von Willebrand factor, Jedi knight of the bloodstream

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice

(2014) Y. Morioka et al.   BLOOD

Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor

(2014) Y.-F. Zhou et al.   BLOOD

Solution structure of the major factor VIII binding region on von Willebrand factor

(2014) N. Shiltagh et al.   BLOOD

Plasmin Cleavage of von Willebrand Factor as an Emergency Bypass for ADAMTS13 Deficiency in Thrombotic Microangiopathy

(2014) Claudia Tersteeg et al.   CIRCULATION

Structural Basis of Regulation of von Willebrand Factor Binding to Glycoprotein Ib

(2014) Mark A. Blenner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B-associated thrombocytopenia

(2013) C. Casari et al.   BLOOD

Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs

(2013) S. Momi et al.   BLOOD

Variability in platelet- and collagen-binding defects in type 2M von Willebrand disease

(2013) D. M. Larsen et al.   HAEMOPHILIA

The N-terminal Flanking Region of the A1 Domain Regulates the Force-dependent Binding of von Willebrand Factor to Platelet Glycoprotein Ibα

(2013) Lining Ju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms by which von Willebrand Disease Mutations Destabilize the A2 Domain

(2013) Amy J. Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterisation of Weibel-Palade body fusion by amperometry in endothelial cells reveals fusion pore dynamics and the effect of cholesterol on exocytosis

(2013) E. A. Cookson et al.   JOURNAL OF CELL SCIENCE

Next-generation sequencing study finds an excess of rare, coding single-nucleotide variants ofADAMTS13in patients with deep vein thrombosis

(2013) L. A. Lotta et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Reduced prevalence of arterial thrombosis in von Willebrand disease

(2013) Y. V. Sanders et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The O-linked glycans of human von Willebrand factor modulate its interaction with ADAMTS-13

(2013) A. A. Nowak et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet-Type von Willebrand Disease: New Insights into the Molecular Pathophysiology of a Unique Platelet Defect

(2013) Harmanpreet Kaur et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Role of reduced ADAMTS13 in arterial ischemic stroke: A Pediatric Cohort Study

(2012) Moritz Lambers et al.   ANNALS OF NEUROLOGY

Sequence and structure relationships within von Willebrand factor

(2012) Y.-F. Zhou et al.   BLOOD

O-linked glycosylation of von Willebrand factor modulates the interaction with platelet receptor glycoprotein Ib under static and shear stress conditions

(2012) A. A. Nowak et al.   BLOOD

In Vivo Analysis of the Role of O-Glycosylations of Von Willebrand Factor

(2012) Idinath Badirou et al.   PLoS One

Calcium stabilizes the von Willebrand factor A2 domain by promoting refolding

(2012) A. J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implications for collagen I chain registry from the structure of the collagen von Willebrand factor A3 domain complex

(2012) T. H. C. Brondijk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thrombosis in VonWillebrand disease

(2012) Waqas Qureshi et al.   THROMBOSIS RESEARCH

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIb  and a GPIb /GPIX chimera

(2011) P. A. McEwan et al.   BLOOD

A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13

(2011) M. Zhou et al.   BLOOD

A pH-regulated dimeric bouquet in the structure of von Willebrand factor

(2011) Yan-Feng Zhou et al.   EMBO JOURNAL

Actomyosin II contractility expels von Willebrand factor from Weibel–Palade bodies during exocytosis

(2011) Thomas D. Nightingale et al.   JOURNAL OF CELL BIOLOGY

Biology and physics of von Willebrand factor concatamers

(2011) T. A. SPRINGER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Giant Nonmonotonic Stretching Response of a Self-Associating Polymer in Shear Flow

(2011) Charles E. Sing et al.   PHYSICAL REVIEW LETTERS

Binding of  -thrombin to surface-anchored platelet glycoprotein Ib  sulfotyrosines through a two-site mechanism involving exosite I

(2011) A. Zarpellon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The International Society on Thrombosis and Haematosis von Willebrand Disease Database: An Update

(2011) Daniel Hampshire et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

von Willebrand Factor

(2011) Simon F. De Meyer et al.   STROKE

Calcium modulates force sensing by the von Willebrand factor A2 domain

(2011) Arjen J. Jakobi et al.   Nature Communications

Unfolding the A2 Domain of Von Willebrand Factor with the Optical Trap

(2010) Junyi Ying et al.   BIOPHYSICAL JOURNAL

Elongational Flow Induces the Unfolding of von Willebrand Factor at Physiological Flow Rates

(2010) Charles E. Sing et al.   BIOPHYSICAL JOURNAL

Common VWF exon 28 polymorphisms in African Americans affecting the VWF activity assay by ristocetin cofactor

(2010) V. H. Flood et al.   BLOOD

von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models

(2010) A. Brill et al.   BLOOD

The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function

(2010) B. M. Luken et al.   BLOOD

Absent collagen binding in a VWF A3 domain mutant: utility of the VWF:CB in diagnosis of VWD

(2010) V. H. FLOOD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A mechanically stabilized receptor–ligand flex-bond important in the vasculature

(2010) Jongseong Kim et al.   NATURE

Characterization of W1745C and S1783A: 2 novel mutations causing defective collagen binding in the A3 domain of von Willebrand factor

(2009) A. F. Riddell et al.   BLOOD

Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13

(2009) T. Wu et al.   BLOOD

von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke

(2009) B.-Q. Zhao et al.   BLOOD

Limitations of the ristocetin cofactor assay in measurement of von Willebrand factor function

(2009) V. H. FLOOD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

(2009) Warwick S Nesbitt et al.   NATURE MEDICINE

Structural organization of Weibel-Palade bodies revealed by cryo-EM of vitrified endothelial cells

(2009) J. A. Berriman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor

(2009) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor

(2009) X. Zhang et al.   SCIENCE

Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura

(2008) J. E. Sadler   BLOOD

Crystal Structure Analysis Reveals How the Chordin Family Member Crossveinless 2 Blocks BMP-2 Receptor Binding

(2008) Jin-li Zhang et al.   DEVELOPMENTAL CELL

Thrombotic thrombocytopenic purpura related to severe ADAMTS13 deficiency in children

(2008) Chantal Loirat et al.   PEDIATRIC NEPHROLOGY

Assembly of Weibel Palade body-like tubules from N-terminal domains of von Willebrand factor

(2008) R.-H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA