Exome sequencing identifies putative drivers of progression of transient myeloproliferative disorder to AMKL in infants with Down syndrome

AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL

(2013) M J Stankiewicz et al.   LEUKEMIA

Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing

(2012) A. Dolnik et al.   BLOOD

High frequency of copy number alterations in myeloid leukaemia of Down syndrome

(2012) Marjolein Blink et al.   BRITISH JOURNAL OF HAEMATOLOGY

A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas

(2012) S. I. Nikolaev et al.   CANCER RESEARCH

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

A complex Polycomb issue: the two faces of EZH2 in cancer

(2012) H. Hock   GENES & DEVELOPMENT

Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas

(2012) Zhaohui Wang et al.   Journal of Translational Medicine

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

(2012) Li Ding et al.   NATURE

EZH2 mutational status predicts poor survival in myelofibrosis

(2011) P. Guglielmelli et al.   BLOOD

Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia

(2011) M. Bonnet et al.   BLOOD

Differential niche and Wnt requirements during acute myeloid leukemia progression

(2011) S. W. Lane et al.   BLOOD

Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulation

(2011) A Gandillet et al.   LEUKEMIA

CREBBP mutations in relapsed acute lymphoblastic leukaemia

(2011) Charles G. Mullighan et al.   NATURE

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

(2011) Sergey I Nikolaev et al.   NATURE GENETICS

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

(2011) Xiao-Jing Yan et al.   NATURE GENETICS

Advances in the 5q- syndrome

(2010) J. Boultwood et al.   BLOOD

Haploinsufficiency of Apc leads to ineffective hematopoiesis

(2010) J. Wang et al.   BLOOD

Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis

(2010) J.-H. Klusmann et al.   GENES & DEVELOPMENT

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells

(2009) V. G. Oehler et al.   BLOOD

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome

(2009) S. Malinge et al.   BLOOD

Discovering Hematopoietic Mechanisms through Genome-wide Analysis of GATA Factor Chromatin Occupancy

(2009) Tohru Fujiwara et al.   MOLECULAR CELL

The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis

(2009) Armen Parsyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia

(2009) I. Radtke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Megakaryocyte hyperproliferation withoutGATA1mutation in foetal liver of a case of Down syndrome with hydrops foetalis

(2008) Serena De Vita et al.   BRITISH JOURNAL OF HAEMATOLOGY

Somatically acquiredJAK1mutations in adult acute lymphoblastic leukemia

(2008) Elisabetta Flex et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of somatic JAK1 mutations in patients with acute myeloid leukemia

(2007) Z. Xiang et al.   BLOOD