Article
Oncology
Yixin Luo, Maarten H. Vermeer, Frank R. de Gruijl, Willem H. Zoutman, Marjolein Sluijter, Thorbald van Hall, Cornelis P. Tensen
Summary: This study investigates the mechanisms of MF by creating mouse models. The results show that knockout of the Socs1 gene can lead to skin lesions and activation of CD4 T cells. However, single copy loss of Socs1 is insufficient to induce a phenotype resembling early stage MF in the presence of sustained inflammation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Enrique Huanosta-Murillo, Marcela Alcantara-Hernandez, Brenda Hernandez-Rico, Georgina Victoria-Acosta, Patricia Miranda-Cruz, Maria Antonieta Dominguez-Gomez, Fermin Jurado-Santacruz, Genaro Patino-Lopez, Vadim Perez-Koldenkova, Alam Palma-Guzman, Paula Licona-Limon, Ezequiel M. Fuentes-Panana, Alicia Lemini-Lopez, Laura C. Bonifaz
Summary: In cutaneous T cell lymphoma (CTCL), a dominant Th2 profile associated with disease progression has been proposed, with TOX+ CD4(+) T cells producing IL-4(+) in early-stage skin lesions. The NLRP3 receptor plays a role in promoting a Th2 response by controlling IL-4 production, which may have significant implications in disease progression. This mechanism of IL-4 regulation mediated by NLRP3 is amplified in late-stage CTCL, indicating its importance in disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Christine L. Jones, Andrea Degasperi, Vieri Grandi, Tauanne D. Amarante, Tracey J. Mitchell, Serena Nik-Zainal, Sean J. Whittaker
Summary: This study identified different mutational signatures and associated recurrent gene mutations in various subtypes of T-cell non-Hodgkin's lymphomas. UV radiation was found to have a strong correlation with cutaneous T-cell lymphoma. This finding highlights the importance of understanding the pathogenesis of the disease.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Bufang Xu, Fengjie Liu, Yumei Gao, Jingru Sun, Yingyi Li, Yuchieh Lin, Xiangjun Liu, Yujie Wen, Shengguo Yi, Jingyang Dang, Ping Tu, Yang Wang
Summary: Cutaneous T cell lymphoma is a chronic disease that can exhibit aggressive behavior in advanced stages, leading to poor prognosis. The transcription factor IKZF2 is found to be overexpressed in malignant T cells, particularly in advanced-stage lesions, promoting disease progression by inhibiting cell apoptosis and potentially contributing to tumor immune evasion.
ACTA DERMATO-VENEREOLOGICA
(2021)
Review
Biochemistry & Molecular Biology
Shuichi Nakai, Eiji Kiyohara, Rei Watanabe
Summary: CTCL is a heterogeneous group of non-Hodgkin lymphoma, mainly including MF and SS, with malignant cells possibly originating from different T cell phenotypes. The pathogenesis and therapeutic strategies for CTCL remain unclear due to the similar characteristics between malignant cells and anti-tumor T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Till Kaemmerer, Pia-Charlotte Stadler, Leonie Helene Frommherz, Anne Guertler, Lars Einar French, Markus Reinholz
Summary: This study analyzed the treatment of 35 patients with MF and SS CTCL using alitretinoin between 2015 and 2020, showing that nearly two thirds of the patients responded positively or had stable disease, with minimal side effects. This suggests that alitretinoin may be a potential alternative for less advanced CTCLs due to its effectiveness and low cost compared to bexarotene.
Article
Biochemistry & Molecular Biology
Tina Petrogiannis-Haliotis, Kevin Pehr, David Roberge, Ryan N. Rys, Yury Monczak, Gizelle Popradi, Lissa Ajjamada, Naciba Benlimame, Christiane Querfeld, Nathalie Johnson, Hans Knecht
Summary: We present a case of CD4+ small/medium-sized pleomorphic lymphoma with extensive lesions in the legs. Immunohistochemistry and flow cytometry analysis showed distinct CD4+ and CD8+ T-cell populations with no CD4/CD8 co-expression. TCR gene rearrangement studies confirmed the neoplastic population to be of T-cytotoxic cell lineage, representing a previously undescribed type of CTCL.
Article
Multidisciplinary Sciences
Xiangjun Liu, Shanzhao Jin, Simeng Hu, Ruoyan Li, Haihao Pan, Yi Liu, Pan Lai, Deshu Xu, Jingru Sun, Ziyang Liu, Yumei Gao, Yifan Zhao, Fengjie Liu, Yu Xiao, Yingyi Li, Yujie Wen, Zhuojing Chen, Bufang Xu, Yuchieh Lin, Menglong Ran, Qianxi Li, Shuxia Yang, Hang Li, Ping Tu, Muzlifah Haniffa, Sarah A. Teichmann, Fan Bai, Yang Wang
Summary: Cutaneous T cell lymphoma (CTCL) is a heterogeneous group of non-Hodgkin lymphoma characterized by clonal malignant T cells. This study analyzed CTCL patient samples using single-cell RNA-seq, TCR and whole-exome sequencing, revealing the molecular profiles of malignant T cells and their association with the microenvironment and clinical outcomes.
NATURE COMMUNICATIONS
(2022)
Article
Dermatology
Sara Peru, Martina Prochazkova-Carlotti, Floriane Cherrier, Joanne Velazquez, Elodie Richard, Yamina Idrissi, David Cappellen, Lamia Azzi-Martin, Anne Pham-Ledard, Marie Beylot-Barry, Jean-Philippe Merlio, Sandrine Poglio
Summary: Cutaneous T-cell lymphoma (CTCL) is characterized by abnormal infiltration of T lymphocytes in the skin. In this study, the researchers found that the expression of cutaneous lymphocyte antigen (CLA) in CTCL cells is crucial for their migration and survival. The use of a CLA antibody significantly reduced the migration and survival of CTCL cells both in vitro and in vivo. These findings suggest that inhibiting CLA could be a potential therapeutic strategy for CTCL patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Dermatology
Mitchell S. Davis, Riley K. Spencer, Chandler E. Johnson, Kareem G. Elhage, Joy Q. Jin, Marwa Hakimi, Tina Bhutani, Wilson Liao
Summary: The risk of developing CTCL in patients using psoriasis biologics appears to be rare, with the highest number of reported cases associated with TNF inhibitors and no reported cases with IL-23 inhibitors.
DERMATOLOGY AND THERAPY
(2023)
Review
Oncology
Ping Zhang, Mingzhi Zhang
Summary: CTCLs are a group of heterogeneous diseases involving malignant T cells, with unclear pathogenesis and etiology. Most CTCLs have an indolent course, but once large-cell transformation occurs, it progresses to more aggressive types. Epigenetic drugs have shown certain curative effects and have been selected as third-line drugs for patients with relapsing and refractory CTCL.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hidetsugu Kawai, Kiyoshi Ando, Dai Maruyama, Kazuhito Yamamoto, Eiji Kiyohara, Yasuhito Terui, Noriko Fukuhara, Tomomitsu Miyagaki, Yoshiki Tokura, Mamiko Sakata-Yanagimoto, Tadahiko Igarashi, Junya Kuroda, Jiro Fujita, Toshiki Uchida, Takayuki Ishikawa, Kentaro Yonekura, Koji Kato, Tadashi Nakanishi, Kenya Nakai, Risa Matsunaga, Kensei Tobinai
Summary: E7777, a recombinant cytotoxic fusion protein, demonstrated efficacy and manageable safety profile in Japanese patients with relapsed or refractory PTCL and CTCL. Common adverse events observed included increased AST/ALT, hypoalbuminemia, among others.
Article
Dermatology
Karol Kolkowski, Jolanta Glen, Berenika Olszewska, Monika Zablotna, Roman J. Nowicki, Malgorzata Sokolowska-Wojdylo
Summary: The tumour microenvironment plays a significant role in the progression of cutaneous T-cell lymphomas. Specific single-nucleotide polymorphisms in the interleu-kin-17 genes have different frequencies in lymphoma patients, which may contribute to impaired immune defence.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Hematology
Fengjie Liu, Yumei Gao, Bufang Xu, Shan Xiong, Shengguo Yi, Jingru Sun, Zhuojing Chen, Xiangjun Liu, Yingyi Li, Yuchieh Lin, Yujie Wen, Yao Qin, Shuxia Yang, Hang Li, Trilokraj Tejasvi, Lam Tsoi, Ping Tu, Xianwen Ren, Yang Wang
Summary: This study identified unique transcriptional programs and enriched expression of genes at the chr7q locus in tumors undergoing large-cell transformation (LCT) in late-stage mycosis fungoides (MF). Aberrant expression of the imprinted gene Paternally Expressed Gene 10 (PEG10) in LCT was shown to drive cell size increase, promote proliferation, and confer treatment resistance through a PEG10/KLF2/NF-kappa B axis. Pharmacological targeting of PEG10 reversed the proliferation and treatment resistance phenotypes in LCT, suggesting PEG10 inhibition as a promising therapeutic approach.
Article
Dermatology
Zhen Han, Renee J. Estephan, Xiwei Wu, Chingyu Su, Yate-Ching Yuan, Hanjun Qin, Sung Hee Kil, Corey Morales, Daniel Schmolze, James F. Sanchez, Lei Tian, Jianhua Yu, Marcin Kortylewski, Steven T. Rosen, Christiane Querfeld
Summary: Cutaneous T cell lymphoma (CTCL) is a malignant tumor characterized by chronic inflammation. This study found that miR-155-5p, miR-130b-3p, and miR-21-3p positively correlated with immune checkpoint gene expression in CTCL and were enriched in the IL-6/Jak/signal transducer and activator of transcription signaling pathway.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Hematology
Maria Gluud, Emil M. H. Pallesen, Terkild B. Buus, Lise Mette Rahbek Gjerdrum, Lise M. Lindahl, Maria R. Kamstrup, Michael Bzorek, Maria Danielsen, Rikke Bech, Madalena N. Monteiro, Edda Blumel, Andreas Willerslev-Olsen, Anders Lykkebo-Valloe, Chella Krishna Vadivel, Thorbjorn Krejsgaard, Charlotte Menne Bonefeld, Carsten Geisler, Juergen C. Becker, Sergei B. Koralov, Lars Iversen, Thomas Litman, Anders Woetmann, Niels Odum
Summary: Cutaneous T-cell lymphoma (CTCL) is a devastating lymphoid malignancy characterized by the accumulation of malignant T cells in the dermis and epidermis. Skin lesions cause serious symptoms and increase the risk of bacterial infection. The study found that malignant T cells secrete cytokines that downregulate the expression of filaggrin and filaggrin-2, leading to compromised skin barrier. Treatment with JAK inhibitors can reverse this effect and increase filaggrin expression in patients with advanced CTCL.
Article
Computer Science, Interdisciplinary Applications
Marleine Azar, Francois Lagace, Anastasiya Muntyanu, Elena Netchiporouk, Youwen Zhou, Charles Lynde, Linda Moreau, Steve Mathieu, Denis Sasseville, Rachel Asiniwasis, Neil H. Shear, Robert Gniadecki, Elham Rahme, Ivan V. Litvinov
Summary: This study examined the relationship between h-index and academic rank, sex, and other factors in dermatology in Canada. The results showed an increase in female dermatologists and found no association between h-index and sex.
Article
Oncology
Eliana-Ruobing Zhang, Sarah Ghezelbash, Pingxing Xie, Misha Fotovati, Ivan Litvinov, Philippe Lefrancois
Summary: Basal cell carcinoma (BCC) is the most common form of skin cancer, with a small percentage being aggressive and having different immune profiles and stem cell populations. Currently, there is no reliable model for advanced BCC. This study used genomic data from various tumors to identify three cancers with similar immune cell composition to BCC, in order to gain insights for potential treatments and model development.
Review
Dermatology
Alex Nguyen, Pingxing Xie, Ivan V. Litvinov, Philippe Lefrancois
Summary: This study reviewed the latest clinical trials and studies on the efficacy and safety of sonic hedgehog inhibitors (SSHis) in the treatment of advanced basal cell carcinoma (BCC). The results showed that SSHis are effective in treating advanced BCC, but patients may experience adverse effects. Therefore, managing patient expectations and ensuring long-term treatment compliance is essential.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Allergy
Anders Boutrup Funch, Julie Friis Weber, Rebecca Kitt Davidson Lohmann, Veronika Mraz, Kelvin Yeung, Mia Hamilton Jee, Niels Odum, Anders Woetmann, Jeanne Duus Johansen, Carsten Geisler, Charlotte Menne Bonefeld
Summary: This study reveals that clinically relevant contact allergens can generate pathogenic, epidermal CD8(+) T-RM cells that recruit neutrophils following re-exposure to the allergen, but this response is normally suppressed by the induction of anti-inflammatory CD4(+) T cells.
CONTACT DERMATITIS
(2023)
Review
Biochemistry & Molecular Biology
Domenico Arcuri, Brandon Ramchatesingh, Francois Lagace, Lisa Iannattone, Elena Netchiporouk, Philippe Lefrancois, Ivan V. Litvinov
Summary: Actinic keratosis, a common skin disease, can be life-threatening if left untreated. Pharmacologic agents such as nicotinamide, acitretin, and 5-fluorouracil (5-FU) are used in prevention and treatment of AKs. 5-FU is considered the most effective therapy, but lower concentrations may also be effective. Uncertainty remains regarding the optimal treatment for immunocompetent vs. immunodeficient/immunosuppressed patients. Photodynamic light therapy is also an accepted treatment strategy for AKs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kelly Cristina Gomes Manfrere, Marina Passos Torrealba, Frederico Moraes Ferreira, Emanuella Sarmento Alho de Sousa, Denis Miyashiro, Franciane Mouradian Emidio Teixeira, Ricardo Wesley Alberca Custodio, Helder I. Nakaya, Yasmin Alefe Leuzzi Ramos, Mirian Nacagami Sotto, Anders Woetmann, Niels odum, Alberto Jose da Silva Duarte, Jose Antonio Sanches, Maria Notomi Sato
Summary: This study investigated the expression levels of inflammatory markers IL-1B and IL-18 in the skin, serum, blood cells, and lymph nodes of patients with Sezary syndrome, as potential markers of inflammasome activation. The findings showed compartmentalized expressions of IL-1B and IL-18, with increased expression of IL-1B in the epidermis and increased expression of IL-18 in the dermis. In advanced stages of the disease, enhanced expression of IL-18 and downregulation of IL-1B were observed in the lymph nodes. This study provided the first evidence of the imbalance of IL-1B and IL-18 in patients with Sezary syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Aaron M. M. Drucker, Omer Kleiner, Rachael Manion, Anie Philip, Jan Dutz, Kathleen Barnard, Julie Fradette, Lucie Germain, Robert Gniadecki, Ivan Litvinov, Sarvesh Logsetty, Morris Manolson, P. Regine Mydlarski, Vincent Piguet, Debbie Ward, Youwen Zhou, An-Wen Chan
Summary: The Skin Investigation Network of Canada (SkIN Canada) identified the top ten research priorities for nine key skin conditions through surveys, scoping reviews, and workshops, emphasizing the importance of involving patients and healthcare providers.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Article
Allergy
Veronika Mraz, Anders B. Funch, Mia H. Jee, Anne-Sofie O. Gadsboll, Julie F. Weber, Kelvin Yeung, Rebecca K. D. Lohmann, Alana Hawkes, Niels Odum, Anders Woetmann, Dianne Mckay, Deborah Witherden, Carsten Geisler, Charlotte M. Bonefeld
Summary: CD8(+) TRM cells play a key role in allergic contact dermatitis (ACD), and CD100 is an essential protein for the activation of CD8(+) TRM cells and the flare-up response of ACD.
CONTACT DERMATITIS
(2023)
Article
Allergy
Veronika Mraz, Rebecca K. D. Lohmann, Mandy Menzel, Alana Hawkes, Helen Vaher, Anders B. Funch, Mia H. Jee, Anne-Sofie o. Gadsboll, Julie F. Weber, Kelvin Yeung, Niels Odum, Anders Woetmann, Dianne Mckay, Deborah Witherden, Carsten Geisler, Charlotte M. Bonefeld
Summary: This study reveals the central role of JAML in CHS and suggests a potential new target for the treatment of ACD in humans.
CONTACT DERMATITIS
(2023)
Letter
Dermatology
Catherine Zhu, Sofianne Gabrielli, Lauren Khoury, Mohamed Osman, Ivan V. Litvinov, Lisa Iannattone, Philippe Lefrancois, Elena Netchiporouk
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Review
Oncology
Santina Conte, Ammar Saed Aldien, Sebastien Jette, Jonathan LeBeau, Sauliha Alli, Elena Netchiporouk, Francois Lagace, Philippe Lefrancois, Lisa Iannattone, Ivan V. Litvinov
Summary: Incidence rates of melanoma and keratinocyte skin cancers have been rising globally. The lack of legislation to support individuals' protection from harmful UV radiation is a concern. Our comprehensive review found that only Australia has banned tanning beds for all ages. Occupational UVR exposure is not sufficiently recognized in workplace policies, and few protective measures are in place. Legislation and standardization are lacking in youth guidelines, and only Australia and select US jurisdictions have exempted sunscreen products from sales tax. We propose recommendations to reduce skin cancer rates, including promoting vitamin D supplementation alongside sun protective practices.
Article
Oncology
Badria Alkazemi, Feras M. Ghazawi, Francois Lagace, Vladimir Nechaev, Andrei Zubarev, Ivan V. Litvinov
Summary: This study analyzed the epidemiology of sarcomas in Canada and found that overall incidence decreased during the study period, but some subtypes showed increasing incidence. Axially located sarcomas had higher mortality rates compared to peripherally located sarcomas. Clustering of Kaposi sarcoma cases was observed in LGBTQ+ communities and postal codes with higher proportions of African-Canadian and Hispanic populations. Additionally, lower socioeconomic status postal codes had higher Kaposi sarcoma incidence rates.
Article
Medicine, General & Internal
Sarah J. Touyz, Feras M. Ghazawi, Elena Netchiporouk, Gizelle Popradi, Rene P. Michel, Sonia Skamene, Christine Lambert, Tarek Hijal, Ivan Litvinov
Summary: Cutaneous T-cell lymphomas are a type of non-Hodgkin lymphomas in which malignant T cells infiltrate the skin. The pathogenesis of these lymphomas is not completely understood, but persistent antigen stimulation of CD4+ memory T cells in the skin, combined with an inflammatory tissue environment rich in cytokines, may play a critical role. This case report demonstrates that primary cutaneous T-cell lymphoma can develop locally at the site of injury or surgery within a relatively short period of time. It contributes to the literature on cutaneous T-cell lymphomas arising after trauma, surgery, or a foreign body.
SAGE OPEN MEDICAL CASE REPORTS
(2023)
Letter
Dermatology
Catherine Zhu, Sofianne Gabrielli, Lauren Khoury, Mohamed Osman, Ivan V. Litvinov, Lisa Iannattone, Philippe Lefrancois, Elena Netchiporouk
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)