Article
Hematology
Alex Reza Gholiha, Peter Hollander, Ingrid Glimelius, Gustaf Hedstrom, Daniel Molin, Henrik Hjalgrim, Karin E. Smedby, Jamileh Hashemi, Rose-Marie Amini, Gunilla Enblad
Summary: IL-6 expression in the tumor microenvironment is associated with adverse survival outcomes in patients with classical Hodgkin lymphoma, while not correlated with other immune markers or serum IL-6 levels.
Article
Oncology
Saisai Chen, Kai Lu, Yue Hou, Zonghao You, Chuanjun Shu, Xiaoying Wei, Tiange Wu, Naipeng Shi, Guangyuan Zhang, Jianping Wu, Shuqiu Chen, Lihua Zhang, Wenchao Li, Dingxiao Zhang, Shenghong Ju, Ming Chen, Bin Xu
Summary: The study found that high expression of YY1 is closely associated with M2 macrophages in prostate cancer, promoting tumor development. The study also revealed that treatment targeting YY1 can suppress tumor metastasis and generate synergistic anti-tumor effects. Furthermore, the study revealed that YY1 upregulates IL-6 expression by regulating enhancer-promoter interactions, thereby promoting tumor progression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Yanglin Zhu, Hong Qin, Kui Ye, Chenglu Sun, Yafei Qin, Guangming Li, Hongda Wang, Hao Wang
Summary: IL-37 is a novel cytokine belonging to the IL-1 family, with potent anti-inflammatory and immunosuppressive properties, it plays an anti-tumor role in various types of tumors by negatively regulating certain signaling pathways.
Article
Oncology
Yu-Fu Zhou, Shu-Shu Song, Meng-Xin Tian, Zheng Tang, Han Wang, Yuan Fang, Wei-Feng Qu, Xi-Fei Jiang, Chen-Yang Tao, Run Huang, Pei-Yun Zhou, Shi-Guo Zhu, Jian Zhou, Jia Fan, Wei-Ren Liu, Ying-Hong Shi
Summary: The study revealed that CBS plays an anti-tumor role in HCC by promoting cellular apoptosis, inhibiting tumor growth through inactivation of the PRRX2/IL-6/STAT3 pathway. Additionally, CBS can reduce the abundance of tumor-infiltrating Tregs, thus suppressing immune evasion.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, Research & Experimental
I-Ying Kuo, You-En Yang, Pei-Shan Yang, Yu-Jou Tsai, Hong-Tai Tzeng, Hung-Chi Cheng, Wan-Ting Kuo, Wu-Chou Su, Chih-Peng Chang, Yi-Ching Wang
Summary: Rab37 regulates IL-6 secretion in macrophages to induce M2 polarization, promoting PD-1 expression in CD8(+) T cells. Tumors with high stromal Rab37 and IL-6 levels are associated with immunotherapeutic resistance and poor prognosis in lung cancer patients.
Article
Oncology
Arthur Battistoni, Louis Lantier, Anne di Tommaso, Celine Ducournau, Laurie Lajoie, Mahtab Samimi, Lois Coenon, Clement Riviere, Mathieu Epardaud, Leslie Hertereau, Agathe Poupee-Beauge, Juliette Rieu, Marie-Noelle Mevelec, Gordon Scott Lee, Nathalie Moire, Stephanie Germon, Isabelle Dimier-Poisson
Summary: Intranasal administration of immunotherapeutic agents shows promise in targeting lung metastases and reducing cancer mortality.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Guilherme Rossi Assis-Mendonca, Andre Fattori, Rafael Malagoli Rocha, Gustavo Jacob Lourenco, Marcia Torresan Delamain, Suely Nonogaki, Vladmir Claudio Cordeiro de Lima, Gisele Wally Braga Colleoni, Carmino Antonio de Souza, Fernando Augusto Soares, Carmen Silvia Passos Lima, Jose Vassallo
Summary: The composition of tumor microenvironment plays a significant role in the prognosis of patients with mantle cell lymphoma (MCL). Immunohistochemical detection of T-reg cells, IL17A, and IL2, combined with SNV genotyping in IL10, TGFBR2, and IL2, may serve as novel prognostic factors in MCL.
Article
Oncology
Tsunenori Yamamoto, Ryouichi Tsunedomi, Masao Nakajima, Nobuaki Suzuki, Shin Yoshida, Shinobu Tomochika, Ming Xu, Yuki Nakagami, Hiroto Matsui, Yukio Tokumitsu, Yoshitaro Shindo, Yusaku Watanabe, Michihisa Iida, Shigeru Takeda, Shoichi Hazama, Tsuyoshi Tanabe, Tatsuya Ioka, Yoshinobu Hoshii, Akifumi Kiyota, Hitoshi Takizawa, Yutaka Kawakami, Tomio Ueno, Hiroaki Nagano
Summary: This study investigated the relationship between an immunosuppressive state and patient prognosis in colorectal cancer (CRC) by evaluating the levels of interleukin (IL)-6 in both the systemic and tumor microenvironment. The results showed that elevated serum IL-6 levels were associated with elevated stromal IL-6 levels and a poor prognosis for CRC patients. In addition, tumor-infiltrating immune cells expressing IL-6 were primarily composed of myeloid cells and rarely lymphoid cells.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Mariola Blanco, Ana Collazo-Lorduy, Natalia Yanguas-Casas, Virginia Calvo, Mariano Provencio
Summary: Follicular lymphoma, a common type of indolent non-Hodgkin lymphoma, is characterized by its heterogeneity and variable course. The immune microenvironment plays a fundamental role in the pathogenesis of the disease. Responses to treatment vary among patients, and outcomes are often unpredictable. The crosstalk between follicular lymphoma B-cells and the tumor microenvironment as well as the impact on prognosis and transformation risk are important research areas. Novel therapies targeting specific mutations and modulating the tumor microenvironment have been developed.
Article
Medicine, Research & Experimental
Ajay Dixit, Aaron Sarver, Jon Zettervall, Huocong Huang, Kexin Zheng, Rolf A. Brekken, Paolo P. Provenzano
Summary: Pancreatic ductal adenocarcinoma (PDA) is resistant to immune therapies due to its fibrotic and immunosuppressive tumor microenvironments. Excessive accumulation of immunosuppressive macrophages has been found to influence immunotherapy resistance. Intervention studies targeting macrophages in combination with checkpoint blockade show promising results.
Review
Biochemistry & Molecular Biology
Carla M. Felcher, Emilia S. Bogni, Edith C. Kordon
Summary: This review summarizes the role of the IL-6 cytokine family in breast cancer progression, suggesting their potential use in diagnosis and treatment, as well as discussing their involvement in breast pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Young Eun Lee, Ga-Yeon Go, Eun-Young Koh, Han-Na Yoon, Minkoo Seo, Seung-Mo Hong, Ji Hye Jeong, Jin-Chul Kim, Duck Cho, Tae Sung Kim, Song Cheol Kim, Eunsung Jun, Mihue Jang
Summary: Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) impair the functionality of natural killer (NK) cells, which are considered as a promising therapeutic modality. Targeted therapies against CAFs may enhance NK-mediated cancer killing.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Cell Biology
Esra Esmeray Sonmez, Tevfik Hatipoglu, Deniz Kursun, Xiaozhou Hu, Burcu Akman, Hongling Yuan, Ayca Ersen Danyeli, Inci Alacacioglu, Sermin Ozkal, Aybuke Olgun, Taner Kemal Erdag, Hua You, Can Kucuk
Summary: This study identified genes and transcripts associated with the development and prognosis of mantle cell lymphoma (MCL) through transcriptome sequencing. The high expression of VWF mRNA and low expression of FTX lncRNA were found to be associated with poor overall survival in MCL cases. Additionally, the ratio of tumor-infiltrating immunocytes was also correlated with overall survival in MCL patients.
Article
Medicine, Research & Experimental
Shi-Wei Guan, Quan Lin, Xi-Dong Wu, Hai-Bo Yu
Summary: The study suggests that there is an association between the tumor microbiome and the tumor genome, and this association is not accidental and could change the landscape of tumor research.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Margaretha G. M. Roemer, Tim van de Brug, Erik Bosch, Daniella Berry, Nathalie Hijmering, Phylicia Stathi, Karin Weijers, Jeannette Doorduijn, Jacoline Bromberg, Mark van de Wiel, Bauke Ylstra, Daphne de Jong, Yongsoo Kim
Summary: In order to understand the clinical relevance of the tumor microenvironment (TME), it is important to study the interactions between malignant and non-malignant cells in clinical samples. Researchers have developed a computational framework to comprehensively analyze the spatial context of the TME, including close and long-distance interactions between different cell types. This framework was applied to imaging data from 88 primary central nervous system lymphomas, revealing significant prognostic subgroups mainly determined by the spatial context. The results highlight the importance of spatial context in predicting patient survival, particularly in relation to macrophage infiltration near specific cell types.
Article
Hematology
Alex F. Herrera, Scott J. Rodig, Joo Y. Song, Young Kim, Gabriel K. Griffin, Dongyun Yang, Liana Nikolaenko, Matthew Mei, Victoria Bedell, Paola Dal Cin, Christine Pak, Edwin P. Alyea, Lihua E. Budde, Robert Chen, Yi-Bin Chen, Wing C. Chan, Corey S. Cutler, Vincent T. Ho, John Koreth, Amrita Krishnan, Joyce L. Murata-Collins, Sarah Nikiforow, Joycelynne Palmer, German A. Pihan, Raju Pillai, Leslie Popplewell, Steven T. Rosen, Tanya Siddiqi, Aliyah R. Sohani, Jasmine Zain, Larry W. Kwak, Dennis D. Weisenburger, David M. Weinstock, Robert J. Soiffer, Joseph H. Antin, Stephen J. Forman, Auayporn R. Nademanee, Philippe Armand
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Article
Oncology
Sheeba K. Thomas, Soung-chul Cha, D. Lynne Smith, Kun Hwa Kim, Sapna R. Parshottam, Sheetal Rao, Michael Popescu, Vincent Y. Lee, Sattva S. Neelapu, Larry W. Kwak
Article
Oncology
Jorge E. Romaguera, Michael Wang, Lei Feng, Luis E. Fayad, Frederick Hagemeister, Peter McLaughlin, M. Alma Rodriguez, Michelle Fanale, Robert Orlowski, Larry W. Kwak, Sattva Neelapu, Yasuhiro Oki, Barbara Pro, Anas Younes, Felipe Samaniego, Nathan Fowler, Kimberly Hartig, Marisa Valentinetti, Judy Smith, Peggy Ford, Adam Naig, L. Jeffrey Medeiros, Hagop M. Kantarjian, Andre Goy
Review
Oncology
Yijun Liu, Guowei Wei, Wesley A. Cheng, Zhenyuan Dong, Han Sun, Vincent Y. Lee, Soung-Chul Cha, D. Lynne Smith, Larry W. Kwak, Hong Qin
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Article
Oncology
Robert W. Chen, Joycelynne M. Palmer, Sarah Tomassetti, Leslie L. Popplewell, Jessica Alluin, Pritsana Chomchan, Auayporn P. Nademanee, Tanya Siddiqi, Ni-Chun Tsai, Lu Chen, Fay Zuo, Rosemarie Abary, Ji-Lian Cai, Alex F. Herrera, John J. Rossi, Steven T. Rosen, Stephen J. Forman, Larry W. Kwak, Leona A. Holmberg
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Xingli Zhao, Zhuoran Zhang, Dayson Moreira, Yu-Lin Su, Haejung Won, Tomasz Adamus, Zhenyuan Dong, Yong Liang, Hongwei H. Yin, Piotr Swiderski, Raju K. Pillai, Larry Kwak, Stephen Forman, Marcin Kortylewski
Article
Hematology
Atish Mohanty, Natalie Sandoval, An Phan, Thang V. Nguyen, Robert W. Chen, Elizabeth Budde, Matthew Mei, Leslie Popplewell, Lan V. Pham, Larry W. Kwak, Dennis D. Weisenburger, Steven T. Rosen, Wing C. Chan, Markus Muschen, Vu N. Ngo
Article
Hematology
Michinori Ogura, Juan Manuel Sancho, Seok-Goo Cho, Hideyuki Nakazawa, Junji Suzumiya, Gayane Tumyan, Jin Seok Kim, Anne Lennard, Jose Mariz, Nikolai Ilyin, Wojciech Jurczak, Aurelio Lopez Martinez, Olga Samoilova, Edvard Zhavrid, Eduardo Yanez Ruiz, Marek Trneny, Leslie Popplewell, Bertrand Coiffier, Christian Buske, Woo-Seog Kim, Sang Joon Lee, Sung Young Lee, Yun Ju Bae, Larry W. Kwak
LANCET HAEMATOLOGY
(2018)
Article
Hematology
Tamer Khashab, Fredrick Hagemeister, Jorge E. Romaguera, Michelle A. Fanale, Barbara Pro, Peter McLaughlin, M. Alma Rodriguez, Sattva S. Neelapu, Luis Fayad, Anas Younes, Lei Feng, Francisco Vega, Larry W. Kwak, Felipe Samaniego
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Article
Cell Biology
Hong Qin, Zhenyuan Dong, Xiuli Wang, Wesley A. Cheng, Feng Wen, Weili Xue, Han Sun, Miriam Walter, Guowei Wei, D. Lynne Smith, Xiuhua Sun, Fan Fei, Jianming Xie, Theano I. Panagopoulou, Chun-Wei Chen, Joo Y. Song, Ibrahim Aldoss, Clarisse Kayembe, Luisa Sarno, Markus Muschen, Giorgio G. Inghirami, Stephen J. Forman, Larry W. Kwak
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Oncology
Hong Qin, Guowei Wei, Ippei Sakamaki, Zhenyuan Dong, Wesley A. Cheng, D. Lynne Smith, Feng Wen, Han Sun, Kunhwa Kim, Soungchul Cha, Laura Bover, Sattva S. Neelapu, Larry W. Kwak
CLINICAL CANCER RESEARCH
(2018)
Article
Hematology
Matthew G. Mei, Thai M. Cao, Lu Chen, Joo Y. Song, Tanya Siddiqi, Ji-Lian Cai, Leonardo T. Farol, Monzr M. Al Malki, Amandeep Salhotra, Ibrahim Aldoss, Joycelynne Palmer, Alex F. Herrera, Jasmine Zain, Leslie L. Popplewell, Robert W. Chen, Steven T. Rosen, Stephen J. Forman, Larry Kwak, Auayporn P. Nademanee, Lihua E. Budde
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2017)
Article
Oncology
Andreas Herrmann, Christoph Lahtz, Toshikage Nagao, Joo Y. Song, Wing C. Chan, Heehyoung Lee, Chanyu Yue, Thomas Look, Ronja Mulfarth, Wenzhao Li, Kurt Jenkins, John Williams, Lihua E. Budde, Stephen Forman, Larry Kwak, Thomas Blankenstein, Hua Yu
Article
Cell Biology
Young-hee Lee, Natalia Martin-Orozco, Peilin Zheng, Jing Li, Peng Zhang, Haidong Tan, Hyun Jung Park, Mira Jeong, Seon Hee Chang, Byung-Seok Kim, Wei Xiong, Wenjuan Zang, Li Guo, Yang Liu, Zhong-jun Dong, Willem W. Overwijk, Patrick Hwu, Qing Yi, Larry Kwak, Zhiying Yang, Tak W. Mak, Wei Li, Laszlo G. Radvanyi, Ling Ni, Dongfang Liu, Chen Dong
Article
Oncology
A. F. Herrera, J. Palmer, P. Martin, S. Armenian, N-C Tsai, N. Kennedy, F. Sahebi, T. Cao, L. E. Budde, M. Mei, T. Siddiqi, L. Popplewell, S. T. Rosen, L. W. Kwak, A. Nademanee, S. J. Forman, R. Chen
ANNALS OF ONCOLOGY
(2018)