Hematopoietic stem cells: to be or Notch to be

Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions

(2011) D. Yao et al.   BLOOD

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

(2011) S. Weber et al.   DEVELOPMENT

Embryonic origin of the adult hematopoietic system: advances and questions

(2011) A. Medvinsky et al.   DEVELOPMENT

Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells

(2011) Barbara Varnum-Finney et al.   JOURNAL OF CLINICAL INVESTIGATION

A somitic Wnt16/Notch pathway specifies haematopoietic stem cells

(2011) Wilson K. Clements et al.   NATURE

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

(2011) Apostolos Klinakis et al.   NATURE

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Notch Lineages and Activity in Intestinal Stem Cells Determined by a New Set of Knock-In Mice

(2011) Silvia Fre et al.   PLoS One

Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo

(2010) J. Y. Bertrand et al.   BLOOD

Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

(2010) Jason M. Butler et al.   Cell Stem Cell

Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation

(2010) Agnieszka A. Wendorff et al.   IMMUNITY

The Notch pathway in the developing hematopoietic system

(2010) Anna Bigas et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

(2010) Colleen Delaney et al.   NATURE MEDICINE

Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin

(2010) Alexis Dumortier et al.   PLoS One

A Transient Niche Regulates the Specification of Drosophila Intestinal Stem Cells

(2010) D. Mathur et al.   SCIENCE

Coexistence of Quiescent and Active Adult Stem Cells in Mammals

(2010) L. Li et al.   SCIENCE

Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis

(2009) Keli Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epidermal Notch1 Loss Promotes Skin Tumorigenesis by Impacting the Stromal Microenvironment

(2009) Shadmehr Demehri et al.   CANCER CELL

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch signaling in bulge stem cells is not required for selection of hair follicle fate

(2009) S. Demehri et al.   DEVELOPMENT

Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain

(2009) Jennifer L. Moran et al.   DEVELOPMENTAL DYNAMICS

Lunatic and Manic Fringe Cooperatively Enhance Marginal Zone B Cell Precursor Competition for Delta-like 1 in Splenic Endothelial Niches

(2009) Joanne B. Tan et al.   IMMUNITY

CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia

(2009) Sara González-García et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

A new paradigm for hematopoietic cell lineages: revision of the classical concept of the myeloid–lymphoid dichotomy

(2009) Hiroshi Kawamoto et al.   TRENDS IN IMMUNOLOGY

Defective Notch activation in microenvironment leads to myeloproliferative disease

(2008) Y.-W. Kim et al.   BLOOD

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling

(2008) Melih Acar et al.   CELL

Notch Signaling Specifies Megakaryocyte Development from Hematopoietic Stem Cells

(2008) Thomas Mercher et al.   Cell Stem Cell

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

(2008) Ivan Maillard et al.   Cell Stem Cell

Fate Tracing Reveals the Endothelial Origin of Hematopoietic Stem Cells

(2008) Ann C. Zovein et al.   Cell Stem Cell

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1

(2008) Àlex Robert-Moreno et al.   EMBO JOURNAL

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

(2008) Morgan E. Carlson et al.   NATURE

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

(2008) Pedro J Real et al.   NATURE MEDICINE

Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition

(2008) Ryoichiro Kageyama et al.   NATURE NEUROSCIENCE

Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity

(2008) Shadmehr Demehri et al.   PLOS BIOLOGY