Review
Biochemistry & Molecular Biology
Yuji Oe, Nobuyuki Takahashi
Summary: Coagulation abnormalities are common in chronic kidney disease (CKD). Tissue factor plays a key role in promoting coagulation and inflammation, exacerbating renal injury.
Article
Biochemistry & Molecular Biology
Sevigean Ali, Mihaela Botnarciuc, Lavinia Carmen Daba, Sorina Ispas, Alina Mihaela Stanigut, Camelia Pana, Marian-Catalin Burcila, Liliana-Ana Tuta
Summary: There is limited research on decreased platelet count in chronic kidney disease (CKD), but platelet functions are altered in the uremic environment, leading to an increased risk of bleeding. This study monitored 104 CKD patients with thrombocytopenia who received platelet transfusion and evaluated their prognosis. The results showed that in patients with multiple comorbidities, 4.83% still experienced severe uncontrolled hemorrhages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Prabhatchandra Dube, Armelle DeRiso, Mitra Patel, Dhanushya Battepati, Bella Khatib-Shahidi, Himani Sharma, Rajesh Gupta, Deepak Malhotra, Lance Dworkin, Steven Haller, David Kennedy
Summary: Vascular calcification (VC) is a major cause of cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD), resembling bone metabolism and driven by factors such as hyperphosphatemia and Ca/Pi imbalance. The process involves various cell types and signaling pathways. In-depth analysis of VC types, therapies, and cellular mechanisms aims to aid in the development of preventive, diagnostic, and therapeutic strategies for CKD patients burdened with this disease.
Review
Food Science & Technology
Mara Lauriola, Ricard Farre, Pieter Evenepoel, Saskia Adriana Overbeek, Bjorn Meijers
Summary: Patients with CKD have a higher cardiovascular risk than the general population due to the accumulation of uremic toxins. Protein-bound uremic toxins originate from various sources and are difficult to remove with conventional therapies. Diet plays an important role in uremic toxicity, with most toxins derived from the gut. This review summarizes the sources of uremic toxins in foods and discusses their metabolism and potential dietary strategies for reducing their plasma levels.
Review
Food Science & Technology
Mateo Ondrussek-Sekac, Diana Navas-Carrillo, Esteban Orenes-Pinero
Summary: In chronic kidney disease, dysbiosis of intestinal microbiota can lead to uremic toxicity, inflammation and disease progression. Modulating gut microbiota through dietary changes and using probiotics, prebiotics, and low protein diets can offer therapeutic interventions to improve this imbalance and manage chronic kidney disease effectively.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Si-Hyun Seong, Hyun Sik Kim, Yong-Moon Lee, Jae-Seok Kim, Sangwoo Park, Jieun Oh
Summary: Breath VOC analysis is a valuable non-invasive tool for identifying patients with chronic kidney disease. This study found that the composition of breath VOCs differs significantly between healthy controls and patients with chronic kidney disease. By incorporating age and specific VOCs into a multivariate model, the accuracy of identifying chronic kidney disease patients can reach 86%.
Review
Cell Biology
Ewa Wojtaszek, Urszula Oldakowska-Jedynak, Marlena Kwiatkowska, Tomasz Glogowski, Jolanta Malyszko
Summary: Patients with CKD are at high risk for CVD, with unique nontraditional risk factors playing a crucial role in the increased cardiovascular burden in these patients.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Nutrition & Dietetics
Zarina Ebrahim, Sebastian Proost, Raul Yhossef Tito, Jeroen Raes, Griet Glorieux, Mohammed Rafique Moosa, Renee Blaauw
Summary: There is growing evidence that gut dysbiosis contributes to the progression of chronic kidney disease. This study found that ss-glucan prebiotic has a positive effect on kidney function, uremic toxins, and the gut microbiome in CKD participants.
Article
Biotechnology & Applied Microbiology
Gerrit A. Stuivenberg, John A. Chmiel, Polycronis P. Akouris, Jessica White, Hannah Wilcox, Shannon Seney, Jeremy P. Burton, Gregor Reid
Summary: Chronic kidney disease (CKD) is a significant problem in developing countries, particularly in sub-Saharan Africa, where its prevalence is high and associated with cardiovascular issues. Uremic toxins, such as p-cresol and p-cresyl sulfate, play a role in CKD. This study found that adding specific bifidobacterial strains to probiotic yogurt produced in Tanzanian communities can potentially reduce uremic toxins and provide additional health benefits.
FERMENTATION-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Kuo-Chin Hung, Wei-Cheng Yao, Yi-Lien Liu, Hung-Jen Yang, Min-Tser Liao, Keong Chong, Ching-Hsiu Peng, Kuo-Cheng Lu
Summary: Patients with chronic kidney disease (CKD) often have a high accumulation of protein-bound uremic toxins (PBUTs), such as indoxyl sulfate (IS) and p-cresyl sulfate (pCS). The buildup of PBUTs inhibits bone and muscle function, worsens muscle wasting, and contributes to low bone turnover disorders. Understanding the underlying mechanisms of bone and muscle loss in CKD can aid in developing new therapies for musculoskeletal diseases.
Article
Food Science & Technology
Carolla El Chamieh, Islam Amine Larabi, Solene M. Laville, Christian Jacquelinet, Christian Combe, Denis Fouque, Maurice Laville, Luc Frimat, Roberto Pecoits-Filho, Celine Lange, Benedicte Stengel, Natalia Alencar De Pinho, Jean-Claude Alvarez, Ziad A. Massy, Sophie Liabeuf
Summary: Proton-pump inhibitors (PPIs) are commonly used in patients with chronic kidney disease (CKD), and are associated with the retention of uremic toxins (UTs). In this cross-sectional study, we found that patients using PPIs had higher levels of certain UTs compared to other patients. These findings are important for understanding factors that modulate serum UT concentration in CKD patients.
Review
Urology & Nephrology
Laetitia Koppe, Christophe O. Soulage
Summary: Chronic kidney disease is associated with changes in the gut microbiota, and diet plays a crucial role in managing the disease. This review discusses the latest research on the interactions between diet and gut microbiota in the context of uremia, and how this knowledge can be used to develop personalized nutrition strategies to prevent the progression of chronic kidney disease to kidney failure and its complications.
KIDNEY INTERNATIONAL
(2022)
Article
Cell Biology
Jung Sun Park, Dong-Hyun Kim, Hoon-In Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Summary: This study investigated the effects of uremic toxins on ferroptosis in the kidney, finding that protein-bound uremic toxins can induce ferroptosis and result in cell death.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Robson E. Silva, Eliziaria C. Santos, Patricia B. Justino, Margarida P. Santos, Giovane Galdino, Reggiani Goncalves, Romulo D. Novaes
Summary: The relationship between dialysis adequacy and circulating levels of inflammatory mediators was investigated, showing that low Kt/V results and creatinine accumulation may serve as potential indicators of systemic inflammatory stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vasily A. Popkov, Anastasia A. Zharikova, Evgenia A. Demchenko, Nadezda V. Andrianova, Dmitry B. Zorov, Egor Y. Plotnikov
Summary: This study presents a novel bioinformatics approach to identify the origin of uremic retention solutes and uremic toxins, particularly those produced by gut microbiota. The research utilizes database analysis and enzymatic reaction data to determine the potential toxins synthesized by bacteria residing in the human gut. The findings reveal the link between toxin concentration in uremia and the proportion of different bacterial species that can produce the toxin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Clothilde Philouze, Jean-Charles Martin, Catherine Riva, Alexandra Marziou, Catherine Defoort, Charlene Couturier, Thierry Berton, Julien Astier, Bernard Jover, Nathalie Gayrard, Cyril Reboul, Sandrine Gayrard, Jean-Francois Landrier, Philippe Obert
Summary: Vitamin D-3 supplementation did not affect glucose homeostasis, but improved cardiac remodeling and regional myocardial function, reducing levels of ceramides and diacylglycerol in the myocardium. This study demonstrated the potential benefits of vitamin D in diabetic cardiac disease.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Jonas Laget, Flore Duranton, Angel Argiles, Nathalie Gayrard
Summary: This review article discusses the interconnections between chronic kidney disease (CKD) and protein post-translational modifications (PTMs), highlighting the role of PTMs in CKD pathophysiology and kidney damage.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Transplantation
Guillaume Lano, Marion Sallee, Marion Pelletier, Stanislas Bataille, Megan Fraisse, Nathalie McKay, Philippe Brunet, Laetitia Dou, Stephane Burtey
Summary: This study found that the neutrophil:lymphocyte ratio (NLR) can predict mortality and cardiovascular events in hemodialysis (HD) patients, and it is positively correlated with the level of the uremic toxin indoxyl sulfate (IS).
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Transplantation
Stanislas Bataille, Laetitia Dou, Marc Bartoli, Marion Sallee, Julien Aniort, Borhane Ferkak, Rania Chermiti, Nathalie McKay, Nathalie Da Silva, Stephane Burtey, Stephane Poitevin
Summary: In chronic kidney disease (CKD), the plasma concentrations of myostatin and activin A are increased, possibly due to reduced renal clearance. Furthermore, we observed increased production of activin A in the kidney and heart, which may be related to muscle wasting. Therefore, myostatin and activin A should be added to the list of uremic toxins.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Dermatology
Xavier Heim, Julien Bermudez, Ahmad Joshkon, Elise Kaspi, Richard Bachelier, Marie Nollet, Melanie Velier, Laetitia Dou, Alexandre Brodovitch, Alexandrine Foucault-Bertaud, Aurelie S. Leroyer, Audrey Benyamine, Aurelie Daumas, Brigitte Granel, Florence Sabatier, Francoise Dignat-George, Marcel Blot-Chabaud, Nathalie Bardin
Summary: This study reveals the involvement of CD146 in the regulation of Wnt/ROS signaling in skin fibrosis of systemic sclerosis. The absence of CD146 leads to procanonical Wnt signaling, increased ROS content, and DNA oxidative damage. Furthermore, CD146 and its ligand are upregulated in fibroblasts from patients with systemic sclerosis. These findings highlight the importance of CD146 in the pathogenesis of systemic sclerosis and provide insights for innovative therapeutic strategies.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Karen Muyor, Jonas Laget, Irene Cortijo, Flore Duranton, Bernard Jover, Angel Argiles, Nathalie Gayrard
Summary: Vascular calcification is a risk factor for cardiovascular and kidney diseases. The anatomical distribution of vascular calcifications on different arteries and artery locations was mapped in cultured artery rings (ex vivo) and in a rat model of elastocalcinosis (in vivo). The study showed that arterial calcification increased with narrowing of vessels and was accompanied by fibrosis and apoptosis. These differences represent the local susceptibility of the vessels to the calcifying processes.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Manon Ebersolt, Tacy Santana Machado, Cecilia Mallmann, Nathalie Mc-Kay, Laetitia Dou, Dammar Bouchouareb, Philippe Brunet, Stephane Burtey, Marion Sallee
Summary: A low protein/fiber index is associated with lower concentrations of uremic toxins in anuric hemodialysis patients. Diets with increased fiber intake should be tested to determine if they can reduce serum concentrations of p-cresyl sulfate and indoxyl sulfate.
Review
Food Science & Technology
Piotr Bartochowski, Nathalie Gayrard, Stephanie Bornes, Celine Druart, Angel Argiles, Magali Cordaillat-Simmons, Flore Duranton
Summary: Chronic kidney disease affects the gut microbiota, and animal models can be used to study the gut-kidney axis. Murine models replicate the symptoms of chronic kidney disease, including slowed gut transit and altered intestinal barrier function.
Article
Biochemistry & Molecular Biology
Ariane Duval-Sabatier, Stephane Burtey, Marion Pelletier, Manon Laforet, Laetitia Dou, Marion Sallee, Anne-Marie Lorec, Hafssa Knidiri, Floriane Darbon, Yvon Berland, Philippe Brunet
Summary: Hemodialysis can reduce uremic toxins, and hemodiafiltration improves the removal of middle molecules. However, it has no effect on indoles concentration, and different treatment methods do not significantly differ in the removal of protein-bound solutes.
Article
Cell Biology
Maelle Plawecki, Nathalie Gayrard, Laura Jeanson, Anthony Chauvin, Anne-Dominique Lajoix, Jean-Paul Cristol, Bernard Jover, Fabrice Raynaud
Summary: Cardiac alteration due to chronic kidney disease is accompanied by tissue fibrosis, which involves myofibroblasts and endothelial to mesenchymal transitions. Additionally, obesity and insulin resistance exacerbate cardiovascular risk in chronic kidney disease (CKD). This study aimed to investigate how pre-existing metabolic disease and endothelial to mesenchymal transition contribute to cardiac fibrosis in CKD. Rats fed a cafeteria diet were found to be obese, hypertensive, and insulin resistant. CKD rats exhibited high levels of cardiac fibrosis, with collagen-1 and nestin expressions increased regardless of diet. Interestingly, rats with CKD and a cafeteria diet showed an increase in CD31 and alpha-SMA co-staining, suggesting the involvement of endothelial to mesenchymal transition in cardiac fibrosis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Transplantation
Stanislas Bataille, Nathalie McKay, Laetitia Koppe, Alice Beau, Berengere Benoit, Marc Bartoli, Nathalie Da Silva, Stephane Poitevin, Julien Aniort, Rania Chermiti, Stephane Burtey, Laetitia Dou
Summary: Indoxyl sulfate (IS), an indolic uremic toxin, inhibits the expression of Myf6/MRF4 and MYH2 during muscle cell differentiation, leading to a defect in myotube structure. This provides new insights into the role of IS in muscle atrophy observed in CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cell Biology
Jonas Laget, Sam Hobson, Karen Muyor, Flore Duranton, Irene Cortijo, Piotr Bartochowski, Bernard Jover, Anne-Dominique Lajoix, Magnus Soderberg, Thomas Ebert, Peter Stenvinkel, Angel Argiles, Karolina Kublickiene, Nathalie Gayrard
Summary: Increased senescent cell burden and dysregulation of the NRF2 pathway play a role in vascular calcification. In vivo and in vitro studies showed increased senescence markers in calcified tissues and VSMCs exposed to uremic serum. NRF2 expression correlated with calcification in vivo but was depleted in vitro. These findings highlight the therapeutic potential of targeting senescence and the NRF2 pathway in the treatment of VC in CKD.
Article
Nutrition & Dietetics
Jonas Laget, Irene Cortijo, Juliana H. H. Boukhaled, Karen Muyor, Flore Duranton, Bernard Jover, Fabrice Raynaud, Anne-Dominique Lajoix, Angel Argiles, Nathalie Gayrard
Summary: Obesity exacerbates renal inflammation and fibrosis in chronic kidney disease (CKD). Certain substances such as interleukin 11, dipeptidyl peptidase 4, and serpin 1 may directly affect the process of fibrosis.
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Bhargava, J. Jankowski, S. Orth-Alampour, N. Gayrard, A. Argiles
