of CCNB1 in COAD and investigates the therapeutic effects of UA on COAD cells. UA effectively inhibits COAD cell proliferation and induces cell cycle arrest in S phase. The molecular mechanisms of UA involve downregulation of CCNB1 and its interacting genes and proteins, contributing to cell cycle blocking and COAD treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Liguo Wang, Zhouli Yang, Guangchen Li, Yongbo Liu, Chao Ai, Yu Rao
Summary: This article summarizes the latest developments in CDK and cyclin protein degraders, covering their selectivity, application, validation, and the current state of development for CDK members lacking degraders. It provides a comprehensive overview for researchers in this field.
FRONTIERS OF MEDICINE
(2023)
Article
Fisheries
Xue Zhang, Jianzhu Zhao, Qing Li, Di Qin, Wenwei Li, Xinyu Wang, Mengfei Bi, Qingwei Li, Tiesong Li
Summary: The lamprey PHB2 gene inhibits the proliferation of NSCLC cells by down-regulating the expression and phosphorylation levels of cell cycle-associated proteins, with the most significant effect observed in Calu-1 cells.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Keiko Taniguchi-Ponciano, Lesly A. Portocarrero-Ortiz, Gerardo Guinto, Sergio Moreno-Jimenez, Erick Gomez-Apo, Laura Chavez-Macias, Eduardo Pena-Martinez, Gloria Silva-Roman, Sandra Vela-Patino, Jesus Ordonez-Garcia, Sergio Andonegui-Elguera, Aldo Ferreira-Hermosillo, Claudia Ramirez-Renteria, Etual Espinosa-Cardenas, Ernesto Sosa, Ana Laura Espinosa-de-los-Monteros, Latife Salame-Khouri, Carolina Perez, Blas Lopez-Felix, Guadalupe Vargas-Ortega, Baldomero Gonzalez-Virla, Marcos Lisbona-Buzali, Daniel Marrero-Rodriguez, Moises Mercado
Summary: The kinome of PA clusters these lesions into three distinct groups according to the transcription factor that drives their terminal differentiation. And these complexes could be harnessed as molecular therapy targets.
BMC MEDICAL GENOMICS
(2022)
Article
Biochemistry & Molecular Biology
Betheney R. Pennycook, Alexis R. Barr
Summary: The use of CDK4/6 inhibitors in cancer treatment is a topic of ongoing investigation, with limited understanding of their mechanisms of action. Recent data have raised questions about how these inhibitors arrest cell proliferation, leading to renewed interest in the roles of CDK4/6. Studying the effects of CDK4/6 inhibitors on the cell cycle can have implications for cancer treatment and patient stratification.
Article
Cell Biology
Zhaoxin Wang, Chenchen Ren, Li Yang, Xiaoan Zhang, Jiaxi Liu, Yuanhang Zhu, Dongyuan Jiang
Summary: The study revealed that circ_0000326 is highly expressed in cervical cancer and acts as a sponge for microRNA-338-3p to upregulate Cyclin-dependent kinase 4, promoting cancer cell proliferation and migration. Inhibition of circ_0000326 showed promising effects in suppressing tumor growth and decreasing Cyclin-dependent kinase 4 expression.
Article
Biodiversity Conservation
Xiaoyu Feng, Ru Huang, Haifeng Zhu, Eryuan Liang, Achim Braeuning, Linhao Zhong, Zhaohui Gong, Peng Zhang, Fayaz Asad, Xiaolong Zhu, Jussi Griessinger
Summary: Vapor pressure deficit (VPD) is an important indicator of atmospheric aridity, but there is a lack of data to represent VPD globally. In this study, tree-ring cellulose oxygen isotope (δ(OTRC)-O-18) in the western Kunlun Mountains is shown to be a hidden frequency-dependent indication of atmospheric aridity. The results reveal that δ(OTRC)-O-18 values are strongly correlated with VPD at timescales < 5 years.
ECOLOGICAL INDICATORS
(2022)
Article
Environmental Sciences
Zhaohui Gong, Jian Zhu, Tingting Li, Danqing Huang, Xianyan Chen, Qiang Zhang
Summary: This study investigates the variation and possible mechanisms of flash droughts in China, finding regional characteristics and proposing potential mechanisms based on water and energy supply factors.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Public, Environmental & Occupational Health
Huihui Huangfu, Zhifan Zhang, Qinwen Yu, Qingyu Zhou, Peiwu Shi, Qunhong Shen, Zhaoyang Zhang, Zheng Chen, Chuan Pu, Lingzhong Xu, Zhi Hu, Anning Ma, Zhaohui Gong, Tianqiang Xu, Panshi Wang, Hua Wang, Chao Hao, Chengyue Li, Mo Hao
Summary: This study evaluates the impact of the 2009 healthcare reform in China on the enabling environment for children's health. The results show that the reform has a positive impact, particularly on human resources and service provision for children. Efforts should be made to improve the clarity of accountability mechanisms in the health-related sectors.
JOURNAL OF GLOBAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Yang Chen, Qingyu Zhou, Xinmei Yang, Peiwu Shi, Qunhong Shen, Zhaoyang Zhang, Zheng Chen, Chuan Pu, Lingzhong Xu, Zhi Hu, Anning Ma, Zhaohui Gong, Tianqiang Xu, Panshi Wang, Hua Wang, Chao Hao, Chengyue Li, Mo Hao
Summary: The study found that strengthening public health services is crucial for tuberculosis prevention and control. Multisector participation and improving the coverage rate of public health services can effectively reduce the incidence of tuberculosis.
FRONTIERS IN PUBLIC HEALTH
(2022)
Editorial Material
Oncology
Shuai Fang, Xiaofeng Jin, Chengwei Zhou, Zhaohui Gong
Summary: The resistance to cisplatin-based chemotherapy is a common cause of poor prognosis in cancer patients. Recent research has found that ubiquitylation and translocation of cyclin C in cancer cells can affect the stability of mitochondria after cisplatin stimulation, providing new insights for studying chemoresistance mechanisms and developing new chemotherapy drugs.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Marine
Xiaoyu Tan, Linhao Zhong, Lin Mu, Zhaohui Gong
Summary: The study investigates the winter cooling in East Asia and its associated atmospheric and oceanic influences. The results show that the cooling is characterized by anticyclonic circulation, mid-to-high-latitude wave trains, decreased sea surface temperature in the tropical Pacific, and reduced sea-ice cover in the Barents and Kara Seas. Two circulation modes, influenced by La Nina-type SST anomaly and reduced SIC in BKS, have a cooling effect on East Asia. The synergy between tropical and polar oceanic forcing can increase the East-Asia cooling days and cold extremes.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Health Care Sciences & Services
Zhaohui Gong, Rong Li, Shulin Chen, Hui Wu, Yinhe Cai, Junlong Li, Xinjun Zhao, Qingmin Chu, Chuanjin Luo, Lijin Qing, Nan Li, Wei Wu
Summary: This study used network pharmacology to identify the active ingredients and targets of Huanglian Jiedu decoction (HLJDD) for treating dyslipidemia. The results showed that HLJDD can regulate multiple signaling pathways and biological processes to treat dyslipidemia.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Xiuchong Yu, Xuemei Song, Yaoyao Xie, Shuangshuang Zhang, Junming Guo
Summary: In this study, a quantitative method was established to detect plasma tRF-27 in gastric cancer patients. It was found that plasma tRF-27 levels were significantly increased and closely related to tumor size and Ki67 expression in gastric cancer patients. tRF-27 may serve as an independent predictor of overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Nan Li, Zhixin Chen, Wei Feng, Zhaohui Gong, Changsong Lin, Jiaxu Chen, Congqiu Chu, Qiang Xu
Summary: This study explores the molecular mechanisms underlying the therapeutic effects of triptolide in rheumatoid arthritis (RA) and identifies the miRNA pathway responsible for these effects. It reveals that triptolide regulates the growth and secretory functions of chondrocytes via inhibiting miR-221 secretion by fibroblast-like synovial cells, providing a potential target for future RA treatments.
Article
Plant Sciences
Nan Li, Xiaojuan Li, Lijuan Deng, Haixin Yang, Zhaohui Gong, Qiang Wang, Dongmei Pan, Shan Zeng, Jiaxu Chen
Summary: This study found that 6-shogaol inhibits proliferation, migration, and invasion, and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes (FLSs). It also reduces the production of inflammatory cytokines and matrix metalloproteinases (MMPs). Molecular mechanism analysis revealed that 6-shogaol inhibits the PI3K/AKT/NF-kappa B pathway by activating PPAR-gamma. Treatment with 6-shogaol ameliorated joint destruction in a mouse model of collagen-induced arthritis (CIA). Therefore, 6-shogaol may be a potential natural drug for future rheumatoid arthritis treatments.
Article
Clinical Neurology
Huiqun Tan, Zhaohui Gong, Sisi Xing, Lanhua Cao, Huan Liu, Lijun Xu
Summary: This study investigated the effect of balance training in addition to auxiliary activity on the balance function of patients with stroke at high risk for falls. The results showed that adding balance training to auxiliary activity can significantly improve balance function, lower extremity motor function, and walking ability, and reduce fall risk.
FRONTIERS IN NEUROLOGY
(2023)
Editorial Material
Meteorology & Atmospheric Sciences
Yao Yao, Wenqin Zhuo, Zhaohui Gong, Binhe Luo, Dehai Luo, Fei Zheng, Linhao Zhong, Fei Huang, Shuangmei Ma, Congwen Zhu, Tianjun Zhou
Summary: From 17 November to 27 December 2022, frequent extremely cold snowstorms occurred in North America and Eurasia. These events were closely related to the establishment of blocking circulations. The Alaska Blocking (AB) and subsequent Ural Blocking (UB) episodes were associated with the phase transition of the North Atlantic Oscillation (NAO) and represented the main atmospheric regimes in the Northern Hemisphere. The dispersion and propagation of Rossby wave packets from Alaska to East Asia created a large-scale connection between AB and UB episodes.
ADVANCES IN ATMOSPHERIC SCIENCES
(2023)
Review
Medicine, General & Internal
Yuanyuan Wang, Huihui Bai, Meina Jiang, Chengwei Zhou, Zhaohui Gong
Summary: Long non-coding RNAs (lncRNAs) are crucial regulators of gene regulation and malignant processes in human cancers. The lncRNA JPX acts as a novel molecular switch for X chromosome inactivation and its differential expression has clinical correlations in various cancers. JPX is involved in cancer growth, metastasis, and chemoresistance through its role as a competing endogenous RNA, protein interaction, and regulation of specific signaling pathways. Furthermore, JPX has potential applications as a biomarker and therapeutic target in cancer diagnosis, prognosis, and treatment. This article provides a comprehensive summary of the structure, expression, and function of JPX in malignant cancer processes, and discusses its molecular mechanisms and potential applications in cancer biology and medicine.
CHINESE MEDICAL JOURNAL
(2023)
Article
Neurosciences
Jingrong Chen, Cheng Chen, Na Wang, Chunyu Wang, Zhaohui Gong, Jingxian Du, Honglin Lai, Xinpei Lin, Wei Wang, Xiangyu Chang, Michael Aschner, Zhenkun Guo, Siying Wu, Huangyuan Li, Fuli Zheng
Summary: Exposure to cobalt nanoparticles (CoNPs) is associated with neurodegenerative disorders, and the mitochondrial mechanisms underlying their neurotoxicity have not been fully characterized. This study found that CoNPs exposure reduced survival and lifespan in nematodes. Additionally, CoNPs exposure aggravated paralysis and beta-amyloid aggregation, accompanied by reactive oxygen species overproduction, ATP reduction, and mitochondrial fragmentation.
Article
Oncology
Nan Liang, Xun Zhang, Luyi Zhang, Meina Jiang, Huihui Bai, Chenhang Ding, Yuanting Cai, Chengwei Zhou, Ying Han, Zhaohui Gong
Summary: Circular RNAs (circRNAs) are dysregulated in cancers and have stable expression in body fluids. This study identified and evaluated the clinical value of circRNA VPS35L (circVPS35L) as a biomarker for diagnosing non-small cell lung cancer (NSCLC). The expression levels of circVPS35L were determined in tissues, blood, and cell lines using RT-qPCR. The stability of circVPS35L was examined with the actinomycin D assay and RNase R treatment. ROC analysis showed that circVPS35L had higher diagnostic value than conventional tumor markers in NSCLC patients. Furthermore, circVPS35L was highly stable in peripheral blood. These findings highlight the potential of circVPS35L as a novel biomarker for NSCLC diagnosis and differentiation from benign lung disease.
