Rational design of small molecules targeting the C2 domain of coagulation factor VIII

Reservations against new oral anticoagulants after stroke and cerebral bleeding

(2013) Claudia Stöllberger et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Inhibitory antibodies in hemophilia A

(2012) Kathleen P. Pratt   CURRENT OPINION IN HEMATOLOGY

The FAF-Drugs2 server: a multistep engine to prepare electronic chemical compound collections

(2011) David Lagorce et al.   BIOINFORMATICS

New anticoagulants - promising and failed developments

(2011) Job Harenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

In silico studies of blood coagulation proteins: from mosaic proteases to nonenzymatic cofactor inhibitors

(2010) Bruno O Villoutreix et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Inhibition of Thrombin Formation by Active Site Mutated (S360A) Activated Protein C

(2010) Gerry A. F. Nicolaes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trp2313-His2315of Factor VIII C2 Domain Is Involved in Membrane Binding

(2010) Zhuo Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The discovery and development of rivaroxaban, an oral, direct factor Xa inhibitor

(2010) Elisabeth Perzborn et al.   NATURE REVIEWS DRUG DISCOVERY

ChemProt: a disease chemical biology database

(2010) O. Taboureau et al.   NUCLEIC ACIDS RESEARCH

The molecular basis of factor V and VIII procofactor activation

(2009) R. M. CAMIRE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The topology of drug–target interaction networks: implicit dependence on drug properties and target families

(2009) Jordi Mestres et al.   Molecular BioSystems

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

(2008) Jacky Chi Ki Ngo et al.   STRUCTURE