Article
Multidisciplinary Sciences
Michele C. Buck, Lisa Bast, Judith S. Hecker, Jennifer Riviere, Maja Rothenberg-Thurley, Luisa Vogel, Dantong Wang, Immanuel Andrae, Fabian J. Theis, Florian Bassermann, Klaus H. Metzeler, Robert A. J. Oostendorp, Carsten Marr, Katharina S. Goetze
Summary: Clonal hematopoiesis of indeterminate potential (CHIP) is the acquisition of somatic mutations in hematopoietic stem/progenitor cells (HSPC) leading to clonal blood cell expansion. Computational modeling shows that alternative hierarchies may better describe HSPC kinetics in CHIP and MDS samples compared to the standard hematopoietic hierarchy. The reorganization of the HSPC compartment can already be detected in the premalignant CHIP state.
Article
Cell Biology
Angelo Michele Lavecchia, Kostas Pelekanos, Fabio Mavelli, Christodoulos Xinaris
Summary: In anamniotes, cell loss can be compensated through proliferation, while in amniotes, post-mitotic cells undergo polyploidization and hypertrophy to cope with increased workload from cell death. The effectiveness of compensatory hypertrophy in sustaining complete recovery of the kidney remains insufficiently addressed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sabrine Hedouin, Glennis A. Logsdon, Jason G. Underwood, Sue Biggins
Summary: This study used a targeted RNA isoform sequencing approach to identify the transcriptional landscape at and surrounding all centromeres in budding yeast. They found that most pericentromeres are transcribed throughout the cell cycle, but centromere accessibility to the transcription machinery is restricted to S-phase, which is controlled by the centromere-binding transcription factor Cbf1. Deletion of Cbf1 leads to an accumulation of cenRNAs at all phases of the cell cycle and increased chromosome mis-segregation.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Porter M. Hall, James T. Inman, Robert M. Fulbright, Tung T. Le, Joshua J. Brewer, Guillaume Lambert, Seth A. Darst, Michelle D. Wang
Summary: This study reveals that the collapse of the dCas R-loop allows RNA polymerase to read-through from the PAM-distal side during CRISPR interference, providing valuable mechanistic insights for the broad applications of CRISPR technology.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2022)
Review
Chemistry, Physical
Wujiu Zhang, Chuhan Yuan, Jifu Zhu, Ting Jin, Chao Shen, Keyu Xie
Summary: This review comprehensively and critically explores the issue of air instability in Ni-rich layered oxides and reviews various modification strategies. The authors propose further research and provide perspectives for achieving practical applications of Ni-rich layered oxides.
ADVANCED ENERGY MATERIALS
(2023)
Review
Rheumatology
Patrick Maschmeyer, Hyun-Dong Chang, Qingyu Cheng, Mir-Farzin Mashreghi, Falk Hiepe, Tobias Alexander, Andreas Radbruch
Summary: The lack of cure for chronic inflammatory diseases may be due to pathogenic memory cells of the immune system driving the inflammation. Resetting the immune system by ablating immune cells and regenerating it from stem cells has shown success in achieving therapy-free remission. Targeting pathogenic immune memory cells, particularly pathogenic T lymphocytes, offers new therapeutic options for chronic inflammation.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Article
Management
Filippo Mezzanotti
Summary: The study found that changes in patent enforcement led to a general increase in innovation and reduced some distortions caused by patent litigation. Patent litigation has a negative impact on investment by lowering returns from R&D and exacerbating financing constraints.
MANAGEMENT SCIENCE
(2021)
Review
Neurosciences
Maxime Gauberti, Sara Martinez de Lizarrondo
Summary: The use of magnetic resonance imaging (MRI) to detect molecular targets in the central nervous system non-invasively has drawn interest for many years. Recent advances in using large superparamagnetic probes like micro-sized particles of iron oxide (MPIO) have significantly improved the sensitivity of molecular MRI in neuroinflammation studies.
Review
Environmental Sciences
Vishal Sharma, Mei-Ling Tsai, Parushi Nargotra, Chiu-Wen Chen, Pei -Pei Sun, Reeta Rani Singhania, Anil Kumar Patel, Cheng-Di Dong
Summary: This review provides an in-depth understanding of the journey of lignin from being considered a roadblock to a bridge connecting diverse industries with widescale applications. It summarizes and compares the recent advances in lignin extraction and depolymerization methods, outlines the industrial potential of lignin-derived products, and highlights the present scenario of technological-industrial applications of lignin with economic perspectives.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Hongjiao Li, Yi Wang, Fenfang Yang, Shuang Feng, Kaijing Chang, Xinwen Yu, Feng Guan, Xiang Li
Summary: In this study, the association between MDS/AML clonal cells and BMMSCs differentiation was explored using clinical samples, coculture models and mouse models. It was found that clonal MDS/AML cells promoted adipogenic differentiation and inhibited osteogenic differentiation of BMMSCs, which in turn promoted MDS expansion. Moreover, the highly expressed transcription factor TWIST1 in clonal MDS/AML cells induced MDS/AML cells to secrete more IFN-gamma, causing enhanced adipogenic differentiation and inhibited osteogenic differentiation in BMMSCs.
Review
Cell Biology
Abigail Johnson, Michelle Townsend, Kim O'Neill
Summary: Chimeric antigen receptor (CAR) T cells have shown significant success in treating hematological cancers, but their effectiveness in solid tumors is hindered by the immunosuppressive factors of the tumor microenvironment (TME). This article discusses these immunosuppressive elements and reviews recent advancements in CAR T-cell development.
Article
Biochemistry & Molecular Biology
Kenneth Lundstrom, Debmalya Barh, Bruce D. Uhal, Kazuo Takayama, Alaa A. A. Aljabali, Tarek Mohamed Abd El-Aziz, Amos Lal, Elrashdy M. Redwan, Parise Adadi, Gaurav Chauhan, Samendra P. Sherchan, Gajendra Kumar Azad, Nima Rezaei, Angel Serrano-Aroca, Nicolas G. Bazan, Sk Sarif Hassan, Pritam Kumar Panda, Pabitra Pal Choudhury, Damiano Pizzol, Ramesh Kandimalla, Wagner Baetas-da-Cruz, Yogendra Kumar Mishra, Giorgio Palu, Adam M. Brufsky, Murtaza M. Tambuwala, Vladimir N. Uversky
Summary: The European Medicines Agency has approved four different types of COVID-19 vaccines, which play an important role in preventing COVID-19. However, in some individuals, adverse reactions such as thrombosis with associated thrombocytopenia may occur. These events may be related to interactions between viral proteins and receptors, viral vector interactions with antibodies, and individual immune mechanisms, especially requiring validation in risk groups.
Article
Chemistry, Analytical
Aaron J. Goodman, Sandra Kanapilly, Anthony J. Bednar, James F. Ranville
Summary: The recent expansion of spICP-MS for analysis of inorganic nanoparticles requires further method development to address spectral interferences, particularly particle-generated interferences. This study investigates the formation of interferences from ablated nanoparticles and proposes strategies for their mitigation.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Green & Sustainable Science & Technology
Caoxing Huang, Xiao Jiang, Xiaojun Shen, Jinguang Hu, Wei Tang, Xinxing Wu, Arthur Ragauskas, Hasan Jameel, Xianzhi Meng, Qiang Yong
Summary: Efficiently producing second-generation biofuels from biomass remains a long-term challenge due to biomass recalcitrance. Lignin significantly contributes to biomass recalcitrance by physically limiting enzyme access to carbohydrates. Research is focused on mitigating the negative effects of lignin on enzyme performance.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2022)
Article
Cell Biology
Jiqin Wu, Haofeng Wang, Qiaojie Liu, Rui Li, Yan Gao, Xiang Fang, Yao Zhong, Meihua Wang, Quan Wang, Zihe Rao, Peng Gong
Summary: Remdesivir, a nucleotide analog, has shown effectiveness in treating COVID19, but its precise working mechanism targeting viral RNA-dependent RNA polymerase is not fully elucidated. This study provides insights into RDV intervention in polymerase elongation phase and highlights the potential of modified nucleotide analogs in developing broad-spectrum anti-RNA virus drugs.