期刊
BLOOD COAGULATION & FIBRINOLYSIS
卷 20, 期 2, 页码 122-128出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MBC.0b013e328323da99
关键词
ABO blood groups; ABO genotypes; venous thromboembolism; young patients
类别
资金
- FAPEMIG
- CNPq
- CAPES
The All and B alleles of the ABO blood system have been associated with high levels of both factor VIII and von Willebrand factor and with a predisposition to venous thromboembolism (VTE). In this study, genotypes of the ABO system were determined by PCR-restriction fragment length polymorphism for 148 young VTE Brazilian patients and 233 unrelated control individuals. The blood group O was more frequent among the controls [odds ratio (OR), 0.21; 95% confidence interval (Cl), 0.13-0.34; P = 0.000) and groups A and B (OR, 2.24; 95%, Cl, 1.46-3.42; P = 0.000 and OR, 2.52; 95% Cl, 1.42-4.48; P = 0.002, respectively) among patients. The patients' group was under Hardy-Weinberg equilibrium, whereas the control group was not (P<0.0051), suggesting that natural selection might be acting in favor of carriers of the 0 blood group. When the allelic frequencies were compared through multivariate logistic regression analysis for adjustments of covariates, the alleles All (OR, 1.69; 95% Cl, 1.17-2.45; P = 0.006), A2 (OR, 2.19; 95% Cl, 1.24-3.87; P = 0.010), and B (OR, 2.65; 95% Cl, 1.64-4.26; P = 0.000) were independently associated with VTE and may represent important risk factors to the development of VTE among young Brazilian patients. Thus, the inclusion of ABO blood group determination may be helpful to discriminate individuals with high risk for VTE allowing target intervention as well as to manage VTE in young patients. Blood Coagul Fibrinolysis 20:122-128 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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