Article
Genetics & Heredity
Tomotaka Tanaka, Masafumi Ihara, Kazuki Fukuma, Haruko Yamamoto, Kazuo Washida, Shunsuke Kimura, Akiko Kada, Shigeki Miyata, Toshiyuki Miyata, Kazuyuki Nagatsuka
Summary: This study evaluated factors affecting warfarin maintenance doses and developed pharmacogenetics-guided algorithms, including renal impairment among other factors. The results showed that estimated glomerular filtration rate (eGFR) had a significant impact on warfarin maintenance doses, independent of VKORC1 and CYP2C9 genotypes in Japanese patients.
Article
Medical Laboratory Technology
Milena Velizarova, Philip Abedinov, Dobrin Svinarov, Valentin Nikolov, Julieta Hristova
Summary: The study aimed to evaluate the frequency of CYP2C9 and VKORC1 gene mutations in the Bulgarian population. The results showed that these mutations were in Hardy-Weinberg equilibrium. The study suggested that identifying VKORC1-1639 G>A (rs9923231) homozygous carriers could be useful in developing personalized therapy recommendations, while homozygous carriers of CYP2C9*2 or *3 would benefit less from dosing algorithms.
CLINICAL LABORATORY
(2022)
Article
Pharmacology & Pharmacy
Teodoro J. Oscanoa, Maria L. Guevara-Fujita, Ricardo M. Fujita, Maria Y. Munoz-Paredes, Oscar Acosta, Roman Romero-Ortuno
Summary: This study aimed to investigate the association between VKORC1 and CYP2C9 gene polymorphisms and the maintenance dose of warfarin in Peruvian patients. The results showed that the AA genotype of the VKORC1 gene was associated with a lower maintenance dose of warfarin, while no significant association was found between the CYP2C9 gene polymorphism and the dose of warfarin.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qing Huang, Ling Cao, Nan Luo, Hanyu Qian, Meng Wei, Ling Xue, Qiang Zhou, Bingjie Zou, Li Tan, Yanan Chu, Xueping Ma, Changtian Wang, Haiwei Wu, Lei Zhang, Lei Sun, Demin Li, Xialei Fan, Liyan Miao, Guohua Zhou
Summary: By combining pharmacometabolomic and pharmacogenetic data, this study successfully predicted individual responses to warfarin and designed an algorithm, IniWarD, for predicting an effective dose range in the initial 7-day therapy to avoid the risk of bleeding or thrombus.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Rattanaporn Sukprasong, Sumonrat Chuwongwattana, Napatrupron Koomdee, Thawinee Jantararoungtong, Santirhat Prommas, Pimonpan Jinda, Jiratha Rachanakul, Nutthan Nuntharadthanaphong, Nutcha Jongjitsook, Apichaya Puangpetch, Chonlaphat Sukasem
Summary: This study examined the allele frequencies of cytochrome P450 polymorphisms in a Thai population and found significant differences in allele frequencies among different regions within Thailand. The results may contribute to understanding ethnic differences in drug responses and support the use of pharmacogenomics testing in clinical practice.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Annesti F. Elmasri, Heejin Hur, Jin Han, James C. Lee
Summary: Genotype-guided warfarin dosing did not improve eventual stable dose discordance or reduce the time to achieve stable dose in this predominantly non-European cohort. Dietary vitamin K intake level did not impact warfarin dose discordance or time to achieve stable warfarin dose. Additional study is needed to identify populations that best benefit from PGx-guided warfarin dosing.
EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT
(2021)
Article
Multidisciplinary Sciences
Adriana Zingone, Sanju Sinha, Michael Ante, Cu Nguyen, Dalia Daujotyte, Elise D. Bowman, Neelam Sinha, Khadijah A. Mitchell, Qingrong Chen, Chunhua Yan, Phillipe Loher, Daoud Meerzaman, Eytan Ruppin, Brid M. Ryan
Summary: The study comprehensively investigated alternative polyadenylation (APA) in lung cancer and found a global shortening of 3' UTR transcripts, with notable functional implications. They discovered that APA of non-coding RNA transcripts is a recurrent event in lung cancer, with European American mRNA transcripts being more likely to undergo APA compared to African American samples.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Pharmacology & Pharmacy
Mwada Jallul, Inas Alhudiri, Laith Al-Eitan, Adam Elzagheid
Summary: It is widely accepted that pharmacogenomics information from Asia and Europe should not be applied to Africa. More research is needed to create population-specific algorithms for different ethnic groups to ensure safe and effective use.
Article
Medicine, Research & Experimental
Nihal El Rouby, Mohamed H. Shahin, Loulia Bader, Sherief I. Khalifa, Hazem Elewa
Summary: This study is the first genomewide association study in the MENA region to identify genetic variants associated with warfarin dose variability. The results confirm the importance of VKORC1 and CYP2C9 variants in warfarin dose variability among patients from the MENA region.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, General & Internal
Ljiljana Rakicevic, Mirjana Kovac, Dragica Radojkovic, Milica Radojkovic
Summary: The aim of this study was to analyze the influence of VKORC1 and CYP2C9 genes on coumarin therapy in patients from Serbia. The study confirmed the significant influence of these genetic factors on acenocoumarol maintenance dose. A mathematical model was designed for predicting individual acenocoumarol dose, which showed better prediction compared to other models. It was also found that certain variants in VKORC1 can cause coumarin resistance.
SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO
(2022)
Article
Multidisciplinary Sciences
Amr Elkholy, Nagavardhini Avuthu, Mohammed Abdalla, Michael Behring, Prachi Bajpai, Hyung-Gyoon Kim, Doaa Header, Reham AH. Abo Elwafa, Hesham Saed, Amira Embaby, Nefertiti El-Nikhely, Sarah Obuya, Mostafa Mohamed, Ahmed Ashour Badawy, Ahmed Nawar, Farrukh Afaq, Laura Q. Rogers, Sejong Bae, James M. Shikany, Lori Brand Bateman, Mona Fouad, Mansoor Saleh, Temesgen Samuel, Sooryanarayana Varambally, Chittibabu Guda, Waleed Arafat, Upender Manne
Summary: Microbiome dysbiosis in colorectal cancer (CRC) patients varies among Egyptian, African American (AA), and European American (EA) populations. Analysis of samples from these populations revealed differences in microbiome composition and metabolic pathways. These findings provide a basis for future studies linking racial/ethnic microbiome differences with distinct clinical behaviors in CRC.
Review
Oncology
Claire Stevens, Alexandria Hightower, Sarah G. Buxbaum, Sara M. Falzarano, Suhn K. Rhie
Summary: Prostate cancer is the second most common cancer in men in the United States, and racial disparities are greatly observed in the disease. In order to narrow the gap between clinical outcomes for African American and European American prostate cancer patients, genetic and molecular signatures contributing to this disparity have been characterized.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Margaret S. Pichardo, Tsion Zewdu Minas, Catherine M. Pichardo, Maeve Bailey-Whyte, Wei Tang, Tiffany H. Dorsey, William Wooten, Brid M. Ryan, Christopher A. Loffredo, Stefan Ambs
Summary: This study found that African American men living in deprived neighborhoods have a higher risk of prostate cancer and related mortality, potentially due to their systemic immune function and inflammation levels.
Article
Oncology
Yaohua Yang, Jirong Long, Cong Wang, William J. Blot, Zhiheng Pei, Xiang Shu, Fen Wu, Nathaniel Rothman, Jie Wu, Qing Lan, Qiuyin Cai, Wei Zheng, Yu Chen, Xiao-Ou Shu
Summary: The study found an inverse relationship between overall microbial richness in the oral microbiome and gastric cancer risk. Specific microbial taxa, gene families, and metabolic pathways were associated with gastric cancer risk. The results suggest that the oral microbiota may play a role in the etiology of gastric cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biology
Walter Rayford, Alp Tuna Beksac, Jordan Alger, Mohammed Alshalalfa, Mohsen Ahmed, Irtaza Khan, Ugo G. Falagario, Yang Liu, Elai Davicioni, Daniel E. Spratt, Edward M. Schaeffer, Felix Y. Feng, Brandon Mahal, Paul L. Nguyen, Robert B. Den, Mark D. Greenberger, Randy Bradley, Justin M. Watson, Matthew Beamer, Lambros Stamatakis, Darrell J. Carmen, Shivanshu Awasthi, Jonathan Hwang, Rachel Weil, Harri Merisaari, Nihal Mohamed, Leslie A. Deane, Dimple Chakravarty, Kamlesh K. Yadav, Kosj Yamoah, Sujit S. Nair, Ashutosh K. Tewari
Summary: Racial disparities in prostate cancer were investigated in a multi-institutional retrospective analysis of African-American and European-American men who underwent radical prostatectomy. Differences were found in gene expression with African-American men showing higher expression of inflammation genes and lower expression of mismatch repair genes.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Brahim Aissani, Kui Zhang, Arjen R. Mensenkamp, Fred H. Menko, Howard W. Wiener
ENDOCRINE-RELATED CANCER
(2015)
Article
Immunology
Sadeep Shrestha, Marguerite R. Irvin, Kent D. Taylor, Howard W. Wiener, Nicholas M. Pajewski, Talin Haritunians, Joseph A. C. Delaney, Morris Schambelan, Joseph F. Polak, Donna K. Arnett, Yii-Der Ida Chen, Carl Grunfeld
Article
Psychiatry
Monica E. Calkins, Ping Tepper, Ruben C. Gur, J. Daniel Ragland, Lambertus Klei, Howard W. Wiener, Jan Richard, Robert M. Savage, Trina B. Allen, Judith O'Jile, Bernie Devlin, Joseph Kwentus, Muktar H. Aliyu, L. DiAnne Bradford, Neil Edwards, Paul D. Lyons, Vishwajit L. Nimgaonkar, Alberto B. Santos, Rodney C. P. Go, Raquel E. Gur
AMERICAN JOURNAL OF PSYCHIATRY
(2010)
Article
Genetics & Heredity
Derek C. Johnson, Sadeep Shrestha, Howard W. Wiener, Robert Makowsky, Ashish Kurundkar, Craig M. Wilson, Brahim Aissani
Article
Multidisciplinary Sciences
Sadeep Shrestha, Howard W. Wiener, Brahim Aissani, Wei Song, Aditi Shendre, Craig M. Wilson, Richard A. Kaslow, Jianming Tang
Article
Psychiatry
H. W. Wiener, L. Klei, M. D. Irvin, R. T. Perry, M. H. Aliyu, T. B. Allen, L. D. Bradford, M. E. Calkins, B. Devlin, N. Edwards, R. E. Gur, R. C. Gur, J. Kwentus, P. D. Lyons, J. P. McEvoy, H. A. Nasrallah, V. L. Nimgaonkar, J. O'Jile, A. B. Santos, R. M. Savage, R. C. P. Go
SCHIZOPHRENIA RESEARCH
(2009)
Article
Endocrinology & Metabolism
Anarina L. Murillo, Olivia Affuso, Courtney M. Peterson, Peng Li, Howard W. Wiener, Carmen D. Tekwe, David B. Allison
Article
Critical Care Medicine
Jason H. Karnes, Howard W. Wiener, Tae-Hwi Schwantes-An, Balaji Natarajan, Andrew J. Sweatt, Abhishek Chaturvedi, Amit Arora, Ken Batai, Vineet Nair, Heidi E. Steiner, Jason B. Giles, Jeffrey Yu, Maryam Hosseini, Michael W. Pauciulo, Katie A. Lutz, Anna W. Coleman, Jeremy Feldman, Rebecca Vanderpool, Haiyang Tang, Joe G. N. Garcia, Jason X-J Yuan, Rick Kittles, Vinicio de Jesus Perez, Roham T. Zamanian, Franz Rischard, Hemant K. Tiwari, William C. Nichols, Raymond L. Benza, Ankit A. Desai
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Infectious Diseases
Yuanfan Ye, Greer A. Burkholder, Howard Wiener, Stella Aslibekyan, Ashraf E. Khan, Sadeep Shrestha
Summary: This study estimated the incidence rates of symptomatic herpetic anogenital ulcer disease (HAUD) among people living with HIV in the southeastern US and found associations between CD4 counts, specifically median CD4 and CD4 trajectories, with HAUD. HAUD was more frequent in women, and there were significant associations with median CD4 counts (<200 cells/uL) and declining or sustained low CD4 trajectory patterns.
SEXUALLY TRANSMITTED INFECTIONS
(2022)
Article
Public, Environmental & Occupational Health
Adeniyi J. Idigo, Matthew L. Brown, Howard W. Wiener, Russell L. Griffin, Yuanfan Ye, Amrita Mukherjee, Allen W. Bryan, Rachael A. Lee, Sadeep Shrestha
Summary: There was an overall increase in the use of third- and fourth-generation cephalosporins after fluoroquinolone preauthorization was implemented, but there was no observed increase in non-susceptibility to these antibiotics.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Bert B. Boyer, Scarlett E. Hopkins, Howard W. Wiener, Jonathan Q. Purnell, Diane M. O'Brien, Cindy X. Zhang, Joseph E. Aslan, Theresa Aliwarga, Jeremy J. Pomeroy, Kenneth E. Thummel, Hemant K. Tiwari
Summary: This study found that habitual intake of marine mammals and fish rich in n-3 PUFAs is associated with reduced systemic inflammation in Yup'ik Alaska Native adults.
JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
James C. Barton, Howard W. Wiener, Ronald T. Acton
Summary: This study estimated the proportion of West African Black ancestry in African Americans using allele frequencies of iron-related genes, showing that the average proportion of West African Black ancestry in African Americans is 87.8%.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2022)
Article
Oncology
Amrita Mukherjee, Yuanfan Ye, Howard W. Wiener, Mark H. Kuniholm, Howard Minkoff, Kate Michel, Joel Palefsky, Gypsyamber D'Souza, Lisa Rahangdale, Kenneth R. Butler, Mirjam-Colette Kempf, Staci L. Sudenga, Bradley E. Aouizerat, Akinyemi I. Ojesina, Sadeep Shrestha
Summary: This study investigated the polymorphisms in receptor genes necessary for HPV cell entry and their associations with clinical progression to precancer. The findings suggest that the SNPs in candiGPC4, GPC5, GPC6, and ITGA6 are associated with the risk of high-grade squamous intraepithelial lesions, and this association may vary among different HPV genotypes.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Genetics & Heredity
Brahim Aissani, Kui Zhang, Howard Wiener
INTERNATIONAL JOURNAL OF MOLECULAR EPIDEMIOLOGY AND GENETICS
(2015)
Article
Hematology
Fanbi Meng, Shuang Chen, Chunliang Liu, Muhammad Shoaib Khan, Yan Yan, Jun Wan, Yue Xia, Chenglin Sun, Mengnan Yang, Renping Hu, Kesheng Dai
Summary: PKC plays a critical role in regulating megakaryocyte development and platelet production in thrombocytopenia. The inhibition of PKC activation delays and reduces radiation-induced megakaryocyte apoptosis, leading to improved platelet count recovery. This study provides a potential therapeutic target for treating thrombocytopenia.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Article
Hematology
Xia Chen, Fang Liu, Yuanyuan Ren, Luyang Zhang, Yang Wan, Wenyu Yang, Xiaojuan Chen, Li Zhang, Yao Zou, Yumei Chen, Xiaofan Zhu, Ye Guo
Summary: Unrelated umbilical cord blood transplantation (UCBT) is an effective alternative treatment for pediatric patients with bone marrow failure. The use of the TBI/BU + FLU + CY conditioning regimen ensures a high engraftment rate for UCBT and overcomes the challenge of graft failure. Secondary salvage use of cord blood transplantation may still be useful for patients who have failed after other transplantation.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Article
Hematology
Chithra D. Palani, Xingguo Zhu, Manickam Alagar, Otis C. Attucks, Betty S. Pace
Summary: This study evaluated the ability of a novel Bach1 inhibitor, HPP-D, to induce HbF in KU812 cells and primary sickle erythroid progenitors. The results showed that HPP-D increased HbF levels and decreased Bach1 protein levels in both cell types. Furthermore, it enhanced NRF2 binding to the gamma-globin promoter antioxidant response elements, leading to an open chromatin configuration and increased gamma-globin transcription.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Letter
Hematology
Marcos Borato Viana, Erica Louback Oliveira, Andre Rolim Belisario
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Article
Hematology
Ke Zhang, Longying Ye, Yanhui Jin, Yuan Chen, Shuting Jiang, Haixiao Xie, Lihong Yang, Mingshan Wang
Summary: This study investigated two pedigrees with FV deficiency and identified three mutations that may have deleterious effects on the function and structure of FV.
BLOOD CELLS MOLECULES AND DISEASES
(2024)