Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?

Relationships Among Hyperuricemia, Metabolic Syndrome, and Endothelial Function

(2011) H. Tomiyama et al.   AMERICAN JOURNAL OF HYPERTENSION

TNF  facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms

(2011) A. G. Fleischman et al.   BLOOD

Chronic myeloproliferative neoplasms and subsequent cancer risk: a Danish population-based cohort study

(2011) H. Frederiksen et al.   BLOOD

Risk factors for arterial and venous thrombosis in WHO-defined essential thrombocythemia: an international study of 891 patients

(2011) A. Carobbio et al.   BLOOD

Whole-blood transcriptional profiling of interferon-inducible genes identifies highly upregulated IFI27 in primary myelofibrosis

(2011) Vibe Skov et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Monocytes link atherosclerosis and cancer

(2011) Mikael J. Pittet et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cancer-promoting tumor-associated macrophages: New vistas and open questions

(2011) Alberto Mantovani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The JAK2 46/1 haplotype: a marker of inappropriate myelomonocytic response to cytokine stimulation, leading to increased risk of inflammation, myeloid neoplasm, and impaired defense against infection?

(2011) S. Hermouet et al.   HAEMATOLOGICA

Pathophysiology of thrombosis in myeloproliferative neoplasms

(2011) R. Landolfi et al.   HAEMATOLOGICA

Circulating Interleukin (IL)-8, IL-2R, IL-12, and IL-15 Levels Are Independently Prognostic in Primary Myelofibrosis: A Comprehensive Cytokine Profiling Study

(2011) Ayalew Tefferi et al.   JOURNAL OF CLINICAL ONCOLOGY

Survival and Disease Progression in Essential Thrombocythemia Are Significantly Influenced by Accurate Morphologic Diagnosis: An International Study

(2011) Tiziano Barbui et al.   JOURNAL OF CLINICAL ONCOLOGY

Chronic Immune Stimulation Might Act As a Trigger for the Development of Acute Myeloid Leukemia or Myelodysplastic Syndromes

(2011) Sigurdur Y. Kristinsson et al.   JOURNAL OF CLINICAL ONCOLOGY

Myeloproliferative neoplasms cause glomerulopathy

(2011) Samar M. Said et al.   KIDNEY INTERNATIONAL

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

A new era for IFN-α in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms

(2011) Hans Carl Hasselbalch   Expert Review of Hematology

Molecular pathways and targets in cancer-related inflammation

(2010) Alberto Mantovani et al.   ANNALS OF MEDICINE

Platelet–Leukocyte Interactions in Cardiovascular Disease and Beyond

(2010) Licia Totani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Biomarkers of the Osteoprotegerin Pathway

(2010) Wolfgang Lieb et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Excess of autoimmune and chronic inflammatory disorders in patients with lymphoma compared with all cancer patients: A cancer registry-based analysis in the south of the Netherlands

(2010) Saskia A.M. van de Schans et al.   AUTOIMMUNITY REVIEWS

The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms

(2010) A. V. Jones et al.   BLOOD

JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation

(2010) Seido Oku et al.   BRITISH JOURNAL OF HAEMATOLOGY

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk

(2010) M. Goicoechea et al.   Clinical Journal of the American Society of Nephrology

The JAK2 V617F somatic mutation, mortality and cancer risk in the general population

(2010) C. Nielsen et al.   HAEMATOLOGICA

Autoimmunity and the risk of myeloproliferative neoplasms

(2010) S. Y. Kristinsson et al.   HAEMATOLOGICA

Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3

(2010) T. Barbui et al.   HAEMATOLOGICA

Osteoprotegerin as a Predictor of Coronary Artery Disease and Cardiovascular Mortality and Morbidity

(2010) Shreenidhi M. Venuraju et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1

(2010) A Tefferi   LEUKEMIA

Does auto-immunity contribute to anemia in myeloproliferative neoplasms (MPN)-associated myelofibrosis?

(2010) Giovanni Barosi et al.   LEUKEMIA RESEARCH

Genetic factors in chronic inflammation: Single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population

(2010) Lynnette R. Ferguson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis

(2010) Srdan Verstovsek et al.   NEW ENGLAND JOURNAL OF MEDICINE

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

(2010) Li Yang et al.   TRENDS IN IMMUNOLOGY

Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis

(2009) Young Hee Rho et al.   ARTHRITIS AND RHEUMATISM

Perspectives on thrombosis in essential thrombocythemia and polycythemia vera: is leukocytosis a causative factor?

(2009) T. Barbui et al.   BLOOD

Risks of myeloid malignancies in patients with autoimmune conditions

(2009) L A Anderson et al.   BRITISH JOURNAL OF CANCER

More than skin deep: atherosclerosis as a systemic manifestation of psoriasis

(2009) A.B. Alexandroff et al.   BRITISH JOURNAL OF DERMATOLOGY

Increased Risk of Lymphoid Neoplasms in Patients with Philadelphia Chromosome-Negative Myeloproliferative Neoplasms

(2009) A. M. Vannucchi et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Deficiency of the Long Pentraxin PTX3 Promotes Vascular Inflammation and Atherosclerosis

(2009) Giuseppe Danilo Norata et al.   CIRCULATION

Arterial cardiovascular risk factors and venous thrombosis: results from a population-based, prospective study (the HUNT 2)

(2009) P. Quist-Paulsen et al.   HAEMATOLOGICA

Cytokine and Cytokine-Like Inflammation Markers, Endothelial Dysfunction, and Imbalanced Coagulation in Development of Diabetes and Its Complications

(2009) Ronald B. Goldberg   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis

(2009)   LANCET

JAK2 germline genetic variation affects disease susceptibility in primary myelofibrosis regardless of V617F mutational status: nullizygosity for the JAK2 46/1 haplotype is associated with inferior survival

(2009) A Tefferi et al.   LEUKEMIA

Autoimmunity and hematologic malignancies: associations and mechanisms

(2009) Damali N. Martin et al.   LEUKEMIA & LYMPHOMA

A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms

(2009) Damla Olcaydu et al.   NATURE GENETICS

A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms

(2009) Outi Kilpivaara et al.   NATURE GENETICS

JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms

(2009) Amy V Jones et al.   NATURE GENETICS

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders

(2008) I. Plo et al.   BLOOD

Autoimmune and inflammatory disorders and risk of malignant lymphomas - an update

(2008) K. E. Smedby et al.   JOURNAL OF INTERNAL MEDICINE

Myelofibrosis with myeloid metaplasia: The advanced phase of an untreated disseminated hematological cancer

(2008) Hans Carl Hasselbalch   LEUKEMIA RESEARCH

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS