Article
Medicine, General & Internal
Anas Alkhani, Cathrine Korsholm, Claire S. S. Levy, Sarah Mohamedaly, Caroline C. C. Duwaerts, Eric M. M. Pietras, Amar Nijagal
Summary: Biliary atresia (BA) is a progressive pediatric liver disease that leads to cirrhosis and requires liver transplantation. Hematopoietic stem and progenitor cells (HSPCs) play a crucial role in the inflammation process of the liver. In this study, it was found that HSPCs expand as a result of RRV infection and contribute to perinatal liver injury (PLI). Elimination of HSPCs rescued animals from PLI, suggesting that targeting HSPCs could be a potential strategy for preventing and treating neonatal liver inflammatory diseases such as BA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Defu Kong, Apostolos Mourtzinos, Janette Heegsma, Hans Blokzijl, Vincent E. de Meijer, Klaas Nico Faber
Summary: This study reveals the role of GDF7 in liver fibrosis and suggests its potential pro-regenerative function in liver fibrosis caused by chronic liver disease.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Nutrition & Dietetics
Qinjin Li, Yuqing Gong, Yi Wang, Bingbing Liu, Yi Chu, Sisi Gui, Yazhen Zheng, Xiaodong Chen
Summary: In a high-fat diet-induced NAFLD mouse model, fatty liver injury led to significant ductular reaction, activated hepatic progenitor cells, and the Wnt/beta-catenin signal pathway. Sirt1 plays a crucial role in activating HPCs to repair fatty liver injury in NAFLD through the Wnt/beta-catenin signal pathway.
FRONTIERS IN NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Asmita Choudhury, Anuradha Ratna, Arlene Lim, Rebecca M. Sebastian, Christopher L. Moore, Aveline A. Filliol, Jacob Bledsoe, Chengkai Dai, Robert F. Schwabe, Matthew D. Shoulders, Pranoti Mandrekar
Summary: This study reveals an important role of HSF1 in liver fibrosis, where deficiency of HSF1 leads to enhanced activation of HSCs and promotes liver fibrosis. Conversely, activation of HSF1 can inhibit fibrogenic activation of HSCs.
HEPATOLOGY COMMUNICATIONS
(2022)
Review
Gastroenterology & Hepatology
Laura J. Kitto, Neil C. Henderson
Summary: Mesenchymal cells play a key role during liver regeneration, with recent single-cell genomics approaches revealing spatial and functional zonation of the hepatic mesenchyme in homeostasis and following liver injury. The use of preclinical models helps to precisely identify highly targeted, pro-regenerative therapies for patients with liver disease.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Miho Tamai, Eijiro Adachi, Masaya Kawase, Yoh-ichi Tagawa
Summary: Liver organoid tissue was successfully generated from portal branch-ligated hepatic lobe using extracellular matrix implantation method. This tissue resembles liver lobules, and the embedded fibroblasts contribute to the reconstruction of hepatic interstitial structure.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell & Tissue Engineering
Mihiri Goonetilleke, Nathan Kuk, Jeanne Correia, Alex Hodge, Gregory Moore, Michael P. Gantier, George Yeoh, William Sievert, Rebecca Lim
Summary: The study found that hAEC administration attenuated the expansion of liver progenitor cells, hepatic inflammation, and oxidative stress in an experimental model of NASH.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoming Li, Xiaohuan Liu, Yupeng Zhang, Cheng Cheng, Jingna Fan, Jinting Zhou, Malgorzata A. Garstka, Zongfang Li
Summary: ApoA4 plays a protective role in CCl4-induced acute liver injury in mice by controlling antioxidant enzyme levels, reducing recruitment of monocytes/macrophages, and lowering plasma levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Food Science & Technology
Qingqing Hu, Jianghao Ye, Meng-Lu Zhu, Yuancheng Jin, Xiaohui Yang, Miaolian Wu
Summary: The study found that a high-fructose diet may lead to the occurrence of NAFLD-related liver cancer by increasing tumorigenic HPCs and promoting an inflammatory microenvironment.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Gastroenterology & Hepatology
Ki-Hyun Kim, Naiyuan Cheng, Lester F. Lau
Summary: CCN1 promotes liver macrophage clearance of apoptotic neutrophils, leading to the production of activated TGF-beta 1, which induces HSC transdifferentiation into myofibroblast-like cells and contributes to liver fibrosis.
HEPATOLOGY COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Yanze Yin, Defu Kong, Kang He, Qiang Xia
Summary: Cirrhosis is a chronic liver disease characterized by regenerative nodules surrounded by fibrous bands, leading to portal hypertension and end stage liver disease. Liver progenitor cells (LPCs) can be activated and differentiate into hepatocytes to promote liver regeneration and reach homeostasis following liver injury. Recent research has discovered new sources of LPCs, providing insights into the mechanisms of liver regeneration in cirrhosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Zhang, Chengwu Huang, Tinghui Yin, Xiaoyan Miao, Huan Deng, Rongqin Zheng, Jie Ren, Shigao Chen
Summary: This study aimed to evaluate the feasibility of ultrasensitive US microvessel imaging in visualizing and quantifying hepatic microvessels in healthy and cirrhotic rats. The findings showed that ultrasensitive US microvessel imaging could detect minute vessels below the liver capsule and quantify the perfusion, tortuosity, and integrity of microvessels. Cirrhotic rats had lower vessel density and fractional moving blood volume, and higher tortuosity compared to control rats, which were strongly correlated with pathologically derived vessel density and hepatic tissue hypoxia.
Article
Cell & Tissue Engineering
Beibei Zhang, Xiaoying Wu, Jing Li, An Ning, Bo Zhang, Jiahua Liu, Langui Song, Chao Yan, Xi Sun, Kuiyang Zheng, Zhongdao Wu
Summary: Our study revealed that during hepatic schistosomiasis, the proliferation of HPCs is associated with inflammatory granulomas and fibrosis formation. The expansion of HPCs promotes liver regeneration and inhibits inflammatory egg granulomas, as well as the deposition of fibrotic collagen. The expression of IL-33 is negatively correlated with the expansion of HPCs in hepatic schistosomiasis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Critical Care Medicine
Marisa E. Luck, Xiaoling Li, Caroline J. Herrnreiter, Mashkoor A. Choudhry
Summary: Ethanol intoxication and burn injury can lead to dysfunction of immune cells in the gastrointestinal system, promoting infections and complications. This study found that both ethanol and burn injury increase the population of regulatory T cells in the small intestine, which have a stronger suppression of effector T cell proliferation.
Review
Gastroenterology & Hepatology
Linda Hammerich, Frank Tacke
Summary: This Review provides an extensive overview of the mechanisms of inflammation and fibrosis in the liver, particularly in NAFLD or NASH, and discusses the current advances and therapeutic implications. Chronic liver diseases characterized by persistent inflammation and subsequent liver fibrosis have significant impact on long-term morbidity and mortality. Inflammatory responses involve hepatic cell types and signals related to intrahepatic injury pathways, gut-liver axis, and circulation.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)