The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment

A Novel Targeted Inhibitor of the Alternative Pathway of Complement and Its Therapeutic Application in Ischemia/Reperfusion Injury

(2014) Y. Huang et al.   JOURNAL OF IMMUNOLOGY

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases

(2011) M. Fridkis-Hareli et al.   BLOOD

Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival

(2011) R. J. Kelly et al.   BLOOD

Achievements and Limitations of Complement Inhibition by Eculizumab in Paroxysmal Nocturnal Hemoglobinuria: The Role of Complement Component 3

(2011) A. M. Risitano et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement

(2010) M. A. Lindorfer et al.   BLOOD

Paroxysmal nocturnal hemoglobinuria and eculizumab

(2010) L. Luzzatto et al.   HAEMATOLOGICA

Eculizumab prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and unmasks low-level extravascular hemolysis occurring through C3 opsonization

(2010) A. Hill et al.   HAEMATOLOGICA

Paroxysmal Nocturnal Hemoglobinuria — Hemolysis before and after Eculizumab

(2010) Antonio M. Risitano et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complement fraction 3 binding on erythrocytes as additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab

(2009) A. M. Risitano et al.   BLOOD

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators

(2009) Jin Wu et al.   NATURE IMMUNOLOGY

The spectrum of complement alternative pathway-mediated diseases

(2008) V. Michael Holers   IMMUNOLOGICAL REVIEWS