期刊
BLOOD CELLS MOLECULES AND DISEASES
卷 40, 期 2, 页码 156-159出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2007.07.016
关键词
noncoding RNA; homeodomain; MLL; alternative splicing
类别
资金
- NCI NIH HHS [P01 CA040046, P01 CA040046-16A10004] Funding Source: Medline
- NHLBI NIH HHS [R01 HL087188] Funding Source: Medline
Evolutionarily conserved HOX genes play an important role during development and hematopoiesis. HOX protein products are transcription factors whose precise mechanism of action is still poorly understood. Regulation of HOX gene expression has been the topic of various studies. While alternative splicing and alternative promoter usage have been known to increase the number of transcripts across the HOX clusters, more recently high-throughput analyses have identified a number of new coding and noncoding RNA molecules whose function is not known. Here we review the transcriptome of the most studied HOX locus, HOX49. Strict control of HOXA9 expression has been shown to play a critical role in hematopoiesis while aberrant expression has been shown to be important to the development of leukemia. However, it is still unclear how various transcripts from this locus are regulated and what specific role(s) each one of them plays. (c) 2007 Elsevier Inc. All rights reserved.
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