Article
Agriculture, Dairy & Animal Science
Corie Darrington, Haijiao Lin, Jean-Marc Lariviere, Janet E. Fulton, Xin Zhao
Summary: This study aims to evaluate the MHC-B variability in the Chantecler breed using an MHC-B SNP panel. The results show reasonable diversity in the MHC-B region of the Chantecler breed, contributing to our understanding of the variability of this region in chickens.
Review
Immunology
Alex E. Wolfe, Kate A. Markey
Summary: Allogenic hematopoietic stem-cell transplantation is an immunotherapy for high-risk hematological malignancies and immune deficiencies. Immune recovery and the relationship with gut microbiome are important factors for transplant outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jaroslaw Dybko, Malgorzata Sobczyk-Kruszelnicka, Sebastian Makuch, Siddarth Agrawal, Krzysztof Dudek, Sebatian Giebel, Lidia Gil
Summary: This study compared the outcomes of patients who received post-transplant cyclophosphamide (PTCy) or conventional immunosuppressants after allogeneic hematopoietic cell transplantation. The study found that patients receiving PTCy had lower rates of acute graft-versus-host disease and cytomegalovirus reactivation, and higher survival rates. Further research with a larger sample size is needed to confirm these results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Makoto Iwasaki, Junya Kanda, Hidenori Tanaka, Takero Shindo, Takahiko Sato, Noriko Doki, Takahiro Fukuda, Yukiyasu Ozawa, Tetsuya Eto, Naoyuki Uchida, Yuta Katayama, Keisuke Kataoka, Takahide Ara, Shuichi Ota, Makoto Onizuka, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Satoko Morishima
Summary: This study retrospectively examined the identification of non-permissive HLA mismatching patterns in hematopoietic stem cell transplantation. The results suggest that HLA-C EMM might be associated with a higher risk of grade III-IV GVHD, leading to increased non-relapse mortality and decreased overall survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
K. A. Saravanan, Manjit Panigrahi, Harshit Kumar, Subhashree Parida, Bharat Bhushan, G. K. Gaur, Pushpendra Kumar, Triveni Dutt, B. P. Mishra, R. K. Singh
Summary: This study presents a comprehensive analysis of genetic diversity, ROH, inbreeding, linkage disequilibrium, effective population size, and haplotype block structure in Tharparkar cattle of India. The study reveals high genetic diversity in Tharparkar cattle but a gradual decline in effective population size over past generations.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Immunology
Ding-Ping Chen, Po-Nan Wang, Ai-Ling Hour, Wei-Tzu Lin, Fang-Ping Hsu, Wei-Ting Wang, Ching-Ping Tseng
Summary: In addition to classical HLA genes, the outcomes of post-HSCT are influenced by HLA-related genes and non-HLA genes involved in immune regulation. The HLA-G gene is crucial for immune tolerance, tumor cell escape, and transplant rejection reduction. This study investigates the association between genetic variants in the 3'-UTR and 5'-URR of HLA-G and adverse outcomes in leukemia patients receiving HSCT. Specific SNPs and haplotypes were found to be linked to the occurrence of chronic graft-versus-host disease (GVHD). These findings suggest that these genetic variants may serve as predictors for poor outcomes after HSCT and guide preventive treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Ashley N. Gray, Nicole H. Tobin, Theodore B. Moore, Fan Li, Grace M. Aldrovandi
Summary: Allogeneic Hematopoietic Cell Transplantation (HCT) offers a chance of survival to children with life-threatening diseases, but complications from graft-versus-host disease (GVHD) have been identified as a significant cause of morbidity and mortality. Recent research has found that gut dysbiosis is associated with GVHD in adult HCT patients. In this study, a longitudinal analysis of the gut microbiota in nine pediatric allogeneic HCT participants revealed that HCT and antibiotic therapy caused acute shifts in gut microbiota diversity, with those experiencing stages 3-4 gut GVHD having greater microbiota variation over time. Pre-HCT microbiota diversity showed a trend towards an inverse relationship with gut microbiota stability over time. Further large-scale prospective studies are needed to understand the mechanisms underlying these dynamic changes in the gut microbiota after pediatric allogeneic HCT.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Article
Genetics & Heredity
Andre C. Araujo, Paulo L. S. Carneiro, Hinayah R. Oliveira, Flavio S. Schenkel, Renata Veroneze, Daniela A. L. Lourenco, Luiz F. Brito
Summary: Haplotype-based models did not improve the performance of genomic predictions in genetically diverse populations.
FRONTIERS IN GENETICS
(2021)
Review
Biology
Manfred Milinski
Summary: This article discusses the diversity of immune genes in the vertebrate MHC, as well as MHC-dependent mate choice and odor signals. The search for signal molecules went through various stages, and it was finally discovered that the bound peptides themselves were the sought info-chemicals. Although commensal microbiota are associated with an individual's MHC genes, they do not affect the transmission of odor signals in mate choice. Studies have shown that synthesized peptides and olfactory neurons play important roles in mate choice. Additionally, eggs also select MHC-compatible sperm to produce high-quality offspring.
Article
Cell Biology
Tengteng Zhang, Yang Li, Xiaoni Yuan, Xiaojing Bao, Luyao Chen, Xue Jiang, Jun He
Summary: In this study, HLA typing data from 653 families in the Eastern Han Chinese population were collected. HLA-A, B, C, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, and DPB1 (HLA-11 loci) typing was performed using a commercial next-generation sequencing (NGS) method. Haplotype analysis revealed different haplotypes, with the predominant haplotype being A*30:01-C*06:02-B*13:02-DRB1*07:01-DRB4*01:03-DQA1*02:01-DQB1*02:02-DPA1*02:01-DPB1*17:01. The study also found that HLA-DP affects the donor selection strategy and emphasized the importance of considering 9-locus HLA haplotype matching, particularly the effect of DP loci.
Article
Medicine, General & Internal
Gabriele Facchin, Chiara Savignano, Marta Lisa Battista, Miriam Isola, Maria De Martino, Giuseppe Petruzzellis, Chiara Rosignoli, Umberto Pizzano, Michela Cerno, Giulia De Cecco, Antonella Bertone, Giovanni Barillari, Renato Fanin, Francesca Patriarca
Summary: This study compared the characteristics and outcomes of cryopreserved peripheral blood stem cell transplantation and fresh peripheral blood stem cell transplantation from matched unrelated donors. The results showed no significant differences between the two groups in terms of engraftment, acute GVHD incidence, overall survival, progression-free survival, and treatment-related mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Hengyou Zhang, He Jiang, Zhenbin Hu, Qijian Song, Yong-Qiang Charles An
Summary: This study consolidated the raw resequencing data of 1465 soybean genomes from public databases and newly sequenced 91 highly diverse wild soybean genomes, providing a collection of 1556 sequenced genomes. Analysis revealed 32 million single nucleotide polymorphisms (SNPs), indicating high genomic diversity. Paired accessions were identified to facilitate soybean germplasm exchange between countries, and the utility of these SNPs in post-genomics research was demonstrated.
Article
Agriculture, Dairy & Animal Science
Dongwon Seo, Sunghyun Cho, Prabuddha Manjula, Nuri Choi, Young-Kuk Kim, Yeong Jun Koh, Seung Hwan Lee, Hyung-Yong Kim, Jun Heon Lee
Summary: Classifying a target population at the genetic level using a minimum number of markers from high-density SNP array data can provide stable results. Utilizing GWAS, PCA, and machine learning algorithms to explore various combinations with the minimum number of markers has proven to be effective in distinguishing target populations.
Article
Surgery
Daniel S. Ramon, Danielle M. Troop, Theresa N. Kinard, Caroline C. Jadlowiec, Margaret S. Ryan, Winston R. Hewitt, Linda G. Olsen, Andres Jaramillo, Timucin Taner, Raymond L. Heilman
Summary: Simultaneous liver-kidney transplant (SLKT) with donor-specific antibodies (DSA) is common, but after a second liver transplant, an abrupt increase in DSA levels against the kidney led to antibody-mediated rejection (AMR). The clearance of antibodies depended on the HLA antigens expressed by the transplanted liver cells.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Ding-Ping Chen, Tang-Her Jaing, Ai-Ling Hour, Wei-Tzu Lin, Fang-Ping Hsu
Summary: This study identified specific SNPs in non-HLA genes associated with the effectiveness of unrelated CBT, which can aid in selecting the best donor and predicting the risk of CBT adverse reactions, further suggesting the important role of SNPs in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
