Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism

Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology

(2012) M.-C. Bouton et al.   BLOOD

Serpins Flex Their Muscle

(2010) James C. Whisstock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombin Inhibition by Serpins Disrupts Exosite II

(2010) Wei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand Binding Shuttles Thrombin along a Continuum of Zymogen- and Proteinase-like States

(2010) Parvathi Kamath et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation

(2010) B. C. Lechtenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anticoagulant and antithrombotic properties of platelet protease nexin-1

(2009) Y. Boulaftali et al.   BLOOD

Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function

(2009) Nicolas S. Petrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombin

(2008) Enrico Di Cera   MOLECULAR ASPECTS OF MEDICINE

Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data

(2008) W Nicholson Price II et al.   NATURE BIOTECHNOLOGY

Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex

(2008) W. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA