Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition
出版年份 2014 全文链接
标题
Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition
作者
关键词
-
出版物
BLOOD
Volume 124, Issue 23, Pages 3420-3430
出版商
American Society of Hematology
发表日期
2014-09-25
DOI
10.1182/blood-2014-04-531871
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- PTPRGinhibition by DNA methylation and cooperation withRASgene activation in childhood acute lymphoblastic leukemia
- (2014) Jianqiao Xiao et al. INTERNATIONAL JOURNAL OF CANCER
- Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants
- (2013) E. M. C. Driessen et al. HAEMATOLOGICA
- The genomic landscape of hypodiploid acute lymphoblastic leukemia
- (2013) Linda Holmfeldt et al. NATURE GENETICS
- Targeting oncogenic Ras signaling in hematologic malignancies
- (2012) A. F. Ward et al. BLOOD
- Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
- (2011) J. Zhang et al. BLOOD
- Casitas B lymphoma mutations in childhood acute lymphoblastic leukemia
- (2011) Lindsay Nicholson et al. GENES CHROMOSOMES & CANCER
- Mutations and Deletions of the TP53 Gene Predict Nonresponse to Treatment and Poor Outcome in First Relapse of Childhood Acute Lymphoblastic Leukemia
- (2011) Jana Hof et al. JOURNAL OF CLINICAL ONCOLOGY
- Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update
- (2011) Ching-Hon Pui et al. JOURNAL OF CLINICAL ONCOLOGY
- CREBBP mutations in relapsed acute lymphoblastic leukaemia
- (2011) Charles G. Mullighan et al. NATURE
- Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia
- (2010) Joseph L. Wiemels et al. BLOOD CELLS MOLECULES AND DISEASES
- Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfürt-Münster study group
- (2010) Christine J. Harrison et al. BRITISH JOURNAL OF HAEMATOLOGY
- Activation of Ras-dependent Elk-1 activity by MLL-AF4 family fusion oncoproteins
- (2010) Ming-Him James Ng et al. EXPERIMENTAL HEMATOLOGY
- A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens
- (2010) Jaafar Bennouna et al. INVESTIGATIONAL NEW DRUGS
- Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial
- (2010) Catriona Parker et al. LANCET
- Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations
- (2010) J Davidsson et al. LEUKEMIA
- PTPN11 mutations in childhood acute lymphoblastic leukemia occur as a secondary event associated with high hyperdiploidy
- (2009) C G Molteni et al. LEUKEMIA
- Standardized MRD quantification in European ALL trials: Proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18–20 September 2008
- (2009) M Brüggemann et al. LEUKEMIA
- Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis
- (2008) B. V. Balgobind et al. BLOOD
- Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia
- (2008) Christine J. Harrison BRITISH JOURNAL OF HAEMATOLOGY
- Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia
- (2008) M. Case et al. CANCER RESEARCH
- Converting cell lines representing hematological malignancies from glucocorticoid-resistant to glucocorticoid-sensitive: Signaling pathway interactions
- (2008) Anna S. Garza et al. LEUKEMIA RESEARCH
- Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia
- (2008) M. Braoudaki et al. MEDICAL ONCOLOGY
- Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia
- (2008) C. G. Mullighan et al. SCIENCE
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