期刊
BLOOD COAGULATION & FIBRINOLYSIS
卷 23, 期 4, 页码 324-330出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MBC.0b013e328352cb21
关键词
acute coronary syndrome; major cardiac events; mean platelet volume
类别
We investigated the association of mean platelet volume (MPV) with culprit lesion severity and major cardiac outcomes (MCOs) in patients with acute coronary syndrome (ACS) with non-ST elevation (NSTE). This study included 344 patients with NSTE-ACS who had significant coronary stenosis at least 50%. They were divided into high MPV group (n=109, upper tertile >9.9 fl) and low MPV group (n=235, lower and mid tertile <= 9.9 fl) according to MPV values on admission. They were followed up for MCOs during 12 months. MCO consisted of the composite end-point of cardiac death, myocardial infarction (MI), recurrent angina or hospitalization. High MPV was independently associated with NSTE-MI [odds ratio (OR) 4.24, 95% confidence interval (CI) 2.52-7.15, P=0.001] and severe culprit stenosis (>= 80%) (OR 4.05, 95% CI 2.39-6.83, P=0.001). MPV of 9.9 fl was predictive of severe culprit stenosis with a sensitivity of 73% and specificity of 77% (P<0.001). At 12 months, MCO rate was higher in high MPV group than low MPV group (39 vs. 26%; P=0.016). This difference resulted from death (6.4 vs. 2.1; P=0.06) and recurrent angina (16.5 vs. 8.9%; P=0.045). The MCO-free survival was worse in patients with high MPV than those with low MPV (61 vs. 74%; P=0.01). In Cox regression analysis, high MPV remained an independent predictor of MCO (hazard ratio 1.52, 95% CI 1.01-2.29, P=0.04) after adjusting for baseline characteristics. Elevated MPV was independently associated with NSTE-MI presentation and severity of culprit stenosis in NSTE-ACS patients. Moreover, MPV greater than 9.9 fl was predictive of a 12-month MCO. Blood Coagul Fibrinolysis 23: 324-330 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据