CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease

Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial

(2012) Paul P Tak et al.   ANNALS OF THE RHEUMATIC DISEASES

Pharmacokinetic and Pharmacodynamic Evaluation of the Novel CCR1 Antagonist CCX354 in Healthy Human Subjects: Implications for Selection of Clinical Dose

(2011) D J Dairaghi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Established role of bisphosphonate therapy for prevention of skeletal complications from myeloma bone disease

(2011) Evangelos Terpos et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Can bisphosphonates improve outcomes in patients with newly diagnosed multiple myeloma?

(2011) Gareth J. Morgan   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

CCR1 as a target for multiple myeloma

(2011) Sonia Vallet et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Therapeutic potential of CCR1 antagonists for multiple myeloma

(2011) Angela R Karash et al.   Future Medicinal Chemistry

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

(2011) S Vallet et al.   LEUKEMIA

Advances in the understanding of myeloma bone disease and tumour growth

(2010) Shmuel Yaccoby   BRITISH JOURNAL OF HAEMATOLOGY

Interleukin-6 in bone metastasis and cancer progression

(2010) Tasnim Ara et al.   EUROPEAN JOURNAL OF CANCER

The cytokine/chemokine pattern in the bone marrow environment of multiple myeloma patients

(2010) Yanran Cao et al.   EXPERIMENTAL HEMATOLOGY

Deficiency of Chemokine Receptor CCR1 Causes Osteopenia Due to Impaired Functions of Osteoclasts and Osteoblasts

(2010) Akiyoshi Hoshino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of CCX282-B, an Orally Bioavailable Antagonist of the CCR9 Chemokine Receptor, for Treatment of Inflammatory Bowel Disease

(2010) M. J. Walters et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

RANKL inhibition: Clinical implications for the management of patients with multiple myeloma and solid tumors with bone metastases

(2009) Evangelos Terpos et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Chemokine receptor antagonists: Part 1

(2009) James E Pease et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Increased expression of macrophage inflammatory protein-1α on trephine biopsies correlates with extensive bone disease, increased angiogenesis and advanced stage in newly diagnosed patients with multiple myeloma

(2009) M Roussou et al.   LEUKEMIA

Myeloma Bone Disease: Recent Advances in Biology, Diagnosis, and Treatment

(2009) O. Sezer   ONCOLOGIST

Therapeutic Antitumor Efficacy of Anti-CD137 Agonistic Monoclonal Antibody in Mouse Models of Myeloma

(2008) O. Murillo et al.   CLINICAL CANCER RESEARCH