Article
Hematology
Sebastian Schellong, Walter Ageno, Ivan B. Casella, Kok Han Chee, Sam Schulman, Daniel E. Singer, Marc Desch, Wenbo Tang, Isabelle Voccia, Kristina Zint, Samuel Z. Goldhaber
Summary: Isolated distal deep vein thrombosis (IDDVT) is considered to be less severe than proximal DVT or pulmonary embolism, with younger patients and fewer risk factors. Although differences in patient characteristics and clinical management were identified, anticoagulant treatment of IDDVT was found to be similar to that of proximal DVT or PE.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Review
Critical Care Medicine
Jessica C. Cardenas
Summary: Thrombin plays a central role in coagulation, essential for normal hemostasis. The generation of thrombin in severely injured patients is closely related to the risks of bleeding and thrombotic complications, and understanding the determinants of its production is clinically important.
Article
Hematology
Thomas Sinegre, Cedric Duron, Thomas Lecompte, Geraldine Lamblin, Laurie Talon, Leon Muti, Sylvie Massoulier, Bruno Pereira, Aurelien Lebreton, Armand Abergel
Summary: The aim of this study was to compare the intraindividual variability of thrombin generation over time between patients with cirrhosis and healthy controls. The results showed that patients with cirrhosis had higher endogenous thrombin potential when using the thrombin generation assay, and this increased with the severity of cirrhosis. The thrombin generation parameters were highly stable over time in healthy controls, moderately stable in Child-Turcotte-Pugh (CTP)-A patients, and poorly stable in CTP-B/C patients (severe cirrhosis), with one-third of patients transitioning to normal or hypercoagulable states during the 3-month follow-up.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Alvaro Dubois-Silva, Cristina Barbagelata-Lopez, Patricia Pineiro-Parga, Iria Francisco, Conxita Falga, Raimundo Tirado, Jose Maria Surinach, Jeronimo Ramon Vela, Carmen Mella, Isabelle Quere, Carmine Siniscalchi, Manuel Monreal
Summary: Compared to patients with isolated DVT, those with concomitant SVT in lower-limb deep vein thrombosis have a higher risk of subsequent pulmonary embolism, but no significant differences in rates of recurrent DVT, major bleeding, or death.
THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Hematology
Nikolaus B. Binder, Francois Depasse, Julia Mueller, Thomas Wissel, Stephan Schwers, Matthias Germer, Bjorn Hermes, Peter L. Turecek
Summary: TGA is a global assay that allows for the dynamic and continuous recording of both thrombin generation and inactivation effects. It is widely used in clinical medicine for the diagnosis, prognosis, prophylaxis, and treatment of inherited and acquired bleeding and thrombotic disorders.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Claudia Khayat, Rita Marchi, Stephane Durual, Thomas Lecompte, Marguerite Neerman-Arbez, Alessandro Casini
Summary: This study investigated the impact of fibrinogen concentrate (FC) infusion on thrombin generation parameters and fibrin clot structure in patients with inherited afibrinogenemia. The results showed that FC infusion increased thrombin potential and peaks, but lag times and thrombin peaks were still lower than healthy controls. Fibrin clot structure formed after FC infusion was similar to patients with hypofibrinogenemia. These findings suggest that FC may not induce hypercoagulability in patients with afibrinogenemia.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Cardiac & Cardiovascular Systems
Lars L. F. G. Valke, Sanna Rijpma, Danielle Meijer, Saskia E. M. Schols, Waander L. van Heerde
Summary: The treatment of bleeding and thrombotic disorders can be personalized through the use of global assays such as thrombin generation assays (TGAs). These assays can help identify patients with more severe bleeding phenotypes and guide non-replacement therapy and bypassing therapy. They also have a potential role in monitoring antithrombotic therapy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Hematology
Jun Wan, Joke Konings, Bas de Laat, Tilman M. Hackeng, Mark Roest
Summary: The study discusses plasma thrombin generation (TG) as a tool to assess blood coagulability, highlighting the importance of also considering the role of blood cells in coagulation. Platelets play a significant role in accelerating thrombin generation through various mechanisms, while erythrocytes and other blood cells also contribute to the coagulation process. Further research is needed to validate blood cell-dependent TG assays for clinical use.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Jun Wan, Nadira Vadaq, Joke Konings, Martin Jaeger, Vinod Kumar, Bas de Laat, Leo Joosten, Mihai G. Netea, Andre J. van der Ven, Philip G. de Groot, Quirijn de Mast, Mark Roest
Summary: The KLKB1 gene was found to be associated with the protein C pathway function and thrombin generation. Kallikrein may play a role in regulating the anticoagulant protein C pathway during thrombin generation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Gastroenterology & Hepatology
Marta Magaz, Alberto Alvarez-Larran, Dolors Colomer, Monica Lopez-Guerra, M. Angeles Garcia-Criado, Gabriel Mezzano, Ernest Belmonte, Pol Olivas, Guillem Soy, Francisco Cervantes, Anna Darnell, Jose Ferrusquia-Acosta, Anna Baiges, Fanny Turon, Virginia Hernandez-Gea, Juan Carlos Garcia-Pagan
Summary: The study showed that NGS can identify JAK2-exon 12 mutations in NC-SVT patients that were not previously detected by conventional techniques, and it also detected High Molecular Risk (HMR) variants in approximately one-third of patients with NC-SVT, who seem to have a higher risk of splanchnic rethrombosis. These findings support the potential usefulness of NGS as a diagnostic tool in the management of NC-SVT.
JOURNAL OF HEPATOLOGY
(2021)
Article
Endocrinology & Metabolism
Rita Indirli, Emanuele Ferrante, Erica Scalambrino, Eriselda Profka, Marigrazia Clerici, Tommaso Lettera, Andreea Liliana Serban, Walter Vena, Alessandro Pizzocaro, Marco Bonomi, Biagio Cangiano, Giulia Carosi, Gherardo Mazziotti, Luca Persani, Andrea Lania, Maura Arosio, Flora Peyvandi, Giovanna Mantovani, Armando Tripodi
Summary: Klinefelter syndrome patients exhibit a procoagulant imbalance with increased thrombin generation in both platelet-poor plasma and platelet-rich plasma, potentially due to elevated FVIII levels. Higher levels of FVIII, fibrinogen, and FVIII/protein C ratio were observed in KS patients compared to controls.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Health Care Sciences & Services
Jang-Hyuk Cho, Dong-Gyu Lee
Summary: Based on a retrospective analysis of patients with spinal cord injury from 2016 to 2020, Asian patients with spinal cord injury have a low incidence of below-knee deep vein thrombosis and a favorable natural history of the condition, recommending serial imaging over anticoagulant therapy for these patients.
Article
Hematology
Jiayin Tian, Murray J. Adams, Jasmine Wee Ting Tay, Ian James, Suzanne Powell, Quintin W. Hughes, Grace Gilmore, Ross I. Baker, Jim Yu-Hsiang Tiao
Summary: The study found that plasma samples from pregnant women and women taking contraceptive pills displayed hypercoagulability compared to controls. Under high physiological levels of E (2), miR-365a-3p was downregulated and tissue factor protein was upregulated. This suggests that miR-365a-3p regulates tissue factor and high E (2) levels induce a hypercoagulable state through a specific miR network targeting coagulation factors.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Biotechnology & Applied Microbiology
Hongtao Dai, Senlin Chai, Yao Yao, Wenlai Tang, Jianping Shi, Qing Jiang, Liya Zhu
Summary: In this study, researchers investigated the mechanism of action of intermittent pneumatic compression (IPC) devices on deep vein thrombosis (DVT) using microfluidic chip methodology. The results showed that increasing compression pressure and reducing time intervals can accelerate blood flow rate and shear stress within the vein, reducing thrombosis formation. This study is important for further standardization and optimization of IPC devices in clinical usage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Immunology
Mengting Yao, Jiacheng Ma, Dongwen Wu, Chucun Fang, Zilong Wang, Tianting Guo, Jianwen Mo
Summary: Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that presents as swelling and pain in the lower limbs. The most serious complication of DVT is pulmonary embolism (PE) with high mortality. Understanding the underlying mechanisms of DVT is crucial for early diagnosis and treatment as patients usually show clinical symptoms after thrombus formation.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Dermatology
A. Connolly, S. Walsh, R. Arya
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Hematology
Banne Nemeth, Rob Nelissen, Roopen Arya, Suzanne Cannegieter
Summary: VTE is a common complication following THA and TKA, despite available guidelines for prophylaxis, approximately 1.5% of patients still develop symptomatic VTE. This paper discusses an individualized approach to optimize the balance between VTE and bleeding risks by stratifying patients according to their risk levels.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Editorial Material
Hematology
V. Speed, J. P. Patel, L. N. Roberts, R. K. Patel, R. Arya
THROMBOSIS RESEARCH
(2021)
Letter
Hematology
Nissalini Rajaratnam, Jignesh P. Patel, Lara N. Roberts, Julia Czuprynska, Raj K. Patel, Roopen Arya
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Editorial Material
Hematology
Rachna Patel, Julia Czuprynska, Lara N. Roberts, Bipin Vadher, Catherine Rea, Raj Patel, Emma Gee, Gabrielle Saul, Evelyn Coles, Alison Brown, Rosalind Byrne, Vicky Speed, Jignesh P. Patel, Roopen Arya
THROMBOSIS RESEARCH
(2021)
Letter
Hematology
Victoria Speed, Lara N. Roberts, Roopen Arya, Jignesh P. Patel
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Immunology
Puja R. Mehta, Sean Apap Mangion, Matthew Benger, Biba R. Stanton, Julia Czuprynska, Roopen Arya, Laszlo K. Sztriha
Summary: Recent reports have highlighted rare cases of CVST and thrombocytopenia following Vaxzevria vaccination. An immunological mechanism similar to HIT, but without prior heparin exposure, is suspected. Management of such cases involves PF4 antibody testing and treatment similar to HIT.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Hematology
Lara N. Roberts, Annakan Navaratnam, Roopen Arya, Tim W. R. Briggs, William K. Gray
Summary: The aim of this study was to examine the incidence of venous thromboembolism (VTE) in patients hospitalized with COVID-19 in England. The study found that VTE was a common complication in hospitalized patients and was associated with longer hospital stays and higher mortality rates.
THROMBOSIS RESEARCH
(2022)
Article
Hematology
Lara N. N. Roberts, Beverley J. J. Hunt, Tim W. W. Briggs, Roopen Arya
Summary: A national VTE prevention program was introduced in England, and the first national thrombosis survey was conducted. The survey revealed that 88% of patients received anticoagulant thromboprophylaxis when indicated, with a patient information provision rate of 31%. However, 13% of hospital-associated VTE cases were considered potentially preventable.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Jignesh P. Patel, Obianuju Nzelu, Lara N. Roberts, Jemma Johns, Jackie Ross, Roopen Arya
Summary: This study reports on the occurrence of heavy menstrual bleeding in menstruating women after starting anticoagulant therapy, and its impact on their quality of life. The results showed that women in the anticoagulated group experienced an increase in the length of their menstrual cycle and significantly higher levels of bleeding, leading to a negative impact on their quality of life. Clinicians should be aware of this issue and take measures to minimize the impact of heavy menstrual bleeding on patients.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Umber Sheikh, Amally Ding, Obianuju Nzelu, Lara N. Roberts, Jemma Johns, Jackie Ross, Roopen Arya, Jignesh P. Patel
Summary: This study aimed to understand the lived experience of menstruating women commencing anticoagulants. Through semi-structured interviews, it was found that women experienced heavy menstrual bleeding during the medication period, which had a negative impact on their social life and mood. Therefore, measures should be taken to support and minimize the negative effects of menstrual bleeding on women's lives.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cell Biology
Wasanthi Wickramasinghe, Bhawani Yasassri Alvitigala, Thisarika Perera, Panduka Karunanayake, Saroj Jayasinghe, Senaka Rajapakse, Praveen Weeratunga, Ananda Wijewickrama, Roopen Arya, Klaus Goerlinger, Lallindra Viranjan Gooneratne
Summary: This study evaluated the use of hirudin anticoagulated blood compared to citrate in rotational thromboelastometry (ROTEM) in thrombocytopenic patients. The results showed higher platelet aggregation with hirudin compared to citrate, particularly in patients with severe thrombocytopenia. Therefore, the use of hirudin anticoagulation is important for platelet function tests, especially in patients with severe thrombocytopenia.
Article
Hematology
Stephanie Muller, Luise Tittl, Victoria Speed, Lara Roberts, Jignesh Patel, Raj Patel, Roopen Arya, Nils Kucher, David Spirk, Kurtulus Sahin, Jan Beyer-Westendorf
Summary: This study confirms that rivaroxaban is effective and safe in routine clinical care of patients with VTE, based on data from multiple registries.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Obstetrics & Gynecology
Monica Mittal, Paradzai Chitongo, Prasanna Raj Supramaniam, Linda Cardozo, Mike Savvas, Nick Panay, Roopen Arya, Haitham Hamoda
Summary: This study compares the impact of micronized progesterone (MP) or medroxyprogesterone acetate (MPA) in combination with transdermal estradiol (t-E-2) on traditional coagulation factors and thrombin generation parameters in postmenopausal women with premature ovarian insufficiency or early menopause. The results suggest that the thrombin generation parameters remain neutral after 3 months of hormone therapy, while the traditional coagulation factors show significant changes.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Hematology
Wasanthi Wickramasinghe, Bhawani Yasassri Alvitigala, Thisarika Perera, Panduka Karunanayake, Saroj Jayasinghe, Senaka Rajapakse, Praveen Weeratunga, Ananda Wijewickrama, Roopen Arya, Klaus Goerlinger, Lallindra Viranjan Gooneratne
Summary: This study examines the association between coagulation test parameters and bleeding risk in patients with dengue in the critical phase. The results suggest that TRAPTEM in ROTEM platelet is associated with bleeding manifestations, indicating a potential role for defective platelet aggregation in the pathogenesis of bleeding in the critical phase of dengue.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)