期刊
BMB REPORTS
卷 41, 期 9, 页码 645-650出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2008.41.9.645
关键词
Arabidopsis NDPK2; GTPase activating protein; light signaling; phytochrome; plant NDPK; small G protein
资金
- KOSEF/MOST
- Environmental Biotechnology National Core Research Center (NCRC) [R15-2003-012-01003-0]
- Plant Diversity Research Center of 21st Century Frontier Research Program [PF06302-02]
- National Research Foundation of Korea [04-2006-11-002-00, R15-2003-012-01003-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Nucleoside diphosphate kinase (NDPK) is involved in multiple signaling pathways in mammalian systems, including G-protein signaling. Arabidopsis NDPK2, like its mammalian counterparts, is multifunctional despite its initial discovery phytochrome-interacting protein. This similarity raises the possibility that NDPK2 may play a role in G-protein signaling in plants. in the present study, we explore the potential relationship between NDPK2 and the small G proteins, Pra2 and Pra3, as well as the heterotrimeric G protein, GPA1. We report a physical interaction between NDPK2 and these small G proteins, and demonstrate that NDPK2 can stimulate their GTPase activities. Our results suggest that NDPK2 acts as a GTPase-activating protein for small G proteins in plants. We propose that NDPK2 might be a missing link between the phytochromemediated light signaling and G protein-mediated signaling.
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