Fc -receptor-mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments

Chemoimmunotherapy for relapsed/refractory and progressive 17p13-deleted chronic lymphocytic leukemia (CLL) combining pentostatin, alemtuzumab, and low-dose rituximab is effective and tolerable and limits loss of CD20 expression by circulating CLL cells

(2014) Clive S. Zent et al.   AMERICAN JOURNAL OF HEMATOLOGY

Binding of Rituximab, Trastuzumab, Cetuximab, or mAb T101 to Cancer Cells Promotes Trogocytosis Mediated by THP-1 Cells and Monocytes

(2014) P. V. Beum et al.   JOURNAL OF IMMUNOLOGY

Within Peripheral Blood Mononuclear Cells, Antibody-Dependent Cellular Cytotoxicity of Rituximab-Opsonized Daudi cells Is Promoted by NK Cells and Inhibited by Monocytes due to Shaving

(2014) P. V. Beum et al.   JOURNAL OF IMMUNOLOGY

Induced Resistance to Ofatumumab-Mediated Cell Clearance Mechanisms, Including Complement-Dependent Cytotoxicity, in Chronic Lymphocytic Leukemia

(2014) N. A. Baig et al.   JOURNAL OF IMMUNOLOGY

What Counts in the Immunological Synapse?

(2014) Michael L. Dustin   MOLECULAR CELL

Anti-CD22/CD20 Bispecific Antibody with Enhanced Trogocytosis for Treatment of Lupus

(2014) Edmund A. Rossi et al.   PLoS One

Gnawing at Metchnikoff's paradigm

(2013) R. P. Taylor   BLOOD

Trogocytosis of multiple B-cell surface markers by CD22 targeting with epratuzumab

(2013) E. A. Rossi et al.   BLOOD

Incidence of sinusoidal obstruction syndrome following Mylotarg (gemtuzumab ozogamicin): a prospective observational study of 482 patients in routine clinical practice

(2013) Martin S. Tallman et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Daclizumab reduces CD25 levels on T cells through monocyte-mediated trogocytosis

(2013) Y Zhang et al.   Multiple Sclerosis Journal

Glycan Elongation Beyond the Mucin Associated Tn Antigen Protects Tumor Cells from Immune-Mediated Killing

(2013) Caroline B. Madsen et al.   PLoS One

Mechanism of action of therapeutic monoclonal antibodies: Promises and pitfalls of in vitro and in vivo assays

(2012) Josée Golay et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Rituximab mediates loss of CD19 on B cells in the absence of cell death

(2012) Jonathan D. Jones et al.   ARTHRITIS AND RHEUMATISM

Both activating and inhibitory Fc gamma receptors mediate rituximab-induced trogocytosis of CD20 in mice

(2012) Peter Boross et al.   IMMUNOLOGY LETTERS

Fc RIIb on Liver Sinusoidal Endothelium Clears Small Immune Complexes

(2012) L. P. Ganesan et al.   JOURNAL OF IMMUNOLOGY

Exhaustion of Cytotoxic Effector Systems May Limit Monoclonal Antibody-Based Immunotherapy in Cancer Patients

(2012) F. J. Beurskens et al.   JOURNAL OF IMMUNOLOGY

Mechanism of Fcγ Receptor-Mediated Trogocytosis-Based False-Positive Results in Flow Cytometry

(2012) Sakiko Masuda et al.   PLoS One

Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy

(2011) S. H. Lim et al.   BLOOD

Monocytes mediate shaving of B-cell-bound anti-CD20 antibodies

(2011) Anders E. Pedersen et al.   IMMUNOLOGY

Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells

(2011) P. V. Beum et al.   JOURNAL OF IMMUNOLOGY

Dynamics of Macrophage Trogocytosis of Rituximab-Coated B Cells

(2011) Theodore Pham et al.   PLoS One

A mechanistic rationale for combining alemtuzumab and rituximab in the treatment of ALL

(2010) B. A. Nijmeijer et al.   BLOOD

Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection

(2010) S. A. Beers et al.   BLOOD

Plasma-dependent, antibody- and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes

(2010) Sari Iwasaki et al.   CYTOMETRY PART A

The Direction of Plasma Membrane Exchange between Lymphocytes and Accessory Cells by Trogocytosis Is Influenced by the Nature of the Accessory Cell

(2010) Sandrine Daubeuf et al.   JOURNAL OF IMMUNOLOGY

Antigenic Modulation and Rituximab Resistance

(2010) Ronald P. Taylor et al.   SEMINARS IN HEMATOLOGY

Fractionated subcutaneous rituximab is well-tolerated and preserves CD20 expression on tumor cells in patients with chronic lymphocytic leukemia

(2009) G. Aue et al.   HAEMATOLOGICA

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

(2009) Aran F Labrijn et al.   NATURE BIOTECHNOLOGY

Capture of plasma membrane fragments from target cells by trogocytosis requires signaling in T cells but not in B cells

(2008) A. Aucher et al.   BLOOD

Chronic lymphocytic leukaemia CD20 expression is dependent on the genetic subtype: a study of quantitative flow cytometry and fluorescent in-situ hybridization in 510 patients

(2008) Constantine S. Tam et al.   BRITISH JOURNAL OF HAEMATOLOGY

Immunotherapeutic mechanisms of anti-CD20 monoclonal antibodies

(2008) Ronald P Taylor et al.   CURRENT OPINION IN IMMUNOLOGY