Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death

ATF2: A transcription factor that elicits oncogenic or tumor suppressor activities

(2014) Anindita Bhoumik et al.   CELL CYCLE

Reactive Oxygen Species-Dependent Down-Regulation of Tumor Suppressor Genes PTEN, USP28, DRAM, TIGAR, and CYLD Under Oxidative Stress

(2013) Su-Jung Kim et al.   BIOCHEMICAL GENETICS

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

IGF-1 gene-modified muscle-derived stem cells are resistant to oxidative stress via enhanced activation of IGF-1R/PI3K/AKT signaling and secretion of VEGF

(2013) Chunjing Chen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Novel Agents for Multiple Myeloma to Overcome Resistance in Phase III Clinical Trials

(2013) Robert Z. Orlowski   SEMINARS IN ONCOLOGY

Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma

(2012) D. J. Kuhn et al.   BLOOD

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

(2012) E. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH

(2011) L. Yin et al.   BLOOD

p38α Mediates Cell Survival in Response to Oxidative Stress via Induction of Antioxidant Genes

(2011) Álvaro Gutiérrez-Uzquiza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dependence on the MUC1-C Oncoprotein in Non-Small Cell Lung Cancer Cells

(2011) D. Raina et al.   MOLECULAR CANCER THERAPEUTICS

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Multiple Myeloma

(2011) Antonio Palumbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional targeting of the MUC1 oncogene in human cancers

(2010) Donald W. Kufe   CANCER BIOLOGY & THERAPY

Survival of Human Multiple Myeloma Cells Is Dependent on MUC1 C-Terminal Transmembrane Subunit Oncoprotein Function

(2010) L. Yin et al.   MOLECULAR PHARMACOLOGY

Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells

(2009) Zhen-Xian Du et al.   BMC CANCER

Antimyeloma Activity of the Orally Bioavailable Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235

(2009) D. W. McMillin et al.   CANCER RESEARCH

Direct Targeting of the Mucin 1 Oncoprotein Blocks Survival and Tumorigenicity of Human Breast Carcinoma Cells

(2009) D. Raina et al.   CANCER RESEARCH

Clinical challenges associated with bortezomib therapy in multiple myeloma and Waldenströms Macroglobulinemia

(2009) Jacob P. Laubach et al.   LEUKEMIA & LYMPHOMA

Dysregulation of unfolded protein response partially underlies proapoptotic activity of bortezomib in multiple myeloma cells

(2009) Hongjuan Dong et al.   LEUKEMIA & LYMPHOMA

Oxidative Stress by Targeted Agents Promotes Cytotoxicity in Hematologic Malignancies

(2008) Joya Chandra   ANTIOXIDANTS & REDOX SIGNALING

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

(2008) Deborah J. Kuhn et al.   BLOOD

Molecular basis of bortezomib resistance: proteasome subunit  5 (PSMB5) gene mutation and overexpression of PSMB5 protein

(2008) R. Oerlemans et al.   BLOOD

Redox homeostasis modulates the sensitivity of myeloma cells to bortezomib

(2008) Silvia Nerini-Molteni et al.   BRITISH JOURNAL OF HAEMATOLOGY

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA