期刊
BMB REPORTS
卷 41, 期 9, 页码 640-644出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2008.41.9.640
关键词
hepatitis B virus (HBV); intrinsically unstructured protein (IUP); lipo-peptides; local pre-structured motif; nuclear magnetic resonance (Nmr); preS1
资金
- Korea Science and Engineering Foundation (KOSEF)
- Korea government (MOST) [OGM1100611]
- Korean Ministry of Health and Welfare
- Korea Health Industry Development Institute [A060017]
- Korea Health Promotion Institute [A060017] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The preS1 surface protein of the hepatitis B virus (HBV) is a key factor involved in initial viral entry into hepatocytes. It has been long postulated that an anti-HBV effect should be achievable using peptide fragments of the preS1. Recent reports demonstrated that several preS1-derived lipo-peptides in genotype D HBV exhibit nano to picomolar inhibitory activity against HBV infection. In this study, an acylated analog of a preS1 fragment, a 21-residue lipo-peptide (named 7524 BVS7) with a sequence of palmitoyl-GMGTNLSVPNPLGFFPDHQLDC-NH2, from genotype C HBV was produced base upon a previous structural study and was shown potently inhibits HBV infection with an IC50 of approximate to 20 nM.
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