期刊
BLOOD REVIEWS
卷 25, 期 6, 页码 261-269出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.blre.2011.06.004
关键词
Telomeres; Bone marrow failure disorders; Hematopoietic stem cell transplant; Dyskeratosis congenita; Myelodysplastic syndrome; Pluripotent stem cells
类别
资金
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Telomeres are long (TTAGGG), nucleotide repeats and an associated protein complex located at the end of the chromosomes. They shorten with every cell division and, thus are markers for cellular aging, senescence, and replicative capacity. Telomere dysfunction is linked to several bone marrow disorders, including dyskeratosis congenita, aplastic anemia, myelodysplastic syndrome, and hematopoietic malignancies. Hematopoietic stem cell transplantation (HSCT) provides an opportunity in which to study telomere dynamics in a high cell proliferative environment. Rapid telomere shortening of donor cells occurs in the recipient shortly after HSCT; the degree of telomere attrition does not appear to differ by graft source. As expected, telomeres are longer in recipients of grafts with longer telomeres (e.g., cord blood). Telomere attrition may play a role in, or be a marker of, long term outcome after HSCT, but these data are limited. In this review, we discuss telomere biology in normal and abnormal hematopoiesis, including HSCT. Published by Elsevier Ltd.
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