The function of hematopoietic stem cells is altered by both genetic and inflammatory factors in lupus mice

Demand-adapted regulation of early hematopoiesis in infection and inflammation

(2012) H. Takizawa et al.   BLOOD

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis

(2012) Agneta Zickert et al.   ARTHRITIS RESEARCH & THERAPY

p57Kip2 and p27Kip1 Cooperate to Maintain Hematopoietic Stem Cell Quiescence through Interactions with Hsc70

(2011) Peng Zou et al.   Cell Stem Cell

p57 Is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells

(2011) Akinobu Matsumoto et al.   Cell Stem Cell

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors

(2011) Cornelis J.H. Pronk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

(2011) Brad Dykstra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclin-Dependent Kinase Inhibitor Cdkn2c Regulates B Cell Homeostasis and Function in the NZM2410-Derived Murine Lupus Susceptibility Locus Sle2c1

(2011) Z. Xu et al.   JOURNAL OF IMMUNOLOGY

Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells

(2011) B. L. Esplin et al.   JOURNAL OF IMMUNOLOGY

Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study

(2011) Isabelle Koné-Paut et al.   ARTHRITIS RESEARCH & THERAPY

HMGB1 in systemic lupus Erythematosus: Its role in cutaneous lesions development

(2010) D.A. Abdulahad et al.   AUTOIMMUNITY REVIEWS

Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice

(2010) Chong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Bacterial Infection Induces Hematopoietic Stem and Progenitor Cell Expansion in the Absence of TLR Signaling

(2010) Philip O. Scumpia et al.   JOURNAL OF IMMUNOLOGY

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

Cytokines as therapeutic targets in SLE

(2010) Lars Rönnblom et al.   Nature Reviews Rheumatology

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis

(2009) S. Rodriguez et al.   BLOOD

Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus–prone B6.Sle1.Yaaanimals

(2009) Kenichiro Maeda et al.   BLOOD

Type I interferon and lupus

(2009) Lars Rönnblom et al.   CURRENT OPINION IN RHEUMATOLOGY

The TLR1/2 agonist PAM3CSK4 instructs commitment of human hematopoietic stem cells to a myeloid cell fate

(2009) K De Luca et al.   LEUKEMIA

Cellular therapy of systemic lupus erythematosus

(2009) A Tyndall   LUPUS

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal

(2008) Leonard I. Zon   NATURE

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

(2008) Keith W. Orford et al.   NATURE REVIEWS GENETICS

The role of tumor necrosis factor-alpha in systemic lupus erythematosus

(2008) Martin Aringer et al.   ARTHRITIS RESEARCH & THERAPY