Review
Biochemistry & Molecular Biology
Ji-Yoon Noh
Summary: Platelets, small anucleate blood cells critical in hemostasis, are produced by megakaryocytes from hematopoietic stem cells. Understanding key transcription factors is crucial for platelet biogenesis, as mutations can lead to disorders such as thrombocytopenia. Metabolic changes and diseases like cancer can also impact platelet production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Haodong Huang, Asma Ayaz, Minglu Zheng, Xianpeng Yang, Wajid Zaman, Huayan Zhao, Shiyou Lu
Summary: 3-ketoacyl-CoA synthases (KCSs) are key components of a fatty acid elongase (FAE) complex that determines the chain length of very-long-chain fatty acids (VLCFAs). KCS6 is well known for its role in wax synthesis, while the role of KCS5 remains unknown. This study showed that KCS5 interacts with CER2 and CER26 and displays specificity towards C24 to C28 acids. The results also suggest that KCS5 and KCS6 play redundant roles in wax biosynthesis, with KCS6 playing a major role. The mutations of both KCS5 and KCS6 nearly blocked drought-induced wax production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Milka Koupenova, Alison C. Livada, Craig N. Morrell
Summary: Platelets not only play important roles in hemostasis and thrombosis, but also have significant immune cell functions. Platelets interact and activate immune cells in response to pathogen exposures, infection, and tissue injury. The immune potential of platelets depends on their molecular composition provided by their megakaryocyte precursor, making them first responders in coordinating pathogen immune responses.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Patricia G. Santamaria, Pierre Dubus, Jose Bustos-Tauler, Alfredo Floristan, Alberto Vazquez-Naharro, Saleta Morales, Amparo Cano, Francisco Portillo
Summary: This study found that the lack of LOXL3 leads to perinatal lethality and abnormal skeletal development in mice, and LOXL2 and LOXL3 may have overlapping functions during mouse development. The widespread expression of LOXL2 can suppress the lethality associated with LOXL3 knockout mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Shilei Chen, Kangfu Sun, Baichuan Xu, Songlin Han, Song Wang, Yang Xu, Fang Chen, Mo Chen, Mingqiang Shen, Yukai Lu, Changhong Du, Mengjia Hu, Fengchao Wang, Junping Wang
Summary: Platelet shedding from mature megakaryocytes is crucial for increasing circulating platelets rapidly, and this study investigates the mechanisms behind it and identifies new therapeutic targets for thrombocytopenia.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Oncology
Jing Wang, Yongqiang Sha, Tao Sun
Summary: RNA methylation, particularly N(6)-methyladenosine (m(6)A), plays a crucial role in brain development, neurogenesis, and gliogenesis by regulating neural stem cells and their differentiation into neurons, glial cells, and astrocytes. Dysregulation of RNA methylation has been associated with brain tumor formation, highlighting its potential as a diagnostic and treatment target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Juliane Baumann, Markus Spindler, Yannick Throm, Michael Luebbert, Markus Bender
Summary: Treatment of myelodysplastic syndromes with decitabine is crucial, and early platelet response can predict overall survival. However, the effect of decitabine on megakaryocytes and bone marrow needs further investigation.
SCIENTIFIC REPORTS
(2022)
Article
Developmental Biology
Isabell Niedermoser, Tatiana Lebedeva, Grigory Genikhovich
Summary: This study investigated the role of cWnt signaling in the oral-aboral axis patterning in the cnidarian Nematostella vectensis, revealing the partial redundancy of all four Frizzled receptors in this process. However, their involvement in endoderm specification was not observed.
Review
Virology
Kunihiro Otsuka, Mami Sato, Takaaki Tsunematsu, Naozumi Ishimaru
Summary: Sjogren's syndrome is a complex autoimmune disease with virus infection, particularly Epstein-Barr virus, playing a critical role in its pathogenesis. Virus infection triggers or promotes immune responses leading to the development of Sjogren's syndrome.
Article
Medicine, Research & Experimental
Jia Lai, Yueyue Li, Mei Ran, Qianqian Huang, Feihong Huang, Linjie Zhu, Yuesong Wu, Wenjun Zou, Xiang Xie, Yong Tang, Fei Yang, Anguo Wu, Guangbo Ge, Jianming Wu
Summary: The active monomer xanthotoxin (XAT) was found to promote the differentiation and maturation of megakaryocytes and stimulate platelet formation. It activates the IL-1R1 target and MEK/ERK signaling pathway to accelerate the differentiation and maturation of megakaryocytes, providing a new pharmacotherapy strategy for thrombocytopenia.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biology
Eli K. Moore, Daniella L. Martinez, Naman Srivastava, Shaunna M. Morrison, Stephanie J. Spielman
Summary: The correlations between mineral species and bulk crustal composition of chemical elements are investigated in this study, revealing meaningful associations. Some chemical elements show connections between their presence in minerals and in crust, indicating their importance in biological roles. On the other hand, certain chemical elements show no biological significance.
Article
Nanoscience & Nanotechnology
Xiaoting Jin, Ze Zhang, Ge Guan, Qunfang Zhou, Yuxin Zheng, Guibin Jiang
Summary: The study found that SiO2 nanoparticles can promote the maturation and differentiation of megakaryocytes into platelets, and the effect of SiO2 nanoparticles is positively correlated with their size. This effect of SiO2 nanoparticles may be mediated by the upregulation of GATA-1 and FLI-1 gene expression. This finding provides new insight into the potential health risk of SiO2 nanoparticles by perturbing the platelet-involved hematological homeostasis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Neurosciences
Kexin Zhang, Pei Li, Yuanyuan Jia, Ming Liu, Jingjing Jiang
Summary: This article elucidates the multiple mechanisms of non-coding RNA and m6A methylation in the context of neuropathic pain, and summarizes its potential functions as well as recent advances.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Lisa Maria Metz, Margitta Elvers
Summary: PANX1 channels play a crucial role in platelet activation and thrombus formation, and their activation is regulated by phosphorylation. The Src-GPVI signaling pathway is identified as the main pathway for PANX1 activation, with PKC and Akt playing a minor role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Hematology
Alice Tang, Avital Mendelson
Summary: Recent studies have explored niche cells in the bone marrow microenvironment to promote platelet formation and developed an explant-based bioreactor for enhanced ex vivo platelet production. Chemical inhibitors have been investigated for their role in promoting megakaryocyte maturation and expansion. Microparticles derived from megakaryocytes or platelets have been shown to improve megakaryocyte maturation and platelet formation. These advances in regulating megakaryocyte expansion and platelet production offer promising potential for generating platelets in vitro without the need for blood donation.
CURRENT OPINION IN HEMATOLOGY
(2021)
Article
Immunology
Jason S. Weinstein, Brian J. Laidlaw, Yisi Lu, Jessica K. Wang, Vincent P. Schulz, Ningcheng Li, Edward I. Herman, Susan M. Kaech, Patrick G. Gallagher, Joe Craft
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Review
Cell Biology
Jonathan N. Thon, Brad J. Dykstra, Lea M. Beaulieu
Editorial Material
Biochemistry & Molecular Biology
Jonathan N. Thon, Sven Karlsson
TRENDS IN BIOCHEMICAL SCIENCES
(2017)
Article
Immunology
Sang Taek Kim, Jin-Young Choi, Begona Lainez, Vincent P. Schulz, David E. Karas, Eric D. Baum, Jennifer Setlur, Patrick G. Gallagher, Joe Craft
JOURNAL OF IMMUNOLOGY
(2018)
Article
Medicine, Research & Experimental
Patrick G. Gallagher, Yelena Maksimova, Kimberly Lezon-Geyda, Peter E. Newburger, Desiree Medeiros, Robin D. Hanson, Jennifer Rothman, Sara Israels, Donna A. Wall, Robert F. Sidonio, Colin Sieff, L. Kate Gowans, Nupur Mittal, Roland Rivera-Santiago, David W. Speicher, Susan J. Baserga, Vincent P. Schulz
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Multidisciplinary Sciences
Xiao Hu, Zongzhi Z. Liu, Xinyue Chen, Vincent P. Schulz, Abhishek Kumar, Amaleah A. Hartman, Jason Weinstein, Jessica F. Johnston, Elisa C. Rodriguez, Anna E. Eastman, Jijun Cheng, Liz Min, Mei Zhong, Christopher Carroll, Patrick G. Gallagher, Jun Lu, Martin Schwartz, Megan C. King, Diane S. Krause, Shangqin Guo
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Vincent P. Schulz, Hongxia Yan, Kimberly Lezon-Geyda, Xiuli An, John Hale, Christopher D. Hillyer, Narla Mohandas, Patrick G. Gallagher
Article
Hematology
Martina H. Lundberg Slingsby, Prakrith Vijey, I-Ting Tsai, Harvey Roweth, Genevieve Couldwell, Adrian R. Wilkie, Hans Gaus, Jazana M. Goolsby, Ross Okazaki, Brooke E. Terkovich, John W. Semple, Jonathan N. Thon, Scott P. Henry, Padmakumar Narayanan, Joseph E. Italiano
Summary: ASO, specifically 2'MOE ASO, have shown dose- and sequence-specific effects on platelet counts, with some sequences leading to moderate platelet activation. Higher platelet glycoprotein VI levels in donors may indicate a greater risk of ASO-induced platelet side effects.
Article
Multidisciplinary Sciences
Benedikt Hermann Siegler, Marc Altvater, Jan Niklas Thon, Christopher Neuhaus, Christoph Arens, Florian Uhle, Christoph Lichtenstern, Markus Alexander Weigand, Sebastian Weiterer
Summary: Postoperative abdominal infections are common triggers of sepsis and septic shock in intensive care units worldwide. This study found that sepsis-induced differential occupancy of CTCF within the MHC-II region in patients with postoperative sepsis leads to altered monocytic transcriptional response, suggesting an important role of CTCF in modulating the transcriptional response of immunocompromised human monocytes during critical illness.
Article
Hematology
Amanda L. Evans, Amanda Dalby, Holly R. Foster, Daniel Howard, Amie K. Waller, Momal Taimoor, Moyra Lawrence, Souradip Mookerjee, Marcus Lehmann, Annie Burton, Jorge Valdez, Jonathan Thon, Joseph Italiano, Thomas Moreau, Cedric Ghevaert
Summary: This study focuses on producing high-quality platelets using forward programming technology. By selecting suitable pluripotent stem cell lines, optimizing culture conditions, and improving factors during differentiation, successful conversion from stem cells to platelets is achieved. Additionally, by using a bioreactor to mimic the physical environment of the bone marrow, biologically active platelets are produced.
Article
Hematology
Elisabeth M. Battinelli, Jonathan N. Thon, Ross Okazaki, Christian G. Peters, Prakrith Vijey, Adrian R. Wilkie, Leila J. Noetzli, Robert Flaumenhaft, Joseph E. Italiano
Article
Hematology
Nur-Taz Rahman, Vincent P. Schulz, Lin Wang, Patrick G. Gallagher, Oleg Denisenko, Francesco Gualdrini, Cyril Esnault, Diane S. Krause
Letter
Hematology
Zhihua Jiang, Hong-Yuan Luo, John J. Farrell, Zhengjian Zhang, Vincent P. Schulz, Dilan Albarawi, Martin H. Steinberg, Nasir A. S. Al-Allawi, Patrick G. Gallagher, Bernard G. Forget, David H. K. Chui
BRITISH JOURNAL OF HAEMATOLOGY
(2018)
Article
Hematology
Edyta Glogowska, Eve R. Schneider, Yelena Maksimova, Vincent P. Schulz, Kimberly Lezon-Geyda, John Wu, Kottayam Radhakrishnan, Sioban B. Keel, Donald Mahoney, Alison M. Freidmann, Rachel A. Altura, Elena O. Gracheva, Sviatoslav N. Bagriantsev, Theodosia A. Kalfa, Patrick G. Gallagher
Article
Hematology
Emilie-Fleur Gautier, Marjorie Leduc, Meriem Ladli, Vincent P. Schulz, Carine Lefevre, Ismael Boussaid, Michaela Fontenay, Catherine Lacombe, Frederique Verdier, Francois Guillonneau, Christopher D. Hillyer, Narla Mohandas, Patrick G. Gallagher, Patrick Mayeux