The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents

Daunorubicin induces cell death via activation of apoptotic signalling pathway and inactivation of survival pathway in muscle-derived stem cells

(2012) Aurimas Stulpinas et al.   CELL BIOLOGY AND TOXICOLOGY

TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

(2011) F. G. Rucker et al.   BLOOD

Inhibition of Src Family Kinases and Receptor Tyrosine Kinases by Dasatinib: Possible Combinations in Solid Tumors

(2011) J. C. Montero et al.   CLINICAL CANCER RESEARCH

The transcription factor PlagL2 activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells

(2011) S F Landrette et al.   LEUKEMIA

The potential for dasatinib in treating chronic lymphocytic leukemia, acute myeloid leukemia, and myeloproliferative neoplasms

(2011) Philip C. Amrein   LEUKEMIA & LYMPHOMA

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate

(2010) Bin Zhang et al.   CANCER CELL

Dasatinib Inhibits the Growth of Molecularly Heterogeneous Myeloid Leukemias

(2010) B. S. Guerrouahen et al.   CLINICAL CANCER RESEARCH

Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice

(2010) Jean-Emmanuel Sarry et al.   JOURNAL OF CLINICAL INVESTIGATION

Ubiquitin–proteasome system profiling in acute leukemias and its clinical relevance

(2010) Wanlong Ma et al.   LEUKEMIA RESEARCH

Mouse models of human AML accurately predict chemotherapy response

(2009) J. Zuber et al.   GENES & DEVELOPMENT

Identification of a novel TEL–Lyn fusion gene in primary myelofibrosis

(2009) H Tanaka et al.   LEUKEMIA

Src kinases as therapeutic targets for cancer

(2009) Lori C. Kim et al.   Nature Reviews Clinical Oncology

High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

(2008) M. M. Loriaux et al.   BLOOD

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

(2008) M. H. Tomasson et al.   BLOOD

Metabolism and Disposition of Dasatinib after Oral Administration to Humans

(2008) L. J. Christopher et al.   DRUG METABOLISM AND DISPOSITION

Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT)

(2008) Yukiyasu Ozawa et al.   LEUKEMIA RESEARCH